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41. 发明申请

WO2016144915A9 AUTOMATIC DETERMINATION OF RADIATION BEAM CONFIGURATIONS FOR PATIENT-SPECIFIC RADIATION THERAPY PLANNING 审中-公开
标题翻译：用于患者特异性辐射治疗计划的辐射束配置的自动确定
公开(公告)号：WO2016144915A9
公开(公告)日：2017-03-09
申请号：PCT/US2016021272
申请日：2016-03-07
申请人： UNIV DUKE , WU QINGRONG JACKIE , GE YAORONG , YIN FANGFANG , YUAN LULIN
发明人： WU QINGRONG JACKIE , GE YAORONG , YIN FANGFANG , YUAN LULIN
IPC分类号： G06Q50/00
CPC分类号： G06Q50/00 , A61N5/103 , A61N5/1045 , A61N2005/1041 , G06F19/3481
摘要： Systems and methods for efficient and automatic determination of radiation beam configurations for patient-specific radiation therapy planning are disclosed. According to an aspect, a method includes receiving data based on patient information and geometric characterization of one or more organs at risk proximate to a target volume of a patient. The method includes determining automatically one or more radiation treatment beam configuration sets. Further, the method includes presenting the determined one or more radiation beam configuration sets via a user interface.
摘要翻译：公开了用于患者特定放射治疗计划的辐射束配置的有效和自动确定的系统和方法。根据一方面，一种方法包括基于患者信息和几何特征来接收数据，所述患者信息和几何特征是在接近患者的目标体积的危险的一个或多个器官。该方法包括自动确定一个或多个辐射治疗束配置集合。此外，该方法包括经由用户界面呈现确定的一个或多个辐射束配置集合。

42. 发明申请

WO2015169498A1 TREATMENT PLANNING SYSTEM 审中-公开
标题翻译：治疗计划系统
公开(公告)号：WO2015169498A1
公开(公告)日：2015-11-12
申请号：PCT/EP2015/056108
申请日：2015-03-23
申请人： KONINKLIJKE PHILIPS N.V. , SUNNYBROOK HEALTH SCIENCES CENTRE
发明人： AMTHOR, Thomas Erik , UHLEMANN, Falk , BHARAT, Shyam , DEHGHAN MARVAST, Ehsan , KUNG, Cynthia Ming-fu , RAVI, Ananth , KRUECKER, Jochen
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1027 , A61N2005/1041
摘要： The generation of the pattern and for the adaptation to the specific geometry requires a lot of manual work. It is an object of the invention to simplify the workflow for the clinician during treatment planning. This object is achieved by a treatment planning system configured for determining a set of catheter or needle insertion positions to be used during treatment comprising. The treatment planning system comprises an image providing module for providing a medical image from which at least one treatment target structure can be derived. Further the treatment planning system comprises a pattern providing module for providing one or a set of standard patterns for catheter or needle insertion comprising a plurality of catheter or needle insertion positions, wherein the catheter or needle positions relate to treatment positions in the at least one treatment target structure.
摘要翻译：模式的生成和适应特定几何需要大量的人工工作。本发明的一个目的是简化治疗计划期间临床医生的工作流程。该目的通过一种治疗计划系统来实现，所述治疗计划系统被配置用于确定在治疗期间使用的一组导管或针插入位置，包括。治疗计划系统包括用于提供医学图像的图像提供模块，从该图像可以导出至少一个治疗目标结构。此外，治疗计划系统包括模式提供模块，用于提供包括多个导管或针插入位置的导管或针插入的一个或一组标准图案，其中导管或针位置涉及至少一个治疗中的治疗位置目标结构。

43. 发明申请

WO2015044924A1 DECISION SUPPORT TOOL FOR CHOOSING TREATMENT PLANS 审中-公开
标题翻译：决定支持工具选择治疗计划
公开(公告)号：WO2015044924A1
公开(公告)日：2015-04-02
申请号：PCT/IB2014/064936
申请日：2014-09-29
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
发明人： HARTMAN, Joona , MARCOS, Maria, Isabel, Cordero , KUUSELA, Esa , PELTOLA, Jarkko, Yrjana , NORD, Janne, Ilmari
IPC分类号： G06F19/00
CPC分类号： G06F19/345 , A61N5/103 , A61N2005/1041 , G06F19/00 , G16H50/20
摘要： Patient data can be used to determine input values to different estimation functions for different treatment types. The estimation functions can each be used to estimate one or more outcome values for the respective treatment. A quality score can be be determined using the outcome value(s). A first treatment plan having an optimal quality score can be identified, e.g., by displaying the treatment plans with the quality scores, which may correspond to the outcome values.
摘要翻译：患者数据可用于确定不同治疗类型的不同估计功能的输入值。估计函数可以分别用于估计相应治疗的一个或多个结果值。可以使用结果值确定质量得分。可以例如通过显示具有与结果值对应的质量得分的治疗计划来确定具有最佳质量得分的第一治疗计划。

