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    • 42. 发明申请
    • NANOCOMPOSITE BIOMATERIALS OF NANOCRYSTALLINE CELLULOSE (NCC) AND POLYLACTIC ACID (PLA)
    • 纳米纤维素(NCC)和聚乳酸(PLA)的纳米复合生物体
    • WO2011097700A1
    • 2011-08-18
    • PCT/CA2011/000096
    • 2011-01-26
    • FPINNOVATIONSHAMAD, Wadood, Y.MIAO, Chuanwei
    • HAMAD, Wadood, Y.MIAO, Chuanwei
    • C08B3/00C08G63/81C08L1/02C08L67/04
    • C08L1/02B82Y30/00B82Y40/00C08G63/08C08J5/18C08J2301/02C08J2367/04C08L67/04C08L2205/14D01F1/10D01F6/625
    • A new approach is conceived for the development of sustainable biomaterials comprising nanocrystalline cellulose (NCC) and polylactic acid (PLA) nanocomposites. The invention deals with advancing a method based on in situ ring opening polymerization of L-lactide in the presence of NCC particles to form NCC-PLA supramolecular nanocomposite materials. This material is hydrophobic and compatible with a wide range of synthetic and natural polymers. NCC-PLA nanocomposites have enhanced functionality (e.g. gas barrier), rheological and mechanical performance, as well as dimensional stability (i.e. less hygroexpansivity) relative to PLA. They are made from entirely renewable resources, and are potentially biocompatible as well as recyclable. NCC-PLA supramolecular nanocomposites can be suspended in most organic solvents or dried to form a solid substance. They can be processed using conventional polymer processing techniques to develop 3-dimensional structures, or spun into fibres, yarns or filaments.
    • 构想了一种新的方法来开发包含纳米晶体纤维素(NCC)和聚乳酸(PLA)纳米复合材料的可持续生物材料。 本发明涉及在NCC颗粒存在的情况下推进基于L-丙交酯的原位开环聚合以形成NCC-PLA超分子纳米复合材料的方法。 该材料是疏水性的,与广泛的合成和天然聚合物相容。 NCC-PLA纳米复合材料具有增强的功能(例如阻气性),流变性和机械性能,以及相对于PLA的尺寸稳定性(即较低的湿膨胀性)。 它们由完全可再生资源制成,具有潜在的生物兼容性和可回收利用。 NCC-PLA超分子纳米复合材料可以悬浮在大多数有机溶剂中或干燥形成固体物质。 它们可以使用常规的聚合物加工技术来加工,以开发三维结构,或者纺成纤维,纱线或细丝。
    • 43. 发明申请
    • MEASUREMENT OF THE SURFACE SHAPE MAP OF FLAT AND CURVED OBJECTS, INDEPENDENT OF RELATIVE MOTIONS
    • 平面和弯曲物体的表面形状测量,相关动作独立性的测量
    • WO2011094860A1
    • 2011-08-11
    • PCT/CA2011/000153
    • 2011-02-07
    • FPINNOVATIONSSCHAJER, Gary Stephen
    • SCHAJER, Gary Stephen
    • G01B21/20
    • G01B21/20
    • A plurality of distance sensors are used to measure the surface shape map of objects in the presence of relative motions between the object and sensor in the measurement directions of the sensors. The method involves making multiple sequential measurements from a group of sensors while the object moves longitudinally relative to the sensors. The central idea of the invention is the observation that surface shape features appear in delayed sequence as the observed surface moves longitudinally relative to the sensor array, while any relative motions in the measurement directions appear simultaneously at all sensors. Mathematical procedures are used to identify the relative motions from within the measurements. These motions are then subtracted from the sensor reading to determine the surface shape map of the measured object. The invention can be applied to many different measurement types, including surface shape measurement of one- or multiple-sided generally flat objects, and surface shape measurement of more general three-dimensional objects.
