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41. 发明申请

WO1992001475A1 COMPOSITIONS BASED ON ACTIVE PRINCIPLES OF HYDROPHOBIC MEDICAMENTS SOLUBILIZABLE IN AN AQUEOUS SOLVENT 审中-公开
标题翻译：基于在水溶液中可溶解的疏水性药物的活性成分的组合物
公开(公告)号：WO1992001475A1
公开(公告)日：1992-02-06
申请号：PCT/FR1991000595
申请日：1991-07-18
申请人： VACSYN FRANCE, S.A. , CHEDID, Louis , LEFRANCIER, Pierre
发明人： VACSYN FRANCE, S.A.
IPC分类号： A61K47/26
CPC分类号： A61K31/7004 , A61K9/0019 , A61K31/70 , A61K38/04 , A61K39/39 , A61K47/26 , A61K2039/5555 , A61K2039/55572 , C07H13/04 , C07H13/06 , C07H15/04 , C07H15/06
摘要： The invention relates to any composition caracterized in that it is comprised of: on the one hand, an active principle of a medicament or a pharmacologically active substance, water insoluble, said substance being substituted by at least one lipophylic group, and on the other hand, an osidic derivative of which at least one of the hydroxyl functions is substituted by one or a plurality of phosphate or sulphate group or groups, said compound being also substituted by a lipophylic group, the composition being capable of homogeneous solubilization or dispersion in an aqueous solvent. The invention also relates to the use of such compositions, particularly as pharmaceutical compositions dissolved in a physiologically acceptable aqueous solvent.
摘要翻译：本发明涉及任何组合物，其特征在于它包括：一方面，药物或药理活性物质的活性成分，水不溶性，所述物质被至少一个脂质基取代，另一方面其中羟基官能团中的至少一个羟基官能团被一个或多个磷酸基或硫酸根基团所取代的一种奥西衍生物，所述化合物也被脂环基团取代，所述组合物能够均匀地溶解或分散在水性溶剂。本发明还涉及这种组合物的用途，特别是作为溶解在生理上可接受的水性溶剂中的药物组合物。

42. 发明申请

WO1986002076A1 SURFACTANT CARBON HYDRATE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：表面活性剂碳水化合物衍生物及其制备方法
公开(公告)号：WO1986002076A1
公开(公告)日：1986-04-10
申请号：PCT/AT1985000036
申请日：1985-10-01
申请人： EVIDENZBÜRO ÖSTERREICHISCHER ZUCKERFABRIKEN ... , GREBER, Gerd , GRUBER, Heinrich
发明人： EVIDENZBÜRO ÖSTERREICHISCHER ZUCKERFABRIKEN ...
IPC分类号： C07H15/04
CPC分类号： C07H15/04 , C07H15/06 , C08B31/125
摘要： New carbon hydrate derivatives having the formula (I) are disclosed, wherein X1 is H, X, CH3, C2H5, CH2CH2OH, CH2CH(OH)CH3, CH2CH(OH)CH2OH, (A), or represents soluble starch rests with a medium molecular weight comprised between 1'000 and 30'000 and at least one X represents bound beta -alkylamido- or beta -N-alkylurea groups similar to ethers having the formula (II) wherein R1 and R2 are H, CH3, -(CH2)n-CH3, (n = 1-8) or branched aliphatic rests having from 3 to 10 atoms of carbon and Y is R3 or -NH-R3, R3 representing a linear or branched aliphatic rest having from 1 to 20 atoms of carbon and the other X, representing hydrogen. The new carbon hydrate derivatives (I) may be prepared by reacting the corresponding carbon hydrate derivatives (III) which have at least one ether-like bound beta -amynoethyl group having the general formula (IV) with an alkylcarbon acid or an alkylcarbon acid derivative, respectively an alkylisocyanate having the formula (V) or the formula (VI), wherein R3 has the meaning given hereabove and Z is hydroxy, halogen, alkoxy or alkoxy carbonyl. The new carbon hydrate derivatives (I) are excellent tensioactive agents which are very stable to hydrolysis, and which may be prepared in a simple way and are totally biodegradable.
摘要翻译：公开了具有式（I）的新的碳水化合物衍生物，其中X1是H，X，CH3，C2H5，CH2CH2OH，CH2CH（OH）CH3，CH2CH（OH）CH2OH，（A），或表示可溶性淀粉与中等分子量在1 000至30 000之间，至少1个X表示与式（II）的醚类似的结合的β-烷基酰胺基或β-N-烷基脲基团，其中R 1和R 2为H，CH 3， - （CH 2 ）n-CH 3，（n = 1-8）或具有3至10个碳原子的支链脂肪族残基，Y是R 3或-NH-R 3，R 3表示具有1至20个碳原子的直链或支链脂族基而另一个X代表氢。新的碳水化合物衍生物（I）可以通过使具有至少一个具有通式（Ⅳ）的醚状结合的β-氨基乙基的相应碳水化合物衍生物（III）与烷基碳酸或烷基碳酸衍生物分别具有式（V）或式（VI）的烷基异氰酸酯，其中R 3具有上文给出的含义，Z是羟基，卤素，烷氧基或烷氧基羰基。新的碳水化合物衍生物（I）是对水解非常稳定的优异的张力活性剂，可以以简单的方式制备并且是完全可生物降解的。

