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41. 发明申请

WO2018093903A1 IMMORTALIZED CELL LINES AND METHODS OF USE 审中-公开
公开(公告)号：WO2018093903A1
公开(公告)日：2018-05-24
申请号：PCT/US2017/061804
申请日：2017-11-15
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , FOSTER, Douglas, N. , FOSTER, Linda, K.
发明人： FOSTER, Douglas, N. , FOSTER, Linda, K.
IPC分类号： C12N5/077 , A61K39/12 , A61K39/255
CPC分类号： C12N5/0652 , A61K39/12 , A61K39/255 , C12N2510/00 , C12N2510/04 , C12N2710/16651 , C12N2720/12051
摘要： Provided herein is a non-natural isolated chicken fibroblast cell that has the characteristics of immortalized growth and supporting replication of Marek's Disease Virus (MDV), wherein number of MDV produced by the cell is at least 1.5-fold greater than the number of the same MDV produced by a DF-1 cell under the same conditions. Also provided herein are methods including producing virus using the cell, determining the number of virus in a sample using the cell, and using the cell to produce protein.

42. 发明申请

WO2018013530A1 POULTRY PROBIOTIC VACCINE COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：家禽益生菌疫苗组合物及其使用方法
公开(公告)号：WO2018013530A1
公开(公告)日：2018-01-18
申请号：PCT/US2017/041486
申请日：2017-07-11
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
发明人： TEAGUE, Kyle, D. , BIELKE, Lisa , TELLEZ-ISAIAS, Guillermo , HARGIS, Billy
IPC分类号： A01K45/00 , A61K35/741 , A61K35/747 , A61K35/744 , A61K39/12 , A61K39/255
摘要： Provided herein are compositions including a probiotic including at least one strain of live bacteria and a Marek' s Disease vaccine. Compositions including a probiotic or a probiotic and a Marek' s Disease vaccine may be administered to subjects, including poultry. The compositions may be administered in ovo to increase early lactic acid bacteria in the gastrointestinal tract of the subject, to decrease the gram negative bacteria in the gastrointestinal tract of the subject, to reduce the level of Salmonella in the gastrointestinal tract of the subject and to increase the body weight gain of the subject. Also provided are kits including a probiotic and a Marek' s Disease vaccine.
摘要翻译：本文提供了包含益生菌的组合物，所述益生菌包括至少一种活细菌菌株和马立克氏病疫苗。包括益生菌或益生菌和马立克氏病疫苗的组合物可以施用于受试者，包括家禽。所述组合物可以卵内给药以增加受试者胃肠道中的早期乳酸菌，减少受试者胃肠道中的革兰氏阴性细菌，降低受试者胃肠道中的沙门氏菌水平，并且增加受试者的体重增加。还提供了包括益生菌和马立克氏病疫苗的试剂盒。

