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1. 发明申请

WO2009047663A2 SYSTEM FOR PROVIDING A METHOD FOR APPLYING A SKIN SEALANT HAVING A PHASE CHANGE VISUAL INDICATING COMPONENT 审中-公开
标题翻译：提供具有相变视觉指示组件的皮肤密封剂的方法的系统
公开(公告)号：WO2009047663A2
公开(公告)日：2009-04-16
申请号：PCT/IB2008053779
申请日：2008-09-17
申请人： KIMBERLY CLARK CO , MACDONALD JOHN GAVIN , SMITH MOLLY K , WEART ILONA F , SCHORR PHILLIP A
发明人： MACDONALD JOHN GAVIN , SMITH MOLLY K , WEART ILONA F , SCHORR PHILLIP A
IPC分类号： A61M35/00
CPC分类号： A61M35/003 , A61B2017/00495
摘要： A system for providing a method of sealing skin with a film forming polymer is provided. The system includes providing an at least two part applicator containing a sealant composition in one or more frangible containers, providing instructions for using the applicator associated therewith, where the method including moving at least one of said applicator parts from a first position to a second position and applying said sealant to skin. The composition has film former, a plasticizer and 3000 to 10000 ppm of a dye that changes color when is undergoes a phase change. The color change is visible to a human eye under normal light conditions. changing dyes may be used to indicate that the composition has dried. The dyes change color in response to the phase change, i.e., drying of the film former. The dye may be added either directly to the composition, incorporated into a sponge on an applicator through which the composition is dispensed and applied, applied separately or applied simultaneously from a separate reservoir. The amount of dye in the composition can be adjusted to provide a visual cue to the user of the application area and the extent of cure though should generally be in the range of 3000 to 10000 ppm.
摘要翻译：提供了一种用于提供用成膜聚合物密封皮肤的方法的系统。该系统包括在一个或多个易碎容器中提供含有密封剂组合物的至少两个部分施用器，其提供使用与其相关联的施用器的指导，其中所述方法包括将所述施用器部件中的至少一个从第一位置移动到第二位置并将所述密封剂施加到皮肤上。该组合物具有成膜剂，增塑剂和3000至10000ppm的染料，当发生相变时颜色变化。在正常光照条件下，人眼可见颜色变化。可以使用改变的染料来表示组合物已经干燥。染料根据相变而变色，即成膜剂的干燥。染料可以直接添加到组合物中，并入施用器上的海绵中，组合物通过其分配和施加，单独施用或从单独的储存器同时施用。可以调整组合物中的染料的量以向使用者提供视觉提示并且固化程度通常应在3000至10000ppm的范围内。

2. 发明申请

WO2009060327A3 COVERAGE INDICATING TECHNOLOGY FOR SKIN SEALANTS USING TANNATES 审中-公开
标题翻译：使用TANNATES的皮肤密封剂的覆盖技术指标
公开(公告)号：WO2009060327A3
公开(公告)日：2009-09-24
申请号：PCT/IB2008054072
申请日：2008-10-03
申请人： KIMBERLY CLARK CO , MACDONALD JOHN GAVIN , SMITH MOLLY K , WEART ILONA F , SCHORR PHILLIP A
发明人： MACDONALD JOHN GAVIN , SMITH MOLLY K , WEART ILONA F , SCHORR PHILLIP A
IPC分类号： A61L24/04 , G01N31/22
CPC分类号： A61K33/18 , A61K9/0014 , A61K47/26 , A61K47/44
摘要： A composition having various color changing tannates may be used to indicate that the composition has dried. The tannates change color in contact with an acid. The composition may be, for example, a skin prep, skin sealant, food product, paint or other building material or other product that undergoes a phase change. The tannate may be added either directly to the composition, incorporated into a sponge on an applicator through which the composition is dispensed and applied, applied separately or applied simultaneously from a separate reservoir. The amount of tannate in the composition can be adjusted to provide a visual cue to the user of the application area and the extent of cure.
摘要翻译：具有各种变色丹宁酸的组合物可用于表示组合物已干燥。丹宁酸改变与酸接触的颜色。组合物可以是例如皮肤制剂，皮肤密封剂，食品，油漆或其他建筑材料或经历相变的其它产品。丹宁酸可以直接添加到组合物中，并入施用组合物中的海绵中，组合物通过其分配和施用，单独施用或从单独的储存器同时施用。可以调整组合物中的单宁酸盐的量，以向使用者提供视觉提示和施用范围。

