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41. 发明申请

WO1996040144A1 ORAL ACYCLOVIR DELIVERY 审中-公开
标题翻译：口服ACYCLOVIR交货
公开(公告)号：WO1996040144A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008401
申请日：1996-06-03
申请人： PHARMAVENE, INC.
发明人： PHARMAVENE, INC. , BURNSIDE, Beth, A. , MATTES, Carol, E. , McGUINNESS, Charlotte, M. , RUDNIC, Edward, M. , BELENDIUK, George, W.
IPC分类号： A61K31/53
CPC分类号： A61K31/522 , A61K9/1075 , Y10S514/938 , Y10S514/943
摘要： A pharmaceutical preparation for oral acyclovir delivery comprising a stable, hydrophobic emulsion comprising continuous phase of a hydrophobic material selected from the group consisting of a long chain carboxylic acid or ester or alcohol thereof dispersed in an aqueous phase or having a hydrophilic discontinuous phase dispersed in a hydrophobic phase of a long chain carboxylic acid or alcohol thereof. The emulsion with acyclovir is incorporated into a pharmaceutical carrier suitable for oral delivery.
摘要翻译：用于口服阿昔洛韦递送的药物制剂包含稳定的疏水性乳剂，其包含疏水性材料的连续相，所述疏水性材料选自分散在水相中的长链羧酸或其酯或醇，或者具有分散在水相中的亲水性不连续相疏水相的长链羧酸或其醇。将含有阿昔洛韦的乳剂掺入适于口服给药的药物载体中。

42. 发明申请

WO1996033697A1 SELF-EMULSIFIABLE FORMULATION PRODUCING AN OIL-IN-WATER EMULSION 审中-公开
标题翻译：自制可生产水性乳液的配方
公开(公告)号：WO1996033697A1
公开(公告)日：1996-10-31
申请号：PCT/FR1995000531
申请日：1995-04-24
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , BENITA, Simon , KLEINSTERN, Jackie , GERSHANIK, Tatyana
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： A61K09/107
CPC分类号： A61K9/4858 , A61K9/107 , A61K9/1075 , Y10S514/938 , Y10S514/943
摘要： The invention concerns a self-emulsifiable formulation (SEOF) comprising an oily constituent and a surfactant, the SEOF being characterized in that the oily constituent contains an oily vector and a cationic lipid and, optionally, a lipophilic oily fatty alcohol. The oil-in-water emulsion produced by mixing the SEOF comprises positively charged oil droplets.
摘要翻译：本发明涉及包含油性成分和表面活性剂的自乳化制剂（SEOF），其特征在于油性成分含有油性载体和阳离子脂质，以及任选的亲油性油性脂肪醇。通过混合SEOF生产的水包油乳液包含带正电的油滴。

43. 发明申请

WO1996018374A1 STABLE WATER-IN-OIL EMULSION SYSTEM 审中-公开
标题翻译：稳定的油水乳化系统
公开(公告)号：WO1996018374A1
公开(公告)日：1996-06-20
申请号：PCT/US1995011061
申请日：1995-09-01
申请人： ESTEE LAUDER, INC.
发明人： ESTEE LAUDER, INC. , STEPNIEWSKI, George, J. , KONIK, Richard, A. , DREHER, John, D. , CIOCA, Gheorghe , COHEN, Isaac, D. , PHILLIPS, Joan, M. , ZECCHINO, Julius, R.
IPC分类号： A61K07/00
CPC分类号： A61K8/894 , A61K8/06 , A61K8/064 , A61K8/345 , A61K8/585 , A61K31/74 , A61Q1/02 , A61Q19/00 , Y10S514/844 , Y10S514/845 , Y10S514/937 , Y10S514/938 , Y10S514/941
摘要： Disclosed is a stable water-in-oil emulsion system formed of an organopolysiloxane elastomer, a vehicle in which the elastomer is dispersed or dispersible, a stabilizing agent, a surfactant and an aqueous component and a process for forming the stable water-in-oil emulsion. The stabilized water-in-oil emulsion is useful in personal care products.
摘要翻译：公开了由有机聚硅氧烷弹性体，其中弹性体分散或分散的载体，稳定剂，表面活性剂和水性组分形成的稳定的油包水乳液体系和形成稳定的油包水的方法乳液。稳定的油包水乳液可用于个人护理产品。