44. 发明申请

WO2015042727A1 PREDICTING ACHIEVABLE DOSE DISTRIBUTION USING 3D INFORMATION AS AN INPUT 审中-公开
标题翻译：使用3D信息作为输入预测可实现的剂量分配
公开(公告)号：WO2015042727A1
公开(公告)日：2015-04-02
申请号：PCT/CH2014/000139
申请日：2014-09-30
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
发明人： KUUSELA, Esa , HARTMAN, Joona , NORD, Janne , BAGHAIE, Ramin
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61N5/1031 , A61N5/1045 , A61N5/1065 , A61N5/1071 , A61N2005/1041 , G06T7/344 , G06T2207/10104 , G06T2207/30096
摘要： Knowledge-based radiotherapy treatment planning is expanded to include spatial information from, for example, positron emission tomography (PET). Information that is specific to a patient is accessed. A prediction of a spatial dose distribution inside a target volume in the patient is determined using the patient-specific information as an input to a prediction model. The prediction model is established using training data that includes data resulting from applying other radiation treatment plans to other patients. The training data includes spatially distributed information indicating a level of activity in target volumes in the other patients (e.g., PET image data). A dose-volume histogram and associated three-dimensional dose distribution information based on the prediction are produced. The dose-volume histogram and the three-dimensional dose distribution information can be used to develop a radiation treatment plan for the patient.
摘要翻译：基于知识的放射治疗计划扩大到包括例如正电子发射断层扫描（PET）的空间信息。访问特定于患者的信息。使用患者特定信息作为预测模型的输入来确定患者中目标体积内的空间剂量分布的预测。使用训练数据建立预测模型，训练数据包括将其他辐射治疗计划应用于其他患者所产生的数据。训练数据包括指示其他患者的目标体积的活动水平的空间分布信息（例如，PET图像数据）。产生了基于预测的剂量体积直方图和相关联的三维剂量分布信息。剂量体积直方图和三维剂量分布信息可用于为患者制定放射治疗计划。

45. 发明申请

WO2014139040A2 RADIATION THERAPY PLANNING USING INTEGRATED MODEL 审中-公开
标题翻译：辐射治疗计划的集成模型
公开(公告)号：WO2014139040A2
公开(公告)日：2014-09-18
申请号：PCT/CH2014/000029
申请日：2014-03-14
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
发明人： KUUSELA, Esa , MARIA, Cordero Marcos , HARTMAN, Joona , PELTOLA, Jarkko , NORD, Janne
IPC分类号： A61N5/10
CPC分类号： G06F19/3437 , A61N5/103 , A61N2005/1041 , G06F19/00 , G06N5/00 , G06N5/022 , G16H50/50
摘要： System and method for automatically generate therapy plan parameters by use of an integrate model with extended applicable regions. The integrated model integrates multiple predictive models from which a suitable predictive model can be selected automatically to perform prediction for a new patient case. The integrated model may operate to evaluate prediction results generated by each predictive model and the associated prediction reliabilities and selectively output a satisfactory prediction. Alternatively, the integrated model may select a suitable predictive model by a decision hierarchy in which each level corresponds to divisions of a patient data feature set and divisions on a subordinate level are nested with divisions on a superordinate level.
摘要翻译：
通过使用扩展适用区域的集成模型自动生成治疗计划参数的系统和方法。该集成模型集成了多个预测模型，从中可以自动选择合适的预测模型来执行新病例的预测。综合模型可用于评估由每个预测模型产生的预测结果和相关联的预测可靠性并选择性地输出令人满意的预测。或者，集成模型可以通过决策层次来选择合适的预测模型，其中每个层次对应于患者数据特征集合的划分，并且下级层级上的划分与上级层级上的划分嵌套。

