专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

WO2021038213A1 ENGINEERED CRISPRA 审中-公开
公开(公告)号：WO2021038213A1
公开(公告)日：2021-03-04
申请号：PCT/GB2020/052031
申请日：2020-08-24
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： WANG, Baojun , LIU, Yang
IPC分类号： C12N15/10 , C12N9/12 , C12N9/22 , C12N15/11
摘要： There is provided a novel, eukaryote-like bacterial CRISPRa system based on δ54- dependent promoters, which supports long-distance, and hence multi-input regulation with unprecedented high dynamic ranges. Also provided is a CRISPRa system that can activate δ54-dependent promoters and supports orthogonal gene regulation on multiple levels. Additionally, there is provided the construction of cascaded CRISPRa circuits and a reusable scanning platform for optimizing metabolic pathways.

52. 发明申请

WO2021023982A1 PYRENOID-LIKE STRUCTURES 审中-公开
公开(公告)号：WO2021023982A1
公开(公告)日：2021-02-11
申请号：PCT/GB2020/051853
申请日：2020-07-31
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： MCCORMICK, Alistair James , ATKINSON, Nicola Jane
IPC分类号： C07K14/415 , C12N9/88 , C12N15/82
摘要： Aspects of the present disclosure relate to genetically altered plants having a modified Rubisco and further having a modified Essential Pyrenoid Component 1 (EPYC1) for formation of an aggregate of modified Rubisco and EPYC1 polypeptides. Other aspects of the present disclosure relate to methods of making such plants as well as cultivating these genetically altered plants.

53. 发明申请

WO2020254813A1 DEFECT MEDIATED LYOTROPIC NEMATIC GEL 审中-公开
公开(公告)号：WO2020254813A1
公开(公告)日：2020-12-24
申请号：PCT/GB2020/051479
申请日：2020-06-18
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： WOOD, Dr Tiffany , KATYAN, Navneeta
IPC分类号： C09K19/52 , C09K19/54
摘要： This invention relates to a gel comprising a colloid dispersed in a lyotropic nematic liquid crystal, the lyotropic nematic liquid crystal comprising defect lines formed by the colloid. The invention also relates to a method for making the gel comprising the steps of: (a) mixing a nematogen with a liquid and the colloid to form a resulting dispersion, and (b) applying shear to the resulting dispersion at a temperature such that a lyotropic nematic liquid crystal phase is formed. In addition, the invention relates to an adhesive, lubricant, ceramic, film, spray, gel, lotion, foam, nanowire, yarn, medical implant, wearable, bone graft material, 3D printing material, ink, agrochemical formulation, topical formulation, paint, coating, composite, energy storage material, advanced material, responsive composite, cosmetic product, personal care product, pharmaceutical or foodstuff comprising the gel.

54. 发明申请

WO2020185898A1 INFLUENZA VIRUS MUTANTS AND USES THEREFOR 审中-公开
公开(公告)号：WO2020185898A1
公开(公告)日：2020-09-17
申请号：PCT/US2020/022104
申请日：2020-03-11
申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF AGRICULTURE , THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： KAPCZYNSKI, Darrell, R. , DIGARD, Paul , VERVELDE, Lonneke , SUAREZ, David, L.
IPC分类号： C12N7/00 , A61K39/145 , A61K39/00
摘要： The disclosure relates to mutant recombinant influenza virus gene segment 7 with at least one mutation that modulates expression of M2 and M42 polypeptide. Also disclosed are recombinant influenza viruses comprising the mutant influenza virus gene segment 7, compositions comprising the mutant recombinant influenza virus gene segment 7, use of such mutant recombinant influenza virus gene segment 7 and mutant recombinant Influenza viruses.

55. 发明申请

WO2020178450A1 MACROPHAGE EXPRESSION IN BREAST CANCER 审中-公开
公开(公告)号：WO2020178450A1
公开(公告)日：2020-09-10
申请号：PCT/EP2020/056125
申请日：2020-03-06
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： POLLARD, Jeff , CASSETTA, Luca , FRAGKOGIANNI, Stamatina
IPC分类号： C12Q1/6886
摘要： The present invention relates to the field of breast cancer diagnosis and treatment. The present invention provides methods comprising a) analysing a biological sample obtained from a subject to determine the presence of target molecules representative of expression of at least two biomarkers selected from the group listed in Table 1, wherein the biological sample is a breast tissue sample or derivative thereof; and b) comparing the expression levels of the biomarkers determined in (a) with one or more reference values, wherein whether there is a difference in the expression of the biomarkers in the sample from the subject compared to the one or more reference values is indicative of a clinical indication.. The invention further provides methods of treatment and kits and assays for use in the methods of the invention.

56. 发明申请

WO2020106813A1 METHODS AND SYSTEMS FOR SPATIALLY DISTRIBUTED STROBING 审中-公开
公开(公告)号：WO2020106813A1
公开(公告)日：2020-05-28
申请号：PCT/US2019/062366
申请日：2019-11-20
申请人： SENSE PHOTONICS, INC. , THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： HENDERSON, Robert , FINKELSTEIN, Hod , CALDER, Neil , AL ABBAS, Tarek
IPC分类号： G01S7/486 , G01S7/48 , G01S17/00 , G01S17/06 , G01S17/88 , G01S17/95
摘要： A Light Detection and Ranging (lidar) apparatus includes an emitter array comprising a plurality of emitter units configured to emit optical signals responsive to respective emitter control signals, a detector array comprising a plurality of detector pixels configured to be activated and deactivated for respective strobe windows between pulses of the optical signals; and a control circuit configured to provide a strobe signal to activate a first subset of the detector pixels while leaving a second subset of the detector pixels inactive.