43. 发明申请

WO2016139127A1 A METHOD OF SEPARATING RHAMNOLIPIDS FROM A FERMENTATION BROTH 审中-公开
标题翻译：一种发酵芽孢杆菌的分离方法
公开(公告)号：WO2016139127A1
公开(公告)日：2016-09-09
申请号：PCT/EP2016/053982
申请日：2016-02-25
申请人： UNILEVER PLC , UNILEVER N.V. , CONOPCO, INC., D/B/A UNILEVER
发明人： MARRIOTT, Raymond, John , STEVENSON, Paul, Simon
IPC分类号： C12P19/44 , C07H13/06 , C07H1/08 , B01D15/00
CPC分类号： C07H1/08 , B01D11/0403 , B01D15/00 , B01J20/14 , C07H15/04 , C07H15/06
摘要： A method of extracting at least one rhamnolipid compound from a rhamnolipid fermentation mixture, the method comprising the steps of: (a) admixing an inert adsorbing support with a rhamnolipid fermentation mixture; (b) dissolving the mixture in an organic solvent at a temperature higher than 31 °C and at a pressure higher than 73 bars; (c) separating at least one fatty compound; (d) adding a co-solvent to said organic solvent; (e) modifying temperature and/or pressure; (f) separating a first rhamnolipid compound; and (g) separating a second rhamnolipid compound.
摘要翻译：一种从鼠李糖脂发酵混合物中提取至少一种鼠李糖脂化合物的方法，所述方法包括以下步骤：（a）将惰性吸附载体与鼠李糖脂发酵混合物混合; （b）在高于31℃和高于73巴的压力下将混合物溶解在有机溶剂中; （c）分离至少一种脂肪化合物; （d）向所述有机溶剂中加入共溶剂; （e）改变温度和/或压力; （f）分离第一鼠李糖脂化合物; 和（g）分离第二鼠李糖脂化合物。