44. 发明申请

WO1996014826A1 LOTION WHICH IS TEMPORARILY COLORED UPON APPLICATION 审中-公开
标题翻译：适用于临时使用的颜色
公开(公告)号：WO1996014826A1
公开(公告)日：1996-05-23
申请号：PCT/US1995014915
申请日：1995-11-16
申请人： SEEUV
发明人： SEEUV , VOCK, Curtis, A. , REENSTRA, Wende , McELENEY, John
IPC分类号： A61K07/42
CPC分类号： A61K8/498 , A61K8/4973 , A61K2800/45 , A61Q17/04 , Y10S514/844 , Y10S514/846 , Y10S514/847 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/946 , Y10S514/947
摘要： A lotion such as a sunscreen includes a pH indicator which colorizes the lotion until the lotion is applied to the human skin, whereinafter the colored lotion turns clear. A physiologically compatible pH indicator such as phenolphthalein is used which has a red appearance from pH 7.5+ and which has a clear appearance from about pH 7.0 to 7.5, the general pH range of the skin. The invention is suitable for use in any lotion, gel, mousse or medication that is best applied in an even and uniform manner to the skin. Accordingly, one preferred use of the invention is in UV-protecting sunscreens so that a user can ensure even distribution of the sunscreen on the body. In certain aspects of the invention, a cap houses the pH indicator and attaches to a container of the lotion, e.g., a sunscreen. The pH indicator mixes with the lotion as it is applied to the skin. The invention further provides methods of manufacturing sunscreens and the like with a pH indicator that turns substantially colorless upon application to the skin.
摘要翻译：诸如防晒剂的洗剂包括将洗剂着色的pH值指示剂，直到洗剂被施用于人体皮肤，其后在彩色乳液变得透明。使用生理上相容的pH指示剂如酚酞，其pH值为7.5+具有红色外观，并且具有皮肤的一般pH范围约7.0至7.5的清晰外观。本发明适用于以均匀均匀的方式最适用于皮肤的任何洗液，凝胶，摩丝或药物。因此，本发明的一个优选用途是在防紫外线防晒剂中，使得使用者可以确保防晒剂在身体上的均匀分布。在本发明的某些方面中，帽容纳pH指示剂并附着在洗剂的容器上，例如防晒霜。当pH值指示剂施用于皮肤时，pH指示剂与洗剂混合。本发明还提供了制备具有pH指示剂的防晒剂等的方法，所述pH指示剂在施用于皮肤时基本上无色。

45. 发明申请

WO9607396A2 RETINOID COMPOSITIONS 审中-公开
标题翻译： RETINOID组合物
公开(公告)号：WO9607396A2
公开(公告)日：1996-03-14
申请号：PCT/US9511750
申请日：1995-09-06
申请人： JOHNSON & JOHNSON CONSUMER , JOHNSON & JOHNSON MEDICAL K K , LIU JUE CHEN , WANG JONAS C T , YAMAMOTO NORIHIRO , KAZAMA SATOSHI , YUSUF MOHAMMED
发明人： LIU JUE-CHEN , WANG JONAS C T , YAMAMOTO NORIHIRO , KAZAMA SATOSHI , YUSUF MOHAMMED
IPC分类号： A61K8/06 , A61K8/67 , A61Q17/04 , A61Q19/00 , A61K7/48
CPC分类号： A61K8/062 , A61K8/06 , A61K8/671 , A61K2800/51 , A61K2800/522 , A61K2800/88 , A61Q17/04 , A61Q19/00 , Y10S514/938 , Y10S514/946
摘要： Skin care compositions comprising an oil-in-water emulsion base containing retinoids and possessing good physical and chemical stability.
摘要翻译：皮肤护理组合物包含含有类视黄醇并具有良好物理和化学稳定性的水包油乳液基质。

46. 发明申请

WO1996003107A1 OIL-IN-WATER COSMETIC COMPOSITION 审中-公开
标题翻译：油水化妆品组合物
公开(公告)号：WO1996003107A1
公开(公告)日：1996-02-08
申请号：PCT/JP1995001445
申请日：1995-07-20
申请人： SHISEIDO COMPANY, LTD. , IKEDA, Tomoko , AIZAWA, Masanori
发明人： SHISEIDO COMPANY, LTD.
IPC分类号： A61K07/00
CPC分类号： A61K8/361 , A61K8/06 , A61K8/062 , A61K8/37 , A61K8/44 , A61K8/585 , A61Q1/02 , A61Q1/06 , Y10S514/937 , Y10S514/938
摘要： A cosmetic composition comprising water, a waxy ester of a C18-C34 fatty acid with a C18-C44 higher alcohol, and at least one component usable in cosmetics, including an amphoteric surfactant, and optionally containing a C18-C34 higher fatty acid itself. The invention can provide an intermediate composition for cosmetics, such as foundation, lipstick or eye shadow, which are mild to the touch and have such physical and chemical characteristics as to permit stable preservation.
摘要翻译：一种化妆品组合物，其包含水，C18-C34脂肪酸的蜡状酯与C18-C44高级醇，以及至少一种可用于化妆品的成分，包括两性表面活性剂，以及任选含有C18-C34高级脂肪酸本身的化妆品组合物。本发明可以提供一种化妆品的中间组合物，例如基础，口红或眼影，其触感温和，具有允许稳定保存的物理和化学特性。

