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51. 发明申请

WO1989012632A1 METHOD OF PREPARING SPHINGOSINE DERIVATIVES AND AN ALDEHYDE USED THEREIN 审中-公开
标题翻译：制备丝氨酸衍生物的方法及其使用的阿尔德
公开(公告)号：WO1989012632A1
公开(公告)日：1989-12-28
申请号：PCT/US1989002633
申请日：1989-06-14
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , MERRILL, Alfred, H., Jr. , LIOTTA, Dennis
IPC分类号： C07D263/06
CPC分类号： C07C215/24 , C07C271/16 , C07D263/06
摘要： A method of preparing a substituted derivative of sphingosine comprising the steps of reducing serine methyl ester by a hydride reagent to form an aldehyde or aldehyde derivative, adding acetylide anions to the aldehyde to form propargyl alcohol, inverting the propargyl alcohol by SN2 inversion to form a threo-isomer, and functionalizing the 4 and 5 position of the threo-isomer.

52. 发明申请

WO1989011277A2 PORPHYRIN AND PHTHALOCYANINE ANTIVIRAL COMPOSITIONS 审中-公开
标题翻译：卟啉和酞菁抗病毒组合物
公开(公告)号：WO1989011277A2
公开(公告)日：1989-11-30
申请号：PCT/US1989002256
申请日：1989-05-23
申请人： GEORGIA STATE UNIVERSITY FOUNDATION, INC. , EMORY UNIVERSITY , SCHINAZI, Raymond, F.
发明人： GEORGIA STATE UNIVERSITY FOUNDATION, INC. , EMORY UNIVERSITY , DIXON, Dabney, White , MARZILLI, Luigi, G.
IPC分类号： A61K31/40
CPC分类号： A61K31/44 , A61K31/40 , A61K31/66 , A61K31/70 , A61K33/24 , A61K38/21 , A61K31/195 , A61K31/185 , A61K2300/00
摘要： Compositions for the inhibition of replication of human immunodeficiency virus containing one or more ''porphyrins'' possessing antiviral activity. As used herein ''porphyrins'' includes porphyrins, phthalocyanines, chlorins, metallo derivatives thereof, and other porphyrin-like compounds. Examples of natural and synthetic, positively, negatively, and neutrally charged porphyrins, phthalocyanines, and derivatives thereof have been found to exhibit selective anti-HIV activity which is not dependent on the presence of light.
摘要翻译：含有一种或多种具有抗病毒活性的卟啉的用于抑制人类免疫缺陷病毒复制的制剂。术语“卟啉”包括适当的卟啉，酞菁，氯，它们的金属衍生物以及其他卟啉类化合物。已经发现具有正电荷，负电荷或中性电荷的卟啉，酞菁及其衍生物的实例表现出与光的存在无关的选择性抗HIV活性。

53. 发明申请

WO1987006836A1 FIBRINOLYTIC COMPOSITION 审中-公开
标题翻译：纤维素组合物
公开(公告)号：WO1987006836A1
公开(公告)日：1987-11-19
申请号：PCT/US1987001067
申请日：1987-05-08
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , HUNTER, Robert, L. , DUNCAN, Alexander
IPC分类号： A61K37/54
CPC分类号： A61K31/765 , A01N1/021 , A01N1/0226 , A61K38/166 , A61K38/446 , A61K38/49 , A61K31/047 , A61K35/14 , A61K31/715 , A61K2300/00
摘要： A composition that is effective in dissolving blood clots and reestablishing and maintaining blood flow through thrombosed coronary or other blood vessels. The fibrinolytic composition of the present invention comprises an enzyme, such as streptokinase, urokinase, tissue plasminogen activator or other fibrinolytic enzyme, and a surface-active copolymer. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH, wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000, preferably approximately 1750 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50 % to 90 % by weight of the compound.
摘要翻译：一种有效地溶解血块并通过血栓冠状动脉或其他血管重新建立和维持血液流动的组合物。本发明的纤维蛋白溶解组合物包含酶，例如链激酶，尿激酶，组织纤溶酶原激活剂或其它纤维蛋白溶解酶，和表面活性共聚物。表面活性共聚物可以是具有以下通式的环氧乙烷 - 环氧丙烷缩合产物：HO（C 2 H 4 O）b（C 3 H 6 O）a（C 2 H 4 O）b H，其中a是（C 3 H 6 O）表示的疏水基具有分子量为约950至4000，优选约1750至3500，b为使（C2H4O）表示的亲水部分构成化合物的约50重量％至90重量％的整数。

