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41. 发明申请

WO2015044180A1 SUBSTANZ ZUR HEMMUNG VON GEWEBSKALZIFIZIERUNG, GEWEBSFIBROSIERUNG UND ALTERSASSOZIIERTEN ERKRANKUNGEN 审中-公开
标题翻译：物质用于抑制GEWEBSKALZIFIZIERUNG，GEWEBSFIBROSIERUNG年龄和相关病症
公开(公告)号：WO2015044180A1
公开(公告)日：2015-04-02
申请号：PCT/EP2014/070333
申请日：2014-09-24
申请人： LANG, Florian
发明人： LANG, Florian
IPC分类号： A61K31/433 , A61K31/4706 , A61K33/02 , A61P39/00 , A61P43/00
CPC分类号： A61K33/02 , A23L33/10 , A23L33/16 , A23V2002/00 , A61K31/433 , A61K31/4706
摘要： Die vorliegende Erfindung betrifft eine Substanzzur Minderung von Gewebskalzifizierung und Gewebsfibrosierung, zur Verzögerung des Eintretens altersassoziierter Erkrankungen eines Lebewesensund damit im Zusammenhang stehende Verfahren.
摘要翻译：本发明涉及一种物质用于减少Gewebskalzifizierung和Gewebsfibrosierung，年龄相关的延迟疾病Lebewesensund任何相关方法的发生。

42. 发明申请

WO2014141295A3 TREATMENT AND PROPHYLAXIS OF KIDNEY DISEASES 审中-公开
标题翻译： KIDNEY病的治疗与预防
公开(公告)号：WO2014141295A3
公开(公告)日：2015-03-12
申请号：PCT/IN2014000148
申请日：2014-03-06
申请人： IPCA LAB LTD
发明人： PAREEK ANIL , CHANDURKAR NITIN
IPC分类号： A61K31/4706 , A61P13/12
CPC分类号： A61K31/4706 , A61K31/401 , A61K31/403 , A61K31/4178 , A61K31/4245 , A61K31/55 , A61K38/05 , A61K45/06 , A61K2300/00
摘要： A method for treatment and/or prophylaxis of Kidney Diseases of Non-inflammatory etiology in mammals is described herein. The method comprises administering Hydroxychloroquine, its enantiomer or a pharmaceutically acceptable salt thereof or its combinations with at least one drug selected from the group of angiotensin receptor blockers and angiotensin converting enzyme inhibitors. More particularly, a method is provided for treatment and/or prophylaxis of Diabetic Kidney Disease in mammals, which comprises administering a therapeutically effective amount of Hydroxychloroquine, its enantiomer or a pharmaceutically acceptable salt thereof or its combinations with an angiotensin receptor blockers or an ACE inhibitors. Pharmaceutical compositions are provided for the above treatment. Provided is the use of Hydroxychloroquine, its enantiomer or a pharmaceutically acceptable salt thereof or its combinations with at least one drug selected from the group of angiotensin receptor blockers and ACE inhibitors, wherein in the treatment and/or prophylaxis of Kidney Diseases of Non- inflammatory etiology in mammals.
摘要翻译：本文描述了用于治疗和/或预防哺乳动物非炎性病因学肾脏疾病的方法。该方法包括向选自血管紧张素受体阻断剂和血管紧张素转换酶抑制剂的至少一种药物施用羟氯喹，其对映异构体或其药学上可接受的盐或其组合。更具体地，提供了用于治疗和/或预防哺乳动物中的糖尿病肾病的方法，其包括给予治疗有效量的羟氯喹，其对映体或其药学上可接受的盐或其与血管紧张素受体阻断剂或ACE抑制剂的组合。为上述处理提供药物组合物。提供羟氯喹，其对映体或其药学上可接受的盐或其与至少一种选自血管紧张素受体阻断剂和ACE抑制剂的药物的组合的用途，其中在治疗和/或预防非炎性肾脏疾病哺乳动物病因。

