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31. 发明申请

WO2019162198A1 DIXON MR IMAGING USING A MULTI-GRADIENT-ECHO SEQUENCE 审中-公开
公开(公告)号：WO2019162198A1
公开(公告)日：2019-08-29
申请号：PCT/EP2019/053754
申请日：2019-02-15
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BECK, Gabriele, Marianne , EGGERS, Holger
IPC分类号： G01R33/24 , G01R33/44 , G01R33/48 , G01R33/50 , G01R33/561 , G01R33/565 , G01R33/563 , G01R33/567
摘要： The invention relates to a method of MR imaging of an object. It is an object of the invention to provide a multi-gradient echo imaging technique with increased acquisition speed and intrinsic suppression of artefacts from Bo inhomogeneities, T 2 * decay, chemical shift, motion, and/or flow, in particular in combination with radial or spiral k-space trajectories. The method of the invention comprises the steps of: - subjecting the object (10) to an imaging sequence comprising RF excitation pulses and switched magnetic field gradients, wherein multiple echo signals are generated at different echo times after each RF excitation pulse, - acquiring the echo signal data along radial or spiral k-space trajectories, wherefore the imaging sequence comprises magnetic field gradient blips in the x-/y- and/or z- directions; - separating signal contributions from water and fat to the echo signals and estimating a B 0 map and/or an apparent transverse relaxation time map (T 2 * map) using a Dixon algorithm; and - synthesizing an image of a specified contrast from the echo signal data, the Bo map and/or the T 2 * map. Moreover, the invention relates to a MR device (1) and to a computer program for a MR device (1).

32. 发明申请

WO2018104372A1 VERFAHREN ZUR ERFASSUNG DER BEWEGUNG EINES KIEFERGELENKS 审中-公开
公开(公告)号：WO2018104372A1
公开(公告)日：2018-06-14
申请号：PCT/EP2017/081641
申请日：2017-12-06
申请人： SIRONA DENTAL SYSTEMS GMBH
发明人： RASCHE, Volker , WUNDRAK, Stefan
IPC分类号： A61C19/045 , G01R33/24 , A61B6/14 , A61B8/13
摘要： Verfahren zur Erfassung und Darstellung der Bewegung eines einen Unterkiefer (2) und einen Oberkiefer (5) verbindenden Kiefergelenks (4) mittels Magnetresonanztomographie, wobei ein Marker (1) an dem Unterkiefer (2) befestigt, während eines ersten Messzeitintervalls (T1) mit einem relativ zu dem Oberkiefer (5) bewegten Unterkiefers (2) anhand von magnetresonaztomographischen Messdatensätzen (6) eine Marker-Bewegungskurve (7) erstellt und ein einer ersten Position (P1) des Unterkiefers (4) relativ zu dem Oberkiefer (5) entsprechender Punkt auf der Bewegungs kurve ermittelt wird. Während eines zweiten Messzeitintervalls (T2) mit einem unbewegten Kiefergelenk (4) wird ein Bilddatensatz (8) erzeugt und daraus ein zumindest einen Teil des Oberkiefers und/oder einen die Kiefergelenkpfanne umfassenden Teil des Schläfenbeins darstellendes erstes Modell (50) und ein zumindest einen Teil des Unterkiefers darstellendes zweites Modell (20) ermittelt. Ein Bewegungsverlauf des zweiten Modells (20, 20') relativ zu dem ersten Modell (50) wird anhand der Marker-Bewegungskurve (7) berechnet und dargestellt.

