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41. 发明申请

WO2010121226A2 ANTICANCER AGENTS 审中-公开
标题翻译：反对者代理人
公开(公告)号：WO2010121226A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/031522
申请日：2010-04-16
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BURKART, Michael, D. , LA CLAIR, James, J. , KANG, Minjin , JONES, Brian, D. , MANDEL, Alexander, L. , YU, Wei-Luen , HAMMONS, Justin, C.
发明人： BURKART, Michael, D. , LA CLAIR, James, J. , KANG, Minjin , JONES, Brian, D. , MANDEL, Alexander, L. , YU, Wei-Luen , HAMMONS, Justin, C.
IPC分类号： C07D407/04 , C07D307/32 , A61K31/343 , A61P35/00
CPC分类号： C07D493/18
摘要： The present disclosure relates generally to compositions and methods for treating cancer. In some aspects, novel spirohexenolides and methods of using and producing them are described.
摘要翻译：本公开一般涉及用于治疗癌症的组合物和方法。在一些方面，描述了新颖的螺烯烯内酯及其使用和制备方法。

42. 发明申请

WO2010120371A1 SOLID ALIQUOTS OF MULTIRESIDUE METHOD SALTS FOR SOLID PHASE EXTRACTION APPLICATIONS 审中-公开
标题翻译：用于固相萃取应用的多种方法的固体浓度
公开(公告)号：WO2010120371A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/001131
申请日：2010-04-16
申请人： RESTEK CORPORATION , MOSESMAN, Neil, H. , JONES, Brian, A. , COCHRAN, Jack, W.
发明人： MOSESMAN, Neil, H. , JONES, Brian, A. , COCHRAN, Jack, W.
IPC分类号： B01D11/02
CPC分类号： G01N1/34 , G01N1/405
摘要： It is an object of the invention to improve the current QuEChERS technology. In one aspect of the invention, the buffer-salt powder mixture of the first stage of the QuEChERS process is compressed into a solid dosage form before it is used in the first stage of the QuEChERS process. Replacing the QuEChERS powders (the buffer-salt powder mixture of the first stage of the QuEChERS process) with solid aliquots eliminates the need for using centrifuge tubes for packaging the product.
摘要翻译：本发明的目的是改进目前的QuEChERS技术。在本发明的一个方面，QuEChERS过程的第一阶段的缓冲盐混合物在QuEChERS过程的第一阶段被用于固体剂型之前。用固体等分试样替代QuEChERS粉末（QuEChERS工艺第一阶段的缓冲盐粉末混合物），无需使用离心管来包装产品。

43. 发明申请

WO2009098229A3 A METHOD OF PREPARING FOOD PRODUCTS USING TS23 ALPHA-AMYLASE 审中-公开
标题翻译：使用TS23 ALPHA-AMYLASE制备食品的方法
公开(公告)号：WO2009098229A3
公开(公告)日：2010-05-27
申请号：PCT/EP2009051268
申请日：2009-02-04
申请人： DANISCO US INC GENENCOR DIV , DANISCO , KRAGH KARSTEN MATTHIAS , CHANG CLAUDINE , ESTABROOK MELODIE , JONES BRIAN , CHOY CLEMENT , KOLKMAN MARC , LEEFLANG CHRIS , VROEMEN CASPER WILLEM , WEYLER WALTER , PEREIRA LUIS GUSTAVO CASCAO , KELLIS JAMES T
发明人： KRAGH KARSTEN MATTHIAS , CHANG CLAUDINE , ESTABROOK MELODIE , JONES BRIAN , CHOY CLEMENT , KOLKMAN MARC , LEEFLANG CHRIS , VROEMEN CASPER WILLEM , WEYLER WALTER , PEREIRA LUIS GUSTAVO CASCAO , KELLIS JAMES T
IPC分类号： A21D8/04 , A23L1/09 , C12N9/28
CPC分类号： C12N9/2417 , A21D8/042 , A23K20/189 , A23K50/75 , A23L29/06
摘要： The present invention relates to the use of a parent AmyTS-23 alpha-amylase as well as variants, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase in the production of food products, such as the use in a baking composition.
摘要翻译：本发明涉及母体AmyTS-23α-淀粉酶以及变体，其中变体具有α-淀粉酶活性并在食品生产中相对于母体α-淀粉酶具有改变的性质，例如使用在烘焙组合物中。

