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51. 发明申请

WO2005054849A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR MC5 (MC5R) 审中-公开
标题翻译：与G蛋白偶联受体MC5（MC5R）相关的疾病的诊断和治疗
公开(公告)号：WO2005054849A3
公开(公告)日：2005-08-11
申请号：PCT/EP2004013277
申请日：2004-11-23
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , SUMMER HOLGER
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , SUMMER HOLGER
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/74 , A61K38/00 , A61K39/395 , A61K48/00 , G01N33/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/74 , G01N2333/726 , G01N2500/00
摘要： The invention provides a human MC5 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders,. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders,. The invention also features compounds which bind to and/or activate or inhibit the activity of MC5 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，胃肠和肝脏疾病，炎性疾病，代谢疾病，血液病症，呼吸系统疾病，神经障碍，泌尿系统疾病和癌症疾病有关的人类MC5。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠和肝脏疾病，炎性疾病，代谢疾病，血液病症，呼吸系统疾病，神经障碍，泌尿系统疾病和癌症疾病的化合物的化验。本发明还涉及结合和/或活化或抑制MC5的活性的化合物以及包含这些化合物的药物组合物。

52. 发明申请

WO2005059546A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35) 审中-公开
标题翻译：与G蛋白偶联受体35（GPR35）相关的疾病的诊断和治疗方法
公开(公告)号：WO2005059546A2
公开(公告)日：2005-06-30
申请号：PCT/EP2004013679
申请日：2004-12-02
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , SUMMER HOLGER
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , SUMMER HOLGER
IPC分类号： C07K14/705 , C07K14/72 , G01N33/53 , G01N33/68 , A61K38/00 , A61K39/395
CPC分类号： G01N33/6893 , C07K14/705 , G01N33/6896 , G01N2500/00
摘要： The invention provides a human GPR35 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR35 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，胃肠和肝脏疾病，癌症病症，炎性疾病，代谢疾病，血液病症，呼吸系统疾病，神经障碍和泌尿系统疾病有关的人类GPR35。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠和肝脏疾病，癌症疾病，炎性疾病，代谢疾病，血液病症，呼吸系统疾病，神经障碍和泌尿系统疾病的化合物的测定。本发明还涉及结合和/或活化或抑制GPR35的活性的化合物以及包含这些化合物的药物组合物。

53. 发明申请

WO2005040828A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 49 (GPR49) 审中-公开
标题翻译： G蛋白偶联受体49（GPR49）相关疾病的诊断和治疗
公开(公告)号：WO2005040828A3
公开(公告)日：2005-06-16
申请号：PCT/EP2004011404
申请日：2004-10-12
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , SUMMER HOLGER
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , SUMMER HOLGER
IPC分类号： G01N33/574 , G01N33/68 , A61K38/00 , A61K48/00 , C12Q1/68
CPC分类号： G01N33/57484 , G01N33/6896
摘要： The invention provides a human GPR64 which is associated with the cardiovascular disorders, dermatological disorders, hematological disorders, respiratory diseases, inflammatory diseases, gastroenterological and liver diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, dermatological disorders, hematological disorders, respiratory diseases, inflammatory diseases, gastroenterological and liver diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR64 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，血液病，呼吸道疾病，炎性疾病，胃肠病和肝病，神经病和泌尿疾病相关的人GPR64。本发明还提供用于鉴定可用于治疗或预防心血管病症，皮肤病症，血液病症，呼吸疾病，炎症性疾病，胃肠病和肝病，神经病症和泌尿系统病症的化合物的测定法。本发明还涉及结合和/或激活或抑制GPR64活性的化合物以及包含这些化合物的药物组合物。