3. 发明申请

WO2009047655A3 PHASE CHANGE VISUAL INDICATING COMPOSITION 审中-公开
标题翻译：相变视觉指示组合物
公开(公告)号：WO2009047655A3
公开(公告)日：2009-05-28
申请号：PCT/IB2008052825
申请日：2008-07-14
申请人： KIMBERLY CLARK CO , MACDONALD JOHN GAVIN , SMITH MOLLY K , WEART ILONA F , SCHORR PHILLIP A
发明人： MACDONALD JOHN GAVIN , SMITH MOLLY K , WEART ILONA F , SCHORR PHILLIP A
IPC分类号： A61K8/00 , A61K49/00 , C12Q1/04
CPC分类号： A61K33/18 , A61L26/0061 , A61L26/0066 , A61L26/0071 , A61L2300/202 , A61L2300/404 , A61L2300/442
摘要： A skin sealant composition of a film former and a plasticizer and having various color changing dyes may be used to indicate that the composition has dried. The dyes change color in response to the phase change, i.e., drying of the film former. The dye may be added either directly to the composition, incorporated into a sponge on an applicator through which the composition is dispensed and applied, applied separately or applied simultaneously from a separate reservoir. The amount of dye in the composition can be adjusted to provide a visual cue to the user of the application area and the extent of cure though should generally be in the range of 3000 to 10000 ppm.
摘要翻译：可以使用成膜剂和增塑剂并具有各种变色染料的皮肤密封剂组合物来表示组合物已经干燥。染料根据相变而变色，即成膜剂的干燥。染料可以直接添加到组合物中，并入施用器上的海绵中，组合物通过其分配和施加，单独施用或从单独的储存器同时施用。可以调整组合物中的染料的量以向使用者提供视觉提示并且固化程度通常应在3000至10000ppm的范围内。

4. 发明申请

WO2010070588A3 PLASTICIZER FOR THERMOPLASTIC POLYMER MATERIALS 审中-公开
标题翻译：用于热塑性聚合物材料的增塑剂
公开(公告)号：WO2010070588A3
公开(公告)日：2010-10-28
申请号：PCT/IB2009055771
申请日：2009-12-15
申请人： KIMBERLY CLARK CO , MACDONALD JOHN GAVIN , ELSHANI TEUTA , HRISTOV HRISTO A , SMITH MOLLY K , WEART ILONA F
发明人： MACDONALD JOHN GAVIN , ELSHANI TEUTA , HRISTOV HRISTO A , SMITH MOLLY K , WEART ILONA F
IPC分类号： C08L67/04 , C08J5/00 , C08K5/15
CPC分类号： C08K5/0016 , A61L15/42 , A61L29/141 , A61L31/141 , C08K5/0033 , C08K5/1545 , C08L67/04
摘要： A thermoplastic polymeric composition having a xanthene or xanthenes-based compound as a plasticizer, a method to modify the thermoplastic polymeric materials to increase their relative plasticity while maintaining good strength or "toughness" characteristics, and various articles of manufacture that can be made using the polymer composition are described.
摘要翻译：一种热塑性聚合物组合物，其具有基于x吨或x吨基的化合物作为增塑剂，改性热塑性聚合物材料以增加其相对可塑性同时保持良好强度或“韧性”特性的方法，以及可使用描述了聚合物组合物。

5. 发明申请

WO2008032231A3 COLOR CHANGING SKIN SEALANT 审中-公开
标题翻译：颜色变化的皮肤密封剂
公开(公告)号：WO2008032231A3
公开(公告)日：2008-09-25
申请号：PCT/IB2007053274
申请日：2007-08-16
申请人： KIMBERLY CLARK CO , MACDONALD JOHN GAVIN , AREHART KELLY , SMITH MOLLY K , WEART ILONA FURMAN , SCHORR PHILLIP A
发明人： MACDONALD JOHN GAVIN , AREHART KELLY , SMITH MOLLY K , WEART ILONA FURMAN , SCHORR PHILLIP A
IPC分类号： A61L24/00
CPC分类号： A61L24/001
摘要： Iodine is used in about 80 percent of surgeries in the US to remove some level of microbial load on the skin prior to making an incision. Skin sealants are applied over skin preps to seal the skin and hold any remaining bacteria in place. Iodine produces a characteristic orange-brown color on skin. A skin sealant is provided that has a decolorant that reacts with the iodine found in most skin preps, rendering the skin prep colorless. A skin sealant containing ascorbic acid (vitamin C), Indigo Carmine or Indigo will react with the iodine, thus visually indicating where the skin prep and sealant have been applied and allowing an unobstructed view of the incision.
摘要翻译：在美国约80％的手术中使用碘，以在切开前去除皮肤上的一定程度的微生物负荷。将皮肤密封剂涂于皮肤上，以密封皮肤并将任何残留的细菌保持在适当的位置。碘在皮肤上产生特征橙棕色。提供具有与大多数皮肤前食中发现的碘反应的脱色剂的皮肤密封剂，使得皮肤无色。含有抗坏血酸（维生素C），靛蓝胭脂红或靛蓝的皮肤密封剂将与碘反应，从而可视地显示出皮肤制剂和密封剂的使用位置，并允许切口无阻碍地观察。

