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41. 发明申请

WO2013162690A1 RADIOPAQUE ENHANCED COBALT ALLOY FOR STENTS 审中-公开
标题翻译：放射性增强钴合金
公开(公告)号：WO2013162690A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/026942
申请日：2013-02-20
申请人： MEDTRONIC VASCULAR INC.
发明人： THOMPSON, Dustin
IPC分类号： A61L31/02 , C22C19/07
CPC分类号： A61F2/915 , A61F2/82 , A61F2002/91558 , A61F2210/0076 , A61F2250/0098 , A61L31/022 , A61L31/18 , C22C19/07
摘要： A stent is formed of at least a cobalt-based alloy. The cobalt-based alloy may include 10-35 weight % metal member selected from the group consisting of platinum (Pt), gold (Au), iridium (Ir), osmium (Os), rhenium (Re), tungsten (W), palladium (Pd), tantalum (Ta), and combinations thereof; 16-21 weight % chromium (Cr); 9-12 weight % molybdenum (Mo); 0-25 weight % nickel (Ni); and balance cobalt (Co). The cobalt-based alloy may be a thin outer shell of a hollow stent. The cobalt-based alloy may be used to form at least one of an inner core and an outer shell of a core-shell structure of a stent. The cobalt-based alloy may be used to form an end of a wire for forming a stent.
摘要翻译：支架由至少一种钴基合金形成。钴基合金可以包括选自铂（Pt），金（Au），铱（Ir），锇（Os），铼（Re），钨（W），钯（Pd），钽（Ta）及其组合; 16-21重量％铬（Cr）; 9-12重量％钼（Mo）; 0-25重量％镍（Ni）; 并平衡钴（Co）。钴基合金可以是中空支架的薄外壳。钴基合金可以用于形成支架的核 - 壳结构的内芯和外壳中的至少一个。钴基合金可用于形成用于形成支架的线的端部。

42. 发明申请

WO2013162676A1 APPARATUS AND METHODS FOR FILLING A DRUG ELUTING MEDICAL DEVICE VIA CAPILLARY ACTION 审中-公开
标题翻译：用于通过毛细管动作填充药物治疗医疗装置的装置和方法
公开(公告)号：WO2013162676A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/026265
申请日：2013-02-15
申请人： MEDTRONIC VASCULAR INC.
发明人： PETERSON, Justin , MITCHELL, James , SCHLICHTING, Abby , GLUCKLICH, Nate , TRAINA, Joe , KUMAR, Rajen
IPC分类号： A61F2/915 , B65B3/00
CPC分类号： A61F2/82 , A61F2/915 , A61F2002/91541 , A61F2002/91575 , A61F2230/0054 , A61F2240/001 , A61F2250/0035 , A61F2250/0068 , A61L31/16 , A61L2300/416 , B05B13/06
摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.
摘要翻译：公开了用于在形成支架的中空丝内填充治疗物质或药物的方法和装置。将支架放置在容纳流体药物制剂的腔室内。在填充期间，室被保持在或接近流体药物制剂的溶剂的气液平衡。为了填充支架，将支架的一部分放置成与流体药物制剂接触，直到由空心线限定的腔空间通过毛细作用填充流体药物制剂。填充完成后，支架缩回，使得支架不再与流体药物制剂接触。室内的溶剂蒸气压降低以蒸发流体药物制剂的溶剂。芯吸装置可以控制流体药物制剂转移到支架中。

43. 发明申请

WO2013151620A1 METHOD AND APPARATUS FOR CREATING FORMED ELEMENTS USED TO MAKE WOUND STENTS 审中-公开
标题翻译：用于创建用于制造伤口的成形元件的方法和装置
公开(公告)号：WO2013151620A1
公开(公告)日：2013-10-10
申请号：PCT/US2013/025673
申请日：2013-02-12
申请人： MEDTRONIC VASCULAR INC.
发明人： ENSIGN, Lance , GRISWOLD, Eric
IPC分类号： B21F1/04 , A61F2/90 , B21F45/00
CPC分类号： B21F45/008 , A61F2/86 , A61F2/88 , A61F2/90 , A61F2/915 , A61F2240/001 , B21F1/04
摘要： A method for forming a wave form for a stent (100) includes moving a first forming portion (22) of a first forming member (20) in a direction substantially perpendicular to a first direction direction (FD) along which a formable material (12) is provided to engage and deform the formable material (12) against a first forming portion (32) of the second forming member (30). Then first and second forming members (20, 30) are jointly moved in a direction substantially opposite the first direction to draw and form the formable material over the first forming portion (32) of the second forming member (30). Then the first forming member (20) is disengaged from the formable material (12) and is rotated to position a second forming portion (24, 26, 28) of the first forming member (20) to face the formable material (12).
摘要翻译：用于形成用于支架（100）的波形的方法包括：在基本上垂直于第一方向（FD）的方向上移动第一形成部件（20）的第一形成部分（22），沿着第一方向）被设置成将可成形材料（12）接合并变形成抵靠第二成形构件（30）的第一成形部分（32）。然后，第一和第二形成构件（20,30）沿与第一方向大致相反的方向共同移动，以在第二成形构件（30）的第一成形部分（32）上方拉伸并形成可成形材料。然后，第一成形构件（20）从可成形材料（12）脱离并转动，使第一成形构件（20）的第二成形部分（24,26,28）定位成与可成形材料（12）相对。

