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1. 发明申请

WO1990007336A1 METHODS AND COMPOSITIONS FOR TREATMENT OF PATHOLOGICAL HYDROPHOBIC INTERACTIONS IN BIOLOGICAL FLUIDS 审中-公开
标题翻译：用于治疗生物流体病理学间的相互作用的方法和组合物
公开(公告)号：WO1990007336A1
公开(公告)日：1990-07-12
申请号：PCT/US1989005852
申请日：1989-12-28
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , HUNTER, Robert, L.
IPC分类号： A61K31/74
CPC分类号： A61K31/765 , A01N1/021 , A01N1/0226 , A61K31/77 , A61K38/166 , A61K38/446 , A61K38/49 , Y10S424/13 , A61K2300/00
摘要： In accordance with the present invention, a method and composition is provided for treating pathological hydrophobic interactions in biological fluids in which there is acute impairment of the circulation, especially the microcirculation. More particularly, the present invention relates to compositions and methods for treating circulatory diseases comprising using certain ethylene oxide-propylene oxide condensation surface active copolymers either alone or in combination with other compounds. The surface active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH, wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000, preferably approximately 1750 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50 % to 95 % by weight of the compound.
摘要翻译：根据本发明，提供了一种治疗生物流体中的病理学疏水相互作用的方法和组合，其中存在循环的急性损伤，特别是微循环。更具体地说，本发明涉及用于治疗循环系统疾病的组合物和方法，包括单独或与其它化合物组合使用某些环氧乙烷 - 环氧丙烷缩合表面活性共聚物。表面活性共聚物可以是具有以下通式的环氧乙烷 - 环氧丙烷缩合产物：HO（C 2 H 4 O）b（C 3 H 6 O）a（C 2 H 4 O）b H，其中a是（C 3 H 6 O）表示的疏水基具有分子量约为950至4000，优选约为1750至3500，b为使（C2H4O）表示的亲水部分构成化合物的约50％至95％的整数。

2. 发明申请

WO1993003738A1 METHOD FOR TREATING VASCULAR OBSTRUCTIONS CAUSED BY ABNORMAL CELLS 审中-公开
标题翻译：用于治疗由异常细胞引起的血管阻塞的方法
公开(公告)号：WO1993003738A1
公开(公告)日：1993-03-04
申请号：PCT/US1992006867
申请日：1992-08-14
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , HUNTER, Robert, L.
IPC分类号： A61K31/745
CPC分类号： A61K31/77 , A61K31/765 , A61K38/166 , A61K38/446 , A61K38/49 , Y02A50/411 , A61K2300/00
摘要： In accordance with the present invention, a method is provided for treating ischemia resulting from microvascular compromise caused by abnormal cells in the blood stream, which is often a complication of malaria and leukemia. The method is especially useful for treating cerebral malaria. The method comprises administering to an animal or human with the microvascular compromise a therapeutically effective amount of a surface active copolymer with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000 daltons, preferably about 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50% to 90% by weight of the copolymer.
摘要翻译：根据本发明，提供了一种用于治疗由血流异常细胞引起的微血管妥协导致的缺血的方法，其通常是疟疾和白血病的并发症。该方法特别适用于治疗脑疟疾。该方法包括向具有微血管损伤的动物或人体施用治疗有效量的具有以下通式的表面活性共聚物：HO（C 2 H 4 O）b（C 3 H 6 O）a（C 2 H 4 O）b H其中a是整数，使得疏水基由（C 3 H 6 O）表示的分子量为约950〜4000道尔顿，优选约1200〜3500道尔顿，b为使（C2H4O）表示的亲水部分占共聚物的约50〜90重量％。