43. 发明申请

WO2014189648A1 METHODS AND COMPOSITIONS FOR TREATMENT OF HIV INFECTION 审中-公开
标题翻译：用于治疗艾滋病毒感染的方法和组合物
公开(公告)号：WO2014189648A1
公开(公告)日：2014-11-27
申请号：PCT/US2014/035354
申请日：2014-04-24
申请人： COOPER HUMAN SYSTEMS LLC
发明人： COOPER, Kenneth G. , DE SOUZA, Mark, S. , EUBANKS, Keith , STARR, David, H. , KAPSON, John, D. , YANG, Hua
IPC分类号： A61K38/20 , A61K45/06 , A61K31/167 , A61K31/46 , A61K31/4706 , A61P31/18
CPC分类号： A61K31/46 , A61K31/167 , A61K31/4706 , A61K38/204 , A61K38/2086 , A61K38/212 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for treatment of human immunodeficiency virus (HIV) infections have been developed which dampen immune activation with a bias more on the CD4 T cells relative to the CD8 T cell response, inhibit HIV replication, reactivate latent HIV, and inhibit infection of cells by HIV. Pushing latent HIV into active infections with hindrance of cell infection by the reactivated HIV can substantially reduce the number of cells infected with HIV and the viral load of HIV, which is not achieved using just the combination of ART and compounds which activate latent HIV. The methods involve administering to an HIV-infected subject three or more compounds which collectively dampen immune activation with a bias more on the CD4 T cells relative to the CD8 T cell response, inhibit HIV replication, reactivate latent HIV, and inhibiting infection of CD4 T cells by HIV.
摘要翻译：已经开发了用于治疗人类免疫缺陷病毒（HIV）感染的方法和组合物，其相对于CD8T细胞应答，抑制CD4T细胞上的偏倚，抑制免疫激活，抑制HIV复制，重新激活潜伏的HIV并抑制细胞的感染艾滋病毒。将潜伏的HIV推向活跃感染，由于再活化的HIV阻碍细胞感染，可以大大减少感染艾滋病病毒的细胞数量和HIV病毒载量，而这并不是仅通过ART和激活潜伏性HIV的化合物的组合才能实现的。所述方法包括向HIV感染的受试者施用三种或更多种化合物，其相对于CD8T细胞应答在CD4T细胞上以更多的偏倚共同抑制免疫激活，抑制HIV复制，重新激活潜伏的HIV，并抑制CD4T的感染艾滋病毒细胞。

44. 发明申请

WO2014122537A3 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING HEPATITIS C VIRUS INFECTION USING A COMBINATION OF HYDROXYCHLOROQUINE AND RIBAVIRIN 审中-公开
标题翻译：药物组合物和使用羟氯喹和蓖麻毒素组合治疗乙型肝炎病毒感染的方法
公开(公告)号：WO2014122537A3
公开(公告)日：2014-11-06
申请号：PCT/IB2014000760
申请日：2014-02-04
申请人： GENOSCIENCE SA
发明人： STEIN GIDEON , HALFON PHILIPPE
IPC分类号： A61K31/4706
CPC分类号： A61K31/4706 , A61K31/7056 , A61K2300/00
摘要： Unit dosage form compositions and methods for preventing hepatitis C virus (HCV) replication in an HCV-infected subject are described herein, The compositions disclosed herein comprise amounts of hydroxychloroquine, or a pharmaceutically acceptable salt thereof, and ribavirin sufficient to prevent HCV replication. The methods of treatment disclosed herein comprise co-administering to the subject in need thereof therapeutically effective amounts of hydroxychloroquine and an antiviral agent for preventing HCV replication.
摘要翻译：在本文中描述了在HCV感染的受试者中预防丙型肝炎病毒（HCV）复制的单位剂量组合物和方法。本文公开的组合物包含足以防止HCV复制的量的羟氯喹或其药学上可接受的盐和利巴韦林。本文公开的治疗方法包括共同施用有需要的受试者治疗有效量的羟氯喹和用于预防HCV复制的抗病毒剂。

45. 发明申请

WO2014063205A1 USE OF ENDOCYTOSIS INHIBITORS AND ANTIBODIES FOR CANCER THERAPY 审中-公开
标题翻译：使用内毒素抑制剂和抗癌药物治疗癌症
公开(公告)号：WO2014063205A1
公开(公告)日：2014-05-01
申请号：PCT/AU2013/001246
申请日：2013-10-28
申请人： THE UNIVERSITY OF QUEENSLAND
发明人： SIMPSON, Fiona , SAUNDERS, Nicholas Andrew
IPC分类号： A61K39/395 , A61K38/46 , A61K31/715 , A61K31/5415 , A61K31/4706 , A61P35/00
CPC分类号： C07K16/32 , A61K31/166 , A61K31/18 , A61K31/351 , A61K31/4706 , A61K31/505 , A61K31/5415 , A61K31/724 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K2317/732 , C07K2317/77 , G01N33/57492 , A61K2300/00
摘要： The present invention relates to the use of endocytosis inhibitors, including clathrin-dependent endocytosis inhibitors such as inhibitors of dynamin and antibodies, for enhancing the immune response to cancer, and thereby treating cancers including cancer associated receptor positive cancers.
摘要翻译：本发明涉及内吞作用抑制剂，包括网格蛋白依赖性内吞抑制剂，如dynamin和抗体的抑制剂，用于增强对癌症的免疫应答，从而治疗包括癌症相关的受体阳性癌症的癌症。

