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41. 发明申请

WO2010000766A2 INTERVERTEBRAL DISC ENDOPROSTHESIS 审中-公开
标题翻译：椎间盘假体
公开(公告)号：WO2010000766A2
公开(公告)日：2010-01-07
申请号：PCT/EP2009058238
申请日：2009-07-01
申请人： CERAMTEC AG , SYNTHES GMBH , NIESS CHRISTINE , PREUSS ROMAN , SCHNEIDER NORBERT , GRAESSEL MATTHIAS
发明人： NIESS CHRISTINE , PREUSS ROMAN , SCHNEIDER NORBERT , GRAESSEL MATTHIAS
IPC分类号： A61F2/44 , A61L27/00
CPC分类号： A61F2/4425 , A61F2002/30331 , A61F2002/30487 , A61F2002/30957 , A61F2310/00203 , A61F2310/00233 , A61F2310/00239 , A61L27/10 , A61L2430/38 , C04B35/119 , C04B35/42 , C04B2235/3205 , C04B2235/3213 , C04B2235/3217 , C04B2235/3222 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3229 , C04B2235/3241 , C04B2235/3246 , C04B2235/3886 , C04B2235/5292
摘要： The invention relates to an intervertebral disc endoprosthesis for implantation in the spinal column, with an upper end plate (1) and a lower end plate (2) for securing respectively to the bones of the vertebral body, and with a slide bearing which is arranged between the end plates (1, 2) and is composed of slide bodies (3, 4) that are designed to slide on each other, wherein both end plates (1, 2) are made of plastic and the slide bodies (3, 4) are made of ceramic, the slide bodies (3, 4) are encapsulated by the plastic of the end plates (1, 2), and the surface areas of the slide bodies (3, 4) encapsulated by the plastic of the end plates (1, 2) have surface area enlargements by comparison with flat surfaces. To ensure that the slide bodies are connected fixedly to the end plates in a manner secure against twisting, it is proposed that the surface area enlargements are elevations (6) or depressions on the slide bodies (3, 4).
摘要翻译：本发明涉及一种椎间盘假体用于脊柱植入，具有顶侧（1）和下侧的端板（2）相应的附连于椎骨骨和端板之间的一个（1，2）排列的轴承，由滑动体（3 ，4），依次形成滑动时，被注射成型的两个端板（1左右，2）由塑料制成并且所述滑动体（3，4）是由陶瓷，所述滑动体（3，4）从所述端板的塑料材料（1,2）并具有端板的塑料材料（1,2）的滑动件的挤出包覆的表面部分（3,4）相比，表面扩印的平坦表面。由此，滑动体是固定的，不可旋转地连接到端板，所以建议在表面扩印是凸起（6）或凹部上的滑动体（3，4）。

42. 发明申请

WO2009144453A1 HYPOXIA INDUCING FACTOR (HIF) STABILISING GLASSES 审中-公开
标题翻译： HYPOXIA诱导因子（HIF）稳定玻璃
公开(公告)号：WO2009144453A1
公开(公告)日：2009-12-03
申请号：PCT/GB2009/001323
申请日：2009-05-27
申请人： IMPERIAL INNOVATIONS LIMITED , JELL, Gavin , HILL, Robert, Graham , STEVENS, Molly, Morag , AZEVEDO, Maria
发明人： JELL, Gavin , HILL, Robert, Graham , STEVENS, Molly, Morag , AZEVEDO, Maria
IPC分类号： A61F2/00 , A61K33/26 , A61K33/32 , A61K33/34 , A61L15/18 , A61L27/02 , C03C3/097
CPC分类号： A61K33/08 , A61K33/00 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34 , A61K33/42 , A61K45/06 , A61L27/10 , A61L27/38 , A61L27/3834 , C03C3/062 , C03C3/097 , C03C3/112 , C03C3/115 , C03C4/0007 , A61K2300/00
摘要： The present invention relates to a glass composition formulated to provide the controlled release of certain transition metal ions to regulate the cellular hypoxia pathway and the use of these hypoxia-pathway regulating glasses in medicine and in biomedical research, including in the repair, restoration or regeneration of diseased or damaged tissue.
摘要翻译：本发明涉及配制成提供某些过渡金属离子的受控释放以调节细胞缺氧途径的玻璃组合物，以及这些缺氧途径调节玻璃在医学和生物医学研究中的应用，包括在修复，恢复或再生患病或损伤的组织。