44. 发明申请

WO2012036890A1 METHOD OF FORMING A DRUG-ELUTING MEDICAL DEVICE 审中-公开
标题翻译：形成药物治疗装置的方法
公开(公告)号：WO2012036890A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/049761
申请日：2011-08-30
申请人： MEDTRONIC VASCULAR , BIENVENU, Ryan
发明人： BIENVENU, Ryan
IPC分类号： A61L31/14 , A61L31/16 , A61L31/18
CPC分类号： A61L31/18 , A61F2/915 , A61F2002/91541 , A61F2002/91575 , A61F2230/0013 , A61F2230/0091 , A61F2240/001 , A61F2250/0068 , A61L31/121 , A61L2300/406 , A61L2300/416 , Y10T29/49885 , Y10T29/49995
摘要： A method of forming a stent includes the steps of forming an elongated composite member or plurality of elongated composite members into a stent pattern having struts interconnected by crowns, the composite member including an outer member and a core member. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from at least a plurality of the struts of the stent without adversely affecting the outer member and such that the core member is not removed from at least a plurality of the crowns of the stent, thereby leaving the outer member with a lumen in at least a plurality of the struts and the outer member with the core member in at least a plurality of the crowns. The lumens may then be filled with a biologically or pharmacologically active substance.
摘要翻译：形成支架的方法包括以下步骤：将细长复合构件或多个细长复合构件形成为具有由冠部互连的支柱的支架图案，所述复合构件包括外部构件和芯构件。通过复合构件的外部构件形成开口。处理复合构件以从支架的至少多个支柱移除芯构件，而不会不利地影响外构件，并且使得芯构件不从支架的至少多个冠部移除，从而留下所述外部构件在至少多个所述支柱中具有内腔，所述外部构件具有至少多个所述冠部中的所述芯构件。然后可以用生物学或药理学活性物质填充内腔。

45. 发明申请

WO2012036875A1 METHOD OF FORMING A DRUG-ELUTING MEDICAL DEVICE 审中-公开
标题翻译：形成药物治疗装置的方法
公开(公告)号：WO2012036875A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/049429
申请日：2011-08-26
申请人： MEDTRONIC VASCULAR , BIENVENU, Ryan , KANTOR, John
发明人： BIENVENU, Ryan , KANTOR, John
IPC分类号： A61L31/02 , A61L31/16 , A61F2/86
CPC分类号： A61F2/89 , A61F2/86 , A61F2/88 , A61F2230/0069 , A61F2250/0067 , A61F2250/0068 , A61L31/022 , A61L31/16 , A61L2400/18 , A61M31/002 , A61M2207/10 , B23P19/04 , C23F1/12 , Y10T29/4987
摘要： A method of forming a stent includes the steps of forming a composite member into a stent pattern, forming openings through an outer member of the composite member, processing the composite member to remove a portion of the composite member without adversely affecting the outer member, and swaging the outer member to create a plurality of lumens. The composite member may be formed of an outer member with an hourglass-shaped inner member, wherein the processing step removes the inner member and the swaging step forms two lumens from the hourglass shaped cavity. The composite member may be formed of an outer member, an inner member, and an intermediate member, wherein the processing step removes the intermediate member and the swaging step presses portions of the outer member into contact with the inner member to form two lumens separated by the inner member.
摘要翻译：形成支架的方法包括以下步骤：将复合构件形成支架图案，通过复合构件的外部构件形成开口，处理复合构件以去除复合构件的一部分而不会不利地影响外部构件;以及模制外部构件以形成多个流明。复合构件可以由具有沙漏形内部构件的外部构件形成，其中处理步骤移除内部构件，并且锻造步骤与沙漏形腔形成两个流明。复合构件可以由外部构件，内部构件和中间构件形成，其中加工步骤移除中间构件，并且锻造步骤将外部构件的部分按压与内部构件接触以形成由内部成员。

