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31. 发明申请

WO2012024083A9 OXATHIAZINE AND DITHIINE OXIDES AS INHIBITORS OF SULFHYDRYL-DEPENDENT BIOMOLECULES 审中-公开
标题翻译：作为巯基依赖性生物分子抑制剂的硫嘌呤和酪氨酸氧化物
公开(公告)号：WO2012024083A9
公开(公告)日：2012-10-04
申请号：PCT/US2011046355
申请日：2011-08-03
申请人： CHEMTURA CORP , UNIV MANITOBA , CHEE GAIK-LEAN , BROUWER WALTER G , OSIKA EWA , HASINOFF BRIAN B , BREWER A DAVID
发明人： CHEE GAIK-LEAN , BROUWER WALTER G , OSIKA EWA , HASINOFF BRIAN B , BREWER A DAVID
IPC分类号： C07D291/06 , A61K31/385 , A61K31/54 , A61P35/00 , C07D339/08
CPC分类号： C07D291/06 , A61K31/385 , A61K31/54 , C07D339/08
摘要： Novel derivatives of dihydro-l,4,2-oxathiazine and dihydro-l,4-dithiine oxides, more particularly, novel derivatives of dihydro-l,4,2-oxathiazine and dmydro-l,4-dithiine oxides that target cysteine residues of biomolecules of pharmacological importance are provided as pharmaceutically useful compounds, for example, as anticancer, antiinfectious, antigastric acid secretion, antiosteoporosic, and antiinflammatory agents.
摘要翻译：二氢-1,4,2-氧杂噻嗪和二氢-1,4-二硫杂环己烯氧化物的新衍生物，更具体地说是靶向半胱氨酸残基的二氢-1,4,2-氧杂噻嗪和二氢-1,4-二硫基氧化物的新衍生物提供药理学重要性的生物分子作为药学上有用的化合物，例如，作为抗癌剂，抗感染剂，抗胃酸分泌剂，抗骨质疏松剂和抗炎剂。

32. 发明申请

WO2012087726A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF "BURNING FEET SYNDROME" 审中-公开
标题翻译：治疗“烧伤综合征”的方法和组合
公开(公告)号：WO2012087726A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/065037
申请日：2011-12-15
申请人： WHITE, John, B.
发明人： WHITE, John, B.
IPC分类号： A61K38/43
CPC分类号： A61K31/385 , A61K31/4188 , A61K31/51 , A61K31/519 , A61K31/525 , A61K31/675 , A61K31/7064 , A61K2300/00
摘要： A composition for the treatment of "Burning Feet Syndrome" includes pantothenic acid or its analogs, or its derivatives, or its synonyms, alpha-lipoic acid or its analogs, or its derivatives, or its synonyms, and L-arginine or its analogs, or its derivatives, or its synonyms. The composition may also include at least one substance selected from the group consisting of B1, B2, B3, B6, B7, B9, B12, Acetly-L-Carnitine, N-acetlycystein, Omega-3 fatty acids, Omega-6 fatty acids, Vitamin E, and Taurine or any of their analogs, derivatives, or synonyms. The composition is used in a method for the treating of "Burning Feet Syndrome" by administering to a human such a composition.
摘要翻译：用于治疗“燃烧性脚综合征”的组合物包括泛酸或其类似物或其衍生物或其同义词，α-硫辛酸或其类似物或其衍生物或其同义词，以及L-精氨酸或其类似物，或其衍生物，或其同义词。组合物还可以包括选自B1，B2，B3，B6，B7，B9，B12，Acetly-L-肉毒碱，N-乙酰半胱氨酸，ω-3脂肪酸，ω-6脂肪酸中的至少一种物质，维生素E和牛磺酸或其任何类似物，衍生物或同义词。该组合物用于通过对人类施用组合物来治疗“燃烧性脚综合征”的方法。

33. 发明申请

WO2012064667A2 TREATMENT OF ADDICTION AND IMPULSE-CONTROL DISORDERS USING PDE7 INHIBITORS 审中-公开
标题翻译：使用PDE7抑制剂治疗ADI和IMPULSE-CONTROL DISDERS
公开(公告)号：WO2012064667A2
公开(公告)日：2012-05-18
申请号：PCT/US2011/059626
申请日：2011-11-07
申请人： OMEROS CORPORATION , DEMOPULOS, Gregory, A. , GAITANARIS, George, A.
发明人： DEMOPULOS, Gregory, A. , GAITANARIS, George, A.
IPC分类号： A61K31/55 , A61K31/519 , A61K31/5377 , A61K31/551 , A61K31/4439 , A61K31/4162 , A61K31/4178 , A61K31/485 , A61K31/454 , A61K31/44 , A61P25/30 , A61P25/36 , A61P25/32 , A61P25/34 , A61P25/00 , A61P25/24 , A61P25/18 , A61P25/08
CPC分类号： A61K31/00 , A61K31/135 , A61K31/137 , A61K31/197 , A61K31/337 , A61K31/357 , A61K31/381 , A61K31/385 , A61K31/4015 , A61K31/4025 , A61K31/4178 , A61K31/44 , A61K31/454 , A61K31/485 , A61K31/4985 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/55 , A61K2300/00
摘要： This disclosure is directed to treatment of addictions and primary impulse-control disorders using phosphodiesterase 7 (PDE7) inhibitors, alone or in combination with other therapeutic agents.
摘要翻译：本公开涉及使用磷酸二酯酶7（PDE7）抑制剂单独或与其它治疗剂组合治疗成瘾和初次冲动控制障碍。