43. 发明申请

WO2009098036A3 BIOCOMPATIBLE COMPONENT AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：生物相容性组件与方法研究
公开(公告)号：WO2009098036A3
公开(公告)日：2009-12-03
申请号：PCT/EP2009000740
申请日：2009-02-04
申请人： FRAUNHOFER GES FORSCHUNG , EMPA , ROTA ASTRID , IMGRUND PHILIPP , BRUININK AREND
发明人： ROTA ASTRID , IMGRUND PHILIPP , BRUININK AREND
IPC分类号： C04B35/111 , A61L27/30 , B22F3/11 , B22F3/115 , C04B35/14 , C04B35/447 , C04B35/486 , C04B35/488
CPC分类号： B22F3/115 , A61F2002/30968 , A61L27/045 , A61L27/06 , A61L27/10 , A61L27/12 , A61L27/30 , A61L27/56 , B22F3/1103 , B22F3/225 , B22F2999/00 , C04B35/111 , C04B35/14 , C04B35/447 , C04B35/486 , C04B2235/3212 , C04B2235/5436 , C04B2235/5445 , C04B2235/5472 , C04B2235/6022 , C04B2235/666 , C04B2235/667 , B22F3/1021 , B22F2202/13 , B22F2202/11 , B22F1/0014
摘要： The invention relates to a method for producing components that have at least partially biocompatible surface areas. A mixture from a powdery biocompatible material and a binder is introduced into an injection mold by way of an injection molding method or is applied to a surface to be coated by way of injection molding method, the components so obtained being then subjected to debinding and sintering. The powdery biocompatible material used is a mixture that consists of particles of a particle size of between 700 nm and 50 µm and of 5% by weight to 50% by weight of particles of a particle size of less than 700 nm.
摘要翻译：本发明涉及一种用于制造具有至少部分的生物相容的表面区域组成。在这种情况下，和生物相容性粘合剂的粉末材料的混合物被引入或通过在注射模具中注射成型工艺的装置被施加到通过注射成型工艺来涂覆的表面上; 随后脱粘结剂和烧结产生的部件的，作为粉末状的生物相容性材料是这里使用的混合物，它由具有700纳米至50微米之间的颗粒尺寸的颗粒的从.- 5重量％至具有粒径50层重量％的颗粒小于700nm是。

44. 发明申请

WO2009072788A1 A IMPLANT CONSISTING OF BALL AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：一种植入物及其制造方法
公开(公告)号：WO2009072788A1
公开(公告)日：2009-06-11
申请号：PCT/KR2008/007107
申请日：2008-12-02
申请人： LEE, Boo Rak
发明人： LEE, Boo Rak
IPC分类号： A61C8/00 , A61C13/00
CPC分类号： A61C8/0012 , A61L27/04 , A61L27/10 , A61L27/56
摘要： Disclosed is an implant composed of an aggregate of spherical balls which are connected to each other through sintering and a manufacturing method thereof. Upon use of the implant having numerous pores defined by spherical ceramic balls which are aggregated, cell affinity and ability of the cells to survive can be increased. The implant can be used for a long period of time without it becoming loose, and can prevent the hole in the alveolar bone where the implant (fixture) is installed from being enlarged.
摘要翻译：公开了一种由通过烧结彼此连接的球形球团聚体构成的植入物及其制造方法。在使用具有由聚集的球形陶瓷球限定的许多孔的植入物的情况下，可以增加细胞亲和力和细胞存活的能力。植入物可以长时间使用，而不会松动，并且可以防止植入物（固定装置）安装的牙槽骨中的孔被扩大。

