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41. 发明申请

WO2008095603A3 COLOR-MARKED OLIGOSACCHARIDES OR POLYSACCHARIDES 审中-公开
标题翻译： COLOR注明寡糖或多糖
公开(公告)号：WO2008095603A3
公开(公告)日：2009-04-16
申请号：PCT/EP2008000479
申请日：2008-01-23
申请人： SUEDZUCKER AG , KOWALCZYK JOERG , ROSE THOMAS , HAUSMANNS STEPHAN , WALTER THOMAS , WACH WOLFGANG , GRETZ NORBERT , SADICK MALIHA , SCHOCK DANIEL
发明人： KOWALCZYK JOERG , ROSE THOMAS , HAUSMANNS STEPHAN , WALTER THOMAS , WACH WOLFGANG , GRETZ NORBERT , SADICK MALIHA , SCHOCK DANIEL
IPC分类号： A61K47/48 , A61K49/00 , C13B50/00
CPC分类号： A61K49/0054 , A61K47/549 , A61K49/0032 , A61K49/0052
摘要： The invention relates to color-marked oligosaccharides or polysaccharides, a method for the production of these color-marked oligosaccharides or polysaccharides, and the use thereof for the determination of kidney function.
摘要翻译：本发明涉及标记的寡糖或多糖的颜色，用于生产这些彩色标记的寡糖或多糖和其对肾功能的确定的用途。

42. 发明申请

WO2009020334A2 POROUS POLYMER PARTICLES IMMOBILIZED WITH CHARGED MOLECULES AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：用充电分子固定的多孔聚合物颗粒及其制备方法
公开(公告)号：WO2009020334A2
公开(公告)日：2009-02-12
申请号：PCT/KR2008/004540
申请日：2008-08-05
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , CHUNG, Bong Hyun , LIM, Yong Taik , HAN, Jung Hyun
发明人： CHUNG, Bong Hyun , LIM, Yong Taik , HAN, Jung Hyun
IPC分类号： C08J3/12
CPC分类号： A61K9/5031 , A61K49/0034 , A61K49/0054 , A61K49/0056 , A61K49/0089 , C08J3/12 , C08J2367/04
摘要： The present invention relates to porous polymer particles containing a charged molecule immobilized therein and a method for preparing the same. According to the disclosed invention, porous particles can be prepared using a biocompatible polymer and, at the same time, a charged molecule can be immobilized in the pores of the porous particles, such that various charged molecules can be loaded in the porous particles. In addition, various kinds of drugs or functional materials can be loaded into the porous particles of the present invention by electrostatic attraction and absorption or adsorption by a capillary phenomenon occurring due to porous properties.
摘要翻译：本发明涉及含有固定在其中的带电分子的多孔聚合物颗粒及其制备方法。根据所公开的发明，可以使用生物相容性聚合物制备多孔颗粒，并且同时可以将带电分子固定在多孔颗粒的孔中，使得各种带电分子可以负载在多孔颗粒中。此外，通过由于多孔性质而发生的毛细管现象的静电吸引和吸收，可以将各种药物或功能材料装载到本发明的多孔颗粒中。