33. 发明申请

WO2017177197A1 METHOD OF FAST IMAGING OF NMR PARAMETERS WITH VARIABLY-ACCELERATED SENSITIVITY ENCODING 审中-公开
标题翻译：快速成像核磁共振参数的变速加速灵敏度编码方法
公开(公告)号：WO2017177197A1
公开(公告)日：2017-10-12
申请号：PCT/US2017/026706
申请日：2017-04-07
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： ZHANG, Yi , ZHOU, Jinyuan , BOTTOMLEY, Paul A.
IPC分类号： A61B5/055 , G01R33/44 , G01R33/24
CPC分类号： G01R33/246 , G01R33/4806 , G01R33/50 , G01R33/5605 , G01R33/5611 , G01R33/56341 , G01R33/56366
摘要： A method of spatially imaging a nuclear magnetic resonance (NMR) parameter whose measurement requires the acquisition of spatially localized NMR signals in a sample includes placing the sample in an MRI apparatus with a plurality of MRI detectors each having a spatial sensitivity map; and applying MRI sequences adjusted to be sensitive to the NMR parameter. At least one of the MRI sequences is adjusted so as to substantially fully sample an image k-space of the sample. The remainder of the MRI sequences is adjusted to under-sample the image k-space. The method further includes acquiring image k-space NMR signal data sets; estimating a sensitivity map of each of the MRI detectors using a strategy to suppress unfolding artefacts; and applying the estimated sensitivity maps to at least one of the image k-space NMR signal data sets to reconstruct a spatial image of NMR signals that are sensitive to the NMR parameter.
摘要翻译：空间成像核磁共振（NMR）参数的方法，其测量需要获取样品中的空间定位的NMR信号，包括将样品置于具有多个MRI检测器的MRI设备中，每个MRI检测器具有空间敏感度图; 并应用调整为对NMR参数敏感的MRI序列。调整至少一个MRI序列以基本上完全采样样本的图像k-空间。将其余的MRI序列调整为对图像k空间进行欠采样。该方法还包括获取图像k空间NMR信号数据组; 使用抑制展开伪影的策略估计每个MRI检测器的敏感度图; 以及将估计的灵敏度图应用于图像k空间NMR信号数据集中的至少一个，以重构对NMR参数敏感的NMR信号的空间图像。

34. 发明申请

WO2017171379A1 전류를 주입 없이 MRI를 이용한 저주파 전도도 영상 복원 장치 및 그 방법 审中-公开
标题翻译：使用无电流注入MRI的低频电导率图像重建装置及其方法
公开(公告)号：WO2017171379A1
公开(公告)日：2017-10-05
申请号：PCT/KR2017/003376
申请日：2017-03-29
申请人： 경희대학교산학협력단
发明人： 우응제 , 권오인 , 김형중 , 정우철 , 사집사우럽자만칸
IPC分类号： A61B5/055 , G01R33/24 , G01R33/483
CPC分类号： A61B5/055 , A61B6/03 , G01R33/24 , G01R33/443 , G01R33/483 , G01R33/56341 , G06T7/0002
摘要： 본 발명은 MR-EPT를 이용하여 획득된 고주파 전도도, 대상체 내의 물 확산 텐서로부터 산출된 이온의 방향성 텐서, 세포 내/외 영역의 볼륨비 및 확산계수를 이용하여 저주파 전도도를 도출하고, 도출된 저주파 전도도에 기반하여 저주파 전도도 영상을 복원하는 MRI를 이용한 저주파 전도도 영상 복원 장치 및 그 방법에 관한 것으로서, 인체 및 물체를 포함하는 대상체에 MRI 장비를 이용하여 측정하고자 하는 대상체에 전류를 주입하지 않고도 내부의 저주파 전도도 영상을 복원할 수 있다.
摘要翻译：
本发明是低频，使用离子定向张量，从在高频电导率的水扩散张量计算单元和/或体积比的其它区域和扩散系数，使用所述MR-EPT获得的对象本发明涉及一种用于使用MRI来重建低频导电图像以基于导出的低频电导率导出电导率并恢复低频电导率图像的设备和方法。低频电导图像可以重建，而不会向器件注入电流。