45. 发明申请

WO2008125331A2 METHOD FOR THE PRODUCTION, AND PARTICULARLY FOR THE RESTORATION, OF A FABRIC STRUCTURE 审中-公开
标题翻译：用于生产尤其是对恢复织物结构
公开(公告)号：WO2008125331A2
公开(公告)日：2008-10-23
申请号：PCT/EP2008002970
申请日：2008-04-15
申请人： GEHL GEROLF
发明人： GEHL GEROLF
IPC分类号： A61L27/10 , A61L27/50
CPC分类号： A61L27/10 , A61L27/50
摘要： In a method for the production, and particularly for the restoration, of a fabric structure using a substance containing at least one ceramic product, the substance is to be used in conjunction with a template for the desired fabric structure.
摘要翻译：在用于产生和特别地用于恢复通过使用至少一种含陶瓷的物质的组织结构的方法，以便在与所期望的织物结构体的模板一起使用的物质。

46. 发明申请

WO2008051555A3 DEPOSITION OF DISCRETE NANOPARTICLES ON A NANOSTRUCTURED SURFACE OF AN IMPLANT 审中-公开
标题翻译：离子纳米粒子在种植体纳米结构表面的沉积
公开(公告)号：WO2008051555A3
公开(公告)日：2008-10-16
申请号：PCT/US2007022511
申请日：2007-10-24
申请人： BIOMET 3I INC , BERCKMANS BRUCE , TOWSE ROSS W , MAYFIELD ROBERT L
发明人： BERCKMANS BRUCE , TOWSE ROSS W , MAYFIELD ROBERT L
IPC分类号： A61F2/28 , A61C8/00 , A61C13/01
CPC分类号： A61C8/0015 , A61B17/86 , A61C8/0012 , A61C8/0013 , A61C8/0022 , A61C13/00 , A61F2/30767 , A61F2002/3084 , A61F2002/30968 , A61F2310/00796 , A61L27/04 , A61L27/10 , A61L27/425 , A61L27/50 , A61L2400/12 , A61L2430/02 , A61L2430/12 , B82Y30/00 , C23C22/02 , C23C24/08 , C23C26/00 , C23C30/00 , C23F1/00
摘要： A method of forming an implant to be implanted into living bone is disclosed. The method comprises the act of roughening at least a portion of the implant surface to produce a microscale roughened surface. The method further comprises forming a nanoscale roughened surface on the microscale roughened surface. The method further comprises the act of depositing discrete nanoparticles on the nanoscale roughened surface though a one-step process of exposing the roughened surface to a solution including the nanoparticles. The nanoparticles comprise a material having a property that promotes osseointegration.
摘要翻译：公开了一种形成植入到活骨中的植入物的方法。该方法包括粗糙化植入物表面的至少一部分以产生微型粗糙表面的动作。该方法还包括在微尺度粗糙表面上形成纳米级粗糙表面。该方法进一步包括通过将粗糙表面暴露于包含纳米颗粒的溶液的一步过程，将分散的纳米颗粒沉积在纳米级粗糙表面上的行为。纳米粒子包含具有促进骨整合性质的材料。

