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    • 44. 发明申请
    • METHODS OF PREPARING METAL-MODIFIED SILICA NANOPARTICLES
    • 制备金属改性二氧化硅纳米粒子的方法
    • WO2010070480A3
    • 2010-09-23
    • PCT/IB2009055090
    • 2009-11-16
    • KIMBERLY CLARK CODO BAO TRONGEHLERT THOMAS DAVIDJANSSEN ROBERT ALLENMACDONALD JOHN GAVINRASMUSSEN PAUL WARRENZHUANG SHIMING
    • DO BAO TRONGEHLERT THOMAS DAVIDJANSSEN ROBERT ALLENMACDONALD JOHN GAVINRASMUSSEN PAUL WARRENZHUANG SHIMING
    • B82B1/00B82B3/00C01B33/02
    • B01F11/0258A61L9/014
    • A method of preparing metal-modified silica particles is disclosed. Specifically, a treatment chamber is provided in which a first and a second formulation are ultrasonically mixed to prepare metal-modified silica particles. The treatment chamber has an elongate housing through which the first and second formulations flow longitudinally from a first inlet port and a second inlet port, respectively, to an outlet port thereof. An elongate ultrasonic waveguide assembly extends within the housing and is operable at a predetermined ultrasonic frequency to ultrasonically energize the formulations within the housing. An elongate ultrasonic horn of the waveguide assembly is disposed at least in part intermediate the inlet and outlet ports, and has a plurality of discrete agitating members in contact with and extending transversely outward from the horn intermediate the inlet and outlet ports in longitudinally spaced relationship with each other. The horn and agitating members are constructed and arranged for dynamic motion of the agitating members relative to the horn at the predetermined frequency and to operate in an ultrasonic cavitation mode of the agitating members corresponding to the predetermined frequency and the formulations being mixed in the chamber.
    • 公开了一种制备金属改性二氧化硅颗粒的方法。 具体地说,提供一种处理室,其中第一和第二制剂被超声波混合以制备金属改性的二氧化硅颗粒。 处理室具有细长的外壳,第一和第二配方通过该外壳从第一入口端口和第二入口端口分别纵向流到其出口。 细长的超声波波导组件在壳体内延伸并且可以预定的超声频率操作以超声波地激励壳体内的配方。 波导组件的细长超声波喇叭至少部分地设置在入口和出口的中间,并且具有多个离散的搅拌构件,其与入口和出口端口处的喇叭中的接触并横向向外延伸,与纵向间隔开的关系 彼此。 喇叭和搅拌构件被构造和布置成用于搅动构件相对于喇叭以预定频率的动态运动,并且在对应于预定频率的搅拌构件的超声空化模式下操作,并且配方在腔室中混合。
    • 47. 发明申请
    • SYSTEM FOR PROVIDING A METHOD FOR APPLYING A SKIN SEALANT HAVING A PHASE CHANGE VISUAL INDICATING COMPONENT
    • 提供具有相变视觉指示组件的皮肤密封剂的方法的系统
    • WO2009047663A2
    • 2009-04-16
    • PCT/IB2008053779
    • 2008-09-17
    • KIMBERLY CLARK COMACDONALD JOHN GAVINSMITH MOLLY KWEART ILONA FSCHORR PHILLIP A
    • MACDONALD JOHN GAVINSMITH MOLLY KWEART ILONA FSCHORR PHILLIP A
    • A61M35/00
    • A61M35/003A61B2017/00495
    • A system for providing a method of sealing skin with a film forming polymer is provided. The system includes providing an at least two part applicator containing a sealant composition in one or more frangible containers, providing instructions for using the applicator associated therewith, where the method including moving at least one of said applicator parts from a first position to a second position and applying said sealant to skin. The composition has film former, a plasticizer and 3000 to 10000 ppm of a dye that changes color when is undergoes a phase change. The color change is visible to a human eye under normal light conditions. changing dyes may be used to indicate that the composition has dried. The dyes change color in response to the phase change, i.e., drying of the film former. The dye may be added either directly to the composition, incorporated into a sponge on an applicator through which the composition is dispensed and applied, applied separately or applied simultaneously from a separate reservoir. The amount of dye in the composition can be adjusted to provide a visual cue to the user of the application area and the extent of cure though should generally be in the range of 3000 to 10000 ppm.
    • 提供了一种用于提供用成膜聚合物密封皮肤的方法的系统。 该系统包括在一个或多个易碎容器中提供含有密封剂组合物的至少两个部分施用器,其提供使用与其相关联的施用器的指导,其中所述方法包括将所述施用器部件中的至少一个从第一位置移动到第二位置 并将所述密封剂施加到皮肤上。 该组合物具有成膜剂,增塑剂和3000至10000ppm的染料,当发生相变时颜色变化。 在正常光照条件下,人眼可见颜色变化。 可以使用改变的染料来表示组合物已经干燥。 染料根据相变而变色,即成膜剂的干燥。 染料可以直接添加到组合物中,并入施用器上的海绵中,组合物通过其分配和施加,单独施用或从单独的储存器同时施用。 可以调整组合物中的染料的量以向使用者提供视觉提示并且固化程度通常应在3000至10000ppm的范围内。