6. 发明申请

WO2010070524A3 XANTHENE-BASED PLASTICIZER OF RESINS AND POLYMERS 审中-公开
标题翻译：基于XANTHENE的树脂和聚合物增塑剂
公开(公告)号：WO2010070524A3
公开(公告)日：2010-09-30
申请号：PCT/IB2009055562
申请日：2009-12-08
申请人： KIMBERLY CLARK CO , MACDONALD JOHN G , ELSHANI TEUTA , HRISTOV HRISTO A , SMITH MOLLY K , WEART ILONA F
发明人： MACDONALD JOHN G , ELSHANI TEUTA , HRISTOV HRISTO A , SMITH MOLLY K , WEART ILONA F
IPC分类号： C08K5/151 , C08K5/1575 , C08L33/20
CPC分类号： A61K9/0014 , A61K47/32 , C08K5/0016 , C08K5/1545
摘要： A composition of matter for increasing the relative flexibility and plasticity of crystalline or semi-crystalline resins and polymers is described. In particular, the compositions include xanthene or anthene-based molecular structures that can increase the plastic properties of curable resins or thermosetting polymers when incorporated into the polymer material. Certain uses for such a polymeric composition are also provided.
摘要翻译：描述了用于增加结晶或半结晶树脂和聚合物的相对柔性和可塑性的物质组合物。特别地，组合物包括呫吨或基于铕的分子结构，其可以在掺入聚合物材料时增加可固化树脂或热固性聚合物的塑性。还提供了这种聚合物组合物的某些用途。

7. 发明申请

WO2009060331A3 MOISTURE INDICATOR FOR HEAT AND MOISTURE EXCHANGE DEVICES 审中-公开
标题翻译：用于热量和水分交换装置的湿度指示器
公开(公告)号：WO2009060331A3
公开(公告)日：2009-08-06
申请号：PCT/IB2008054314
申请日：2008-10-20
申请人： KIMBERLY CLARK CO , MACDONALD JOHN GAVIN , BAGWELL ALLISON SALYER , SMITH MOLLY K , FISH JEFFREY E , LYE JASON , CUEVAS BRIAN J
发明人： MACDONALD JOHN GAVIN , BAGWELL ALLISON SALYER , SMITH MOLLY K , FISH JEFFREY E , LYE JASON , CUEVAS BRIAN J
IPC分类号： A61M16/00 , G01N33/497
CPC分类号： A61M16/1045 , A61M16/161 , A61M2205/584
摘要： There is provided a moisture indicator for a heat and moisture exchange (HME) device that uses a pre-colorant and an activator applied to an inner surface of the HME device. The colorant undergoes a color change of Delta E (?E) of equal to or greater than 3 units upon exposure to moisture but not upon exposure to high humidity. The colorant is visually obvious to the unaided human eye under normal light conditions through the body of the device. The HME device with the visual indicator for moisture can indicate to the care-giver that it is time to change the HME device.
摘要翻译：提供了用于热和湿气交换（HME）装置的湿度指示器，其使用施加到HME装置的内表面的预着色剂和活化剂。着色剂在暴露于湿气时经受等于或大于3个单位的ΔE（ΔE）的颜色变化，但不暴露于高湿度下。在正常光照条件下，通过装置的主体，着色剂在肉眼看不到肉眼。具有湿气视觉指示器的HME设备可以向护理人员指示是时候更换HME设备。

8. 发明申请

WO2008139341A2 COLORANT NEUTRALIZER 审中-公开
标题翻译：有色中和剂
公开(公告)号：WO2008139341A2
公开(公告)日：2008-11-20
申请号：PCT/IB2008051205
申请日：2008-03-31
申请人： KIMBERLY CLARK CO , MACDONALD JOHN GAVIN , SMITH MOLLY K , YANG SHU-PING
发明人： MACDONALD JOHN GAVIN , SMITH MOLLY K , YANG SHU-PING
IPC分类号： A61K8/37 , A61K8/36 , A61K8/92 , A61Q11/00 , A61Q19/02 , A61Q19/10 , C11D11/00
CPC分类号： C11D11/0017 , A61C11/00 , A61C19/02 , A61K8/22 , A61K8/361 , A61K8/39 , A61Q11/00 , A61Q19/02 , C11D3/2079 , C11D3/2093
摘要： A composition for a medium that can discharge the color of organic unsaturated colorant molecules that may stain is described. The composition can quickly and effectively neutralize a discoloration that results from, in particular, blood or blood-based, ink, or grease stains. The composition can remove the stain within, typically about 20-30 minutes, and can achieve color contrast of a ?E value of about 5-20 or greater. The composition can be adapted for different uses and embodied in various cleaning, stain- fighting, cosmetic, personal hygiene, or medical products.
摘要翻译：描述了可以排出可能污染的有机不饱和着色剂分子的颜色的介质的组合物。组合物可以快速有效地中和由特别是血液或血液，油墨或油脂污渍产生的变色。组合物可以除去其中的污渍，通常约20-30分钟，并且可以实现约5-20或更大的ΔE值的颜色对比度。该组合物可适用于不同的用途并体现在各种清洁，防污，化妆品，个人卫生或医疗产品中。

