专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

WO1995004440A1 REMOTELY CONTROLLED, INFRARED BEACON SYSTEM FOR GUIDING THE VISUALLY IMPAIRED 审中-公开
标题翻译：远程控制，红外线信标系统，用于指导视觉受损
公开(公告)号：WO1995004440A1
公开(公告)日：1995-02-09
申请号：PCT/US1994008463
申请日：1994-07-28
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , HANCOCK, Michael, B.
IPC分类号： H04Q07/00
CPC分类号： G08G1/005
摘要： A remote controlled infrared beacon system enables blind individuals to be self-guiding toward desired destinations. A code is entered via keypad (14) and encoder (42) of a hand-held transceiver (10) which emits a pulse code modulated interrogation signal (20) via a radio transmitter (43), thereby selectively activating an infrared beacon unit (13) corresponding to a desired location using a receiver (44), decoder (45), oscillator (46) and infrared light emitting diodes (47). A directional infrared lens (48) and receiver/decoder (49) in the transceiver (10) are used to scan the horizontal plane to locate or home in on the infrared signal (22). An amplifier (50) drives a vibrator (51) to signal the user that the beacon (13) has been directionally located. Multiple beacons (1, 3, 8, 9) are employed to establish paths which may be followed by serially activating successive beacons to navigate to a desired destination.
摘要翻译：远程控制的红外线信标系统使得盲人能够自动引导到期望的目的地。通过经由无线电发射机（43）发出脉冲编码调制询问信号（20）的手持式收发器（10）的键盘（14）和编码器（42）输入代码，从而选择性地激活红外信标单元 13），使用接收器（44），解码器（45），振荡器（46）和红外发光二极管（47）对应于期望的位置。收发器（10）中的定向红外透镜（48）和接收器/解码器（49）用于扫描水平面以定位或置于红外信号（22）上。放大器（50）驱动振动器（51）以向用户发信号（13）已定向定位。采用多个信标（1,3,8,9）来建立路径，其后面可以连续地激活连续信标以导航到期望的目的地。

42. 发明申请

WO1995003554A1 A HIGH PERFORMANCE POSITRON CAMERA 审中-公开
标题翻译：高性能摄像机
公开(公告)号：WO1995003554A1
公开(公告)日：1995-02-02
申请号：PCT/US1994008156
申请日：1994-07-19
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , WONG, Wai-Hoi , HICKS, Keri
IPC分类号： G01T01/164
CPC分类号： G01T1/1644 , A61B6/037 , A61B6/508 , G01T1/2985
摘要： The invention relates to methods and apparatus for cameras for gamma radiation, including cameras for positron emission tomography (PET). Included in the invention are cameras having radiation detector arrays (24) splittable into sections (30, 30', 33, 33'), which then may be used to extend the axial field-of-view in a two-dimensional mode. Individual array sections may be equipped with collimators. Additionally, splittable PET cameras having detector arrays (70) approximately one-fourth the diameter as conventional whole-body PET cameras are disclosed as having insertable conformal collimators (74, 76, 79) comprising stacks of planar rings. The inner contours of the planar rings are adapted to accept objects to be imaged in the camera and to closely conform to the objects' surface contours.
摘要翻译：本发明涉及用于γ辐射的相机的方法和装置，包括用于正电子发射断层摄影（PET）的照相机。本发明中包括具有可分离成部分（30,30'，33,33'）的辐射检测器阵列（24）的相机，其然后可以用于以二维模式延伸轴向视场。单个阵列部分可以配备准直器。此外，公开了具有作为常规全身PET照相机的大约四分之一直径的检测器阵列（70）的可分离PET相机具有包括平面环堆叠的可插入共形准直器（74,76,79）。平面环的内部轮廓适于接收要在相机中成像的物体并且紧密地符合物体的表面轮廓。

43. 发明申请

WO1995000178A1 PORE-FORMING AND SUPERANTIGEN ENCODING TOXIN CASSETTES FOR GENE THERAPY 审中-公开
标题翻译：用于基因治疗的成核和超级编码毒素基因
公开(公告)号：WO1995000178A1
公开(公告)日：1995-01-05
申请号：PCT/US1994007091
申请日：1994-06-22
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , LAPEYRE, Jean-Numa , MARINI, Frank, C.
IPC分类号： A61K48/00
CPC分类号： C07K14/31 , A61K38/00 , A61K39/0011 , A61K48/00
摘要： The present disclosure describes a segment of DNA which comprises a cytotoxin immunomodulatory gene which is modified for expression in eukaryotic cells and which genes are under the control of an inducible promoter. The disclosure also comprises a vector containing said DNA segment and a method of utilizing said DNA segment in cancer gene therapy.
摘要翻译：本公开描述了一段DNA，其包含细胞毒素免疫调节基因，其被修饰用于在真核细胞中表达，哪些基因处于诱导型启动子的控制之下。本公开还包含含有所述DNA区段的载体和在癌症基因治疗中利用所述DNA区段的方法。