46. 发明申请

WO2014018801A1 DIAGNOSIS AND TREATMENT OF CANCER USING DIFFERENTIALLY EXPRESSED STARVATION MARKERS 审中-公开
标题翻译：诊断和治疗癌症使用差异显着的标记
公开(公告)号：WO2014018801A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/052137
申请日：2013-07-25
申请人： THE TEXAS A&M UNIVERSITY SYSTEM , SCOTT & WHITE HEALTHCARE
发明人： NEWELL, Martha, Karen
IPC分类号： C12Q1/68 , A61K31/4706 , A61K39/395 , A61K31/336
CPC分类号： A61K31/336 , A61K31/436 , A61K31/4706 , A61K31/7004 , A61K45/06 , C12Q1/6886 , C12Q2600/158 , A61K2300/00
摘要： The invention relates to methods and related products for diagnosis and treatment of cancer. The methods involve the detection of markers such as LAMP and LC3, and administration of an appropriate therapeutic regimen based on the presence or absence of the markers.
摘要翻译：本发明涉及用于诊断和治疗癌症的方法和相关产品。所述方法包括检测诸如LAMP和LC3的标记物，以及基于标记物的存在或不存在来施用适当的治疗方案。

47. 发明申请

WO2013054345A2 PHARMACEUTICAL COMBINATION 审中-公开
标题翻译：药物组合
公开(公告)号：WO2013054345A2
公开(公告)日：2013-04-18
申请号：PCT/IN2012/000491
申请日：2012-07-11
申请人： IPCA LABORATORIES LIMITED , PAREEK, Anil
发明人： PAREEK, Anil
IPC分类号： A61K31/4706
CPC分类号： A61K31/4706 , A61K9/0053 , A61K31/40 , A61K31/403 , A61K31/4985 , A61K31/522 , A61K45/06 , A61K2300/00
摘要： The present invention discloses a pharmaceutical combination comprising Hydroxychloroquine and a DPP-IV inhibitor or their pharmaceutically acceptable salts, solvates or prodrugs thereof, for preventing, slowing the progression of, delaying, improving, restoring, or treating a condition or a disease resulting from metabolic disorders.
摘要翻译：本发明公开了一种药物组合，其包含羟氯喹和DPP-IV抑制剂或其药学上可接受的盐，溶剂化物或前药，用于预防，延缓其进展，延缓，改善，恢复或治疗由代谢紊乱引起的病症或疾病。

48. 发明申请

WO2012143413A1 TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS 审中-公开
标题翻译：四氢呋喃衍生物有用的BROMODOMAIN抑制剂
公开(公告)号：WO2012143413A1
公开(公告)日：2012-10-26
申请号：PCT/EP2012/057111
申请日：2012-04-19
申请人： GLAXOSMITHKLINE LLC , AMANS, Dominique , DEMONT, Emmanuel Hubert , MITCHELL, Darren Jason , WATSON, Robert J
发明人： AMANS, Dominique , DEMONT, Emmanuel Hubert , MITCHELL, Darren Jason , WATSON, Robert J
IPC分类号： C07D215/42 , C07D215/44 , C07D401/12 , A61K31/4706 , A61K31/4709 , A61P29/00 , A61P35/00
CPC分类号： C07D215/44 , C07D215/42 , C07D401/12
摘要： Tetrahydroquinoline (I) derivatives, pharmaceutical compositions containing such compounds and to their use in therapy.
摘要翻译：四氢喹啉（I）衍生物，含有这些化合物的药物组合物及其在治疗中的用途。