47. 发明申请

WO1996002247A1 STABLE OIL-IN-WATER EMULSIONS INCORPORATING A TAXINE (TAXOL) AND METHOD OF MAKING SAME 审中-公开
标题翻译：纳入TAXINE（TAXOL）及其制造方法的稳定的水包油乳液
公开(公告)号：WO1996002247A1
公开(公告)日：1996-02-01
申请号：PCT/US1995008007
申请日：1995-06-22
申请人： HEMAGEN/PFC
发明人： HEMAGEN/PFC , KAUFMAN, Robert, J. , RICHARD, Thomas, J. , FUHRHOP, Ralph, W.
IPC分类号： A61K31/335
CPC分类号： A61K31/337 , A61K9/1075 , Y10S514/908 , Y10S514/938
摘要： This invention is directed to a composition of a taxine in a stable oil-in-water emulsion for intravenous administration. The invention also relates to a method for incorporating a taxine into an oil and making a stable oil-in-water emulsion. The composition includes a taxine, an oil, water and a surfactant. In a preferred embodiment, the taxine is taxol, the oil is safflower oil and the surfactant is lecithin. The taxine is incorporated into the oil by dissolving the taxine in a solution of an oil and a taxine co-solvent, such as isopropanol, for example. The co-solvent then is removed to form a solution of the taxine in oil. This solution may be dispersed in water with a surfactant to form a stable oil-in-water emulsion for intravenous administration.
摘要翻译：本发明涉及用于静脉内施用的稳定的水包油乳剂中的紫杉烷的组合物。本发明还涉及一种将紫杉烷掺入油中并制备稳定的水包油乳液的方法。组合物包括紫杉烷，油，水和表面活性剂。在优选的实施方案中，紫杉醇是紫杉醇，油是红花油，表面活性剂是卵磷脂。通过将紫杉烷溶解在例如异丙醇等油和紫杉醇助溶剂的溶液中而将紫杉烷掺入到油中。然后除去助溶剂以形成紫杉烷在油中的溶液。该溶液可以用表面活性剂分散在水中以形成用于静脉内给药的稳定的水包油乳液。

48. 发明申请

WO1995033447A1 STABLE REVERSE AND MULTIPLE FLUOROCARBON EMULSIONS 审中-公开
标题翻译：稳定的反相和多种氟代乳液
公开(公告)号：WO1995033447A1
公开(公告)日：1995-12-14
申请号：PCT/EP1995002205
申请日：1995-06-07
申请人： ALLIANCE PHARMACEUTICAL CORP.
发明人： ALLIANCE PHARMACEUTICAL CORP. , RIESS, Jean, G. , KRAFFT, Marie-Pierre
IPC分类号： A61K09/107
CPC分类号： A61K9/0026 , A61K9/113 , B01F2003/0838 , Y10S514/832 , Y10S514/937 , Y10S514/938
摘要： Stable reverse water-in-fluorocarbon emulsions and water-in-fluorocarbon-in-water multiple emulsions comprising the reverse fluorocarbon emulsions. The reverse emulsions comprise a continuous phase which is a highly fluorinated or perfluorinated compound, a discontinuous aqueous phase and a fluorinated surfactant or mixture of surfactants. The multiple emulsions comprise an aqueous continuous phase and a discontinuous phase comprising globules formed of aqueous droplets dispersed into a highly fluorinated or perfluorinated compound. The emulsions can contain pharmacologically active agents, and are particularly suitable for pulmonary drug delivery.
摘要翻译：包含反向碳氟化合物乳液的稳定的反向含氟碳乳液和含氟碳水化合物的多重乳液。反向乳液包括连续相，其是高度氟化或全氟化合物，不连续水相和氟化表面活性剂或表面活性剂的混合物。多重乳液包含水性连续相和不连续相，其包含由分散在高度氟化或全氟化合物中的水性液滴形成的小球。乳剂可以含有药理活性剂，特别适用于肺部药物递送。