44. 发明申请

WO1994028178A1 IN-SITU HYBRIDIZATION PROBES FOR IDENTIFICATION AND BANDING OF SPECIFIC HUMAN CHROMOSOMES AND REGIONS 审中-公开
标题翻译：用于识别和分离特定人类染色体和区域的现场杂交探针
公开(公告)号：WO1994028178A1
公开(公告)日：1994-12-08
申请号：PCT/US1994006194
申请日：1994-06-01
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , SICILIANO, Michael, J. , LIU, Pu
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6827 , C12N15/1093 , C12Q1/6841 , C12Q1/6858 , C12Q1/686 , C12Q1/6876 , C12Q2600/156 , C12Q2525/151
摘要： The invention relates to novel primer sets useful in preparing DNA probes specific for any chromosome or part of a chromosome, particularly human chromosomes. The DNA probes so produced may be used to paint individual chromosomes or portions of chromosomes in metaphase cell spreads and in interphase nuclei. When used to paint chromosomes in metaphase spreads, R-bands are readily detectable. The method is sensitive and has been shown to paint R-bands on chromosomes pieces having as few as several hundred kilobases.
摘要翻译：本发明涉及可用于制备对任何染色体或部分染色体特别是人染色体特异的DNA探针的新型引物组。如此制备的DNA探针可用于在中期细胞扩散和间期细胞核中染色单个染色体或部分染色体。当用于在中期传播中染色体时，可以容易地检测到R带。该方法是敏感的，并且已经显示出在具有几百千碱基的染色体片上绘制R带。

45. 发明申请

WO1994026922A2 METHODS AND COMPOSITIONS RELATING TO STEROL REGULATORY ELEMENT BINDING PROTEINS 审中-公开
标题翻译：与甾体调节元件结合蛋白相关的方法和组合物
公开(公告)号：WO1994026922A2
公开(公告)日：1994-11-24
申请号：PCT/US1994005300
申请日：1994-05-13
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , GOLDSTEIN, Joseph, L. , BROWN, Michael, S. , BRIGGS, Michael, R. , WANG, Xiaodong
IPC分类号： C12P21/02
CPC分类号： C07K14/525 , C07K14/4702 , C07K14/61 , C12N9/6459 , C12N15/67 , C12N15/85 , C12N2830/002 , C12N2830/008 , C12N2830/15 , C12N2830/85 , C12Y304/21069
摘要： A sterol regulatory element (SRE) binding protein (SREBP) which activates transcription from SREs, such as SRE-1 of the low density lipoprotein (LDL) receptor gene, is disclosed, as are DNA segments encoding SREBPs such as an SREBP-1 or SREBP-2. Also described are methods for using SREBP to promote SRE-mediated transcription and LDL receptor production in the presence of sterols, and screening assay for the identification of further agents with such properties. The SREBP and other agents may be used to reduce plasma cholesterol levels and to treat various medical problems associated with hypercholesterolemia.
摘要翻译：公开了激活SREs的转录的固醇调节元件（SREBP）结合蛋白（SREBP），例如低密度脂蛋白（LDL）受体基因的SRE-1，编码SREBP的DNA片段如SREBP-1或 SREBP-2。还描述了使用SREBP在甾醇存在下促进SRE介导的转录和LDL受体产生的方法，并筛选用于鉴定具有这些性质的其它药剂的测定。 SREBP和其他药剂可用于降低血浆胆固醇水平并治疗与高胆固醇血症相关的各种医疗问题。