47. 发明申请

WO2008105739A1 DRUG IMPLANT CARRIER FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的药物植入物
公开(公告)号：WO2008105739A1
公开(公告)日：2008-09-04
申请号：PCT/SE2008/050233
申请日：2008-02-29
申请人： Doxa AB , HERMANSSON, Leif , ENGQVIST, Håkan
发明人： HERMANSSON, Leif , ENGQVIST, Håkan
IPC分类号： A61L27/10 , A61K47/02 , C04B38/08 , A61C13/083 , A61F2/00 , A61K6/06 , A61K9/22 , C04B28/06 , C04B35/10 , C04B7/32
CPC分类号： C04B28/06 , A61K6/0008 , A61K6/0067 , A61K6/0235 , A61K6/024 , A61K6/0606 , A61K6/0612 , A61K6/0625 , A61K6/0631 , A61K6/0643 , A61K6/087 , A61L24/0015 , A61L24/02 , A61L27/10 , A61L27/105 , A61L27/54 , A61L27/56 , A61L2300/602 , A61L2400/06 , C04B28/18 , C04B38/08 , C04B2111/00836 , C04B14/306 , C04B14/366 , C04B20/008 , C04B38/0054 , C04B38/0058 , C08L69/00
摘要： The present invention relates to ceramic precursor material exhibiting injectability and properties that make the material suitable as a carrier material used in drug delivery. According to the invention this is accomplished by selecting a microstructure based on pre-reacted phases and after injection established phases, which contain anti-infective and/or anti-inflammatory drugs. The present invention also relates to a cured ceramic material and a method of manufacturing said cured material. The precursor and the cured ceramic material according to the present invention can suitably be used for filling orthopaedic cavities and other bone voids.
摘要翻译：本发明涉及陶瓷前体材料，其具有使材料适合作为药物递送中使用的载体材料的可注射性和性质。根据本发明，这通过选择基于预反应阶段的微观结构和注射建立阶段来实现，其含有抗感染和/或抗炎药物。本发明还涉及固化的陶瓷材料和制造所述固化材料的方法。根据本发明的前体和固化的陶瓷材料可以适用于填充矫形腔和其他骨空隙。

48. 发明申请

WO2008101011A1 NANO/MACROPOROUS BIOACTIVE GLASSES MADE BY MELT-QUENCH METHODS 审中-公开
标题翻译： NANO /通过熔融法制造的大面积生物玻璃
公开(公告)号：WO2008101011A1
公开(公告)日：2008-08-21
申请号：PCT/US2008/053851
申请日：2008-02-13
申请人： LEHIGH UNIVERSITY , JAIN, Himanshu , MOAWAD, Hassan, Mohamady, Mohamed
发明人： JAIN, Himanshu , MOAWAD, Hassan, Mohamady, Mohamed
IPC分类号： B82B3/00
CPC分类号： A61L27/10 , A61L27/56
摘要： The methods and materials described herein provide novel and simple procedures for the preparation of nano/macroporous glasses, in which the pore structure is characterized by interconnected pores of, e.g., both hundreds of micrometers and several to tens of nanometers in size. Such materials may be used for enhanced bone regeneration, bioscaffolds, drug delivery devices, and filtration media, among other uses. For example, silica-based bone tissue scaffolds are made with a controlled nano/macroporosity, which enhances bone regeneration performance. Also provided herein are new biocompatible CaO-Na 2 O-P 2 O 5 -S i O 2 glasses prepared by thermal melt-quench methods that result in spinodal phase separation and crystallization of phases at very different length scales. Selective chemical leaching of these phases causes formation of interconnected multi-modal porosity, with pore sizes ranging from several nanometers to tens of micrometers.
摘要翻译：本文所述的方法和材料提供了用于制备纳米/大孔玻璃的新颖且简单的方法，其中孔结构的特征在于尺寸为几百微米和数十纳米的互连孔。除了其它用途之外，这种材料可用于增强骨再生，生物支架，药物递送装置和过滤介质。例如，二氧化硅基骨组织支架用受控的纳米/大孔隙度制成，这增强了骨再生性能。本文还提供了新的生物相容性CaO-Na 2 O 2 O 2 O 2 -Si O 2 通过热熔融淬火方法制备的玻璃杯，其导致相分离并在非常不同的长度尺度下结晶相。这些相的选择性化学浸出导致互连的多模式孔隙的形成，其孔径范围从几纳米到几十微米。