54. 发明申请

WO2005040824A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 24 (GPR24) 审中-公开
标题翻译： G蛋白偶联受体24相关疾病的诊断和治疗（GPR24）
公开(公告)号：WO2005040824A2
公开(公告)日：2005-05-06
申请号：PCT/EP2004011392
申请日：2004-10-12
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , SUMMER HOLGER
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , SUMMER HOLGER
IPC分类号： C12Q1/68 , G01N33/574 , G01N33/68 , A61K38/00 , A61K39/00 , A61K48/00
CPC分类号： G01N33/57484 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N33/57446 , G01N33/57449 , G01N33/6893 , G01N33/6896
摘要： The invention provides a human GPR24 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR24 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，胃肠和肝脏疾病，癌症疾病，炎性疾病，代谢疾病，血液疾病，呼吸系统疾病，神经系统疾病和泌尿系统疾病相关的人GPR24。本发明还提供了用于鉴定可用于治疗或预防心血管病症，胃肠和肝脏疾病，癌症病症，炎性疾病，代谢疾病，血液病症，呼吸系统疾病，神经病症和泌尿系统病症的化合物的测定法。本发明还涉及结合和/或激活或抑制GPR24活性的化合物以及包含此类化合物的药物组合物。

55. 发明申请

WO2008046509A8 LTBP2 AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET 审中-公开
标题翻译： LTBP2作为生物标记，治疗和诊断目标
公开(公告)号：WO2008046509A8
公开(公告)日：2013-06-20
申请号：PCT/EP2007008558
申请日：2007-10-02
申请人： BAYER SCHERING PHARMA AG , GOLZ STEFAN , SUMMER HOLGER , GEERTS ANDREAS , BRUEGGEMEIER ULF , ALBRECHT-KUEPPER BARBARA , KLEIN MARTINA , STEPPAN SONJA , ELLINGHAUS PETER , D URSO DONATELLA , SEEWALD MICHAEL , MILTING HENDRIK
发明人： GOLZ STEFAN , SUMMER HOLGER , GEERTS ANDREAS , BRUEGGEMEIER ULF , ALBRECHT-KUEPPER BARBARA , KLEIN MARTINA , STEPPAN SONJA , ELLINGHAUS PETER , D URSO DONATELLA , SEEWALD MICHAEL , MILTING HENDRIK
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , Y10S530/841
摘要： The invention provides LTBP2 which is associated with the cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of LTBP2 as well as pharmaceutical compositions comprising such compounds. The invention also provides LTBP2 as a biomarker for diseases as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases and urological diseases
摘要翻译：本发明提供了与心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病相关的LTBP2。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制LTBP2的活性的化合物以及包含这些化合物的药物组合物。本发明还提供LTBP2作为心血管疾病，血液疾病，神经系统疾病，癌症，内分泌疾病和泌尿系疾病的疾病的生物标志物

56. 发明申请

WO2007147497A3 USE OF A DISINTEGRIN-LIKE AND METALLOPROTEINASE WITH THROMBOSPONDIN TYPE 1 MOTIF (ADAMTS1) AS A THERAPEUTIC OR DIAGNOSTIC TARGET 审中-公开
标题翻译：以血栓形式1型MOTIF（ADAMTS1）作为治疗或诊断性目标使用类毒素和金属蛋白酶
公开(公告)号：WO2007147497A3
公开(公告)日：2008-03-27
申请号：PCT/EP2007005119
申请日：2007-06-11
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/68 , A61P7/00 , A61P9/00 , A61P13/00 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： G01N33/5008 , G01N33/573 , G01N2333/96486 , G01N2500/00
摘要： The invention provides a human ADAMTSl which is associated with the cardiovascular diseases, cancer, inflammation, hematologica diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, inflammation, hematologica diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of ADAMTSl as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，癌症，炎症，血液学疾病，神经系统疾病和泌尿系疾病相关的人ADAMTS1。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，炎症，血液病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制ADAMTS1活性的化合物以及包含这些化合物的药物组合物。