44. 发明申请

WO2008042885A2 INTEGRATED COLLECTION, ANALYSIS, AND RECYCLING METHOD 审中-公开
标题翻译：综合收集，分析和回收方法
公开(公告)号：WO2008042885A2
公开(公告)日：2008-04-10
申请号：PCT/US2007080149
申请日：2007-10-02
申请人： DOW CORNING , JONES BRIAN L , HEMPFLING JEFFREY , BARONDEAU ANGELA DOHERTY
发明人： JONES BRIAN L , HEMPFLING JEFFREY , BARONDEAU ANGELA DOHERTY
IPC分类号： G06F19/00
CPC分类号： G06Q10/08 , G06Q10/06 , G06Q50/04 , Y02P90/30
摘要： A recycling method that can be used by an OEM products company or other entity to obtain recovered raw materials for use in its manufacturing operations in a manner that helps ensure the quality and traceability of the recovered raw materials. The process involves first collecting the material from one or more sources, then determining suitability of the material for processing using a series of qualifying tests separated into a two-phase review, wherein each of the qualifying tests is carried out using a composition profile for the material. The first phase of the review utilizes a source composition profile that describes salient features of the material so that it can be reviewed for suitability for processing and end uses as well as for regulatory compliance. The second phase involves similar reviews based on an analytical composition profile that is determined by physical analysis of the material.
摘要翻译：可以由OEM产品公司或其他实体使用的回收方法，以获得用于其制造操作的回收原材料，以有助于确保回收原材料的质量和可追溯性。该过程包括首先从一个或多个来源收集材料，然后使用分成两阶段审查的一系列合格测试来确定材料的处理适用性，其中每个合格测试使用组合物简档进行材料。审查的第一阶段使用描述材料的重要特征的源组合简档，以便对其进行审查以适用于处理和最终用途以及遵守法规。第二阶段涉及基于通过材料的物理分析确定的分析组成分布的相似评价。

45. 发明申请

WO2005060536A3 si-RNA-MEDIATED GENE SILENCING TECHNOLOGY TO INHIBIT TYROSINASE AND REDUCE PIGMENTATION 审中-公开
标题翻译： si-RNA介导的基因沉默技术抑制酪氨酸激酶和减少色素沉着
公开(公告)号：WO2005060536A3
公开(公告)日：2007-03-22
申请号：PCT/US2004039941
申请日：2004-11-30
申请人： AVON PROD INC , BINETTI RALPH R , JONES BRIAN C
发明人： BINETTI RALPH R , JONES BRIAN C
IPC分类号： A61K48/00 , C07H21/04 , C12N15/11 , C12N15/113
CPC分类号： C12N15/1137 , C12N15/111 , C12N2310/14 , C12N2320/32 , C12Y114/18001
摘要： The present invention describes compositions and methods for treating, preventing and improving hyperpigmentation, or other unwanted pigmentation of the skin, or other unwanted skin condition, such as age spots, aged skin, skin discoloration, etc., wherein the compositions include siRNA-gene silencing oligomers specific for tyrosinase. The compositions are used to treat a broad variety of pigmentation conditions, and are preferably applied to the skin, or are delivered by directed means to a site in need thereof.
摘要翻译：本发明描述了用于治疗，预防和改善皮肤色素沉着过度或其它不需要的色素沉着或其它不需要的皮肤状况（如老年斑，老化皮肤，皮肤变色等）的组合物和方法，其中组合物包括siRNA-基因沉默酪氨酸酶特异性低聚物。所述组合物用于治疗各种各样的色素沉着状况，并且优选施用于皮肤，或通过定向方式递送至有需要的部位。