43. 发明申请

WO2009006046A1 DENDRIMER CONJUGATES OF AGONISTS AND ANTAGONISTS OF THE GPCR SUPERFAMILY 审中-公开
标题翻译： GPCR超级药物的激素和拮抗剂的抑制剂
公开(公告)号：WO2009006046A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/067683
申请日：2008-06-20
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , INSERM , JACOBSON, Kenneth A. , KIM, Yoonkyung , KLUTZ, Athena , HECHLER, Beatrice , GACHET, Christian
发明人： JACOBSON, Kenneth A. , KIM, Yoonkyung , KLUTZ, Athena , HECHLER, Beatrice , GACHET, Christian
IPC分类号： A61K47/48 , A61K49/00 , A61P35/00 , A61P29/00 , A61P31/00 , A61P25/00 , A61P1/00 , A61P13/00 , A61P9/00
CPC分类号： A61K49/0054 , A61K47/59 , A61K47/595 , A61K47/60 , A61K49/0041
摘要： Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for example, wherein the functionalized congener is an A 1 adenosine receptor agonist having a purine nucleoside moiety and a functional group at the N 6 position of the purine nucleoside moiety, wherein the functional group has the formula (I): N 6 H-Ar 1 -CH 2 -C(=0)NH-R 1 (I), wherein Ar 1 and R 1 as defined herein. Also disclosed are pharmaceutical compositions, methods of treating various diseases, and a diagnostic method employing such conjugates.
摘要翻译：公开了包含树枝状大分子和配体的缀合物，其是G-蛋白质偶联受体（GPCR）超家族的受体的激动剂或拮抗剂的官能化同族物，其中所述官能化同系物是具有嘌呤核苷部分和嘌呤核苷部分的N6位置的官能团，其中官能团具有式（I）：N6H-Ar1-CH2-C（= O）NH-R1（I），其中Ar1和R1 如本文所定义。还公开了药物组合物，治疗各种疾病的方法和使用这种缀合物的诊断方法。

44. 发明申请

WO2008088865A3 ANTISENSE AND PRETARGETING OPTICAL IMAGING 审中-公开
标题翻译：反射和预激光学成像
公开(公告)号：WO2008088865A3
公开(公告)日：2008-10-09
申请号：PCT/US2008000669
申请日：2008-01-18
申请人： UNIV MASSACHUSETTS , KEIO UNIVERSITY SCHOOL OF MEDI , UNIV CALIFORNIA SAN FRANCISCO , HNATOWICH DONALD , NAKAMURA KAYOKO , WANG YI , LIU XINRONG , HE JIANG , ZHANG SURONG , RUSCKOWSKI MARY
发明人： HNATOWICH DONALD , NAKAMURA KAYOKO , WANG YI , LIU XINRONG , HE JIANG , ZHANG SURONG , RUSCKOWSKI MARY
IPC分类号： C12Q1/68
CPC分类号： G01N33/582 , A61K49/0032 , A61K49/0054 , G01N33/542 , G01N33/574
摘要： The present invention relates, in part, to detectably labeled oligomer duplexes and their use in optical imaging, including, in vivo optical imaging. The invention includes methods of optical imaging including in vivo pretargeting methods andin vivo antisense optical imaging methods.
摘要翻译：本发明部分涉及可检测标记的低聚物双链体及其在光学成像（包括体内光学成像）中的用途。本发明包括光学成像方法，包括体内预靶向方法和体内反义光学成像方法。

45. 发明申请

WO2008003682A1 NON INVASIVE METHOD FOR ASSESSING MUCUS CLEARANCE 审中-公开
标题翻译：非侵入式检测方法
公开(公告)号：WO2008003682A1
公开(公告)日：2008-01-10
申请号：PCT/EP2007/056652
申请日：2007-07-02
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , BECKMANN, Nicolau , KNEUER, Rainer , SCHMIDT, Philipp
发明人： BECKMANN, Nicolau , KNEUER, Rainer , SCHMIDT, Philipp
IPC分类号： A61K49/06
CPC分类号： A61K49/0054 , A61K49/0002 , A61K49/0032 , A61K49/128
摘要： The present invention relates to the field of imaging. More specifically, the invention provides a probe for use in a method for assessing mucus clearance, comprising a polysaccharide polymer capable of binding to mucus, coupled to at least one imaging contrast agent. In a preferred embodiment, the probe is made of aminodextran and coupled to MRI contrast agent and/or a near infra-red fluorochrome, such as Gadolinium chelating group complex and/or Cy5.5, respectively.
摘要翻译：本发明涉及成像领域。更具体地，本发明提供了一种用于评估粘液清除率的方法的探针，其包含能够结合至少一种成像造影剂的粘液的多糖聚合物。在优选的实施方案中，探针由氨基葡聚糖制成并分别与MRI造影剂和/或近红外荧光染料如钆螯合基团和/或Cy5.5偶联。