43. 发明申请

WO2017027946A1 COMPLEXO VACINAL NUTRITIVO PARA UTILIZAÇÃO EXCLUSIVA INTRA OVO, PROCESSO DE OBTENÇÃO DO COMPLEXO E PROCESSO DE APLICAÇÃO SIMULTÂNEA DE IMUNIZAÇÃO E NUTRIÇÃO INTRA OVO DE ESPÉCIES AVÍCOLAS 审中-公开
标题翻译：用于独家使用内脏的营养型疫苗复合物，用于生产复合物的方法和用于同时进行的室内免疫和营养的AVIAN物种的方法
公开(公告)号：WO2017027946A1
公开(公告)日：2017-02-23
申请号：PCT/BR2016/050193
申请日：2016-08-16
申请人： BASTOS, César da Silva
发明人： BASTOS, César da Silva
IPC分类号： A61K39/00 , A61K39/255 , A01K45/00 , A23K20/142 , A23K20/147 , A23K20/153 , A23K20/158 , A23K20/163
CPC分类号： A01K45/00 , A23K20/142 , A23K20/147 , A23K20/153 , A23K20/158 , A23K20/163 , A61K39/00 , A61K39/255
摘要： Complexo vacinal nutritivo para utilização exclusiva intra ovo, processo de obtenção do complexo e processo de aplicação simultânea de imunização e nutrição intra ovo de espécies avícolas representado por uma solução inventiva no setor de produção de aves, sendo particularmente útil na seara e proteção imunológica e de nutrição de embriões de espécies avícolas especialmente de aves de corte, mais especificamente no campo de aplicação de aplicação de vacinas e nutrientes intra ovo, onde foi idealizado um complexo vacinal nutritivo (C), na forma de uma solução aquosa estéril de pH neutro e osmolaridade na faixa de 450 e 600 mOsm, que é composta por uma parte na forma de vacina ativada (X), uma parte na forma de diluente (Y) e uma parte na forma de nutriente (Z), onde este complexo vacinal nutritivo (C) é carregado em um equipamento de injeção de substâncias intra ovo, que com a devida regulagem o inoculará no líquido amniótico (Li) de um ovo (Ov) com embrião (Em).
摘要翻译：本发明涉及一种专门用于卵内的营养型疫苗复合物，一种生产该复合物的方法以及用于禽类物种同时进行卵内免疫和营养的方法，该复合物代表了在家禽养殖特别适用于禽类种类的收获，免疫保护和胚胎营养，特别是肉鸡，尤其是在卵子内使用疫苗和营养的领域。营养型疫苗复合物（C）被设计为无菌水溶液，其中性pH和摩尔渗透压浓度范围为450-600mOsm，部分由活化疫苗（X）组成，部分稀释剂（Y）和部分营养物（Z），营养性疫苗复合物（C）被装载到用于注射卵内物质的装置中，当适当地将胚胎（Em）接种在卵（Ov）内部的羊水（li）时。

44. 发明申请

WO2004100640A2 MAREK’S DISEASE VIRUS VACCINE 审中-公开
标题翻译：玛格病毒病毒疫苗
公开(公告)号：WO2004100640A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/014079
申请日：2004-05-05
申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF AGRICULTURE , REDDY, Sanjay, M. , LUPIANI, Blanca, M.
发明人： REDDY, Sanjay, M. , LUPIANI, Blanca, M.
IPC分类号： A61K39/255 , C12N7/04
CPC分类号： C12N7/00 , A61K39/12 , A61K39/255 , A61K2039/5254 , A61K2039/552 , C12N2710/16334 , C12N2710/16361
摘要： An effective vaccine for Marek's disease may be prepared using a viral agent which is a Marek's disease virus unable to express a functional meq protein. This viral agent is effective to elicit an immune response in a chicken to very virulent strains of Marek's disease virus without causing a significant degree of pathogenicity in the inoculated bird. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent with a pharmaceutically acceptable carrier or diluent.
摘要翻译：马立克氏病的有效疫苗可以使用不能表达功能性meq蛋白的马立克氏病病毒的病毒剂来制备。这种病毒剂可有效地引起鸡中非常毒性的马立克氏病病毒株的免疫应答，而不会在接种的鸟中引起显着程度的致病性。用于鸡的合适的疫苗制剂包括具有药学上可接受的载体或稀释剂的该新型病毒剂的有效免疫剂量。