49. 发明申请

WO2008090533A2 A BONE CEMENT 审中-公开
标题翻译：骨水泥
公开(公告)号：WO2008090533A2
公开(公告)日：2008-07-31
申请号：PCT/IE2008/000005
申请日：2008-01-25
申请人： UNIVERSITY OF LIMERICK , TOWLER, Mark, Robert , BOYD, Daniel , CLARKIN, Owen
发明人： TOWLER, Mark, Robert , BOYD, Daniel , CLARKIN, Owen
IPC分类号： A61L27/10 , A61L27/50 , C03C3/078
CPC分类号： A61L27/50 , A61L27/10 , A61L2430/02 , C03C3/078 , C03C4/0007 , C03C14/004 , C03C2214/12 , C03C2214/30
摘要： A bone cement comprises a zinc-based glass and polyalkenoate acid. In addition, the cement comprises a controlled amount of tri-sodium citrate (Na3C6HsO7) ("TSC"). The cement has enhanced rheology without negatively impacting on the mechanical properties. Controlled addition of TSC significantly improves the rheology of the bone cements, increasing working and setting times (illustrated in Fig. 1). For three formulations of the working time can be adjusted from less than 50 seconds to almost 120 seconds; concomitantly working times improve from 58 seconds to duration in excess of 300s.
摘要翻译：骨水泥包括锌基玻璃和聚烯丙酸。此外，水泥包含受控量的柠檬酸三钠（Na 3 C 6 H 6 O 7）（“TSC”）。该水泥具有增强的流变性，而不会对机械性能产生负面影响。控制添加TSC显着改善骨水泥的流变性，增加工作和凝固时间（如图1所示）。对于三种配方的工作时间可以从小于50秒调整到近120秒; 伴随工作时间从58秒提高到持续时间超过300秒。

50. 发明申请

WO2007004913A8 BIOLOGICALLY COMPATIBLE MULTICOMPONENT NANOSTRUCTURAL COATINGS FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：生物兼容的多功能纳米结构涂层用于医疗应用
公开(公告)号：WO2007004913A8
公开(公告)日：2008-07-31
申请号：PCT/RU2005000529
申请日：2005-10-28
申请人： LEVASHOV EVGENY ALEKSANDROVICH , SHTANSKY DMITRY VLADIMIROVICH , GLOUSHANKOVA NATALYA ALEKSANDR , RESHETOV IGOR VLADIMIROVICH
发明人： LEVASHOV EVGENY ALEKSANDROVICH , SHTANSKY DMITRY VLADIMIROVICH , GLOUSHANKOVA NATALYA ALEKSANDR , RESHETOV IGOR VLADIMIROVICH
IPC分类号： A61L27/02 , A61K6/02 , A61L27/10
CPC分类号： A61L27/306 , A61L27/02 , A61L27/10 , A61L2400/12
摘要： This invention relates to medical engineering, more particularly, to biocompatible wear resistant nanostructured thin film materials for application as coatings in the fabrication of loadbearing implants, for example, orthopedic and dental prosthetics, dental crowns, implants for maxillofacial surgery, artificial limbs, fixtures etc. Requirements to these materials include high hardness, fatigue resistance, wear and corrosion resistance, biocompatibility and absence of toxicity. The technical result achieved in this invention is providing a multicomponent nanostructured coating (MNC) having high hardness, low elastic modulus, high adhesion to the substrate, low friction coefficient and wear rate, high resistance to long elastic strain to failure and plastic deformation, low surface roughness, negative surface charge in physiological media (4.5 i is the overall concentration of the main elements (Ti, C, N) in the coating and Y j is the overall concentration of the additional elements (Ca, Zr, Si, K, Mn, O, P) in the coating. The elemental concentration in the coating is chosen to keep the following component ratios, at.%: Ti : 30 - 50 C : 15 - 40 N : 0.5 - 30 O: 5 - 25 Ca: 0 - 7 Zr: 0 - 20 Si: 0 - 30 P: 0 - 1.5 Mn: 0 - 1.0 K: 0 - 1.0
摘要翻译：本发明涉及医疗工程，更具体地说，涉及生物相容性耐磨纳米结构薄膜材料，用于制造承载植入物例如矫形和牙科假肢，牙冠，颌面外科植入物，假肢，固定器等中的涂层。对这些材料的要求包括高硬度，耐疲劳性，耐磨损和耐腐蚀性，生物相容性和无毒性。本发明实现的技术成果是提供一种具有高硬度，低弹性模量，对基材的高附着力，低摩擦系数和磨损率，高抗弹性应变和破坏和塑性变形的高分子纳米结构涂层（MNC），低表面粗糙度，生理介质中的负表面电荷（4.5

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