3. 发明申请

WO1988006038A1 ANTIINFECTIVE COMPOUNDS AND METHOD OF USE 审中-公开
标题翻译：抗生物化合物及其使用方法
公开(公告)号：WO1988006038A1
公开(公告)日：1988-08-25
申请号：PCT/US1988000510
申请日：1988-02-19
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , HUNTER, Robert, L.
IPC分类号： A61K31/77
CPC分类号： C08G65/30 , A61K31/765 , A61K31/77 , A61K31/70 , A61K31/74 , C08L71/02 , A61K2300/00
摘要： Compound and method which inhibits the growth of mycobacteria and a method of treating humans or animals with the compound. The present invention also includes a composition useful for treating bacterial infections comprising a mixture of a nonionic block copolymer and a conventional antibiotic. Several conventional antibiotics that can be used with the nonionic copolymer include, but are not limited to, refampin, isoniazid, ethambutol, gentamicin, tetracycline, and erythromycin. The present invention also includes a method for treating a viral infection in a human or animal including infections caused by the HLTV-III virus or virus strains related to the HLTV-III virus. The present invention comprises a surface active copolymer, preferably an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of about 1200 to 4000, preferably about 1750 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 10 % to 50 % by weight of the compound.
摘要翻译：抑制分枝杆菌生长的化合物和方法以及用该化合物治疗人或动物的方法。本发明还包括可用于治疗细菌感染的组合物，其包含非离子嵌段共聚物和常规抗生素的混合物。可以与非离子共聚物一起使用的几种常规抗生素包括，但不限于，补血因子，异烟肼，乙胺丁醇，庆大霉素，四环素和红霉素。本发明还包括治疗人或动物的病毒感染的方法，包括由HLTV-III病毒引起的感染或与HLTV-III病毒相关的病毒株。本发明包括表面活性共聚物，优选具有以下通式的环氧乙烷 - 环氧丙烷缩合产物：HO（C 2 H 4 O）b（C 3 H 6 O）a（C 2 H 4 O）b H其中a是整数，使得由（C 3 H 6 O））的分子量为约1200至4000，优选约1750至3500，并且b为整数，使得由（C 2 H 4 O）表示的亲水部分构成化合物的约10重量％至50重量％。

4. 发明申请

WO1995012310A1 COMPOSITION FOR TISSUE AND ORGAN TRANSPLANTATION PRESERVATION 审中-公开
标题翻译：组织和组织移植保存组合物
公开(公告)号：WO1995012310A1
公开(公告)日：1995-05-11
申请号：PCT/US1994012622
申请日：1994-11-02
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , HUNTER, Robert, L.
IPC分类号： A01N01/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： In accordance with the present invention, a composition and method is provided for preserving organs and tissue for transplantation. More particularly, the present invention relates to a method for preserving organs and tissues by perfusing the organ or tissue with a perfusion medium containing an effective amount of a polyoxypropylene/polyoxyethylene surface-active copolymer. The surface-active copolymer may be an ethylene oxide-propylene oxide condensation product with the following general formula (I): HO(C2H4O)b(C3H6O)a(C2H4O)bH, wherein a is an integer such that the hydrophobe represented by (C3H6O) has molecular weight of approximately 950 to 4000 daltons, preferably approximately 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50 % to 90 % by weight of the compound.
摘要翻译：根据本发明，提供了用于保存移植器官和组织的组合物和方法。更具体地，本发明涉及通过用含有效量的聚氧丙烯/聚氧乙烯表面活性共聚物的灌注培养基灌注器官或组织来保存器官和组织的方法。表面活性共聚物可以是具有以下通式（I）的环氧乙烷 - 环氧丙烷缩合产物：HO（C 2 H 4 O）b（C 3 H 6 O）a（C 2 H 4 O）b H，其中a是整数，使得由（ C3H6O）的分子量为约950〜4000道尔顿，优选为1200〜3500道尔顿，b为使（C2H4O）表示的亲水部分构成化合物的约50〜90重量％的整数。

5. 发明申请

WO1992000101A1 IMPROVED ADJUVANTS AND VACCINES 审中-公开
标题翻译：改进的调查和疫苗
公开(公告)号：WO1992000101A1
公开(公告)日：1992-01-09
申请号：PCT/US1991004716
申请日：1991-06-27
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , HUNTER, Robert, L. , TAKAYAMA, Kuni, K.
IPC分类号： A61K39/42
CPC分类号： A61K39/39 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , Y02A50/396
摘要： The present invention comprises adjuvants which, when admixed with an antigen and administered into a human or animal, will induce a more intense immune response to the antigen than when the antigen is administered alone. In many cases, the adjuvant that is described as the present invention will increase overall titer of antibodies of a specific isotype which are specific for the antigen. For example, in mice, when the adjuvant of the present invention is admixed with a conventional antigen, the isotype that is induced in the mouse is changed from a predominantly IgG1 isotype to the more protective IgG2 isotype and, in some cases, IgG3 isotype. Thus, by practicing the present invention, one can improve the overall protective effect of conventional vaccines.
摘要翻译：本发明包括当与抗原混合并施用于人或动物时，与单独施用抗原时相比，诱导对抗原的更强烈的免疫应答的佐剂。在许多情况下，描述为本发明的佐剂将增加特异性抗原特异性同种型的抗体的总滴度。例如，在小鼠中，当将本发明的佐剂与常规抗原混合时，在小鼠中诱导的同种型从主要IgG1同种型变为更保护的IgG2同种型，并且在一些情况下由IgG3同种型改变。因此，通过实施本发明，可以提高常规疫苗的整体保护作用。