44. 发明申请

WO2015187040A1 AMINO SPHINGOGLYCOLIPID ANALOGUES 审中-公开
标题翻译：氨基磷酸酯类似物
公开(公告)号：WO2015187040A1
公开(公告)日：2015-12-10
申请号：PCT/NZ2015/050070
申请日：2015-06-05
申请人： ANDERSON, Regan James , COMPTON, Benjamin Jason , HAYMAN, Colin Malcolm , HERMANS, Ian Francis , JOHNSTON, Karen Anne , PAINTER, Gavin Frank
发明人： ANDERSON, Regan James , COMPTON, Benjamin Jason , HAYMAN, Colin Malcolm , HERMANS, Ian Francis , JOHNSTON, Karen Anne , PAINTER, Gavin Frank
IPC分类号： C07H15/18 , C07H15/26 , C07H15/06 , A61K39/385 , A61K31/7028 , A61P11/06 , A61P35/00 , A61P37/02 , A61P3/10 , C07D309/14
CPC分类号： A61K39/385 , A61K39/0011 , A61K39/39 , A61K47/542 , A61K47/549 , A61K47/65 , A61K2039/55511 , A61K2039/60 , C07H15/04 , C07H15/06 , C07H15/18 , C07K9/001
摘要： The invention relates to amino sphingoglycolipid analogues and peptide derivatives thereof, compositions comprising these compounds and methods of treating or preventing diseases or conditions using such compounds, especially diseases or conditions relating to cancer, infection, atopic disorders, autoimmune disease or diabetes.
摘要翻译：本发明涉及氨基鞘糖脂类似物及其肽衍生物，包含这些化合物的组合物以及使用这些化合物治疗或预防疾病或病症的方法，特别是与癌症，感染，特应性疾病，自身免疫性疾病或糖尿病有关的疾病或病症。

45. 发明申请

WO2015153476A1 METHODS OF PRODUCING GLYCOLIPIDS 审中-公开
标题翻译：生产甘油的方法
公开(公告)号：WO2015153476A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/023370
申请日：2015-03-30
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： BOUNDY-MILLS, Kyria , GARAY ALMADA, Luis Antonio , SITEPU, Irnayuli , GERMAN, J. Bruce
IPC分类号： C12N1/16
CPC分类号： C12P19/44 , C07H15/06 , C12N1/16 , C12P7/64 , C12R1/645
摘要： Provided are methods and yeast cultures for producing glycolipids and glycolipid compositions. In varying embodiments, the yeast culture comprises a population of basidiomycetous yeast cells, one or more hydrophilic (e.g., non-hydrophobic) carbon sources, and/or at least about 1 g/L glycolipid (e.g., sophorolipid), wherein the culture does not comprise one or more hydrophobic carbon sources. In varying embodiments, the culture does not comprise one or more hydrophobic carbon sources selected from the group consisting of oils, alkanes, fatty acids, fatty esters and mixtures thereof.
摘要翻译：提供用于产生糖脂和糖脂组合物的方法和酵母培养物。在不同的实施方案中，酵母培养物包含一系列basidiomycetous酵母细胞，一种或多种亲水（例如，非疏水性）碳源和/或至少约1g / L糖脂（例如，槐糖脂），其中培养物不包含一个或多个疏水性碳源。在不同的实施方案中，培养物不包含选自油，烷烃，脂肪酸，脂肪酯及其混合物的一种或多种疏水性碳源。

46. 发明申请

WO2014077960A1 SYNTHESIS OF CARBOHYDRATE-BASED SURFACTANTS 审中-公开
标题翻译：基于碳酸氢盐的表面活性剂的合成
公开(公告)号：WO2014077960A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/062575
申请日：2013-09-30
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , PEMBERTON, Jeanne, E. , POLT, Robin, L. , MAIER, Raina, M. , COSS, Clifford, S.
发明人： PEMBERTON, Jeanne, E. , POLT, Robin, L. , MAIER, Raina, M. , COSS, Clifford, S.
IPC分类号： C07H15/02 , C07F9/94 , C07H13/06 , C08B37/00 , B01J23/00
CPC分类号： C07H15/14 , C07F3/003 , C07F9/94 , C07H1/00 , C07H15/04 , C07H15/06
摘要： The present invention provides carbohydrate-based surfactants and methods for producing the same. Methods for producing carbohydrate -based surfactants include using a glycosylation promoter to link a carbohydrate or its derivative to a hydrophobic compound.
摘要翻译：本发明提供了基于碳水化合物的表面活性剂及其制备方法。制备碳水化合物基表面活性剂的方法包括使用糖基化启动子将碳水化合物或其衍生物与疏水性化合物连接。