34. 发明申请

WO2012018980A3 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISEASES 审中-公开
标题翻译：治疗炎性疾病的组合物和方法
公开(公告)号：WO2012018980A3
公开(公告)日：2012-05-03
申请号：PCT/US2011046544
申请日：2011-08-04
申请人： SHIM YUN MICHAEL , PAIGE MIKELL
发明人： SHIM YUN MICHAEL , PAIGE MIKELL
IPC分类号： A61K31/415 , A61K31/357 , A61K31/385 , A61K31/4192 , A61K31/53 , A61P11/06 , A61P29/00
CPC分类号： C07C43/205 , A61K9/08 , A61K31/085 , A61K31/357 , A61K31/385 , A61K31/415 , A61K31/4192 , A61K31/53 , A61K47/40 , A61K47/6951 , B82Y5/00
摘要： The present application discloses compositions and methods useful for treating and preventing inflammation associated with inflammatory diseases and disorders.
摘要翻译：本申请公开了用于治疗和预防与炎性疾病和病症相关的炎症的组合物和方法。

35. 发明申请

WO2012018145A3 AGENT FOR IMPROVING QUALITY OF LIFE 审中-公开
标题翻译：代理提高生活质量
公开(公告)号：WO2012018145A3
公开(公告)日：2012-03-29
申请号：PCT/JP2011068339
申请日：2011-08-04
申请人： JAPAN BIOPRODUCTS CO LTD , KAWAGUCHI MITSUHIKO , UNE YOSHITO , GOTOU KENSUKE , KAKU TAIICHI , KADOTA YOSHIHARU , HIRANO EIICHI
发明人： KAWAGUCHI MITSUHIKO , UNE YOSHITO , GOTOU KENSUKE , KAKU TAIICHI , KADOTA YOSHIHARU , HIRANO EIICHI
IPC分类号： A61K35/50 , A61K31/19 , A61K31/198 , A61K31/385 , A61K31/409 , A61K31/575 , A61K31/7012 , A61K31/704 , A61K31/7064 , A61K31/7076 , A61K35/407 , A61K38/21 , A61K45/00 , A61P1/16 , A61P35/00
CPC分类号： A61K31/19 , A61K31/198 , A61K31/385 , A61K31/409 , A61K31/575 , A61K31/7012 , A61K31/704 , A61K31/7064 , A61K31/7076 , A61K35/407 , A61K35/50 , A61K38/21 , A61K2300/00
摘要： Provided is an agent for improving the quality of life of hepatocellular carcinoma patients. The agent for improving the quality of life of hepatocellular carcinoma patients is characterized by including a human placenta extract, and is preferably used concomitantly with a liver function-improving agent (for example, a glycyrrhizinate). The agent for improving quality of life shrinks hepatoma cells, improves the subjective symptoms of patients and improves quality of life, and thus is particularly effective for the treatment of hepatocellular carcinoma, including end-stage hepatocellular carcinoma.
摘要翻译：提供了用于改善肝细胞癌患者生活质量的药剂。用于改善肝细胞癌患者的生活质量的药剂的特征在于包含人胎盘提取物，并且优选与肝功能改善剂（例如甘草酸盐）同时使用。用于改善生活质量的药物缩小了肝癌细胞，改善了患者的主观症状并改善了生活质量，因此对于包括末期肝细胞癌在内的肝细胞癌的治疗特别有效。

36. 发明申请

WO2011146101A1 CHEMICAL AGENTS FOR THE PREVENTION OR INHIBITION OF TUMOR METASTASIS 审中-公开
标题翻译：用于预防或抑制肿瘤分化的化学试剂
公开(公告)号：WO2011146101A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/000740
申请日：2011-04-28
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , BRESNICK, Anne, R.
发明人： BRESNICK, Anne, R.
IPC分类号： A01N43/42
CPC分类号： A61K31/4709 , A61K31/00 , A61K31/122 , A61K31/135 , A61K31/136 , A61K31/16 , A61K31/235 , A61K31/341 , A61K31/382 , A61K31/385 , A61K31/4035 , A61K31/404 , A61K31/427 , A61K31/437 , A61K31/4436 , A61K31/47 , A61K31/655
摘要： The present invention provides methods of preventing or inhibiting tumor metastasis in a subject by administering a therapeutically effective amount of (1) a compound from a group of enumerated compounds, or a pharmaceutically acceptable salt thereof; (2) an agent that covalently modifies at least one cysteine residue of S100A4 protein; or (3) an agent that inhibits the interaction between S100A4 and myosin-IIA.
摘要翻译：本发明提供了通过施用治疗有效量的（1）来自一组列举的化合物或其药学上可接受的盐的化合物来预防或抑制受试者的肿瘤转移的方法; （2）共价修饰S100A4蛋白的至少一个半胱氨酸残基的试剂; 或（3）抑制S100A4与肌球蛋白IIA之间相互作用的药剂。