46. 发明申请

WO2014063748A1 DETERMINING AN IRRADIATION REGION FOR RADIOTHERAPY BASED ON MODEL PATIENT DATA AND PATIENT IMAGE DATA 审中-公开
标题翻译：基于模型患者数据和患者图像数据确定放射治疗的辐射区域
公开(公告)号：WO2014063748A1
公开(公告)日：2014-05-01
申请号：PCT/EP2012/071245
申请日：2012-10-26
申请人： BRAINLAB AG
发明人： VILSMEIER, Stefan
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61N5/103 , A61N2005/1041 , A61N2005/1055
摘要： The invention relates to a data processing method of determining a radiotherapy treatment plan for radiotherapy treatment of a treatment body part (P) of a patient's body, the method being executed by a computer and comprising the following steps: a) acquiring treatment target position data comprising treatment target position information describing the position of a treatment target (TT1,..., TT3) to be treated by radiotherapy in the treatment body part (P); b) acquiring statistic model target region position data comprising statistic model target region position information describing the position of a model target region (MT11, MT13, MT21, MT23) in a model body part (M1, M2) corresponding to the treatment body part (P); c) determining, based on the treatment target data and the statistic model target region position data, irradiation region position data comprising irradiation region position information describing the position of an irradiation region (IR1, IR3) to be treated by irradiation with treatment radiation in the treatment body part (P).
摘要翻译：本发明涉及一种确定用于患者身体的治疗体部位（P）的放射治疗处理放射治疗计划的数据处理方法，该方法由计算机执行，包括以下步骤：a）获取治疗目标位置数据包括描述通过放疗在治疗体部分（P）中治疗的治疗对象（TT1，...，TT3）的位置的治疗目标位置信息; b）获取统计模型目标区域位置数据，该统计模型目标区域位置数据包括描述模型目标区域（MT11，MT13，MT21，MT23）在对应于治疗主体部分的模型体部分（M1，M2）中的位置的统计模型目标区域位置信息 P）; c）基于处理目标数据和统计模型目标区域位置数据确定包括照射区域位置信息的照射区域位置数据，该照射区域位置数据描述通过照射区域位置信息来描述待处理的照射区域（IR1，IR3）的位置治疗体部位（P）。

47. 发明申请

WO2013180969A1 APPARATUS AND METHOD PERTAINING TO OPTIMIZING A RADIATION-TREATMENT PLAN USING HISTORICAL INFORMATION 审中-公开
标题翻译：使用历史信息优化放射治疗计划的装置和方法
公开(公告)号：WO2013180969A1
公开(公告)日：2013-12-05
申请号：PCT/US2013/041400
申请日：2013-05-16
申请人： VARIAN MEDICAL SYSTEMS, INC. , VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
发明人： ZANKOWSKI, Corey E. , NORD, Janne , PELTOLA, Jarkko , KUUSELA, Esa
IPC分类号： G06Q50/22 , A61N5/00
CPC分类号： A61N5/1031 , A61N5/1038 , A61N2005/1041 , G06F19/00
摘要： A control circuit operably couples to a memory having historical information stored therein. This historical information comprises information regarding delivered radiation doses to non-targeted patient volumes for a plurality of different volume presentations. The control circuit iteratively optimizes a radiation-treatment plan for a specific plan using that historical information. The aforementioned historical information can comprise delivered-dose metrics as correspond to different relative distances within given patients. The control circuit can employ such information to determine, for example, an estimated dosage (including, if desired, a corresponding range of estimated dosages) for at least one volume within the specific patient at a specific distance from a specific point of reference. The control circuit can compare such historical information against radiation-treatment plan optimization results to qualitatively assess the radiation-treatment plan optimization results.
摘要翻译：控制电路可操作地耦合到存储有历史信息的存储器。该历史信息包括关于针对多个不同体积呈现的非目标患者体积的递送辐射剂量的信息。控制电路使用该历史信息对特定计划的辐射处理计划进行迭代优化。上述历史信息可以包括对应于给定患者内的不同相对距离的递送剂量度量。控制电路可以使用这样的信息来确定特定患者中距离特定参考点特定距离的至少一个体积的估计剂量（包括如果需要，相应的估计剂量范围）。控制电路可以将这些历史信息与放射治疗计划优化结果进行比较，对辐射治疗计划优化结果进行定性评估。

48. 发明申请

WO2013049845A2 SEMANTIC RADIATION TREATMENT PLAN OPTIMIZATION GUIDANCE 审中-公开
标题翻译：语义辐射治疗计划优化指导
公开(公告)号：WO2013049845A2
公开(公告)日：2013-04-04
申请号：PCT/US2012/058355
申请日：2012-10-01
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG , TOIMELA, Lasse , NORD, Janne , ZANKOWSKI, Corey
发明人： TOIMELA, Lasse , NORD, Janne , ZANKOWSKI, Corey
CPC分类号： A61N5/1031 , A61N2005/1041
摘要： A method for radiation therapy treatment plan optimization, comprising generating a first radiation therapy treatment plan for a patient using a selected treatment type from a database and optimizing the first radiation therapy treatment plan. A selection of metrics from the first radiation therapy treatment plan are identified and compared to metrics from aggregated prior patient records selected from the database. At least one parameter is identified that affects the ability of the first radiation therapy treatment plan to meet an identified metric. The at least one parameter is defined with a single, clinically meaningful, human understandable language statement. The at least one parameter for the identified metric is compared to at least one parameter for a competing metric and at least one alternative treatment step for the treatment plan is determined that will change the identified at least one parameter to improve the identified metric. The at least one alternative treatment step is expressed in clinically meaningful, human understandable language.
摘要翻译：一种用于放射治疗治疗计划优化的方法，包括利用来自数据库的选定治疗类型为患者生成第一放射疗法治疗计划并优化第一放射疗法治疗计划。识别来自第一放射治疗治疗计划的指标的选择，并将其与从数据库中选择的汇总的先前患者记录进行比较。至少有一个参数会影响第一个放射疗法治疗计划达到识别度量的能力。至少一个参数是用单一的，临床有意义的，人类可理解的语言语句定义的。将所识别的度量的至少一个参数与竞争度量的至少一个参数进行比较，并且确定用于治疗计划的至少一个替代治疗步骤，其将改变所识别的至少一个参数以改善所识别的度量。至少一个替代治疗步骤用临床上有意义的人类可理解的语言表达。

