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    • 43. 发明申请
    • STABLE MEDICATED CHEWING GUM COMPRISING ANTIOXIDANT
    • 含有抗氧化剂的稳定的药用茶叶
    • WO2009006892A1
    • 2009-01-15
    • PCT/DK2007/050093
    • 2007-07-11
    • FERTIN PHARMA A/SANDERSEN, CarstenLAO, My Ly
    • ANDERSEN, CarstenLAO, My Ly
    • A61K9/00A61K9/20
    • A61K9/0058A61K9/1635A61K9/1652A61K9/2027A61K9/205A61K9/2086A61K31/00A61K31/495
    • The present invention provides medicament-containing chewing gums comprising one or more active compound(s) according to formula I, such as cetirizine, and an antioxidant which effectively stabilise the active compound, and methods for preparing such chewing gum the general formula (I): selected from 2- [4-(diphenylmethyl)-1-piperazine] derivatives having wherein R 1 is selected from the group consisting of -CH 2 CH 2 -O-CH 2 -R 2 , -CH 2 CH=CH-Ar 1 , CH2-Ar 2 and R 2 may be selected from the group consisting of a -CH 2 OH group, a -COOH group and a -CONH 2 group; Ar 1 and Ar 2 are independently an aromatic or heteroaromaticring with 5 or 6 atoms in the ring, said heteroaromatfc ring having 1, 2 or 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, said ring being unsubstituted or substituted with C 1-4 alkyl, preferably methyl or tertiary butyl, and A r2 preferably being unsubstituted phenyl or phenyl substituted with C 1-4 alkyl, preferably methyl or tertiary butyl; and X 1 and X 2 may independently be selected from the group consisting of a hydrogen atom, a halogen atom, a straight-chain or branched C 1 -C 4 alkoxy group or a tnfluoromethyl group; as well as pharmaceutically acceptable salts, geometrical isomers, eπantiomers, diastereomers and mixtures thereof;
    • 本发明提供了含有一种或多种式I的活性化合物(如西替利嗪)和有效稳定活性化合物的抗氧化剂的药物含有口香糖,以及制备通式(I)的口香糖的方法, :选自其中R 1选自-CH 2 CH 2 -O-CH 2 -R 2,-CH 2 CH = CH-Ar 1,CH 2 -Ar 2和R 2的2- [4-(二苯基甲基)-1-哌嗪]衍生物 由-CH 2 OH基,-COOH基和-CONH 2基组成的基团; Ar 1和Ar 2独立地是在环中具有5或6个原子的芳族或杂芳族化合物,所述杂芳环具有1,2或3个选自氮,氧和硫的杂原子,所述环是未取代的或被C 1-4烷基 优选甲基或叔丁基,Ar 2优选为未取代的苯基或被C 1-4烷基取代的苯基,优选甲基或叔丁基; X 1和X 2可以独立地选自氢原子,卤素原子,直链或支链C 1 -C 4烷氧基或全氟甲基; 以及药学上可接受的盐,几何异构体,对映异构体,非对映异构体及其混合物;
    • 45. 发明申请
    • MACHINE FOR BEDDING OUT SEED OR PLANT TAPES
    • 用于种植种子或植物带的机器
    • WO2005036946A1
    • 2005-04-28
    • PCT/DK2004/000720
    • 2004-10-20
    • BENTLE PRODUCTS AGAHM, Poul, HenrikANDERSEN, Carsten
    • AHM, Poul, HenrikANDERSEN, Carsten
    • A01C7/04
    • A01C7/048
    • A machine for bedding out seed or plant tapes includes a frame (4), where a bedding out unit (2) provided with a plough member (6) is mounted on said frame. The plough member is associated with a conveyor (9) with continuous belts. The bedding out unit is furthermore provided with a supporting plate (13) for a supply container (14) for seed or plant tapes (3) to be bedded out. The plough member (6) of the bedding out unit (2) is of a U-shaped cross section, and at the top the U-shaped cross section includes stabilising webs (7a, 7b). The plough member (6) is of a length (6) of at least approximately 30 cm and a width (b) across the U of 15 to 40 mm. The conveyor of the plough member (6) is a very inclined main conveyor (9) with two continuous conveyor belts (10, 11) arranged close to one another, but with a mutual adjustable distance (a). The main conveyor (9) extends across a major portion of the length (L) of the plough member (6). The supporting plate (13) is angularly adjustable, and two pressure wheels (16a, 16b) are mounted on the rear end of the machine for pressing down the earth around the seed or plant tape portion bedded out.
    • 一种用于种植种子或植物带子的机器包括框架(4),其中在所述框架上安装设置有犁部件(6)的寝具单元(2)。 犁构件与具有连续带的输送机(9)相关联。 床上用品单元还设置有用于种子或植物带(3)的供给容器(14)的支撑板(13)。 寝具单元(2)的犁部件(6)具有U形横截面,并且在顶部,U形横截面包括稳定纤维网(7a,7b)。 犁部件(6)具有至少约30cm的长度(6)和跨越U的宽度(b)为15至40mm。 犁部件(6)的输送机是非常倾斜的主输送机(9),其中两个连续的传送带(10,11)彼此靠近设置,但具有相互可调的距离(a)。 主输送机(9)延伸穿过犁部件(6)的长度(L)的主要部分。 支撑板(13)是可角度调节的,并且两个压力轮(16a,16b)安装在机器的后端,用于将地球围绕在床上的种子或植物带部分压下。