54. 发明申请

WO1986007539A1 BIOLOGICALLY-ACTIVE COPOLYMERS 审中-公开
标题翻译：生物活性共聚物
公开(公告)号：WO1986007539A1
公开(公告)日：1986-12-31
申请号：PCT/US1986001315
申请日：1986-06-18
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , HUNTER, Robert, L.
IPC分类号： A61K31/74
CPC分类号： C08L71/02 , A61K31/785 , C08G65/2624
摘要： Biologically-active copolymers and compounds that can be safely used to cause the thymus of an animal or human to increase in size, thereby replenishing the T-lymphocyte population. When injected into an animal or human with an antigen, the biologically-active copolymers cause immunosuppression to the antigen. The biologically active copolymers are also useful as growth promoters for animals. Compounds within the biologically-active copolymers of the present invention are effective tumoricidal agents. The biologically-active copolymer of the present invention is a safe and non-toxic formulation that can effectively be administered to animals or humans. The biologically-active copolymer can be mixed in an oil and water emulsion and administered to an animal or human by injection.
摘要翻译：生物活性共聚物和化合物可以安全地用于引起动物或人的胸腺的大小增加，从而补充T淋巴细胞群体。当用抗原注射到动物或人类中时，生物活性共聚物对抗原产生免疫抑制。生物活性共聚物也可用作动物的生长促进剂。本发明生物活性共聚物内的化合物是有效的杀肿剂。本发明的生物活性共聚物是可以有效地施用于动物或人的安全且无毒的制剂。生物活性共聚物可以在油和水乳液中混合，并通过注射给予动物或人。

55. 发明申请

WO1998020037A1 METHOD FOR TREATING CERTAIN PEDIATRIC ACUTE LEUKEMIAS 审中-公开
标题翻译：治疗某些轻度急性淋巴细胞白血病的方法
公开(公告)号：WO1998020037A1
公开(公告)日：1998-05-14
申请号：PCT/US1997020066
申请日：1997-11-05
申请人： EMORY UNIVERSITY , FINDLEY, Harry, W. , YEAGER, Andrew, M.
发明人： EMORY UNIVERSITY
IPC分类号： C07K14/21
CPC分类号： C07K16/2866 , A61K38/00 , A61K47/6829 , A61K47/6849 , C07K14/5412 , C07K2319/00
摘要： Applicants purge leukemia cells from pediatric patients having certain acute leukemias, by contacting cells with a conjugate of a cellular toxin and a cell binding agent specific for such leukemia cells, such as fusion protein IL-6-PE, which binds to cells with large quantities of cell surface IL-6 receptor. Various procedures can be used in such treatment, including ex vivo bone marrow purging, autologous bone marrow transplantation, and in vivo treatment of minimal residual disease after such transplantation.
摘要翻译：通过将细胞与细胞毒素和对这种白血病细胞特异性的细胞粘附剂（例如融合蛋白IL-6-PE）接触的细胞与大量的细胞结合，从而清除具有某些急性白血病的儿科患者的白血病细胞。的细胞表面IL-6受体。在这种治疗中可以使用各种方法，包括离体骨髓清除，自体骨髓移植，以及移植后的最小残留疾病的体内治疗。

