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41. 发明申请

WO2020190852A2 TOPOLOGICAL CONTROL OF RECEPTOR SIGNALING USING SYNTHETIC HOMO- AND HETERO-DIMERIC CYTOKINE MIMETICS 审中-公开
公开(公告)号：WO2020190852A2
公开(公告)日：2020-09-24
申请号：PCT/US2020/022939
申请日：2020-03-16
申请人： FALLAS, Jorge , BAKER, David , UEDA, George , GARCIA, Kenan, Christopher , MOHAN, Kritika , JUDE, Kevin , YEN, Michelle
发明人： FALLAS, Jorge , BAKER, David , UEDA, George , GARCIA, Kenan, Christopher , MOHAN, Kritika , JUDE, Kevin , YEN, Michelle
IPC分类号： C07K14/46
摘要： Disclosed herein are multimer-forming polypeptides that bind the erythropoietin receptor (EpoR) and thus can be used as designed ligands to topologically control EpoR receptor dimerization and induce differential effects in hematopoiesis, such as expanding red blood cells.

42. 发明申请

WO2020086793A1 SELF-ASSEMBLING PROTEIN HOMO-POLYMERS 审中-公开
公开(公告)号：WO2020086793A1
公开(公告)日：2020-04-30
申请号：PCT/US2019/057768
申请日：2019-10-24
申请人： SHEN, Hao , FALLAS, Jorge , BAKER, David
发明人： SHEN, Hao , FALLAS, Jorge , BAKER, David
IPC分类号： G16B15/20 , A61K38/16 , C12P21/02
摘要： Disclosed herein are polypeptides having the amino acid sequence that is at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the full length of the amino acid sequence selected from the group consisting of SEQ ID NO: 1-33 and 36, wherein the polypeptides include at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of the identified interface residues, and wherein the polypeptides are capable of end- to-end homo-polymerization, homo-polymers of the polypeptides, and related capping and anchor proteins to facilitate homo-polymer formation.

43. 发明申请

WO2018148647A2 GENOME EDITING REAGENTS AND THEIR USE 审中-公开
公开(公告)号：WO2018148647A2
公开(公告)日：2018-08-16
申请号：PCT/US2018/017796
申请日：2018-02-12
申请人： LAJOIE, Marc, Joseph , GRAY, Elizabeth, Erin , KING, Neil, P. , STETSON, Daniel, Brewster , BAKER, David , DaPRON, Katherine
发明人： LAJOIE, Marc, Joseph , GRAY, Elizabeth, Erin , KING, Neil, P. , STETSON, Daniel, Brewster , BAKER, David , DaPRON, Katherine
IPC分类号： A61K48/00 , A61K47/64
摘要： The application discloses multimeric assemblies packaging one or more active component and their use to carry out nucleic acid regulation or gene editing.

44. 发明申请

WO2013011262A2 INJECTION MOULDING NOZZLE 审中-公开
标题翻译：注射成型喷嘴
公开(公告)号：WO2013011262A2
公开(公告)日：2013-01-24
申请号：PCT/GB2012/000603
申请日：2012-07-19
申请人： UNIVERSITY OF EXETER , GHITA, Oana, Roxana , BAKER, David
发明人： GHITA, Oana, Roxana , BAKER, David
CPC分类号： B29C45/20 , B29C45/76 , B29C2945/76006 , B29C2945/7604 , B29C2945/7614 , B29C2945/76147 , B29C2945/7621 , B29C2945/76287 , B29C2945/76381 , B29C2945/76461 , B29C2945/76491
摘要： An 'injection nozzle comprises a nozzle body defining an injection passage along which a material to be injected passes, in use, and a removable sensor body receivable within an opening formed in the nozzle body and having an opening formed therein which, in use, aligns with the injection passage such that material passing along the injection passage flows through the opening, the sensor body having at least one. probe mounted thereon and operable to permit sensing of a parameter of the material passing through the opening.
摘要翻译：喷嘴包括喷嘴主体，该喷嘴主体限定了喷射通道，待使用的材料沿着喷射通道通过，并且可拆卸的传感器主体可接收在形成于喷嘴主体中的开口内，并具有形成在其中的开口，通过喷射通道使得沿着喷射通道的材料流过开口，传感器主体具有至少一个。探针安装在其上并且可操作以允许感测穿过开口的材料的参数。

45. 发明申请

WO2011051724A2 IMPROVEMENTS RELATING TO ARMOUR 审中-公开
标题翻译：与武装相关的改进
公开(公告)号：WO2011051724A2
公开(公告)日：2011-05-05
申请号：PCT/GB2010/051816
申请日：2010-10-29
申请人： BAE SYSTEMS PLC , MCDONALD, Jennifer, Laura , BAKER, David , REZAI, Amir
发明人： MCDONALD, Jennifer, Laura , BAKER, David , REZAI, Amir
IPC分类号： F41H5/02 , F41H5/04
CPC分类号： F41H5/023 , F41H5/0457 , Y10T156/10
摘要： There is disclosed armour comprising an outer metallic layer, an inner fibre composite layer, and a supporting framework between the inner and outer layers. The supporting framework can comprise projections from the outer layer arranged to mechanically interlock with the fibres of the fibre composite, and can be arranged to provide an open region between the inner and outer layers that can be filled with a functional filler material.
摘要翻译：公开了一种包括外金属层，内纤维复合层和在内层和外层之间的支撑框架的装甲。支撑框架可以包括从外层布置成与纤维复合材料的纤维机械互锁的突起，并且可以布置成在可以填充功能填充材料的内层和外层之间提供开放区域。