46. 发明申请

WO2007109121A2 A ZEBRAFISH MODEL FOR ASSESSING GASTROINTESTINAL MOTILITY 审中-公开
标题翻译：一种用于评估胃肠运动功能的ZBRAFISH模型
公开(公告)号：WO2007109121A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/006616
申请日：2007-03-16
申请人： RICH, Adam
发明人： RICH, Adam
IPC分类号： A61K49/00
CPC分类号： A61K49/0008 , A61K49/0043 , A61K49/0054
摘要： The present invention has demonstrated the presence of the zebrafish KIT protein resulting from the expression of the kit gene in the zebrafish GI tract. As expression of the KIT protein is correlated with ICC in other species, the expression of the KIT protein in zebrafish indicates the presence of ICC in the zebrafish GI tract. ICC are required for spontaneous, coordinated contractions of GI smooth muscle. The present invention provides a zebrafish-based model system useful for elucidating the cellular and molecular mechanisms of gastrointestinal (GI) function and for identifying molecular targets for treating GI motility disorders in human.
摘要翻译：本发明已经证明由于斑马鱼GI道中的试剂盒基因的表达而产生的斑马鱼KIT蛋白的存在。由于KIT蛋白的表达与其他物种中的ICC相关，斑马鱼中KIT蛋白的表达表明斑马鱼胃肠道中存在ICC。 ICC对胃肠平滑肌的自发协调收缩是必需的。本发明提供了一种基于斑马鱼的模型系统，可用于阐明胃肠（GI）功能的细胞和分子机制，并用于鉴定治疗人类GI动力障碍的分子靶点。

47. 发明申请

WO2007025768A1 OPTICALLY FLUORESCENT NANOPARTICLES 审中-公开
标题翻译：光学荧光纳米粒子
公开(公告)号：WO2007025768A1
公开(公告)日：2007-03-08
申请号：PCT/EP2006/008568
申请日：2006-09-01
申请人： SCHERING AG , FISCHER, Katrin, Claudia , GENERAL, Sascha , LICHA, Kai
发明人： FISCHER, Katrin, Claudia , GENERAL, Sascha , LICHA, Kai
IPC分类号： G01N33/58 , G01N21/35 , A61K9/51 , A61K49/04
CPC分类号： G01N33/588 , A61K9/5138 , A61K9/5146 , A61K49/0032 , A61K49/0034 , A61K49/0052 , A61K49/0054 , A61K49/0056 , A61K49/0093 , B82Y15/00 , G01N33/533 , G01N33/582
摘要： The present invention refers to nanoparticles having optically fluorescent activity. In more detail, the invention refers to a nanoparticle matrix comprising a co- aggregate of at least one charged polyelectrolyte and at least one oppositely charged active agent, wherein the active agent is a hydrophilic optically fluorescent agent, and the invention further refers to a nanoparticle comprising said nanoparticle matrix. Optionally, the nanoparticle is surface modified. The invention also refers to a method for preparing said nanoparticle, and to a method of surface modification. Furthermore, the invention refers to uses of said nanoparticle in vitro and in vivo , and to methods for in vitro and in vivo diagnosis.
摘要翻译：本发明涉及具有光学荧光活性的纳米颗粒。更详细地，本发明涉及包含至少一个带电聚电解质和至少一个相反电荷的活性剂的共聚集体的纳米颗粒基质，其中活性剂是亲水性光学荧光剂，本发明还涉及一种纳米颗粒包括所述纳米颗粒基质。任选地，纳米颗粒被表面改性。本发明还涉及一种制备所述纳米颗粒的方法和一种表面改性方法。此外，本发明涉及体外和体内所述纳米颗粒的用途，以及用于体外和体内诊断的方法。