35. 发明申请

WO2016180640A1 PARALLEL MR IMAGING WITH RF COIL SENSITIVITY MAPPING 审中-公开
标题翻译：平行MR成像与RF线圈灵敏度映射
公开(公告)号：WO2016180640A1
公开(公告)日：2016-11-17
申请号：PCT/EP2016/059454
申请日：2016-04-28
申请人： KONINKLIJKE PHILIPS N.V.
发明人： NEHRKE, Kay , BOERNERT, Peter
IPC分类号： G01R33/24 , G01R33/561
CPC分类号： G01R33/5611 , G01R33/243 , G01R33/246 , G01R33/5608 , G01R33/5612
摘要： The invention relates to a method of MR imaging of an object (10). The problem of the invention is to provide an improved MR imaging technique that enables fast and robust determination of spatial sensitivity profiles of RF receiving antennas (11, 12, 13) used in parallel imaging as well as B1 and/or B0 mapping. The method of the invention comprises subjecting the object (10) to a stimulated echo sequence. Two or more stimulated echo signals (STE, STE*) are acquired, namely a direct stimulated echo signal (STE) and a conjugated stimulated echo signal (STE*), wherein at least one of the stimulated echo signals (STE, STE*) is received in parallel via an array of two or more RF receiving antennas (11, 12, 13) having different spatial sensitivity profiles, and wherein at least another one of the stimulated echo signals (STE, STE*)is received via a body RF coil (9) having an essentially homogeneous spatial sensitivity profile. Sensitivity maps indicating the spatial sensitivity profiles of the individual RF receiving antennas (11, 12, 13) of the array are derived by comparing the stimulated echo signals (STE, STE*) received via the array of RF receiving antennas (11, 12, 13) with the stimulated echo signals (STE, STE*) received via the body RF coil (9). Moreover, the invention relates to a MR device (1) and to a computer program for a MR device (1).
摘要翻译：本发明涉及一种物体（10）的MR成像方法。本发明的问题是提供一种改进的MR成像技术，其能够快速和鲁棒地确定在并行成像以及B1和/或B0映射中使用的RF接收天线（11,12,13）的空间灵敏度分布。本发明的方法包括使物体（10）经受刺激的回波序列。获得两个或多个受激回波信号（STE，STE *），即直接受激回波信号（STE）和共轭刺激回波信号（STE *），其中至少一个受激回波信号（STE，STE *）经由具有不同空间灵敏度分布的两个或更多个RF接收天线（11,12,13）的阵列并行接收，并且其中至少另一个被刺激的回波信号（STE，STE *）经由身体RF 线圈（9）具有基本均匀的空间灵敏度分布。通过比较经由RF接收天线阵列（11,12,13）接收的受激回波信号（STE，STE *），得到表示阵列的各个RF接收天线（11,12,13）的空间灵敏度分布的灵敏度图， 13）通过身体RF线圈（9）接收的受激回波信号（STE，STE *）。此外，本发明涉及MR装置（1）和用于MR装置（1）的计算机程序。

36. 发明申请

WO2016179264A1 MAGNETIC RESONANCE IMAGING (MRI) SYSTEMS AND METHODS USING ADIABATIC TIP-DOWN AND MATCHED ADIABATIC FLIP-BACK PULSES 审中-公开
标题翻译：磁共振成像（MRI）系统和方法使用ADIABATIC TIP-DOWN和匹配的ADIABATIC FLIP-BACK PULSES
公开(公告)号：WO2016179264A1
公开(公告)日：2016-11-10
申请号：PCT/US2016/030758
申请日：2016-05-04
申请人： DUKE UNIVERSITY
发明人： WENDELL, David , REHWALD, Wolfgang , CHEN, Enn-Ling , KIM, Raymond
IPC分类号： A61B5/055 , G01R33/24
CPC分类号： G01R33/4616 , A61B5/055 , G01R33/3614 , G01R33/446 , G01R33/4838 , G01R33/5605 , G01R33/5607
摘要： Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses are disclosed. According to an aspect, a system includes a signal generator configured to generate a pulse sequence for on-resonance magnetization transfer preparation. The pulse sequence includes an adiabatic tip-down pulse and a matched adiabatic flip-back pulse for separating spins in a mobile spin pool from spins in a bound spin pool of an anatomical region of interest for imaging. The system includes radio frequency (RF) coils configured to transmit RF pulses in response to the pulse sequence and to acquire RF data in response to transmission of the RF pulses. Further, the system includes a processing system configured to process the RF data to provide a display image indicating different tissue types with discrimination.
摘要翻译：公开了使用绝热向下和匹配的绝热反向脉冲的磁共振成像（MRI）系统和方法。根据一个方面，系统包括被配置为产生用于共振磁化转移准备的脉冲序列的信号发生器。该脉冲序列包括绝热的向下翻转脉冲和匹配的绝热反向脉冲，用于将移动旋转池中的旋转与用于成像的感兴趣解剖区域的结合的旋转池中的旋转分离。该系统包括被配置为响应脉冲序列发射RF脉冲并且响应于RF脉冲的传输而获取RF数据的射频（RF）线圈。此外，该系统包括处理系统，该处理系统被配置为处理RF数据以提供指示不同组织类型与辨别的显示图像。