6. 发明申请

WO1988001873A1 VACCINE AND METHOD OF PREPARATION 审中-公开
标题翻译：疫苗及其制备方法
公开(公告)号：WO1988001873A1
公开(公告)日：1988-03-24
申请号：PCT/US1987002056
申请日：1987-08-19
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , HUNTER, Robert, L.
IPC分类号： A61K39/02
CPC分类号： A61K39/385 , A61K39/39 , A61K2039/55555 , A61K2039/6068 , Y02A50/412 , Y02A50/482 , Y02A50/484
摘要： A bacterial protein conjugated to small antigenic determinants such as peptides or other small haptens. The bacterial protein that is used in the present invention is bacterial flagella. The flagella may be derived from any flagellated microorganisms; however, those from Salmonella species are preferred. The bacterial flagella can be in the native polymerized form or can be repolymerized flagellin. The vaccine is especially effective for vaccinating a human or animal against a peptide or other small hapten. The improved vaccine provides a prolonged and potent immune response against the peptide or other small hapten.
摘要翻译：与小抗原决定簇如肽或其他小型半抗原结合的细菌蛋白。本发明中使用的细菌蛋白是细菌鞭毛。鞭毛可能来源于任何鞭毛的微生物; 然而，来自沙门氏菌属的那些是优选的。细菌鞭毛可以是天然聚合形式或可以是鞭毛蛋白的重聚。该疫苗对于针对肽或其他小半抗原接种人或动物特别有效。改进的疫苗提供针对肽或其他小半抗原的延长且有效的免疫应答。

7. 发明申请

WO1987006831A1 COMPOSITION AND METHOD FOR TREATING A THROMBUS AND EMBOLUS 审中-公开
标题翻译：用于治疗血栓栓塞和栓塞的组合物和方法
公开(公告)号：WO1987006831A1
公开(公告)日：1987-11-19
申请号：PCT/US1986001747
申请日：1986-08-25
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , HUNTER, Robert, L. , DUNCAN, Alexander
IPC分类号： A61K31/74
CPC分类号： A61K38/446 , A01N1/021 , A01N1/0226 , A61K31/765 , A61K38/166 , A61K38/49 , A61K2300/00
摘要： Composition which provides a synergistic action in dissolving blood clots and reestablishing and maintaining blood flow through a thrombosed coronary vessel or other blood vessel. The clot-dissolving composition of the present invention is a solution containing an effective concentration of a proteolytic enzyme and an effective concentration of a surface active copolymer. The surface active copolymer is preferably an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH, wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of about 950 to 4000 and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes from about 50 % to 90 % by weight of the compound. The proteolytic enzymes that can be used in the clot-dissolving composition of the present invention include, but are not limited to, streptokinase, urokinase, and tissue plasminogen activator.
摘要翻译：在溶血凝块中提供协同作用并重建和维持血流通过血栓冠状血管或其他血管的组合物。本发明的凝块溶解性组合物是含有有效浓度的蛋白水解酶和有效浓度的表面活性共聚物的溶液。表面活性共聚物优选为具有以下通式的环氧乙烷 - 环氧丙烷缩合产物：HO（C 2 H 4 O）b（C 3 H 6 O）a（C 2 H 4 O）b H，其中a为（C 3 H 6 O）表示的疏水基具有分子量为约950〜4000，b为使（C2H4O）表示的亲水部分占化合物的约50〜90重量％的整数。可用于本发明的凝块溶解组合物中的蛋白水解酶包括但不限于链激酶，尿激酶和组织纤溶酶原激活剂。