46. 发明申请

WO2012036868A1 APPARATUS AND METHODS FOR LOADING A DRUG ELUTING MEDICAL DEVICE 审中-公开
标题翻译：装载药物装置的装置和方法
公开(公告)号：WO2012036868A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/049230
申请日：2011-08-25
申请人： MEDTRONIC VASCULAR , AVELAR, Salvador , MITCHELL, James E.
发明人： AVELAR, Salvador , MITCHELL, James E.
IPC分类号： A61L31/16 , A61F2/86
CPC分类号： A61L31/16 , A61F2/86 , A61F2240/001 , A61F2250/0068 , A61L31/14 , A61L2300/416 , A61L2300/802
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
摘要翻译：公开了用于将治疗物质或药物装载在具有沿其长度的多个侧面开口的中空丝的内腔空间内，形成具有多个侧面药物递送开口的中空药物洗脱支架。在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充内腔空间。在药物填充步骤之后，进行溶剂或分散介质提取步骤以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。可以对中空支架的外表面进行支架清洁步骤。

47. 发明申请

WO2011130005A2 HANDLE ASSEMBLIES FOR INTRAVASCULAR TREATMENT DEVICES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于静脉内治疗装置和相关系统和方法的手柄组件
公开(公告)号：WO2011130005A2
公开(公告)日：2011-10-20
申请号：PCT/US2011/030496
申请日：2011-03-30
申请人： MEDTRONIC ARDIAN LLC , CLARK, Benjamin, C. , GEORGE, William, R. , MICHLITSCH, Kenneth, J. , SAM, John, Paul , THAI, Erik , WU, Andrew
发明人： CLARK, Benjamin, C. , GEORGE, William, R. , MICHLITSCH, Kenneth, J. , SAM, John, Paul , THAI, Erik , WU, Andrew
IPC分类号： A61B18/14 , A61B19/00 , A61B17/00
CPC分类号： A61B18/08 , A61B34/74 , A61B2017/003 , A61B2018/00916
摘要： The present disclosure comprises handle assemblies for intravascular treatment devices. In one embodiment, a handle assembly comprises an actuator for deflecting a distal region of an intravascular treatment device. In one embodiment, a handle assembly comprises a rotator for rotating an intravascular treatment device independently of the handle assembly. In one embodiment, a handle assembly comprises a rotation limiting element for limiting independent rotation of an intravascular treatment device relative to the handle assembly. Methods and systems for intravascular delivery, deflection and placement of an intravascular treatment device via a handle assembly of the present invention are also provided.
摘要翻译：本公开包括用于血管内治疗装置的手柄组件。在一个实施例中，手柄组件包括用于偏转血管内治疗装置的远侧区域的致动器。在一个实施例中，手柄组件包括用于独立于手柄组件旋转血管内治疗装置的旋转器。在一个实施例中，手柄组件包括旋转限制元件，用于限制血管内治疗装置相对于手柄组件的独立旋转。还提供了通过本发明的手柄组件进行血管内递送，偏转和放置血管内治疗装置的方法和系统。

48. 发明申请

WO2010147687A1 BIODEGRADABLE MEDICAL DEVICE WITH HYDROXYAPATITE FILAMENTS AND BIODEGRADABLE POLYMER FIBERS 审中-公开
标题翻译：可生物降解的医用设备，具有羟基磷酸酯纤维和可生物降解的聚合物纤维
公开(公告)号：WO2010147687A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/027336
申请日：2010-03-15
申请人： MEDTRONIC VASCULAR INC. , BILGE, Iskender
发明人： BILGE, Iskender
IPC分类号： A61F2/82 , A61L27/12 , A61L27/58 , A61L27/14 , A61M29/02
CPC分类号： A61L31/028 , A61F2/82 , A61F2/90 , A61F2/958 , A61F2210/0004 , A61F2250/003 , A61L31/026 , A61L31/06 , A61L31/123 , A61L31/127 , A61L31/148 , A61L31/16 , Y10T442/105 , Y10T442/2525 , C08L67/04
摘要： A system for treating a vascular condition includes a stent including hydroxyapatite fibers interwoven to define a stent lumen. Another aspect of the invention is a method of manufacturing a stent by forming hydroxyapatite fibers and biodegradable polymeric fibers, and interweaving the fibers to form a stent wall. The hydroxyapatite fibers can be formed by a sol-gel process, followed by spinning of the gel to form the hydroxyapatite fibers.
摘要翻译：用于治疗血管病症的系统包括支架，其包括交织以固定支架内腔的羟基磷灰石纤维。本发明的另一方面是通过形成羟基磷灰石纤维和可生物降解的聚合物纤维来制造支架的方法，并且交织纤维以形成支架壁。羟基磷灰石纤维可以通过溶胶 - 凝胶法形成，然后旋转凝胶以形成羟基磷灰石纤维。