46. 发明申请

WO2006122019A2 INTRAGASTRIC DEVICE FOR TREATING OBESITY 审中-公开
标题翻译：用于治疗肥胖的内脏装置
公开(公告)号：WO2006122019A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/017704
申请日：2006-05-08
申请人： WILSON-COOK MEDICAL, INC. , HASHIBA, Kiyoshi , JONES, Brian, K. , KENNEDY, Kenneth, C., II , SURTI, Vihar, C.
发明人： HASHIBA, Kiyoshi , JONES, Brian, K. , KENNEDY, Kenneth, C., II , SURTI, Vihar, C.
IPC分类号： A61F5/00
CPC分类号： A61F5/0036
摘要： An apparatus comprising an intragastric member re-configurable from a first configuration to a second configuration, the first configuration being sufficiently small to permit introduction of said intragastric member into a gastric lumen of a mammal, the second configuration being sufficiently large to prevent said intragastric device from passing through the mammal's pylorus, wherein said intragastric member comprises a plurality of spaced apart openings. The intragastric member comprises an elongate member having a proximal end and a distal end, wherein the elongate member is threaded through the openings of the intragastric member, and the intragastric member is disposed between the proximal end and the distal end of the elongate member. The apparatus also comprises a proximal stopper engaged to the distal end of the elongate member and a proximal stopper engaged to the proximal end of the elongate member for securing the intragastric member upon delivery into the gastric lumen of the patient. The elongate member can also comprise a cinching member to facilitate delivery of the intragastric member into the gastric lumen of the patient.
摘要翻译：一种包括可从第一配置重新配置到第二配置的胃内成员的装置，所述第一配置足够小以允许将所述胃内部件引入哺乳动物的胃腔，所述第二配置足够大以防止所述胃内装置通过哺乳动物的幽门，其中所述胃内构件包括多个间隔开的开口。胃内构件包括具有近端和远端的细长构件，其中细长构件穿过胃内构件的开口，并且胃内构件设置在细长构件的近端和远端之间。该装置还包括接合到细长构件的远端的近侧止动件和接合到细长构件的近端的近侧止动件，用于在输送到患者的胃腔中时固定胃内构件。细长构件还可以包括收紧构件以便于将胃内构件递送到患者的胃腔中。

47. 发明申请

WO2005052146A8 SERINE PROTEASES, NUCLEIC ACIDS ENCODING SERINE ENZYMES AND VECTORS AND HOST CELLS INCORPORATING SAME 审中-公开
标题翻译：丝氨酸蛋白酶，核酸编码丝氨酸酶和载体和宿主细胞
公开(公告)号：WO2005052146A8
公开(公告)日：2006-08-24
申请号：PCT/US2004039066
申请日：2004-11-19
申请人： GENENCOR INT , PROCTER & GAMBLE , JONES BRIAN EDWARD , KOLKMAN MARC , LEEFLANG CHRIS , OH HIROSHI , POULOSE AYROOKARAN J , SADLOWSKI EUGENE S , SHAW ANDREW , VAN DER KLEIJ WILHELMUS A H , VAN MARREWIJK LEO
发明人： JONES BRIAN EDWARD , KOLKMAN MARC , LEEFLANG CHRIS , OH HIROSHI , POULOSE AYROOKARAN J , SADLOWSKI EUGENE S , SHAW ANDREW , VAN DER KLEIJ WILHELMUS A H , VAN MARREWIJK LEO
IPC分类号： C11D3/386 , C12N9/52 , C12N9/64
CPC分类号： C12N9/52 , C07K2299/00 , C11D3/386
摘要： The present invention provides novel serine proteases, novel genetic material encoding these enzymes, and proteolytic proteins obtained from Micrococcineae spp., including but not limited to Cellulomonas spp. and variant proteins developed therefrom. In particular, the present invention provides protease compositions obtained from a Cellulomonas spp, DNA encoding the protease, vectors comprising the DNA encoding the protease, host cells transformed with the vector DNA, and an enzyme produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising protease(s) obtained from a Micrococcineae spp., including but not limited to Cellulomonas spp. In alternative embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These mutant proteases also find use in numerous applications.
摘要翻译：本发明提供了新的丝氨酸蛋白酶，编码这些酶的新型遗传物质，以及从微球菌属（Micrococcineae spp。）获得的蛋白水解蛋白，包括但不限于纤维单胞菌属（Cellulomonas spp）和从其开发的变体蛋白质。特别地，本发明提供了从纤维单胞菌属（Splulomonas spp）获得的蛋白酶组合物，编码蛋白酶的DNA，包含编码蛋白酶的载体，载体DNA转化的宿主细胞和由宿主细胞产生的酶。本发明还提供了清洁组合物（例如洗涤剂组合物），动物饲料组合物，以及包含从微球菌（Micrococcineae spp。）获得的蛋白酶的纺织和皮革加工组合物，其包括但不限于纤维单胞菌属（Cellulomonas spp）在替代实施方案中，本发明提供衍生自本文所述的野生型蛋白酶的突变体（即，变体）蛋白酶。这些突变型蛋白酶也可用于许多应用。