47. 发明申请

WO2012094540A3 METHODS FOR PREPARATION OF GLYCOSPHINGOLIPIDS AND USES THEREOF 审中-公开
标题翻译：制备糖苷类化合物的方法及其用途
公开(公告)号：WO2012094540A3
公开(公告)日：2012-08-30
申请号：PCT/US2012020388
申请日：2012-01-05
申请人： LIANG PI-HUI , UNIV NAT TAIWAN
发明人： LIANG PI-HUI
IPC分类号： C07H15/06 , A61K39/39 , A61P31/04 , A61P31/12 , A61P35/00 , C07H15/04 , C07H15/18
CPC分类号： C07H1/00 , A61K39/39 , C07B2200/07 , C07H15/04 , C07H15/06 , C07H15/18 , Y02P20/55 , A61K31/7028 , A61K31/715
摘要： Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of a-galactosyl ceramides, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells. A process for preparing a chiral compound comprising an R-form or S- form of a glycosphingolipid of formula (1 ) is provided, wherein R1=OH, NH2, NHCOR2, R2 = H or an alkyl, alkenyl, or alkyl terminating in aryl, substituted aryl, heteroaryl, or substituted heteroaryl, X=alkyl group, R3= OH or H, R4=OH or H, R5= aryl, substituted aryl, heteroaryl, or substituted heteroaryl, or a pharmaceutically acceptable salt thereof, wherein the compound of formula 1 is prepared by (a) deprotecting a compound of formula (2): wherein PG is a hydroxyl protecting group, with hydrogen under hydrogenation catalysis.
摘要翻译：提供了α-糖苷脂的合成和制备方法。提供了α-半乳糖苷类神经酰胺的合成方法及其药物活性类似物及其变体。提供了新的α-糖苷脂，其中所述化合物是用作NKT（天然杀伤T）细胞配体的免疫原性化合物。提供了制备包含式（1）的R型或S-形式的鞘糖脂的手性化合物的方法，其中R 1 = OH，NH 2，NHCOR 2，R 2 = H或烷基，烯基或烷基，其末端芳基，取代的芳基，杂芳基或取代的杂芳基，X =烷基，R 3 = OH或H，R 4 = OH或H，R 5 =芳基，取代的芳基，杂芳基或取代的杂芳基或其药学上可接受的盐，通过（a）在氢化催化下用氢去除保护式（2）的化合物：其中PG是羟基保护基。

48. 发明申请

WO2011112889A2 β-MANNOSYLCERAMIDE AND STIMULATION OF NKT CELL ANTI-TUMOR IMMUNITY 审中-公开
标题翻译： ß-MANNOSYLCERAMIDE和NKT细胞抗肿瘤免疫刺激
公开(公告)号：WO2011112889A2
公开(公告)日：2011-09-15
申请号：PCT/US2011/028024
申请日：2011-03-11
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , THE UNIVERSITY OF BIRMINGHAM OF EDGBASTON , BERZOFSKY, Jay A. , O'KONEK, Jessica , TERABE, Masaki , ILLARIONOV, Petr A. , BESRA, Gurdyal S.
发明人： BERZOFSKY, Jay A. , O'KONEK, Jessica , TERABE, Masaki , ILLARIONOV, Petr A. , BESRA, Gurdyal S.
IPC分类号： A61K9/08 , A61K9/10 , A61K9/14 , A61K31/7004 , A61K9/00 , A61P35/00
CPC分类号： A61K31/7032 , A61K31/7004 , A61K38/2013 , A61K39/00 , A61K39/0011 , A61K45/06 , A61K2039/585 , C07H15/04 , C07H15/06
摘要： β-mannosylceramides or salts or solvates thereof in a pharmaceutically acceptable carrier, for use as a Type I NKT cell agonist in conjunction with a therapeutically effective amount of α-galactosylceramide or a salt or a solvate thereof, and/or at least one or more T-cell co-stimulatory molecules, disclosed. Compositions comprising β-mannosylceramide, as well as methods of treatment of tumors are also provided.
摘要翻译： β-甘露糖基神经酰胺或其盐或溶剂合物在药学上可接受的载体中，用作I型NKT细胞激动剂与治疗有效量的α-半乳糖神经酰胺或其盐或溶剂合物，和/或至少一种或多种 T细胞共刺激分子，公开。还提供了包含β-甘露糖基神经酰胺的组合物以及治疗肿瘤的方法。