56. 发明申请

WO1998010057A1 METHODS FOR TESTING COMPOUNDS FOR USE AS THERAPEUTIC ANTIOXIDANTS 审中-公开
标题翻译：测试化合物用作治疗抗氧化剂的方法
公开(公告)号：WO1998010057A1
公开(公告)日：1998-03-12
申请号：PCT/US1997015814
申请日：1997-09-05
申请人： EMORY UNIVERSITY , DUKE UNIVERSITY
发明人： EMORY UNIVERSITY , DUKE UNIVERSITY , WALLACE, Douglas, C. , MELOV, Simon, L. , CRAPO, James, D. , DAY, Brian, J.
IPC分类号： C12N05/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , A61K49/0008 , C12N9/0089
摘要： The present application describes methods for the testing of compounds of potential usefulness as therapeutic antioxidants and/or as therapeutic free radical scavengers. The animal model for testing such compounds is the Sod2CJE homozygous Manganese Superoxide Dismutase-deficient mouse. When pups of these mice are treated with certain antioxidants, they survive past about 7 days of age, and later develop characteristic histological changes and characteristic neurobehavioral disorders. Those treated mice can be further treated with test compounds which may or may not cross the blood brain barrier, and the life span and physical and neurobehavioral characteristics of those mice provide information about the potential utility of the test compound as a therapeutic antioxidant. Phenotypes of the treated mice allow conclusions regarding targeted areas of the brain and thus, applications to particular disorders such as Parkinsonism.
摘要翻译：本申请描述了测试作为治疗性抗氧化剂和/或作为治疗性自由基清除剂的潜在有用性的化合物的方法。用于测试这些化合物的动物模型是Sod2CJE纯合的锰超氧化物歧化酶缺陷型小鼠。当这些小鼠的幼仔用某些抗氧化剂处理时，它们可以在约7天龄之后存活，并且随后发展特征性组织学变化和特征性神经行为障碍。那些治疗的小鼠可以进一步用可能或不可能穿过血脑屏障的测试化合物进行治疗，并且这些小鼠的寿命和物理和神经行为特征提供了关于测试化合物作为治疗性抗氧化剂的潜在效用的信息。经处理的小鼠的表型允许关于脑的目标区域的结论，因此可以应用于特定疾病如帕金森综合征。

57. 发明申请

WO1997049725A1 MODIFIED FACTOR VIII 审中-公开
标题翻译：修改因子八
公开(公告)号：WO1997049725A1
公开(公告)日：1997-12-31
申请号：PCT/US1997011155
申请日：1997-06-26
申请人： EMORY UNIVERSITY , LOLLAR, John, S.
发明人： EMORY UNIVERSITY
IPC分类号： C07K14/00
CPC分类号： C07K14/755 , A61K38/00 , C07K2319/00
摘要： Modified Factor VIII proteins, methods of making modified Factor VIII proteins and DNA encoding modified Factor VIII proteins are disclosed.
摘要翻译：公开了修饰的因子VIII蛋白质，制备修饰的因子VIII蛋白质的方法和编码修饰的因子VIII蛋白质的DNA。

58. 发明申请

WO1997037738A1 SYSTEM FOR TREATING PATIENTS WITH ANXIETY DISORDERS 审中-公开
标题翻译：用恶性疾病治疗患者的系统
公开(公告)号：WO1997037738A1
公开(公告)日：1997-10-16
申请号：PCT/US1997004880
申请日：1997-03-26
申请人： EMORY UNIVERSITY , GEORGIA TECH RESEARCH CORPORATION
发明人： EMORY UNIVERSITY , GEORGIA TECH RESEARCH CORPORATION , HODGES, Larry, F. , ROTHBAUM, Barbara, O.
IPC分类号： A63G31/00
CPC分类号： A61M21/00 , A61M2021/0027 , A61M2021/0033 , A61M2021/005
摘要： A virtual reality system provides effective exposure treatment for psychiatric patients suffering from a particular anxiety disorder. The system is characterized by a video screen (22) disposed in front of the patient to display an image of a specific graphical environment that is intended to trigger anxiety within the patient as a result of the particular patient phobia. A headset (20) is worn by the patient, and has sensors (25) disposed to detect movement and positioning of the patient's head. A computer program controls the operation of the system, and is designed to control the display of the graphical environment on the video screen, monitor the headset sensors, determine the position of the patient's head, and controllably manipulate the graphical environment displayed on the video screen to reflect the movement and position of the patient's head. In a preferred embodiment, a sensor is provided to automatically detect a level of patient anxiety. The computer program is designed to monitor this sensor, and controllably manipulate the graphical environment displayed on the video screen in response thereto. In other embodiments, sound and tactile feedback are provided to further enhance the graphic emulation.
摘要翻译：虚拟现实系统为患有特殊焦虑障碍的精神病患者提供有效的暴露治疗。该系统的特征在于设置在患者前面的视频屏幕（22），以显示特定图形环境的图像，该特定图形环境旨在由于特定的患者恐惧而引起患者内的焦虑。头戴式耳机（20）由患者佩戴，并且设置有用于检测患者头部的移动和定位的传感器（25）。计算机程序控制系统的操作，并且被设计为控制在视频屏幕上的图形环境的显示，监视耳机传感器，确定患者头部的位置，以及可控地操纵显示在视频屏幕上的图形环境以反映患者头部的运动和位置。在优选实施例中，提供传感器来自动检测患者焦虑程度。计算机程序被设计为监视该传感器，并且响应于此可控地操纵显示在视频屏幕上的图形环境。在其他实施例中，提供声音和触觉反馈以进一步增强图形仿真。