46. 发明申请

WO2009042726A1 HEAT CONCENTRATOR PISTON AND CHAMBER 审中-公开
标题翻译：热集中器活塞和室
公开(公告)号：WO2009042726A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/077580
申请日：2008-09-24
申请人： BAKER, David
发明人： BAKER, David
IPC分类号： F03G7/06 , F03G6/00
CPC分类号： F01K3/06 , Y02E10/46
摘要： A piston and chamber system to be used in connection with a heat concentrator such as those used for converting low grade thermal energy into useful energy. The example apparatus disclosed herein includes a heat engine floating piston which inhibits condensation normally associated with thermodynamic cycles which run at or near vapor saturation. The resulting improvement allows increased efficiency for lower temperature systems.
摘要翻译：与用于将低等级热能转换为有用能量的那些集热器结合使用的活塞和室系统。本文公开的示例性装置包括热引擎浮动活塞，其抑制通常与在蒸汽饱和处于或接近蒸气饱和的热力循环相关联的冷凝。所得到的改进允许提高低温系统的效率。

47. 发明申请

WO2006067450A2 MODULATOR 审中-公开
标题翻译：调制器
公开(公告)号：WO2006067450A2
公开(公告)日：2006-06-29
申请号：PCT/GB2005/004990
申请日：2005-12-21
申请人： UCL BIOMEDICA PLC , SELWOOD, David , VISINTIN, Cristina , BAKER, David , PRYCE, Gareth , OKUYAMA, Masahiro
发明人： SELWOOD, David , VISINTIN, Cristina , BAKER, David , PRYCE, Gareth , OKUYAMA, Masahiro
IPC分类号： C07C37/055 , C07C37/11 , C07C37/62 , C07C39/06 , C07C39/15 , C07C39/27 , C07C39/367 , C07C45/00 , C07C59/90 , C07C67/343 , C07C233/25 , C07C235/34 , C07D213/30
CPC分类号： C07D213/30 , C07C37/055 , C07C37/18 , C07C37/62 , C07C39/15 , C07C39/367 , C07C41/30 , C07C45/004 , C07C59/90 , C07C67/343 , C07C233/25 , C07C235/34 , C07C49/84 , C07C69/738 , C07C43/205 , C07C39/06 , C07C39/27 , C07C39/12
摘要： The present invention relates to a compound of formula I, or a pharmaceutically acceptable salt thereof, Formula (I), wherein R 1 and R 2 are each independently H or alkyl; Y is an alkyl group, CONR 3 R 4 , COOR 5 SO 2 NR 16 R 17 , NHSO 2 R 18 or CN; X is an aryl or heteroaryl group, each of which may be optionally substituted with one or more substituents selected from (CH2) m Z where Z is halogen, OH, CN, alkyl, alkoxy, NO 2 , CF 3 , CONR 6 R 7 , CN, NR 8 R 9 , COOR 10 or NHCOR 11, and m is 0 to 3; R 3 to R 11 are each independently H, alkyl or aryl, wherein said alkyl and aryl groups are optionally substituted by one or more substituents selected from halogen, OH, CN, alkyl, alkoxy, NO 2 , CF 3 , CONR 12 R 13 , CN, NH 2 , COOR 14 , NHCOR 15 , and CN; R 12 to R 18 are each independently H or alkyl, more preferably H or Me; n is 1 to 6; wherein the compound is other than 3' ,5'-dimethyl-4-(1,1-dimethylheptyl)-1,1'-biphenyl-2-ol. Further aspects of the invention relate to the use of such compounds in the preparation of a medicament for the treatment of a muscular disorder, a gastrointestinal disorder, or for controlling spasticity or tremors.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，式（I）其中R 1和R 2各自独立地为H或烷基; Y是烷基，CONR 3，R 4，COOR 5，SO 2，NR 16，或者CN;其中R 1，R 2，R 3，R 4， X是芳基或杂芳基，其各自可以任选地被一个或多个选自（CH 2）m Z的取代基取代，其中Z是卤素，OH，CN，烷基，烷氧基，NO > 2 ，CF 3，CONR 6，R 7，CN，NR 8 R SUP > 9，COOR 10或NHCOR 11，和m为0至3; R 3至R 11各自独立地为H，烷基或芳基，其中所述烷基和芳基任选被一个或多个选自以下的取代基取代：卤素，OH，CN，烷基，烷氧基，NO 2，CF 3，CONR 12，R 13，CN，NH 2 COOR 14，NHCOR 15和CN; R 12至R 18各自独立地为H或烷基，更优选为H或Me; n为1至6; 其中该化合物不是3'，5'-二甲基-4-（1,1-二甲基庚基）-1,1'-联苯-2-醇。本发明的其它方面涉及这样的化合物在制备用于治疗肌肉疾病，胃肠道疾病或用于控制痉挛或震颤的药物中的用途。