8. 发明申请

WO1993000160A1 MULTIPLE EMULSIONS AND METHODS OF PREPARATION 审中-公开
标题翻译：多种乳液和制备方法
公开(公告)号：WO1993000160A1
公开(公告)日：1993-01-07
申请号：PCT/US1992005419
申请日：1992-06-25
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , HUNTER, Robert, L. , BENNETT, Carol, Elizabeth
IPC分类号： B01J13/00
CPC分类号： A61Q19/00 , A61K8/06 , A61K8/064 , A61K8/066 , A61K8/90 , A61K9/113 , A61K39/39 , A61K2039/55566 , Y02A50/466
摘要： The present invention relates to water-in-oil and water-in-oil multiple emulsions and methods of preparation for use in numerous applications including vaccine adjuvants, pharmaceuticals, cosmetics, foods, and various household and industrial applications.
摘要翻译：本发明涉及油包水和油包水多重乳液以及用于许多应用中的制备方法，包括疫苗佐剂，药物，化妆品，食品以及各种家用和工业应用。

9. 发明申请

WO1987006836A1 FIBRINOLYTIC COMPOSITION 审中-公开
标题翻译：纤维素组合物
公开(公告)号：WO1987006836A1
公开(公告)日：1987-11-19
申请号：PCT/US1987001067
申请日：1987-05-08
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , HUNTER, Robert, L. , DUNCAN, Alexander
IPC分类号： A61K37/54
CPC分类号： A61K31/765 , A01N1/021 , A01N1/0226 , A61K38/166 , A61K38/446 , A61K38/49 , A61K31/047 , A61K35/14 , A61K31/715 , A61K2300/00
摘要： A composition that is effective in dissolving blood clots and reestablishing and maintaining blood flow through thrombosed coronary or other blood vessels. The fibrinolytic composition of the present invention comprises an enzyme, such as streptokinase, urokinase, tissue plasminogen activator or other fibrinolytic enzyme, and a surface-active copolymer. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH, wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000, preferably approximately 1750 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50 % to 90 % by weight of the compound.
摘要翻译：一种有效地溶解血块并通过血栓冠状动脉或其他血管重新建立和维持血液流动的组合物。本发明的纤维蛋白溶解组合物包含酶，例如链激酶，尿激酶，组织纤溶酶原激活剂或其它纤维蛋白溶解酶，和表面活性共聚物。表面活性共聚物可以是具有以下通式的环氧乙烷 - 环氧丙烷缩合产物：HO（C 2 H 4 O）b（C 3 H 6 O）a（C 2 H 4 O）b H，其中a是（C 3 H 6 O）表示的疏水基具有分子量为约950至4000，优选约1750至3500，b为使（C2H4O）表示的亲水部分构成化合物的约50重量％至90重量％的整数。

10. 发明申请

WO1986007539A1 BIOLOGICALLY-ACTIVE COPOLYMERS 审中-公开
标题翻译：生物活性共聚物
公开(公告)号：WO1986007539A1
公开(公告)日：1986-12-31
申请号：PCT/US1986001315
申请日：1986-06-18
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , HUNTER, Robert, L.
IPC分类号： A61K31/74
CPC分类号： C08L71/02 , A61K31/785 , C08G65/2624
摘要： Biologically-active copolymers and compounds that can be safely used to cause the thymus of an animal or human to increase in size, thereby replenishing the T-lymphocyte population. When injected into an animal or human with an antigen, the biologically-active copolymers cause immunosuppression to the antigen. The biologically active copolymers are also useful as growth promoters for animals. Compounds within the biologically-active copolymers of the present invention are effective tumoricidal agents. The biologically-active copolymer of the present invention is a safe and non-toxic formulation that can effectively be administered to animals or humans. The biologically-active copolymer can be mixed in an oil and water emulsion and administered to an animal or human by injection.
摘要翻译：生物活性共聚物和化合物可以安全地用于引起动物或人的胸腺的大小增加，从而补充T淋巴细胞群体。当用抗原注射到动物或人类中时，生物活性共聚物对抗原产生免疫抑制。生物活性共聚物也可用作动物的生长促进剂。本发明生物活性共聚物内的化合物是有效的杀肿剂。本发明的生物活性共聚物是可以有效地施用于动物或人的安全且无毒的制剂。生物活性共聚物可以在油和水乳液中混合，并通过注射给予动物或人。

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