37. 发明申请

WO2014071196A1 SYSTEM AND APPARATUS FOR COMBINED MAGNETIC RESONANCE IMAGING WITH MAGNETIC SPECTROSCOPY OF BROWNIAN MOTION AND/OR MAGNETIC NANOPARTICLE IMAGING 审中-公开
标题翻译：用于布朗运动和/或磁性纳米成像的磁性光谱的组合磁共振成像的系统和装置
公开(公告)号：WO2014071196A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/068082
申请日：2013-11-01
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE
发明人： WEAVER, John, B. , HARTOV, Alexander
IPC分类号： G01R33/36 , G01R33/32 , G01R33/24 , A61B5/055
CPC分类号： A61B5/055 , A61B5/0035 , A61B5/0515 , G01R33/4808
摘要： A system for measuring responses of magnetic nanoparticles has static magnetic bias field along first axis, and AC driving coils providing AC magnetic field along second axis perpendicular to the first axis, both fields passing through an imaging zone. Sensing coils are oriented to sense fields parallel to the first axis, but not parallel to the second axis. A processor determines responses of nanoparticles in the imaging zone to the AC field. Another system has DC bias on first axis and AC driving coils providing an AC magnetic field along a second axes, magnetic gradient oriented along the first and/or second axis, and the second axis is rotated mechanically or electronically. The signal processor provides a voxel-based model of magnetic nanoparticle distribution in imaging zone. In some embodiments, the static magnet is a main magnet of a magnetic resonance imaging system.
摘要翻译：用于测量磁性纳米颗粒的响应的系统具有沿着第一轴的静态磁偏置场，并且AC驱动线圈沿着垂直于第一轴的第二轴提供交流磁场，两个场通过成像区。感测线圈被定向成感测平行于第一轴线但不平行于第二轴线的场。处理器确定成像区域中的纳米颗粒对AC场的响应。另一个系统在第一轴上具有DC偏置，并且AC驱动线圈沿着第二轴线提供交流磁场，沿着第一和/或第二轴线定向的磁梯度，并且第二轴线被机械地或电子地旋转。信号处理器在成像区域中提供基于体素的磁性纳米粒子分布模型。在一些实施例中，静磁体是磁共振成像系统的主磁体。

38. 发明申请

WO2014051886A1 NANOSCALE SCANNING SENSORS 审中-公开
标题翻译： NANOSCALE扫描传感器
公开(公告)号：WO2014051886A1
公开(公告)日：2014-04-03
申请号：PCT/US2013/055644
申请日：2013-08-20
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： GRINOLDS, Michael, S. , HONG, Sungkun , MALETINKSY, Patrick , YACOBY, Amir
IPC分类号： G01Q60/54 , G01N24/10 , G01R33/032 , G01Q70/14 , G01R33/12 , G01R33/24 , G01R33/60
CPC分类号： G01Q70/14 , G01N21/645 , G01N24/10 , G01N2201/10 , G01Q30/025 , G01Q60/08 , G01Q60/38 , G01Q60/54 , G01R33/022 , G01R33/032 , G01R33/1284 , G01R33/323 , G01R33/60
摘要： A sensing probe may be formed of a diamond material comprising one or more spin defects that are configured to emit fluorescent light and are located no more than 50 nm from a sensing surface of the sensing probe. The sensing probe may include an optical outcoupling structure formed by the diamond material and configured to optically guide the fluorescent light toward an output end of the optical outcoupling structure. An optical detector may detect the fluorescent light that is emitted from the spin defects and that exits through the output end of the optical outcoupling structure after being optically guided therethrough. A mounting system may hold the sensing probe and control a distance between the sensing surface of the sensing probe and a surface of a sample while permitting relative motion between the sensing surface and the sample surface.
摘要翻译：感测探针可以由金刚石材料形成，该金刚石材料包括配置成发射荧光的一个或多个自旋缺陷，并且距离感测探针的感测表面不超过50nm。感测探头可以包括由金刚石材料形成并被配置为将荧光光导向光输出耦合结构的输出端的光输出耦合结构。光学检测器可以检测从旋转缺陷发出的荧光，并且在光学引导通过其后从光学输出耦合结构的输出端射出。安装系统可以保持感测探头并且控制感测探头的感测表面与样本表面之间的距离，同时允许感测表面和样品表面之间的相对运动。