59. 发明申请

WO1996040079A1 METHOD AND COMPOSITIONS FOR CONTROLLING ORAL AND PHARYNGEAL PAIN USING CAPSAICINOIDS 审中-公开
标题翻译：方法和组合物，用于控制口服和皮肤疼痛使用CAPSAICINOIDS
公开(公告)号：WO1996040079A1
公开(公告)日：1996-12-19
申请号：PCT/US1996010034
申请日：1996-06-07
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , BYAS-SMITH, Michael, G.
IPC分类号： A61K09/24
CPC分类号： A61K9/0056 , A61K31/165
摘要： Methods and compositions are provided for the oral delivery of temporally increasing concentrations of capsaicin, its derivatives, and analogs (collectively, "capsaicinoids"), to provide oral or pharyngeal analgesia while minimizing sensations of nausea and burning associated with the oral administration of capsaicinoids. The methods and compositions described herein soothe and relieve oral or pharynx pain. In one embodiment, one or more capsaicinoids are dispersed within a lollipop, with successively decreasing concentrations of capsaicin from the center out to the periphery, and administered to a patient in need of amelioration of oral pain. Alternatively, the capsaicinoid can be dispersed, with decreasing concentrations from the center to the periphery, in a tablet, caplet, lozenge, troche, pill, candy, or similar formulation. Capsaicinoids include dihydrocapsaicin, norhydrocapsaicin, homocapsaicin, homodihydrocapsaicin I, norhydrocapsaicin, homodihydrocapsaicin, nordihydrocapsaicin, civamide, nonivamide, NE-19550 (also called olvanil), NE-21610, NE-28345 (also called N-oleylhomovanillamide, their analogs, and derivatives.
摘要翻译：提供方法和组合物用于口服递送浓度的辣椒素，其衍生物和类似物（统称为“辣椒素”），以提供口服或咽痛镇痛，同时最小化与口服给予辣椒素相关的恶心和灼热感。本文描述的方法和组合物舒缓和缓解口腔或咽部疼痛。在一个实施方案中，将一种或多种辣椒素分散在棒棒糖中，并且从中心向外周期逐渐降低辣椒素的浓度，并将其施用于需要改善口腔疼痛的患者。或者，辣椒素可以以片剂，小片，锭剂，锭剂，丸剂，糖果或类似制剂的浓度从中心到周围分散。辣椒素类包括二氢氢化辣椒素，去氢辣椒素，高二氢辣椒素，异二氢辣椒碱I，去氢辣椒素，同二氢辣椒素，去二氢辣椒素，麝香酰胺，非酰胺，NE-19550（也称为olvanil），NE-21610，NE-28345（也称为N-油基高丝氨酰胺，其类似物和衍生物）。

60. 发明申请

WO1996035398A1 INTRAOCULAR LENS FOR ADJUSTMENT OF OPTICAL POWER 审中-公开
标题翻译：用于调整光功率的内窥镜
公开(公告)号：WO1996035398A1
公开(公告)日：1996-11-14
申请号：PCT/US1996006451
申请日：1996-05-08
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , THOMPSON, Keith, P.
IPC分类号： A61F02/16
CPC分类号： A61F2/1635 , A61F2/1613 , A61F2/1648
摘要： An accommodating lens (22) is designed to be inserted into a substantially intact capsulary bag having a capsulorexis opening in its anterior wall. The lens has an accommodating portion adapted to be affixed to the anterior wall of the capsulary bag adjacent the opening. The focal length of the deformable portion is alterable by insertion of a deforming material into the deformable portion (28) thereof. In another embodiment, the focal length of a second deformable portion of the lens is varied by insertion or extraction of deformable material into or from the second portion (48).
摘要翻译：设置容纳透镜（22）插入到其前壁中具有开放的脓毒症的基本完整的荚膜袋中。透镜具有容纳部分，其适于固定到邻近开口处的荚膜袋的前壁。可变形部分的焦距可以通过将变形材料插入到其变形部分（28）中来改变。在另一个实施例中，透镜的第二可变形部分的焦距通过将可变形材料插入或从第二部分（48）中提取而变化。

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