9. 发明申请

WO2009077905A3 GONIOCHROMIC INDICATOR FOR SKIN SEALANT 审中-公开
标题翻译：皮肤密封剂的皮肤色素指示剂
公开(公告)号：WO2009077905A3
公开(公告)日：2009-10-01
申请号：PCT/IB2008055058
申请日：2008-12-02
申请人： KIMBERLY CLARK CO , SMITH MOLLY K , MACDONALD JOHN GAVIN , DO BAO TRONG
发明人： SMITH MOLLY K , MACDONALD JOHN GAVIN , DO BAO TRONG
IPC分类号： A61L15/56 , A61F13/02 , A61L15/20
CPC分类号： A61K8/26 , A61K8/0241 , A61K8/8152 , A61K2800/436 , A61Q1/02
摘要： A skin sealant composition having a film former like cyanoacrylate and a goniochromic dye or pigment is provided. The addition of mica/metal oxide powders to the sealant formulation makes it possible to see where it has been applied, due to the mica/metal oxide's goniochromic (e.g. irhdescent or pearlescent) appearance, and it is also still possible to view the underlying skin, especially from an angle at which the color is less apparent. Thus, mica/titanium dioxide or other goniochromic or light interfering particles may be used as an additive to allow for determination of complete coverage, while not significantly obscuring the incision site.
摘要翻译：提供了具有成膜剂如氰基丙烯酸酯和角闪色素染料或颜料的密封剂组合物。由于云母/金属氧化物的角化变色（例如红外或珠光）外观，在密封剂配方中添加云母/金属氧化物粉末使得可以看到它已经施加在哪里，并且仍然可以查看下面的皮肤特别是从颜色不太明显的角度来看。因此，可以使用云母/二氧化钛或其他的角色变色或光干涉颗粒作为添加剂以允许确定完全覆盖，同时不显着模糊切口部位。

10. 发明申请

WO2008072117A3 SKIN COATING WITH MICROBIAL INDICATOR 审中-公开
标题翻译：皮肤涂料与微生物指示剂
公开(公告)号：WO2008072117A3
公开(公告)日：2009-02-19
申请号：PCT/IB2007054052
申请日：2007-10-04
申请人： KIMBERLY CLARK CO , MACDONALD JOHN GAVIN , MARTIN STEPHANIE , SMITH MOLLY K , LYE JASON
发明人： MACDONALD JOHN GAVIN , MARTIN STEPHANIE , SMITH MOLLY K , LYE JASON
IPC分类号： A61L15/14 , A61L24/00 , A61L26/00
CPC分类号： A61L26/0061 , A61L24/001
摘要： Skin sealants are usually applied over skin preps to seal the skin and hold any remaining bacteria in place prior to surgical incisions. This sealant is generally left on the skin after surgery. A skin coating is provided that has an indicator that gives a visible color change upon contact with microbes or microbial by-products and so provides an early warning of infection. The coating is a curable coating composition that may also be used without skin preps and may be used to protect other disruptions in the skin like wounds, bruises, abrasions, burns, acne, blisters, bites, stings, punctures and cuts. It may also be used to close wounds or provide an additional barrier to other parts of the skin, such as the nails and mucosa.
摘要翻译：皮肤密封剂通常用于皮肤制服上以密封皮肤，并在手术切口之前将任何残留的细菌保持在位。这种密封剂通常在手术后留在皮肤上。提供皮肤涂层，其具有指示剂，其在与微生物或微生物副产物接触时产生可见的颜色变化，因此提供感染的早期预警。该涂层是可固化的涂料组合物，其也可以不使用皮肤制剂使用，并且可以用于保护皮肤中的其它破坏，例如伤口，瘀伤，擦伤，烧伤，痤疮，水疱，叮咬，刺痛，穿刺和切口。它还可以用于闭合伤口或提供对皮肤其他部分（例如指甲和粘膜）的额外屏障。

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