45. 发明申请

WO2003066093A1 A CONTINUOUS CELL LINE FOR THE PRODUCTION OF VACCINES 审中-公开
标题翻译：用于生产疫苗的连续细胞系
公开(公告)号：WO2003066093A1
公开(公告)日：2003-08-14
申请号：PCT/EP2003/001213
申请日：2003-02-05
申请人： INSTITUTE OF MOLECULAR BIOLOGY FRIEDRICH-LOEFFLER- INSTITUTES , OSTERRIEDER, Nikolaus , SCHUMACHER, Daniel
发明人： OSTERRIEDER, Nikolaus , SCHUMACHER, Daniel
IPC分类号： A61K39/255
CPC分类号： C12N15/85 , A61K39/12 , A61K39/255 , C07K14/005 , C12N7/00 , C12N2510/02 , C12N2510/04 , C12N2710/16321 , C12N2710/16322 , C12N2710/16334 , C12N2710/16351 , C12N2810/60
摘要： The invention provides a method for producing a continuous cell line capable of supporting the growth of a Marek's disease virus strain comprising infecting or transfecting a cell with a vector comprising a nucleic acid or fragment thereof of a Marek's disease virus strain and culturing said infected or transfected cell or progeny thereof under conditions suitable for the expression of said nucleic acid and propagation of said cell or progeny thereof. Preferably said nucleic acid or fragment thereof comprises a Marek's disease virus glycoprotein gE gene or functional fragment thereof. The invention further provides a method to generate and/or isolate and/or maintain a hypervirulent and/or very virulent, and/or very virulent plus, and/or virulent and/or avirulent Marek's disease virus strain comprising infecting a cell according to the invention with a hypervirulent, and/or very virulent, and/or very virulent plus, and/or virulent and/or avirulent Marek's disease virus strain and culturing said cell under conditions suitable for the propagation of said cell and the generation, maintenance and isolation of said hypervirulent, and/or very virulent, and/or very virulent plus, and/or virulent and/or avirulent Marek's disease virus strain. The invention further provides a method to prepare a vaccine capable of inducing protection against disease, preferably a Marek's disease virus associated disease in an avian comprising culturing a continuous cell according to the invention and harvesting cell culture components therefrom.
摘要翻译：本发明提供了一种能够支持马立克氏病病毒株生长的连续细胞系的方法，其包括用包含马立克氏病病毒株的核酸或其片段的载体感染或转染细胞，并培养所述感染或转染在适于表达所述核酸的条件和所述细胞或其后代的繁殖条件下的细胞或其后代。优选地，所述核酸或其片段包含马立克氏病病毒糖蛋白gE基因或其功能片段。本发明进一步提供了产生和/或分离和/或维持高毒力和/或非常有毒的和/或非常有毒的加和/或毒性和/或无毒的马立克氏病病毒株的方法，包括根据发明具有高毒力和/或非常有毒的和/或非常有毒的加和/或毒性和/或无毒的马立克氏病病毒株，并且在适合于传播所述细胞的条件下培养所述细胞以及产生，维持和分离的所述高毒力和/或非常有毒的，和/或非常有毒的加和/或毒性和/或无毒的马立克氏病病毒株。本发明进一步提供一种制备能够诱导针对疾病的疫苗的疫苗的方法，优选禽类中的马立克氏病病毒相关疾病，包括培养根据本发明的连续细胞并从其中收获细胞培养成分。

46. 发明申请

WO02098369A2 MUTANT FORMS OF CHOLERA HOLOTOXIN AS AN ADJUVANT 审中-公开
标题翻译：作为补充剂的霍洛莫辛的突变形式
公开(公告)号：WO02098369A2
公开(公告)日：2002-12-12
申请号：PCT/US0221008
申请日：2002-06-05
申请人： AMERICAN CYANAMID CO , US GOV UNIV HEALTH SCIENCES , GREEN BRUCE A , HOLMES RANDALL K , JOBLING MICHAEL G , ZHU DUZHANG
发明人： GREEN BRUCE A , HOLMES RANDALL K , JOBLING MICHAEL G , ZHU DUZHANG
IPC分类号： C12N15/09 , A61K39/00 , A61K39/002 , A61K39/008 , A61K39/015 , A61K39/02 , A61K39/04 , A61K39/05 , A61K39/07 , A61K39/08 , A61K39/085 , A61K39/09 , A61K39/095 , A61K39/10 , A61K39/102 , A61K39/106 , A61K39/108 , A61K39/112 , A61K39/118 , A61K39/12 , A61K39/125 , A61K39/13 , A61K39/145 , A61K39/15 , A61K39/155 , A61K39/165 , A61K39/175 , A61K39/20 , A61K39/205 , A61K39/21 , A61K39/215 , A61K39/23 , A61K39/235 , A61K39/245 , A61K39/255 , A61K39/265 , A61K39/29 , A61K39/35 , A61K39/39 , A61P35/00 , C07K14/185 , C07K14/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , A61K
CPC分类号： C07K14/28 , A61K39/39 , A61K2039/55544
摘要： Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.
摘要翻译：具有单或双氨基酸取代或插入的突变型霍乱全毒素与野生型霍乱全毒素相比具有降低的毒性。突变型霍乱全毒素可用作抗原组合物中的佐剂，以增强脊椎动物宿主中来自致病细菌，病毒，真菌或寄生虫，癌细胞，肿瘤细胞，变应原或自身的选定抗原的免疫应答 -分子。