48. 发明申请

WO2005017713A2 SCREEN READER HAVING CONCURRENT COMMUNICATION OF NON-TEXTUAL INFORMATION 审中-公开
标题翻译：具有非文本信息的同时通信的屏幕阅读器
公开(公告)号：WO2005017713A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/026554
申请日：2004-08-16
申请人： FREEDOM SCIENTIFIC, INC. , HOFSTADER, Christian, D. , GORDON, Glen , DAMERY, Eric , OCAMPO, Ralph , BAKER, David , STEPHEN, Joseph, K.
发明人： HOFSTADER, Christian, D. , GORDON, Glen , DAMERY, Eric , OCAMPO, Ralph , BAKER, David , STEPHEN, Joseph, K.
IPC分类号： G06F
CPC分类号： G10L13/0335 , G09B21/006 , G10L13/033 , G10L13/043 , G10L13/08 , G10L2013/083
摘要： A screen reader software product for low-vision users, the software having a reader module collecting textual and non-textual display information generated by a web browser or word processor. Font styling, interface layout information and the like are communicated to the end user by sounds broadcast simultaneously rather than serially with the synthesized speech to improve the speed and efficiency in which information may be digested by the end user.
摘要翻译：一种用于低视力用户的屏幕阅读器软件产品，该软件具有收集由网页浏览器或文字处理器生成的文本和非文本显示信息的阅读器模块。字体样式，界面布局信息等通过同时声音广播而不是与合成语音串行地传送给最终用户，以提高最终用户可以消化信息的速度和效率。

49. 发明申请

WO2005015765A1 UWB COMMUNICATION SYSTEM AND CORRESPONDING METHOD 审中-公开
标题翻译： UWB通信系统及其对应方法
公开(公告)号：WO2005015765A1
公开(公告)日：2005-02-17
申请号：PCT/GB2004/003105
申请日：2004-07-19
申请人： ARTIMI LTD , BAKER, David , MOORE, Mark, Justin
发明人： BAKER, David , MOORE, Mark, Justin
IPC分类号： H04B1/69
CPC分类号： H04B1/71637 , H04B1/7176 , H04B1/719
摘要： This invention generally relates to wired and wireless ultra wideband (UWB) data communications apparatus and methods, and in particular to UWB receiver systems and architectures, and to UWB transmission systems and signals. A UWB receiver system for receiving a UWB signal comprising a plurality of pulses, the system comprising: a receiver front end to receive a UWB signal; a reference UWB signal store for storing a reference UWB signal; and a correlator configured to correlate said received UWB signal with a plurality of differently delayed versions of said stored reference signal to codetermine a timing and a phase of a received UWB signal pulse; whereby a UWB signal carrying data encoded by both pulse position and pulse phase is decodeable.
摘要翻译：本发明一般涉及有线和无线超宽带（UWB）数据通信设备和方法，特别涉及UWB接收机系统和体系结构以及UWB传输系统和信号。一种用于接收包括多个脉冲的UWB信号的UWB接收机系统，所述系统包括：用于接收UWB信号的接收机前端; 用于存储参考UWB信号的参考UWB信号存储器; 以及相关器，被配置为将所述接收的UWB信号与所述存储的参考信号的多个不同延迟的版本相关，以便编码所接收的UWB信号脉冲的定时和相位; 由此携带由脉冲位置和脉冲相位编码的数据的UWB信号是可解码的。

50. 发明申请

WO2004107678A3 ULTRA-WIDEBAND NETWORK, DEVICE, DEVICE CONTROLLER, METHOD AND DATA PACKET FOR ESTABLISHING A MESH NETWORK AND FORWARDING PACKETS ON ANOTHER CHANNEL 审中-公开
公开(公告)号：WO2004107678A3
公开(公告)日：2004-12-09
申请号：PCT/GB2004/002201
申请日：2004-05-21
申请人： ARTIMI LTD , BAKER, David , MOORE, Mark, Justin
发明人： BAKER, David , MOORE, Mark, Justin
IPC分类号： H04L12/56
摘要： An ultra-wideband (UWB) network comprising a plurality of UWB devices each forming a node of said network, pairs of said UWB devices being configured for communication with one another using one of a plurality of UWB charnels, each said UWB device comprising a UWB transceiver (610) for bidirectional communication over one or more of said UWB channels (610a, 610b) with at least one other of said UWB devices; and a device controller coupled to said UWB transceiver, said controller being configured to determine a said UWB channel for use in establishing a communication link with each other UWB device and to store connection data associating a list of said channels bearing incoming data with a second of said channels for use in forwarding said incoming data to another of said devices. In one embodiment, the controller of an UWB device comprises a memory access controller (614) being the master of a second data bus (616).

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