49. 发明申请

WO2012085722A1 SYSTEM AND METHOD FOR AUTOMATIC GENERATION OF INITIAL RADIATION TREATMENT PLANS 审中-公开
标题翻译：用于自动生成初始辐射治疗计划的系统和方法
公开(公告)号：WO2012085722A1
公开(公告)日：2012-06-28
申请号：PCT/IB2011/055507
申请日：2011-12-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LEE, Michael Chun-Chieh , BOROCZKY, Lills
发明人： LEE, Michael Chun-Chieh , BOROCZKY, Lills
IPC分类号： G06T7/00 , G06K9/62
CPC分类号： G06T7/0012 , A61N5/103 , A61N2005/1041 , G06F19/00 , G06F19/34 , G06T2207/30016 , G16H50/70
摘要： A non-transitory computer-readable storage medium storing a set of instructions executable by a processor. The set of instructions is operable to receive a current patient medical image of a current patient, compare the current patient medical image to a plurality of previous patient medical images, each of the previous patient medical images corresponding to a previous patient, select one of the previous patients based on a geometric similarity between the previous patient medical image of the selected one of the previous patients and the current patient medical image, and determine an initial radiation treatment plan based on a radiation treatment plan of the selected one of the previous patients.
摘要翻译：一种非暂时的计算机可读存储介质，其存储可由处理器执行的一组指令。所述指令集合可操作以接收当前患者的当前患者医学图像，将当前患者医学图像与多个先前患者医学图像进行比较，每个先前的患者医学图像对应于先前的患者，选择基于之前患者的先前患者医学图像与当前患者医学图像之间的几何相似度的先前患者，并且基于所选先前患者的放射治疗计划确定初始辐射治疗计划。

50. 发明申请

WO2010036732A1 TREATMENT PLANNING SYSTEMS AND METHODS FOR BODY CONTOURING APPLICATIONS 审中-公开
标题翻译：治疗计划系统和身体结构应用的方法
公开(公告)号：WO2010036732A1
公开(公告)日：2010-04-01
申请号：PCT/US2009/058088
申请日：2009-09-23
申请人： ZELTIQ AESTHETICS, INC. , ALLISON, John, W.
发明人： ALLISON, John, W.
IPC分类号： A61B18/02
CPC分类号： A61F7/00 , A61B18/203 , A61B34/10 , A61B2018/00452 , A61B2034/102 , A61B2034/256 , A61F7/10 , A61F2007/0075 , A61N5/00 , A61N7/00 , A61N7/02 , A61N2005/1041 , A61N2007/0008 , G06F19/00 , G06F19/3481 , G16H50/20
摘要： Methods and system for treatment planning for non- and minimally-invasive alteration of body adipose tissue for reduction and contouring of body fat are described Treatment plans can be generated by capturing current body data (e g, positioning, contour/shape, thickness of adipose tissue, etc), determining desired outcome of treatment (β g, percent reduction of adipose tissue thickness, degree of contour change, etc), and determining treatment parameters to achieve desired results Algorithms can be used to determine best-fit treatment parameters to use in treatment sessions In some embodiments, the system can provide a predictive endresult image for communication to patient and/or for determining alteration of desired outcome Real-time monitoring of feedback data can be used to determine treatment plan efficacy Additional algorithms can provide real-time comparison of feedback data to anticipated feedback data, and can be used to change treatment parameters in real-time to achieve desired effects
摘要翻译：描述用于身体脂肪组织的非微创改变的治疗计划的方法和系统，用于身体脂肪的减少和轮廓描述治疗计划可以通过捕获当前身体数据（例如，定位，轮廓/形状，脂肪组织的厚度等），确定预期的治疗结果（βg，脂肪组织厚度的减少百分比，轮廓变化程度等），以及确定治疗参数以达到期望的结果算法可用于确定最适合的治疗参数以用于治疗会话在一些实施例中，系统可以提供用于与患者通信的预测性结果图像和/或用于确定期望结果的改变。可以使用反馈数据的实时监测来确定治疗计划功效。附加算法可以提供实时比较的反馈数据到预期的反馈数据，并可用于实时改变治疗参数有效的效果

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