47. 发明申请

WO0061736A9 RECOMBINANT AND MUTANT MAREK'S DISEASE VIRUS 审中-公开
标题翻译：重组和突变MAREK病毒病毒
公开(公告)号：WO0061736A9
公开(公告)日：2002-06-13
申请号：PCT/US0009518
申请日：2000-04-07
申请人： SCHERING PLOUGH LTD , JUNKER DAVID E
发明人： JUNKER DAVID E
IPC分类号： C12N15/09 , A61K35/76 , A61K39/17 , A61K39/255 , A61K39/265 , A61K48/00 , A61P31/12 , A61P37/04 , C12N7/00 , C12N15/869 , C12R1/93 , C12N15/38 , A61K39/215 , C12N15/45 , C12N15/50
CPC分类号： C12N15/86 , A61K2039/525 , C12N2710/16343
摘要： The present invention provides methods and reagents for inducing active immunity in animals. In particular, the present invention provides recombinant herpesviruses having foreign DNA that are capable of inducing immunity to the herpesvirus and/or the source of the foreigh DNA. The present invention also provides mutant herpesviruses having portions of their genome deleted. Preferably, foreign DNA is introduced, or portions of the genome are deleted, in the UL54.5 open reading frame of avian herperviruses or the UL43 open reading frame of Marek's disease virus.
摘要翻译：本发明提供用于诱导动物中的主动免疫的方法和试剂。特别地，本发明提供具有能够诱导对疱疹病毒和/或甲状腺源的免疫的外源DNA的重组疱疹病毒。本发明还提供具有其基因组部分缺失的突变疱疹病毒。优选地，在禽类疫苗的UL54.5开放阅读框或马立克氏病病毒的UL43开放阅读框中，引入外来DNA或基因组的部分缺失。

48. 发明申请

WO0212288A3 VACCINATION AGAINST HOST CELL-ASSOCIATED HERPESVIRUSES 审中-公开
标题翻译：对与宿主细胞相关的病毒感染的疫苗
公开(公告)号：WO0212288A3
公开(公告)日：2002-04-11
申请号：PCT/EP0108893
申请日：2001-08-01
申请人： LOHMANN ANIMAL HEALTH GMBH , FEHLER FRANK , OSTERRIEDER KLAUS
发明人： FEHLER FRANK , OSTERRIEDER KLAUS
IPC分类号： C12N15/09 , A61K31/70 , A61K39/112 , A61K39/245 , A61K39/25 , A61K39/255 , A61P31/12 , A61P31/22 , C07K14/055 , C12N1/21 , C12N15/10 , C12N15/38
CPC分类号： C07K14/005 , A61K2039/523 , A61K2039/5256 , A61K2039/53 , C07K2319/00 , C12N2710/16322
摘要： The invention relates to the field of so-called host cell-associated herpesviruses such as Marek's disease like virus (MDV) of poultry and of Varicella Zoster virus (VZV) of man and to vaccination against disease caused by these viruses. The invention provides a vaccine directed against an infection caused by an herpesvirus that is essentially host cell associated comprising a recombinant viral genome derived from said herpesvirus, said genome allowing recombination essentially free of said host cell.
摘要翻译：本发明涉及所谓的宿主细胞相关疱疹病毒，例如家禽的马立克氏病，病毒（MDV）和人类水痘带状疱疹病毒（VZV）以及由这些病毒引起的疾病的疫苗接种领域。本发明提供了针对由疱疹病毒引起的感染的疫苗，所述感染基本上是宿主细胞相关的，包含源自所述疱疹病毒的重组病毒基因组，所述基因组允许基本上不含所述宿主细胞的重组。