48. 发明申请

WO2006069072A3 METHOD AND COMPOSITION FOR REDUCING THE APPEARANCE OF WRINKLES 审中-公开
公开(公告)号：WO2006069072A3
公开(公告)日：2006-06-29
申请号：PCT/US2005/046190
申请日：2005-12-20
申请人： AVON PRODUCTS INC. , JONES, Brian, C. , HINES, Michelle, D.
发明人： JONES, Brian, C. , HINES, Michelle, D.
IPC分类号： A01N65/00
摘要： The present invention provides a cosmetic composition having a cosmetically acceptable vehicle and one or more gap junction inhibitors and/or one or more choline acetyl transferase (CAT) inhibitors in an amount effective for reducing the appearance of deep wrinkles on the skin. Also provided is a method of reducing the appearance of deep wrinkles on the skin, including the steps of topically applying to the skin the above cosmetic composition in an amount and for a period of time sufficient to reduce the appearance of deep wrinkles on the skin.

49. 发明申请

WO2006026034A3 PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES 审中-公开
标题翻译：制备异噻唑衍生物的方法
公开(公告)号：WO2006026034A3
公开(公告)日：2006-06-29
申请号：PCT/US2005027398
申请日：2005-08-02
申请人： PFIZER PROD INC , OSI PHARM INC , DAMON DAVID B , JONES BRIAN P
发明人： DAMON DAVID B , JONES BRIAN P
IPC分类号： A61K31/425 , C07D275/02
CPC分类号： C07D275/03
摘要： Processes and intermediates for the preparation of compounds of the Formula (1) and the pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, wherein R 1 , R 2 , and R 3 have the definitions provided herein.
摘要翻译：用于制备式（1）化合物及其药学上可接受的盐，前药，溶剂化物和水合物的方法和中间体，其中R 1，R 2和R 2 ^{3具有本文提供的定义。}

50. 发明申请

WO2005086652A2 POLYCARBOSILANE TREATMENT OF SUBSTRATES 审中-公开
标题翻译：基质的多硫化物处理
公开(公告)号：WO2005086652A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/005731
申请日：2005-02-24
申请人： SELERITY TECHNOLOGIES, INCORPORATED , JONES, Brian, A.
发明人： JONES, Brian, A.
IPC分类号： B32B25/20 , C08K9/06 , C09D183/14 , C09D183/16
CPC分类号： C09D183/14 , C08K9/06 , C09D183/16 , Y10T428/31663
摘要： A polycarbosilane functionalized substrate can comprise a substrate having a surface including surface oxide or surface hydroxyl groups, and a polycarbosilane layer covalently bonded thereto. The polycarbosilane layer can include a web of interconnected polycarbosilane groups wherein the carbon bonded silane portions of the polycarbosilane groups are alkylene moieties. Optionally, an additional polycarbosilane layer(s) can be applied to the polycarbosilane layer.
摘要翻译：聚碳硅烷官能化基材可以包括具有包括表面氧化物或表面羟基的表面的基材和与其共价键合的聚碳硅烷层。聚碳硅烷层可以包括互连的聚碳硅烷基的网，其中聚碳硅烷基的碳键合硅烷部分是亚烷基部分。任选地，可以向聚碳硅烷层施加另外的聚碳硅烷层。

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