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51. 发明申请

WO1995027195A1 MEMBRANE CUTTER AND RETRIEVER 审中-公开
标题翻译：膜切割机和回收机
公开(公告)号：WO1995027195A1
公开(公告)日：1995-10-12
申请号：PCT/US1995003751
申请日：1995-03-29
申请人： MILLIPORE CORPORATION
发明人： MILLIPORE CORPORATION , GAGNE, Helen, Marie
IPC分类号： G01N01/34
CPC分类号： B01L99/00 , B01D65/00 , G01N1/286 , G01N2001/288
摘要： A membrane cutter and retriever (10) is disclosed which includes a hollow circular die (12) securely fastened through a hollow connector (13) to the luer opening (16) of a syringe (15). The die/syringe assembly (10) is inserted within a filter holder unit (20) having a membrane (22) secured to the bottom thereof. The die (12) contacts the periphery of the membrane and is rotated to cut and release the membrane from the holder unit. The plunger of the syringe is then raised to create a vacuum which forces the cut membrane into the hollow die where it is retained until such time as the plunger is lowered to create sufficient pressure to deposit the membrane at a desired location for subsequent analysis.
摘要翻译：公开了一种膜切割器和回收器（10），其包括通过中空连接器（13）牢固地紧固到注射器（15）的鲁尔开口（16）的中空圆形模具（12）。模具/注射器组件（10）插入具有固定到其底部的膜（22）的过滤器保持器单元（20）内。模具（12）接触膜的周边并旋转以从保持器单元切割并释放膜。然后将注射器的柱塞升高以产生真空，迫使切割的膜进入中空模具，直到其被保持直到柱塞降低的时间以产生足够的压力以将膜沉积在期望的位置用于随后的分析。

52. 发明申请

WO2022109145A1 FINAL FILL ASSEMBLY AND METHOD OF INTEGRITY TESTING 审中-公开
公开(公告)号：WO2022109145A1
公开(公告)日：2022-05-27
申请号：PCT/US2021/059907
申请日：2021-11-18
申请人： EMD MILLIPORE CORPORATION
发明人： RAHANE, Santosh , RAYE, Charles , LEONG, An son
IPC分类号： B01D61/14 , A61L2/00 , B01D61/20 , B01D65/10 , G01N15/08
摘要： Apparatus and methods for redundant filtration assemblies containing filters comprising a multi-purpose vent port are disclosed, wherein the redundant filtration assemblies reduce the amount of components and overall size of the assemblies, promoting the minimization of product losses. A method(s) to conduct pre-use post- sterilization integrity test (PUPSIT) are also disclosed.

53. 发明申请

WO2021101987A1 HYDROPHILIC MEMBRANES 审中-公开
公开(公告)号：WO2021101987A1
公开(公告)日：2021-05-27
申请号：PCT/US2020/061046
申请日：2020-11-18
申请人： EMD MILLIPORE CORPORATION , GE, Jijun , ZHOU, Xiaozhu , TKACIK, Gabriel
发明人： GE, Jijun , ZHOU, Xiaozhu , TKACIK, Gabriel
IPC分类号： B01D61/14 , B01D67/00 , B01D69/02 , B01D71/58 , B01D71/68
摘要： The present application relates to an unsupported, permanently hydrophilic filtration membrane, and its method of formation. The membrane comprises a polymeric matrix material and a cross-linked polyoxazoline hydrophilic additive blended throughout said matrix material.

54. 发明申请

WO2020264138A1 CELL EXPANSION WITH SELF-REPLICATING RNA VECTORS EXPRESSING IMMORTALIZATION PROTEINS 审中-公开
公开(公告)号：WO2020264138A1
公开(公告)日：2020-12-30
申请号：PCT/US2020/039585
申请日：2020-06-25
申请人： EMD MILLIPORE CORPORATION
发明人： YOSHIOKA, Naohisa
IPC分类号： C12N15/86 , C12N9/12 , C12N5/071
摘要： Synthetic, self-replicating RNA vectors comprising sequence encoding at least one immortalization protein, and use of the self-replicating RNA vectors to extend the lifespan of primary cell populations and expand said populations of primary cells.