57. 发明申请

WO2020020905A1 NEAR-INFRARED (NIR) TRICARBOCYANINE N-TRIAZOLE CHROMOPHORES 审中-公开
公开(公告)号：WO2020020905A1
公开(公告)日：2020-01-30
申请号：PCT/EP2019/069834
申请日：2019-07-23
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： VENDRELL, Marc , FERNANDEZ, Antonio , MELLANBY, Richard , SCOTT, Jamie , MAIR, Iris , GUZMAN, Claudia, Garcia , DHILLON, Baljean , BAGNANINCHI, Pierre
IPC分类号： C09B23/01 , C07D403/14
摘要： The present invention provides a tricarbocyanine N -triazoles family of bright, photostable and cell- permeable NIR chromophores containing neutral triazole groups. In particular, a compound of formula (I), a derivative or a salt thereof is provided. Formula (I) wherein, R1 is absent or selected from the group consisting C1-C6 alkyl, and C1-C9 alkyl substituted with one or more of the following groups: halogen, hydroxyl, aryl, carboxylic acids; C3-C6 cycloalkyl, aryl groups substituted with one or more of the following groups: alkyl, cycloalkyl, naphthalenyl, phenanthrenyl, amino, aminoalkyl, aminocycloalkyl, formyl, trifluoromethyl, carboxyl, halogen, hydroxyl, hydroxyalkyl, alkyloxy, hydroxyaryl, nitro; thiophenyl, pyridinyl, imidazolyl, acetal, benzyl; R2 and R3 are each independently selected from the group consisting of C1-C6 alkyl, and C1-C6 alkyl substituted with one or more of the following groups: carboxylic acids, substituted amides, sulphonate groups, aryl, succinimidyl esters, maleimides, polyethyleneglycol-based substituents; R4, R5, R8 and R9 are each independently absent, C1-C6 alkyl or H; R6 and R10 are each independently H; R7 and R11 are each independently selected from the group consisting of H, Me and sulphonate; or R6-R7 and/or R10-R11 form an aromatic ring and/or R5-R6 and/or R9-R10 form an aromatic ring; R12 is selected from the group consisting of H, C1-C6 alkyl, and C1-C9 alkyl substituted with one or more of the following groups: hydroxyl, aryl, carboxylic esters, carboxylic acids; amine, aminoalkyl, aminocycloalkyl, aminoaryl, tosyl, hydroxyalkyl, hydroxyaryl, thioalkyl, thioaryl; X and Y are each independently selected from the group consisting of C, S, O and N; and Z is either C or N. The invention further relates to processes for the preparation of the compounds, and uses of the compounds in therapeutic, diagnostic, surgery and analytical applications.

58. 发明申请

WO2019243760A1 COHERENT IMAGING FIBRE AND METHOD 审中-公开
公开(公告)号：WO2019243760A1
公开(公告)日：2019-12-26
申请号：PCT/GB2019/000087
申请日：2019-06-20
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： WOOD, Harry A. C. , STONE, James M. , HARRINGTON, Kerrianne
IPC分类号： C03B37/012 , C03B37/028
摘要： A method of forming an imaging fibre apparatus comprises: • arranging core rods 102 and cladding rods 104 to form at least one primary stack 100a, each primary stack 100a comprising a plurality of core rods 102 and cladding rods 104 arranged in a stack arrangement thereby to form a plurality of core regions within a cladding region; • performing a drawing process to form a plurality of drawn stacks from the at least one primary stack; • wherein the plurality of core rods and cladding rods are further arranged to have a selected shape such that the plurality of stacks stack together in a desired arrangement and wherein the stack arrangement comprises an at least partial outer layer of cladding rods thereby to provide separation between core regions of respective adjacent stacks when stacked in the desired arrangement, the method further comprising: • stacking the plurality of drawn stacks together in the desired arrangement to form a further stack; • drawing the further stack; and • using the drawn further stack to form an imaging fibre apparatus.

59. 发明申请

WO2019243616A1 TSPO BINDERS 审中-公开
公开(公告)号：WO2019243616A1
公开(公告)日：2019-12-26
申请号：PCT/EP2019/066546
申请日：2019-06-21
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW , THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： SUTHERLAND, Andrew , PIMLOTT, Sally , TAVARES, Adriana , LUCATELLI, Christophe
IPC分类号： C07D215/22 , G01N33/00 , A61K51/04 , A61B5/00
摘要： The invention provides a compound of formula (I), and salts, solvates and radiolabelled forms thereof, together with complexes of the compound of formula (I) with TSPO, and methods for forming such complexes, and methods for detecting the compound of formula (I), such as in complex with TSPO.

60. 发明申请

WO2019207299A1 METHOD OF TREATMENT 审中-公开
公开(公告)号：WO2019207299A1
公开(公告)日：2019-10-31
申请号：PCT/GB2019/051141
申请日：2019-04-23
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： CAPORALI, Andrea , MISCIANINOV, Vladislav
IPC分类号： A61P17/02 , A61K31/7105 , A61P9/00
摘要： Described herein are methods for the regulation of angiogenesis and endothelial to mesenchymal transition, the methods involving administration of modulators of miRNA-148b levels. Also described are the use of modulators of miRNA-148b levels in medical treatments such as the treatment of wounds, in particular soft tissue wounds.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式