49. 发明申请

WO02012288A2 VACCINATION AGAINST HOST CELL-ASSOCIATED HERPESVIRUSES 审中-公开
标题翻译：与宿主细胞相关的HERPESVIRUS疫苗接种
公开(公告)号：WO02012288A2
公开(公告)日：2002-02-14
申请号：PCT/EP2001/008893
申请日：2001-08-01
IPC分类号： C12N15/09 , A61K31/70 , A61K39/112 , A61K39/245 , A61K39/25 , A61K39/255 , A61P31/12 , A61P31/22 , C07K14/055 , C12N1/21 , C12N15/10 , C12N15/38
CPC分类号： C07K14/005 , A61K2039/523 , A61K2039/5256 , A61K2039/53 , C07K2319/00 , C12N2710/16322
摘要： The invention relates to the field of so-called host cell-associated herpesviruses such as Marek's disease like virus (MDV) of poultry and of Varicella Zoster virus (VZV) of man and to vaccination against disease caused by these viruses. The invention provides a vaccine directed against an infection caused by an herpesvirus that is essentially host cell associated comprising a recombinant viral genome derived from said herpesvirus, said genome allowing recombination essentially free of said host cell.
摘要翻译：本发明涉及与宿主细胞相关的疱疹病毒领域，例如鸡型马立克氏病病毒和人水痘 - 带型病毒，以及针对由这些病毒引起的疾病的疫苗接种。一种针对由与宿主细胞基本上相关的疱疹病毒引起的感染的疫苗，所述疫苗包含衍生自所述疱疹病毒的重组病毒基因组并且允许基本独立于宿主细胞的重组。

50. 发明申请

WO01000234A2 METHODS AND COMPOSITIONS FOR ENGINEERING OF ATTENUATED VACCINES 审中-公开
标题翻译：衰老疫苗工程方法与组合
公开(公告)号：WO01000234A2
公开(公告)日：2001-01-04
申请号：PCT/US2000/016984
申请日：2000-06-20
IPC分类号： C12N15/09 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K39/255 , A61K39/265 , A61K39/29 , A61K39/295 , A61P31/00 , C12N7/04 , C12Q1/68
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K39/255 , A61K39/265 , A61K39/29 , A61K2039/5254 , A61K2039/53 , C12N2710/16034 , C12N2710/16334 , C12N2720/12334 , C12N2740/16034 , C12N2760/16134 , C12N2760/18534 , C12N2770/10034 , C12N2770/12034 , C12N2770/20034 , C12N2770/24134 , C12N2770/24161 , C12N2770/32434 , C12N2770/36034 , Y02A50/464 , Y02A50/487 , Y02A50/491
摘要： This invention provides attenuated vaccines, and methods of obtaining attenuated vaccines. The vaccines of the invention include recombinant viral, bacterial, parasite, and other organisms that are evolved to exhibit increased attenuation without loss of effectiveness as a vaccine. The methods involve the creation of libraries of recombinant nucleic acids (e.g., whole or partial genomes, or particular nucleic acids) which are introduced into the vaccine viruses or other organisms, followed by screening and/or selection for those viruses or organisms that are attenuated.
摘要翻译：本发明提供减毒疫苗以及获得减毒疫苗的方法。本发明的疫苗包括重组病毒，细菌，寄生虫和其他生物体，其被演化以表现出增加的衰减，而不损失作为疫苗的有效性。该方法包括产生引入疫苗病毒或其他生物体的重组核酸（例如全部或部分基因组或特定核酸）的文库，随后筛选和/或选择那些被减毒的病毒或生物体。

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