46. 发明申请

WO1994026168A1 DIAGNOSIS OF DYSPLASIA USING LASER INDUCED FLUORESCENCE 审中-公开
标题翻译：使用激光诱导荧光检测DYSPLASIA
公开(公告)号：WO1994026168A1
公开(公告)日：1994-11-24
申请号：PCT/US1994005230
申请日：1994-05-11
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , RAMANUJAM, Nirmala , MAHADEVAN, Anita , RICHARDS-KORTUM, Rebecca , MITCHELL, Michele, Follen , THOMSEN, Sharon
IPC分类号： A61B06/00
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/0075 , A61B5/4331 , G01N21/6402 , G01N2021/6417
摘要： Apparatus and in vivo methods for distinguishing normal and abnormal cervical tissue and detecting cervical intraepithelial neoplasia (CIN) in a diagnostic tissue sample. A source of electromagnetic radiation (36) is applied to the diagnostic cervical tissue sample and the presumptively known normal cervical tissue. Fluorescence intensity spectra induced in the diagnostic tissue sample and the presumptively known tissue by the radiation source is detected by at least one radiation detector (26). A computer (20) is programmed to measure a peak normal fluorescence intensity value in each of the normal fluorescence intensity spectra, to calculate an average peak normal fluorescence intensity from the peak normal fluorescence intensity values, to measure a peak fluorescence intensity value from the fluorescence intensity spectrum induced in the diagnostic tissue sample, to calculate a slope parameter which is indicative of tissue abnormality, to calculate relative peak fluorescence intensity as a function of the peak intensity value, the average peak normal intensity, and to detect tissue abnormality as a function of the slope parameter and the relative peak fluorescence intensity.
摘要翻译：用于区分正常和异常宫颈组织和检测诊断组织样品中宫颈上皮内瘤变（CIN）的装置和体内方法。将电磁辐射源（36）应用于诊断子宫颈组织样品和推测已知的正常宫颈组织。通过至少一个放射线检测器（26）检测在诊断组织样品和由辐射源推测的已知组织中诱导的荧光强度光谱。计算机（20）被编程为测量每个正常荧光强度光谱中的峰值正常荧光强度值，以从峰值正常荧光强度值计算平均峰值正常荧光强度，以测量来自荧光的峰值荧光强度值在诊断组织样本中诱导的强度光谱，计算指示组织异常的斜率参数，计算作为峰值强度值，平均峰值正常强度的函数的相对峰值荧光强度，并将组织异常检测为功能的斜率参数和相对峰值荧光强度。

47. 发明申请

WO1994025880A1 MEGAVOLTAGE SCANNING IMAGER AND METHOD FOR ITS USE 审中-公开
标题翻译： MEGAVOLTAGE SCANNING IMAGER及其使用方法
公开(公告)号：WO1994025880A1
公开(公告)日：1994-11-10
申请号：PCT/US1994003023
申请日：1994-03-21
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , ANTICH, Peter, P. , ANDERSON, Jon, A. , FENYVES, Ervin, J.
IPC分类号： G01T05/08
CPC分类号： G01T1/201 , A61B6/037 , G01T1/2985
摘要： Apparatus for generating a high contrast image of a living subject includes an X-ray source capable of generating an X-ray beam (50) having an energy between about 4 MeV and about 40 MeV, means for directing the X-ray beam generated by the X-ray source to a preselected area (56) of the body of a living subject, and at least one scintillating detector (52a, 52b) capable of detecting photons which are generated as a result of the interaction of the X-ray beam with the body of the living subject.
摘要翻译：用于生成活体的高对比度图像的装置包括能够产生具有在约4MeV至约40MeV之间的能量的X射线束（50）的X射线源，用于引导由X射线束 X射线源到活体的身体的预选区域（56），以及至少一个能够检测由于X射线束的相互作用而产生的光子的闪烁检测器（52a，52b）与活体的身体。

48. 发明申请

WO1994018331A2 FUSION PROTEINS INCLUDING A CLEAVAGE SITE RECOGNIZED BY A PLANT VIRUS PROTEASE 审中-公开
标题翻译：融合蛋白，包括植物病毒蛋白质识别的清除位点
公开(公告)号：WO1994018331A2
公开(公告)日：1994-08-18
申请号：PCT/US1994001176
申请日：1994-01-31
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , OREGON STATE UNIVERSITY
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , OREGON STATE UNIVERSITY , JOHNSTON, Stephen, A. , DOUGHERTY, William, G.
IPC分类号： C12N15/62
CPC分类号： C12N15/62 , C07K2319/21 , C07K2319/23 , C12N9/503
摘要： Methods for isolation and purification of recombinant proteins are described. Fusion proteins incorporating a cleavage site sensitive to proteolysis by a plant virus proteinase may be cleaved from carrier proteins to provide high yields of protein product. Methods employing a plant virus proteinase to cleave expressed fusion proteins are particularly suitable for obtaining proteolytically sensitive polypeptides in the presence of added cell protease inhibitors. Also disclosed are recombinant vectors useful for overproducing plant virus proteinases in a suitable host.
摘要翻译：描述了分离和纯化重组蛋白的方法。结合对植物病毒蛋白酶的蛋白水解敏感的切割位点的融合蛋白可以从载体蛋白切割以提供高产量的蛋白质产物。使用植物病毒蛋白酶切割表达的融合蛋白的方法特别适用于在添加的细胞蛋白酶抑制剂存在下获得蛋白水解敏感多肽。还公开了可用于在合适宿主中过量产生植物病毒蛋白酶的重组载体。