49. 发明申请

WO1995031181A1 HEPATOCYTE-SELECTIVE OIL-IN-WATER EMULSION 审中-公开
标题翻译：肝脏选择性水中乳化液
公开(公告)号：WO1995031181A1
公开(公告)日：1995-11-23
申请号：PCT/US1995005974
申请日：1995-05-16
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF MICHIGAN , COUNSELL, Raymond, E. , LONGINO, Marc, A. , WEICHERT, Jamey, P. , BAKAN, Douglas, A.
发明人： THE BOARD OF REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： A61K09/107
CPC分类号： A61K9/1075 , A61K9/1275 , A61K49/0433 , A61K49/1806 , A61K51/1217 , Y10S514/893 , Y10S514/894 , Y10S514/938 , Y10S514/941 , Y10S516/923 , Y10S516/93
摘要： A heat and shelf-stable oil-in-water emulsion useful as a tissue or cell-selective delivery vehicle. Radioactive or stable, synthetic or semi-synthetic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bis[7-(3-amino-2,4,6-triiodophenyl)heptanoate] or 2-oleoylglycerol-1,3-bis[ omega -(3,5-bis-trifluoromethyl)-heptanoate] or phenyl acetate, can be incorporated into the lipophilic core of a lipoprotein-like emulsion particle. The lipophilic core is surrounded by a phospholipid membrane comprising cholesterol and apolipoproteins. For hepatocyte-selective delivery, the emulsion is chylomicron remnant-like by being in a size range of 50 to 200 nm as measured by number weighting analysis with a narrow size distribution (
摘要翻译：可用作组织或细胞选择性递送载体的热和储存稳定的水包油乳液。放射性或稳定的合成或半合成多卤甘油三酸酯，如2-油酰甘油-1,3-双[7-（3-氨基-2,4,6-三碘苯基）庚酸酯]或2-油酰甘油-1,3-二双（ω-（3,5-双 - 三氟甲基） - 庚酸酯]或乙酸苯酯可加入脂蛋白样乳液颗粒的亲脂性核心中。亲脂性核被包含胆固醇和载脂蛋白的磷脂膜包围。对于肝细胞选择性递送，通过具有窄尺寸分布的数量加权分析（<3％大于300nm）测量并具有自然模拟的组成，通过在50至200nm的尺寸范围内，乳液是乳糜微粒残留的发生乳糜微粒残留物。在乳液配方中使用胆固醇促进载脂蛋白，特别是由肝细胞识别并且是结合和摄取所必需的Apo E的缔合。稳定性和尺寸限制可以通过超高能量混合设备（例如MicroFluidizer（Microfluidics Corp.，Newton，MA））来实现，以形成乳液。在优选的实施方案中，乳液的重量摩尔渗透压浓度由甘油而不是生理盐水控制。

50. 发明申请

WO1995028136A1 TREATMENT OF WARTS USING ANTHRALINS AND OCCLUSION 审中-公开
标题翻译：治疗使用神经痛和闭塞症的治疗
公开(公告)号：WO1995028136A1
公开(公告)日：1995-10-26
申请号：PCT/US1995004436
申请日：1995-04-14
申请人： TOWSEND, Marvin, S. , BLOOM, Leonard , ROBINSON, Howard, N. , MARTIN, Neil, F.
发明人： TOWSEND, Marvin, S. , BLOOM, Leonard
IPC分类号： A61F13/00
CPC分类号： A61K9/7084 , A61F13/0203 , A61F2013/00506 , A61F2013/00646 , A61F2013/0074 , A61F2013/00885 , A61F2013/00927 , Y10S514/938
摘要： A method of treating a patient having one or more warts includes the steps of: applying to the wart an amount of a composition consisting essentially of an anthralin active ingredient and a pharmaceutical carrier; covering the wart and skin areas peripheral to the wart with an adhesive tape (20), such that the adhesive tape adheres to peripheral skin areas, whereby the adhesive tape (20) provides an occluding environment for the wart treated with the composition. The occluding environment is maintained for a desired period of time, and the adhesive tape (20) is removed. For a number of times as desired, a fresh amount of anthralin-containing compositions is applied, and a fresh piece of adhesive tape (20) is applied to recreate the occluding environment.
摘要翻译：一种治疗具有一个或多个疣的患者的方法包括以下步骤：向疣施用一定量的基本上由蒽醌活性成分和药物载体组成的组合物; 用粘合带（20）覆盖疣周围的疣和皮肤区域，使得粘合带粘附到周边皮肤区域，由此胶带（20）为用组合物处理的疣提供阻塞环境。将封闭环境保持期望的时间段，并且去除胶带（20）。根据需要多次，施加新鲜量的含有蒽菌素的组合物，并且施加新鲜的胶带（20）以重新形成闭塞环境。

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