49. 发明申请

WO2012087182A3 SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译：取代的甲基氨基磺酸盐，丝氨酸5-HT6受体拮抗剂，其生产和使用方法
公开(公告)号：WO2012087182A3
公开(公告)日：2012-09-13
申请号：PCT/RU2011000981
申请日：2011-12-13
申请人： IVACHTCHENKO ALEXANDRE VASILIEVICH , ALLA CHEM LLC , MITKIN OLEG DMITRIEVICH , KADIEVA MADINA GEORGIEVNA
发明人： IVACHTCHENKO ALEXANDRE VASILIEVICH , MITKIN OLEG DMITRIEVICH , KADIEVA MADINA GEORGIEVNA
IPC分类号： C07C317/36 , A61K31/13 , A61K31/341 , A61K31/381 , A61K31/421 , A61K31/422 , A61K31/437 , A61K31/44 , A61K31/4706 , A61K31/4709 , A61K31/495 , A61K31/496 , A61P3/06 , A61P9/10 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/28 , C07D211/84 , C07D213/34 , C07D213/38 , C07D215/38 , C07D215/42 , C07D263/48 , C07D295/096 , C07D307/64 , C07D307/66 , C07D317/32 , C07D333/34 , C07D333/36 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D471/04
CPC分类号： C07D471/04 , C07C317/36 , C07D213/40 , C07D215/42 , C07D295/135 , C07D413/04 , C07D413/14
摘要： The invention relates to novel substituted methyl amines, serotonin 5-HT6 receptor antagonists, active ingredients, pharmaceutical compositions and a method for preventing and treating diseases of the central nervous system, as well as to molecular instruments, wherein the novel substituted methyl amines are compounds of general formula 1 and crystalline forms, polycrystalline forms, pharmaceutically acceptable salts and/or hydrates thereof, where: W is naphthalene, indolizine or quinoline; R1 is hydrogen, fluorine, chlorine, methyl; R2 is hydrogen, fluorine, methyl, phenyl, thiophen-2-yl, furan-2-yl, pyridyl, piperazin-1-yl or 4-methylpiperazin-1-yl; R3 is methyl; or W is benzene, R3 has the above meaning; R1 is 3-C 1, R2 is ?-piperazin-1-yl or 3-(4-methylpiperazin-1-yl); or R1 is hydrogen, R2 is phenyl or pyridyl; or R1 is hydrogen, fluorine, chlorine, methyl; R2 is 4-piperazin-1-yl or 4-(4-methylpiperazin-1-yl); or W is oxazole, R3 is optionally substituted methyl; R1 is chlorine or fluorine, R2 is methyl, or R1 is hydrogen, fluorine, chlorine, methyl; R2 is piperazin-1-yl, 4-methylpiperazin-1-yl, or R1 is chlorine, fluorine or methyl; R2 is furan-2-yl, or R1 is hydrogen, fluorine, chlorine, methyl; R2 is furan-2-yl, R3 is (tetrahydrofuran-2-yl)methyl, or R1 is hydrogen, fluorine, chlorine, methyl; R2 is thiophen-2-yl, R3 is 2-methoxyethyl, or R1 is chlorine or fluorine, R2 is thiophen-2-yl, R3 is methyl.
摘要翻译：本发明涉及新型取代的甲胺，5-羟色胺5-HT 6受体拮抗剂，活性成分，药物组合物和预防和治疗中枢神经系统疾病的方法，以及分子仪器，其中新取代的甲胺是化合物通式1和结晶形式，多晶形式，其药学上可接受的盐和/或水合物，其中：W是萘，中氮茚或喹啉; R1是氢，氟，氯，甲基; R 2是氢，氟，甲基，苯基，噻吩-2-基，呋喃-2-基，吡啶基，哌嗪-1-基或4-甲基哌嗪-1-基; R3是甲基; 或W为苯，R3具有上述含义; R1是3-C 1，R2是α-哌嗪-1-基或3-（4-甲基哌嗪-1-基）; 或R 1为氢，R 2为苯基或吡啶基; 或R 1为氢，氟，氯，甲基; R2是4-哌嗪-1-基或4-（4-甲基哌嗪-1-基）; 或W为恶唑，R3为任选取代的甲基; R1是氯或氟，R2是甲基，或R1是氢，氟，氯，甲基; R2是哌嗪-1-基，4-甲基哌嗪-1-基，或R1是氯，氟或甲基; R2是呋喃-2-基，或R1是氢，氟，氯，甲基; R2是呋喃-2-基，R3是（四氢呋喃-2-基）甲基，或R1是氢，氟，氯，甲基; R2是噻吩-2-基，R3是2-甲氧基乙基，或R1是氯或氟，R2是噻吩-2-基，R3是甲基。

50. 发明申请

WO2012085171A2 PHARMACEUTICAL COMPOSITIONS OF PYRIDINIUM AND QUINOLINIUM DERIVATIVES 审中-公开
标题翻译：吡啶和喹啉衍生物的药物组合物
公开(公告)号：WO2012085171A2
公开(公告)日：2012-06-28
申请号：PCT/EP2011/073722
申请日：2011-12-22
申请人： TRASLATIONAL CANCER DRUGS PHARMA, S.L. , PALACIOS IZQUIERDO, Beatriz , VAN HOOGEVEST, Peter , L.S. LEIGH, Mathew
发明人： PALACIOS IZQUIERDO, Beatriz , VAN HOOGEVEST, Peter , L.S. LEIGH, Mathew
IPC分类号： A61K9/127 , A61K47/48 , A61K9/00 , A61K31/4425 , A61K31/4706 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00
CPC分类号： A61K47/40 , A61K9/0019 , A61K9/08 , A61K9/127 , A61K31/4425 , A61K31/4706 , A61K47/6951 , B82Y5/00 , C07D213/74 , C07D215/44
摘要： The present invention relates to pharmaceutical compositions comprising a compound of formula (I) and a cyclodextrin or a liposome, to the process of preparing said compositions and their use for antitumor, antiviral, antiparasitic and antifungal treatment.
摘要翻译：本发明涉及包含式（I）化合物和环糊精或脂质体的药物组合物，涉及制备所述组合物的方法及其用于抗肿瘤，抗病毒，抗寄生虫和抗真菌治疗的用途。

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