48. 发明申请

WO2006137341A1 硝子体可視化剤审中-公开
标题翻译：用于观察身体健康的代理
公开(公告)号：WO2006137341A1
公开(公告)日：2006-12-28
申请号：PCT/JP2006/312134
申请日：2006-06-16
申请人：国立大学法人京都大学 , 吉村長久 , 武蔵国弘 , 田畑泰彦
发明人：吉村長久 , 武蔵国弘 , 田畑泰彦
IPC分类号： A61L31/00 , A61K31/717 , A61K31/728 , A61K31/765 , A61K38/43 , A61K45/00 , A61L27/00 , A61P27/02 , A61P27/12 , A61P41/00 , A61P43/00
CPC分类号： A61K49/0076 , A61K31/717 , A61K31/728 , A61K31/765 , A61K49/0054 , A61K49/006
摘要：　安全且つ確実な方法によって硝子体を可視化するため眼内に注入する硝子体可視化剤である。正負いずれかの電荷を帯びる官能基を有する高分子物質に対し、前記高分子物質を懸濁させる難水溶性かつ非ステロイド性の有色物質を含有させ、硝子体可視化剤とする。非ステロイド性のため、眼内に注入しても安全であり、高分子物質を懸濁させる有色物質により、硝子体を視覚的に認識できるようになる。
摘要翻译：一种用于可视化玻璃体的剂，其将被注入到眼睛中以通过安全可靠的方法使玻璃体可视化。通过使用具有带正电荷或带正电荷的官能团的高分子物质并添加其中悬浮有高分子物质的几乎难溶的和非甾体着色物质来制备用于可视化玻璃体的试剂。由于具有非甾体性质，因此可以将其安全地注入眼睛，高分子物质悬浮在其中的有色物质可使视觉上可辨认玻璃体。

49. 发明申请

WO2006001848A2 QUANTUM DOTS AS HIGH-SENSITIVITY OPTICAL SENSORS AND BIOCOMPATIBLE IMAGING PROBES, COMPOSITIONS THEREOF, AND RELATED METHODS 审中-公开
标题翻译：量子点作为高灵敏度光学传感器和生物成像成像探针，其组成及相关方法
公开(公告)号：WO2006001848A2
公开(公告)日：2006-01-05
申请号：PCT/US2005/004310
申请日：2005-02-11
申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. , NAUMANN, Christoph A. , YOUNG, Bruce A. , LONG, Eric C.
发明人： NAUMANN, Christoph A. , YOUNG, Bruce A. , LONG, Eric C.
IPC分类号： A61K39/00 , A61K49/14
CPC分类号： B82Y5/00 , A61K47/6923 , A61K49/0054 , A61K49/0067 , B82Y10/00
摘要： The invention provides a semiconductor nanoparticle with improved stability and biocompatibility properties. Accordingly, the present invention provides a nanoparticle that is capped with two separate protective layers: an inner inert layer and an outer inert layer and related in vitro and in vivo methods of use.
摘要翻译：本发明提供具有改进的稳定性和生物相容性的半导体纳米颗粒。因此，本发明提供一种纳米颗粒，该纳米颗粒用两个单独的保护层封盖：内部惰性层和外部惰性层，并且在体外和体内相关的使用方法。

50. 发明申请

WO2005097073A1 MACROMOLECULAR DELIVERY SYSTEMS FOR NON-INVASIVE IMAGING, EVALUATION AND TREATMENT OF ARTHRITIS AND OTHER INFLAMMATORY DISEASES 审中-公开
标题翻译：用于非侵入性成像，评估和治疗关节炎和其他炎症疾病的大分子输送系统
公开(公告)号：WO2005097073A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/010801
申请日：2005-03-30
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , WANG, Dong , KOPECEK, Jindrich , MILLER, Scott, C. , KOPECKOVÁ, Pavla
发明人： WANG, Dong , KOPECEK, Jindrich , MILLER, Scott, C. , KOPECKOVÁ, Pavla
IPC分类号： A61K9/14
CPC分类号： A61K49/0054 , A61K47/58 , A61K49/0041 , A61K49/128
摘要： This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.
摘要翻译：本发明涉及生物技术，更具体地涉及用于类风湿性关节炎和其他炎性疾病的成像，评估和/或治疗的水溶性聚合物递送系统。使用现代MR成像技术，证明了大鼠佐剂诱导的关节炎中关节炎关节中大分子的特异性聚集。 MR造影剂标记的聚合物的吸收和保留与炎症的组织病理学特征和局部组织损伤之间的强相关性证明了本发明的大分子递送系统的实际应用。

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