57. 发明申请

WO2005100997A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH TACHYKININ RECEPTOR 3 (TACR3) 审中-公开
标题翻译：与TACHYKININ受体3（TACR3）相关的疾病的诊断和治疗
公开(公告)号：WO2005100997A3
公开(公告)日：2006-05-18
申请号：PCT/EP2005003473
申请日：2005-04-02
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/574 , G01N33/576
CPC分类号： G01N33/57423 , G01N33/57415 , G01N33/57434 , G01N33/57438 , G01N33/57442 , G01N33/57446 , G01N33/57449 , G01N2333/70571
摘要： The invention provides a human TACR3 which is associated with the cardiovascular diseases, infections, respiratory diseases, gastroenterological diseases, cancer, inflammation, metabolic diseases, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, respiratory diseases, gastroenterological diseases, cancer, inflammation, metabolic diseases, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of TACR3 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，感染，呼吸系统疾病，胃肠疾病，癌症，炎症，代谢疾病，血液疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病相关的人类TACR3。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，感染，呼吸系统疾病，胃肠疾病，癌症，炎症，代谢疾病，血液疾病，肌肉骨骼疾病，神经系统疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制TACR3的活性的化合物以及包含这些化合物的药物组合物。

58. 发明申请

WO2005118833A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH STERILE-ALPHA MOTIF AND LEUCINE ZIPPER CONTAINING KINASE (ZAK) 审中-公开
标题翻译：与非ALPHA动物相关疾病的诊断和治疗方法和含有激素（ZAK）的拉皮钳
公开(公告)号：WO2005118833A3
公开(公告)日：2006-05-11
申请号：PCT/EP2005005436
申请日：2005-05-19
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： C12Q1/00 , G01N33/574
CPC分类号： G01N33/574 , G01N2333/70567 , G01N2333/9121
摘要： The invention provides a human ZAK which is associated with cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, (thyroid, esophagus, stomach, colon, ovary, protate tumor) inflammation, gastroenterological diseases, (e.g. liver virrhosis) hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of ZAK as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症（甲状腺，食道，胃，结肠，卵巢，保护性肿瘤）炎症，肠胃病（例如肝硬化）血液疾病相关的人ZAK 呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经疾病和泌尿系统疾病疾病。本发明还涉及结合和/或活化或抑制ZAK活性的化合物以及包含这些化合物的药物组合物。

59. 发明申请

WO2006010489A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH CHOLINE KINASE LIKE PROTEIN (CHKL) 审中-公开
标题翻译：与胆碱激酶样蛋白相关的疾病的诊断和治疗（CHKL）
公开(公告)号：WO2006010489A3
公开(公告)日：2006-04-27
申请号：PCT/EP2005007698
申请日：2005-07-15
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/573
CPC分类号： C12Q1/485 , G01N2500/04
摘要： The invention provides a human CHKL which is associated with infections, cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections, cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CHKL as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与感染，心血管疾病，癌症，内分泌疾病，代谢疾病，胃肠疾病，炎症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病，泌尿系统疾病有关的人类CHKL。本发明还提供了用于鉴定可用于治疗或预防感染，心血管疾病，癌症，内分泌疾病，代谢疾病，胃肠疾病，炎症，血液病，呼吸系统疾病，肌肉骨骼疾病，神经疾病，泌尿科疾病。本发明还涉及结合和/或激活或抑制CHKL活性的化合物以及包含此类化合物的药物组合物。

60. 发明申请

WO2005101004A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH PURINOCEPTOR 1 TYPE Y (P2Y1) 审中-公开
标题翻译：与PURINOCEPTOR 1类型Y（P2Y1）相关的疾病的诊断和治疗
公开(公告)号：WO2005101004A3
公开(公告)日：2006-04-27
申请号：PCT/EP2005003410
申请日：2005-04-01
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： A61K31/70 , A61K38/00 , A61K39/395 , A61K47/46 , A61P1/00 , A61P5/00 , A61P7/00 , A61P25/00 , A61P31/00 , A61P35/00 , C07K14/71 , C12Q1/68 , G01N33/68 , G01N33/72 , G01N33/74
CPC分类号： G01N33/74 , G01N2333/726 , G01N2500/00
摘要： The invention provides a human P2Y1 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of P2Y1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠病，癌症，血液病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人P2Y1。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠疾病，癌症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系统疾病疾病。本发明还涉及结合和/或活化或抑制P2Y1的活性的化合物以及包含这些化合物的药物组合物。

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