55. 发明申请

WO2019194935A1 CHROMATOGRAPHY MEDIA HANDLING AND PACKING EQUIPMENT 审中-公开
公开(公告)号：WO2019194935A1
公开(公告)日：2019-10-10
申请号：PCT/US2019/021545
申请日：2019-03-11
申请人： EMD MILLIPORE CORPORATION
发明人： MORELLI, Michele , WEISSENBACH, Jean-Louis
IPC分类号： A47B57/04 , A47B96/14 , A47F3/10 , A47F7/28 , B01D15/10 , B01D15/24
摘要： Apparatus and method for packing a chromatography column. The apparatus is a rack that may support and/or transport one or more containers of the same or different sizes. The one or more containers and their contents may be agitated in the rack to homogeneously re-suspend the resin. The one or more containers may be fluidly connected to a common manifold for dispensing their contents into a downstream apparatus such as a slurry tank or chromatography column, and for re-introducing contents into the containers such as upon unpacking of a chromatography column.

56. 发明申请

WO2018209020A1 MULTIWELL PLATE WITH VARIABLE COMPRESSION SEAL 审中-公开
公开(公告)号：WO2018209020A1
公开(公告)日：2018-11-15
申请号：PCT/US2018/031958
申请日：2018-05-10
申请人： EMD MILLIPORE CORPORATION
发明人： CLARK, Phillip , GREENIZEN, Kurt E. , DOYLE, John
IPC分类号： B01D29/00
摘要： Filtration apparatus for the assay of biological and biochemical reactants, for example, is provided and includes a substrate such as a plate having one or more wells open at each end, and a porous membrane positioned in each well forming a discrete filtering area. The filtration apparatus includes a seal that is in a compressible relationship with the face of the porous membrane, the surface of the compression element, and the well wall. Each well includes a compression element, such as an internal well insert or sleeve, which compresses the seal so that the seal contacts the membrane face, the surface of the compression element, and the well wall in a liquid-tight manner. The compression element may be configured so that it is fixed in the well such as by an interference fit with the well wall or by bonding to a surface of the substrate.

57. 发明申请

WO2018182932A9 INSTALLATION FOR TREATING BIOLOGICAL LIQUID 审中-公开
公开(公告)号：WO2018182932A9
公开(公告)日：2018-10-04
申请号：PCT/US2018/021153
申请日：2018-03-06
申请人： EMD MILLIPORE CORPORATION
发明人： CIROU, Sebastien , ABOUAYAD EL IDRISSI, Christine
IPC分类号： B01D15/00 , C12M1/00 , G01N30/88
摘要： The invention concerns an installation for treatment of biological liquid by chromatography, extending in a longitudinal direction and comprising a supply valve (20b), a supply pump (30) downstream of the valve, instrument members downstream of the pump including distribution valves (81a-c, 82a-c, 83a-c) and devices (78a-c, 85a-c, 86a-c) for measuring physico-chemical parameters of the liquid, chromatography columns (99a-c) downstream of the instrument members and pipes connecting the valve, the pump, the instrument members and the columns so as to form at least one supply line for biological liquid to treat of a treatment circuit of said installation, the chromatography columns being disposed relative to each other in a direction of extension generally transverse to said generally longitudinal direction of extension of the installation.

58. 发明申请

WO2017116543A1 INTERACTIVE SYSTEM AND METHOD OF INSTRUMENTING A BIO-MANUFACTURING PROCESS 审中-公开
标题翻译：交互式系统和测量生物制造过程的方法
公开(公告)号：WO2017116543A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/059108
申请日：2016-10-27
申请人： EMD MILLIPORE CORPORATION
发明人： SCIOLA, Laurelle , RICKETTS, Paul, John , COLT, Susan
IPC分类号： G06Q10/06
CPC分类号： G06Q10/06
摘要： Instrumenting or modeling a bio-manufacturing process is disclosed. A data store holds information regarding one or more bio-manufacturing processes. For each process, the data store information includes workflow steps and per step indications of required equipment, services and consumables according to best practice and/or experts. A videographic user interface enables user interactive input regarding a subject bio- manufacturing process from the data store. The user-interface presents a model representation of deployment of the subject bio-manufacturing process. The user interactively navigates and makes selections in the displayed model representation. The user selections include certain bio-manufacturing products, equipment and services from an image database. The images from the image database enable the views of the model representation to appear true to life demonstrating equipment/product layout and physical equipment/computer connections used in the subject bio-manufacturing process. The videographic user interface utilizes various visual effects to guide the user sequentially or logically (and based on best practice and right fit rules) through the steps and pieces of equipment forming the subject bio-manufacturing process.
摘要翻译：公开了对生物制造过程进行仪表或建模。数据存储保存关于一个或多个生物制造过程的信息。对于每个流程，根据最佳实践和/或专家，数据存储信息包括工作流程步骤和所需设备，服务和消耗品的每步指示。录像用户界面使用户可以从数据存储中获得关于主题生物制造过程的交互式输入。用户界面呈现了主题生物制造过程的部署的模型表示。用户交互式导航并在显示的模型表示中进行选择。用户选择包括来自图像数据库的某些生物制造产品，设备和服务。来自图像数据库的图像使得模型表示的视图看起来像真实的演示在生物制造过程中使用的设备/产品布局和物理设备/计算机连接。视频用户界面利用各种视觉效果，通过形成主题生物制造过程的设备的步骤和部分，依次或逻辑地引导用户（并且基于最佳实践和正确适应规则）。