49. 发明申请

WO2008047249A3 ALPHA-GALACTOSYLCERAMIDE ANALOGS, THEIR METHODS OF MANUFACTURE, INTERMEDIATE COMPOUNDS USEFUL IN THESE METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译： ALPHA-GALACTOSYLCERAMIDE ANALOGS，他们的制造方法，这些方法中有用的中间体化合物和含有它们的药物组合物
公开(公告)号：WO2008047249A3
公开(公告)日：2010-02-11
申请号：PCT/IB2007004270
申请日：2007-10-18
申请人： CENTRE NAT RECH SCIENT , UNIV PARIS DESCARTES , INST NAT SANTE RECH MED , DUBREUIL DIDIER , PIPELIER MURIEL , MICOUIN LAURENT , LECOURT THOMAS , LACONE VIVIEN , BONNEVILLE MARC , LEPENDU JACQUES , TURCOT-DUBOIS ANNE-LAURE
发明人： DUBREUIL DIDIER , PIPELIER MURIEL , MICOUIN LAURENT , LECOURT THOMAS , LACONE VIVIEN , BONNEVILLE MARC , LEPENDU JACQUES , TURCOT-DUBOIS ANNE-LAURE
IPC分类号： C07H15/06 , A61K31/7032 , C07H15/14
CPC分类号： C07H15/06 , C07H15/14
摘要： The invention relates to a -galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the a-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize a-galactoceramide analogs by a mere metathesis reaction. The a -galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.
摘要翻译：本发明涉及β-半乳甘油酰胺类似物，其制备方法，可用于这些方法的中间体化合物。它还涉及含有α-半乳糖苷类似物的药物组合物。本发明的制造方法涉及使用不纯中间体化合物，其通过仅仅通过复分解反应合成α-半乳甘露聚糖类似物。本发明的α-半乳糖苷类似物可用作药物组合物的活性成分，特别是在具有抗癌性质的药物组合物中。

50. 发明申请

WO2009060086A2 INCREASE OF IMMUNE RESPONSE AND TARGETING BY ANTIGENS AND/OR DRUG LINKAGE 审中-公开
标题翻译：增加免疫反应和抗原和/或药物联结靶向
公开(公告)号：WO2009060086A2
公开(公告)日：2009-05-14
申请号：PCT/EP2008065179
申请日：2008-11-07
申请人： WITTYCELL , SERRA VINCENT
发明人： SERRA VINCENT
IPC分类号： A61K47/48 , A61K39/385 , C07H15/06
CPC分类号： C07H15/06 , A61K39/385 , A61K47/549 , A61K47/646 , A61K2039/57 , A61K2039/6018
摘要： The present invention relates to compounds consisting of glycolipids covalently bound to an antigen or a drug via a linker. The said compounds are able to induce a stronger immune response than a composition comprising separated glycolipids and antigen. The said compounds are also able to target drug to CD1d restricted cells.
摘要翻译：本发明涉及由经接头共价结合抗原或药物的糖脂组成的化合物。所述化合物能够诱导比包含分离的糖脂和抗原的组合物更强的免疫应答。所述化合物还能够将药物靶向CD1d限制性细胞。

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