49. 发明申请

WO2013162692A1 METHOD FOR FORMING A STENT 审中-公开
标题翻译：形成手段的方法
公开(公告)号：WO2013162692A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/027167
申请日：2013-02-21
申请人： MEDTRONIC VASCULAR INC.
发明人： BALDWIN, Matthew , BLISS, Richard
IPC分类号： B23K26/36 , A61F2/88 , B23K26/00
CPC分类号： A61F2/88 , A61F2002/91558 , A61F2240/001 , B21F3/04 , B23K26/0075 , B23K26/361 , Y10T29/49995
摘要： A method of forming a stent (10) includes forming a wave form (12) from a formable material. The wave form includes a plurality of substantially straight portions (18) and a plurality of curved portions (20), each curved portion (20) connecting adjacent substantially straight portions (18). The method includes wrapping the wave form (12) around a mandrel (30) at an angle a to form a helical coil comprising a plurality of turns (22), connecting a first curved portion (20a) of a first turn (22a) to an adjacent second curved portion (20b) of a second turn (22b) at a position along the wave form to define an end of the stent (10), and removing excess material (15) from an end of the wave form (12) extending past the first curved portion (20a) while smoothing the end of the stent (10).
摘要翻译：形成支架（10）的方法包括从可成形材料形成波形（12）。波形包括多个基本上直的部分（18）和多个弯曲部分（20），每个弯曲部分（20）连接相邻的基本上直的部分（18）。该方法包括将波形（12）围绕心轴（30）以角度α包围以形成螺旋线圈，该螺旋线圈包括多个匝（22），将第一匝（22a）的第一弯曲部分（20a）连接到沿着波形的位置处的第二匝（22b）的相邻的第二弯曲部分（20b），以限定所述支架（10）的端部，以及从所述波形（12）的端部移除多余的材料（15）延伸过第一弯曲部分（20a），同时平滑支架（10）的端部。

50. 发明申请

WO2013158218A1 METHOD AND APPARATUS FOR CREATING FORMED ELEMENTS USED TO MAKE WOUND STENTS 审中-公开
标题翻译：用于创建用于制造伤口的成形元件的方法和装置
公开(公告)号：WO2013158218A1
公开(公告)日：2013-10-24
申请号：PCT/US2013/027797
申请日：2013-02-26
申请人： MEDTRONIC VASCULAR INC.
发明人： GRISWOLD, Erik , ENSIGN, Lance
IPC分类号： B21F1/04 , A61F2/90 , B21F45/00
CPC分类号： B21F45/008 , A61F2/885 , A61F2240/001 , B21F1/04
摘要： A method for forming a wave form for a stent (100, 200) includes moving a first forming portion (24) having a first engaging surface (25) of a first forming member (20) across an axis (AX) along which a formable material (12) is provided in a direction (X) substantially perpendicular to the axis (AX) to engage and deform the formable material (12) while engaging the formable material with a first forming portion (34) having a first engaging surface (35) of the second forming member (30). The method further includes disengaging the first forming member (20) from the formable material (12) and moving the first forming member (20) such that a second forming portion (22, 26, 28) of the first forming member (20) faces the formable material.
摘要翻译：用于形成用于支架（100,200）的波形的方法包括：移动具有第一成形构件（20）的第一接合表面（25）的第一成形部分（24）穿过轴（AX）材料（12）沿基本上垂直于轴线（AX）的方向（X）设置，以使可成形材料（12）接合并变形，同时将可成形材料与具有第一接合表面（35）的第一成形部分（34）接合）的第二成形构件（30）。该方法还包括使第一成形构件（20）与可成形材料（12）分离并使第一成形构件（20）移动，使得第一成形构件（20）的第二形成部分（22,26,28）面对可成型材料。

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