59. 发明申请

WO2016182624A1 FILM BONDED FLATPACK 审中-公开
公开(公告)号：WO2016182624A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/021698
申请日：2016-03-10
申请人： EMD MILLIPORE CORPORATION
发明人： ALMASIAN, Joseph M. , CHISHOLM, Mark E. , GAGNE, George A., Jr. , SZYK, Martin
IPC分类号： A61F2/00
CPC分类号： B01D63/082 , B01D63/14 , B01D69/10 , B01D2313/025 , B01D2313/04 , B01D2319/04 , C02F1/001 , C02F2103/003 , C02F2103/343 , C02F2201/002 , C02F2203/006 , C02F2301/04 , C02F2303/04
摘要： A membrane-based separation device comprises multiple interconnected flat sheets of membrane bonded to a flexible film. The bonded films are bonded in a way to create an accordion or zig-zag shape. In certain embodiments, the first or upstream layer is affixed to a suitable housing, and the last or most downstream layer is also affixed to the suitable housing. The housing may contain an inlet port for the introduction of sample, and an outlet port for the removal of filtered sample. Flow through the segments is in parallel. Since the membranes are not folded or pleated, higher performance membranes (e.g., polysulfone based membranes with some degree of asymmetry) than those usable in pleated or folded systems can be used.
摘要翻译：膜分离装置包括多个互连的膜片，其粘合到柔性膜。粘结薄膜以形成手风琴或曲折形状的方式粘结。在某些实施例中，第一或上游层被固定到合适的壳体上，并且最后的或最下游的层也被固定到合适的壳体上。壳体可以包含用于引入样品的入口端口和用于去除过滤样品的出口。流经段是并行的。由于膜不折叠或打褶，所以可以使用比用于打褶或折叠系统的膜更高性能的膜（例如，具有一定程度的不对称性的聚砜基膜）。

60. 发明申请

WO2016154180A1 ABRASION RESISTANT FILM FOR BIOCONTAINERS 审中-公开
标题翻译：生物测定仪的耐磨膜
公开(公告)号：WO2016154180A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/023534
申请日：2016-03-22
申请人： EMD MILLIPORE CORPORATION
发明人： DECOSTE, David , CIANCIOLO, Joseph , FURBUSH, Michael , SARAGOSA, John
IPC分类号： B32B27/12 , B32B5/02 , B32B27/08 , B32B27/32 , B32B27/34 , B32B27/40 , B65D33/04
CPC分类号： B32B5/024 , B01L3/508 , B01L2300/0887 , B01L2300/16 , B32B5/02 , B32B5/022 , B32B27/08 , B32B27/12 , B32B27/32 , B32B27/34 , B32B27/40 , B32B2262/0253 , B32B2262/0261 , B32B2262/0269 , B32B2262/0276 , B32B2262/103 , B32B2262/106 , B32B2307/554 , B32B2307/7242 , B32B2439/40 , B32B2439/80 , B65D65/40 , B65D75/58 , B65D2275/00 , G01M3/3272
摘要： A biocontainer film enhanced with an abrasion resistant or "cut-proof" substrate. Such substrates can be combined with current biocontainer materials, via various techniques of embedding, coextrusion or laminating, to maintain the cleanliness and low extractables already validated for biotech manufacturing. The substrate of choice may be constructed from materials known to be more resistant to abrasion and sharp razor type cuts or from materials oriented in such a way to prevent puncture to occur. The new substrate must also be flexible to allow for typical folding as demonstrated by current packaging practices. The new substrate may be constructed from materials other than polymers such as metal, glass or carbon or in combination with polymers. A non-constrained pressure test is also disclosed.
摘要翻译：具有耐磨损或“切割”基材增强的生物容器膜。这种基材可以通过各种嵌入，共挤出或层压技术与目前的生物容器材料结合，以保持已经为生物技术制造验证的清洁度和低提取物。所选择的基底可以由已知更耐磨损和锋利的剃刀类型切割的材料构成，或者由以防止穿刺发生的方式定向的材料构成。新的基材也必须是柔性的，以允许通过当前包装实践证明的典型折叠。新基材可以由除了聚合物以外的材料如金属，玻璃或碳或与聚合物组合构成。还公开了非约束压力试验。

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