    • 在传感器的测量方向上存在物体和传感器之间的相对运动的情况下,使用多个距离传感器来测量物体的表面形状图。 该方法涉及当物体相对于传感器纵向移动时,从一组传感器进行多次连续测量。 本发明的中心思想是随着观察表面相对于传感器阵列纵向移动,表面形状特征以延迟的顺序出现,而在测量方向上的任何相对运动同时出现在所有传感器上。 数学程序用于识别测量内的相对运动。 然后从传感器读数中减去这些运动,以确定测量对象的表面形状图。 本发明可以应用于许多不同的测量类型,包括单面或多面大体平坦物体的表面形状测量以及更一般的三维物体的表面形状测量。
    • 46. 发明申请
    • PROGNOSTIC MARKERS OF INHERITED VARIATIONS IN THE UGT2B GENES FOR PROSTATE CANCER RECURRENCE
    • UGT2B基因中前列腺癌复发的入选标记
    • WO2012071665A1
    • 2012-06-07
    • PCT/CA2011/001338
    • 2011-12-02
    • UNIVERSITE LAVALLEVESQUE, EricGUILLEMETTE, ChantalFRADET, YvesLACOMBE, Louis
    • LEVESQUE, EricGUILLEMETTE, ChantalFRADET, YvesLACOMBE, Louis
    • C12Q1/68C07H21/00C40B30/04
    • C12Q1/6886C12Q2600/156
    • The present application discloses that reduced copy number variations (CNVs) in UGT2B17 and UGT2B28 were significantly associated with bRFS while no significant association was observed for additional UGT variants tested. The co-occurrence of two or more deletions of UGT2B17 and UGT2B28 genes resulted in an HR of 1.377 (95% CI [1.105; 1.716]; p=0.004) for Caucasians and 2.151 (95% CI [1.239; 3.372]; p=0.006) for Asians. In all studied men, risk of BCR was 1.510; 95% CI [1.178 - 1.950]; p=0.001 ). The addition of the UGT2B CNV status in the D'Amico risk classification further enhanced the risk prediction mainly for the low and intermediate risk categories (Log-rank test, p=0.022 and 0.011, respectively). In addition, after adjusting for all clinicopathologic risk factors, we found a strong association between the risk of BCR and 7 SNPs in SRD5A genes. The combination of 2 SNPs respectively in SRD5A1 and SRD5A2 were highly favourable, reducing drastically the risk of BCR for carriers of 3-4 alleles (HR=0.34; 95% CN0.18- 0.64; P=9x10"4). Other variations in the SRD5A2 gene were associated with an increased rate of BCR, namely the coding SNPs rs523349 with a HR of 2.12 (95% CI, 1.21 -3.75; P=0.009) and reaching 4.97 when combined with deleted copies of UGT2B genes (95% CI, 2.38-10.36; P=0.00002). Further, BCR-free survival rate was significantly reduced to 27% in patients with unfavourable genotypes compared to 75% for patients with favourable genotypes (P=7x10 -6 ). This study is the first to recognize CNV in genes at the end of the androgenic signal as significant and independent predictors of PCa recurrence after prostatectomy. In addition, inherited polymorphisms in the SRD5A and UGT2B genes are independent predictors of biochemical recurrence after radical prostatectomy.
    • 本申请公开了UGT2B17和UGT2B28中的减少的拷贝数变异(CNV)与bRFS显着相关,而对于另外的测试的UGT变体,没有观察到显着的关联。 UGT2B17和UGT2B28基因的两个或多个缺失的共同发生导致白种人的HR为1.377(95%CI [1.105; 1.716]; p = 0.004),而2.151(95%CI [1.239; 3.372]; p = 0.006)亚洲人。 在所有研究的男性中,BCR的风险为1.510; 95%CI [1.178 - 1.950]; p = 0.001)。 在D'Amico风险分类中增加UGT2B CNV状态进一步增强了风险预测,主要针对中低风险类别(Log-rank检验,分别为p = 0.022和0.011)。 此外,在调整所有临床病理危险因素后,我们发现BCR和SRD5A基因中7个SNP的风险之间存在很强的相关性。 SRD5A1和SRD5A2中2个SNP的组合非常有利,大大降低了3-4个等位基因携带者的BCR风险(HR = 0.34; 95%CN0.18-0.64; P = 9×10-4),其他变异 SRD5A2基因与BCR的增加率相关,即编码SNPs rs523349,HR为2.12(95%CI,1.21〜3.75; P = 0.009),与UGT2B基因缺失拷贝(95%CI)组合时达到4.97 ,2.38-10.36; P = 0.00002),而不良基因型患者BCR无生存率显着降低至27%,而有良好基因型患者为75%(P = 7×10-6),本研究首次 在雄激素信号结束时将基因中的CNV识别为前列腺切除术后PCa复发的重要和独立预测因子,此外,SRD5A和UGT2B基因的遗传多态性是根治性前列腺切除术后生化复发的独立预测因子。