49. 发明申请

WO1994014469A1 MULTIVALENT AB1 ANTIBODIES AS VACCINES 审中-公开
标题翻译：多抗AB1抗体作为疫苗
公开(公告)号：WO1994014469A1
公开(公告)日：1994-07-07
申请号：PCT/US1993012413
申请日：1993-12-20
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , RODKEY, L., Scott , SEFERIAN, Peter, G.
IPC分类号： A61K37/04
CPC分类号： C07K16/4233 , A61K39/00 , Y02A50/466
摘要： Immunization with a multivalent form of Ab1 F(ab')2 fragments was shown to induce antibodies specific for the original antigen in the absence of antigen stimulation. The specificity of the resulting Ab1', demonstrated with tetanus toxoid, was established by an absorption procedure and inhibition with the toxoid. As predicted by network theory, Ab2 and Ab1' titers cycled alternatively throughout the period of measurement. Biological assay indicated that Ab1' induction was not due to residual tetanus toxoid epitopes in the immunizing preparation. Limited mumbers of clonal products contributed to the Ab1' population.
摘要翻译：显示Ab1 F（ab'）2片段的多价形式的免疫诱导在没有抗原刺激的情况下对原始抗原特异性的抗体。用破伤风类毒素证明的所得Ab1'的特异性是通过吸收程序和类毒素的抑制来建立的。正如网络理论所预测的那样，Ab2和Ab1'滴度在整个测量期间相互循环。生物测定表明，Ab1'诱导不是由于免疫制剂中残留的破伤风类毒素表位。克隆产品的有限公司对Ab1的人口做出了贡献。

50. 发明申请

WO1994009003A1 SAPPHYRIN DERIVATIVES, CONJUGATES AND POLYMERS THEREOF AND EXPANDED PORPHYRIN CHROMATOGRAPHIC SUPPORTS 审中-公开
标题翻译： SAPPHYRIN衍生物，结合物及其聚合物和扩展的吡啶色谱支持
公开(公告)号：WO1994009003A1
公开(公告)日：1994-04-28
申请号：PCT/US1993009994
申请日：1993-10-18
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , SESSLER, Jonathan, L. , IVERSON, Brent, L. , KRAL, Vladimir , SHREDER, Kevin , FURUTA, Hiroyuki , THOMAS, Richard E.
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： C07D487/22
CPC分类号： C07H21/00 , A61K41/0076 , A61K47/54 , A61K47/546 , A61K47/558 , C07D487/22 , C07H15/26 , C12N15/101
摘要： The present invention provides various novel covalently modified sapphyrin derivatives and conjugates; polymers including sapphyrin or derivatives thereof; and chromatographic supports including sapphyrins and other expanded porphyrins and derivatives thereof. Disclosed are water soluble sapphyrins, including polyhydroxysapphyrins and sapphyrin-sugar derivatives; sapphyrin-metal chelating conjugates; sapphyrin nucleobase conjugates; oligosapphyrins and polysapphyrins, including sapphyrin dimers, trimers, oligomers and higher polymers; and polymer supported expanded porphyrin compositions, including advantageous rubyrin- and sapphyrin-based chromatography columns and electrophoretic supports. Sapphyrin oligomers and polymers and polymer supported expanded porphyrins, such as, e.g., glass and silica expanded porphyrin constructs, are disclosed which include both repeating units of sapphyrin derivatives alone and which include other units, for example, nucleobases, sapphyrin-nucleobase conjugates and long chain alkyl groups.
摘要翻译：本发明提供了各种新颖的共价修饰的曙红衍生物和缀合物; 包括卟啉或其衍生物的聚合物; 和含有卟啉和其他膨化的卟啉及其衍生物的色谱载体。公开了水溶性莽草酸，包括多羟基ph卟啉和sap in糖衍生物; 卟啉金属螯合物 sap卟啉核碱基缀合物寡聚卟啉和多卟啉，包括卟啉二聚体，三聚体，低聚物和更高级的聚合物; 和聚合物负载的发泡卟啉组合物，包括有利的基于红宝石和卟啉的色谱柱和电泳载体。公开了卟啉低聚物和聚合物和聚合物负载的发泡卟啉，例如玻璃和二氧化硅膨胀的卟啉构建体，其包含单独的双重重复单元的莽草苷衍生物，其包括其它单元，例如核碱基，莽草酮 - 核碱基缀合物和长链烷基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式