39. 发明申请

WO2014001035A1 MODIFICATION OF MAGNETIC FIELD USING SUSPENSION ELEMENTS 审中-公开
标题翻译：磁悬浮元件的磁场修正
公开(公告)号：WO2014001035A1
公开(公告)日：2014-01-03
申请号：PCT/EP2013/061478
申请日：2013-06-04
申请人： SIEMENS PLC
发明人： DIXEY, Paul , MANN, Nicholas , NOYS, Jonathan
IPC分类号： G01R33/387 , G01R33/3815 , F17C13/08 , G01R33/24
CPC分类号： G01R33/3802 , G01R33/243 , G01R33/3815 , G01R33/387
摘要： A method for transporting and shimming a superconducting magnet comprising a coil assembly (110) supported by support elements (30, 32; 86) within a cryostat comprising an outer vacuum container (OVC) (14), wherein the support elements bear upon the OVC and the coil assembly. The method comprises the steps of: tensioning the support elements to a tension sufficient to protect the coil assembly and the cryostat from damage in transit; transporting the magnet to its intended installation site; installing the magnet; once the magnet is installed, reducing the tension on the support structure is reduced to a pre-determined value, thereby reducing distortion of the coils assembly due to tension of the support structure; energising the magnet; measuring magnetic field strength homogeneity in an imaging region; and adjusting the tension in certain support structure elements, thereby to adjust deformation of the coil assembly.
摘要翻译：一种用于输送和匀场超导磁体的方法，包括由包括外部真空容器（OVC）（14）的低温恒温器内的支撑元件（30,32; 86）支撑的线圈组件（110），其中所述支撑元件承载在OVC 和线圈组件。该方法包括以下步骤：将支撑元件张紧到足以保护线圈组件和低温恒温器免于运输损坏的张力; 将磁铁运送到其预期的安装地点; 安装磁铁一旦安装了磁体，将支撑结构上的张力减小到预定值，从而减少由于支撑结构的张力引起的线圈组件的变形; 激励磁体; 测量成像区域中的磁场强度均匀性; 并且调整某些支撑结构元件中的张力，从而调节线圈组件的变形。

40. 发明申请

WO2013064642A1 APPAREIL DE SURVEILLANCE DANS UN ENVIRONNEMENT MAGNETIQUE ET PROCEDE ASSOCIE 审中-公开
标题翻译：用于监测磁性环境的装置及其相关方法
公开(公告)号：WO2013064642A1
公开(公告)日：2013-05-10
申请号：PCT/EP2012/071734
申请日：2012-11-02
申请人： UNIVERSITE DE LORRAINE , CENTRE HOSPITALIER DE NANCY HOPITAL CENTRAL
发明人： PASQUIER, Cédric , FELBLINGER, Jacques , JOVANOVIC, Slavisa
IPC分类号： G01R33/24 , G01V3/15 , G01R33/28 , G01R33/02
CPC分类号： G01R33/0076 , G01R33/007 , G01R33/072 , G01R33/24 , G01R33/288
摘要： La présente invention concerne un appareil de surveillance (1) de conditions d'exposition auxquelles est soumis un opérateur ou une machine situé dans un environnement magnétique. L'appareil (1) selon l'invention comprend : - un module portatif (2) de mesure, à plusieurs instants t connus, d'une donnée indicative comprenant les trois composantes d'un vecteur champ magnétique; - un module portatif (3) de détermination les trois composantes d'un vecteur vitesse de déplacement; et - des moyens de calcul (4) pour estimer un courant induit traversant l'opérateur ou la machine, à partir des valeurs de champ magnétique et de vitesse de déplacement. L'invention concerne également un procédé mis en œuvre dans l'appareil selon l'invention.
摘要翻译：本发明涉及一种用于监测位于磁环境中的操作者或机器受到的暴露条件的装置（1）。根据本发明的装置（1）包括便携式模块（2），用于在多个已知时间t测量包括磁场矢量的三个分量的指示数据，用于确定三个分量的便携式模块（3）以及用于从磁场和行驶速度矢量估计通过操作者或机器的感应电流的计算装置（4）。本发明同样涉及在根据本发明的装置中实现的方法。

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