37. 发明申请

WO2011059733A2 USE OF LIPOIC ACID IN CELL TRANSPLANTATION 审中-公开
标题翻译：硫酸在细胞移植中的应用
公开(公告)号：WO2011059733A2
公开(公告)日：2011-05-19
申请号：PCT/US2010/054451
申请日：2010-10-28
申请人： THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL , AUSTEN, William, G.
发明人： AUSTEN, William, G.
IPC分类号： A61K35/28 , A61K35/35
CPC分类号： A61K35/35 , A61K31/385 , A61K35/28 , A61K38/1866 , A61K38/28 , A61K38/44 , A61K38/446 , C12Y111/01006 , C12Y111/01009 , C12Y115/01001 , G01N33/5044 , G01N2405/00 , A61K2300/00
摘要： The present invention provides lipoic acid or derivatives thereof for use in graft stabilization of fat grafts. Mixing of lipoic acid or a derivative thereof with adipocytes or adipose tissue to be transplanted into a subject leads to more succesful fat transplantation in soft tissue augmentation or reconstruction. Such methods may also be used in the transplantation of adult stem cells or other cells derived from fat tissue. Other agents such as antioxidants, vitamins, pharmaceutical agents, or osmotic protectants may also be added to the lipoic acid/cell compositions for cell transplantation.
摘要翻译：本发明提供了用于移植物稳定脂肪移植物的硫辛酸或其衍生物。将硫辛酸或其衍生物与待移植到受试者体内的脂肪细胞或脂肪组织混合导致软组织增大或重建中更成功的脂肪移植。这样的方法也可以用于成人干细胞或其他源自脂肪组织的细胞的移植。其他试剂例如抗氧化剂，维生素，药剂或渗透保护剂也可加入用于细胞移植的硫辛酸/细胞组合物中。

38. 发明申请

WO2011044138A1 LIPOIC ACID ACYLATED SALICYLATE DERIVATIVES AND THEIR USES 审中-公开
标题翻译： LIPOIC ACID ACYLATED SALICYLATE DERIVATIVES及其用途
公开(公告)号：WO2011044138A1
公开(公告)日：2011-04-14
申请号：PCT/US2010/051491
申请日：2010-10-05
申请人： CATABASIS PHARMACEUTICALS, INC. , MILNE, Jill, C. , JIROUSEK, Michael, R. , BEMIS, Jean, E. , VU, Chi, B.
发明人： MILNE, Jill, C. , JIROUSEK, Michael, R. , BEMIS, Jean, E. , VU, Chi, B.
IPC分类号： A01N37/36
CPC分类号： C07D409/12 , A61K31/385 , C07D339/04
摘要： The invention relates to lipoic acid acylated salicylate derivatives; compositions comprising an effective amount of a lipoic acid acylated salicylate derivative; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a lipoic acid acylated salicylate derivative.
摘要翻译：本发明涉及硫辛酸酰化水杨酸衍生物; 包含有效量的硫辛酸酰化水杨酸酯衍生物的组合物; 以及用于治疗或预防代谢疾病的方法，包括施用有效量的硫辛酸酰化水杨酸酯衍生物。

39. 发明申请

WO2010106083A1 COMBINATION THERAPIES FOR TREATING METABOLIC DISORDERS 审中-公开
标题翻译：治疗代谢障碍的组合治疗
公开(公告)号：WO2010106083A1
公开(公告)日：2010-09-23
申请号：PCT/EP2010/053419
申请日：2010-03-16
申请人： GENMEDICA THERAPEUTICS SL , MAYOUX, Eric , MARTI CLAUZEL, Luc , GARCIA VICENTE, Silvia , SERRANO MUÑOZ, Marta , ZORZANO OLARTE, Antonio , MIAN, Alec
发明人： MAYOUX, Eric , MARTI CLAUZEL, Luc , GARCIA VICENTE, Silvia , SERRANO MUÑOZ, Marta , ZORZANO OLARTE, Antonio , MIAN, Alec
IPC分类号： A61K31/00 , A61K31/192 , A61K31/196 , A61K31/198 , A61K31/385 , A61K31/60 , A61P3/06 , A61P3/08
CPC分类号： A61K31/198 , A61K31/00 , A61K31/192 , A61K31/196 , A61K31/385 , A61K31/60 , A61K45/06 , A61K2300/00
摘要： This invention is directed to pharmaceutical combinations comprising an antioxidant agent, an anti-inflammatory agent, and optionally at least one other anti-diabetic agent useful for treating metabolic disorders. This invention also encompasses pharmaceutically acceptable compositions comprising an antioxidant agent, an anti-inflammatory agent, optionally at least one other anti-diabetic agent, and at least one pharmaceutically acceptable earner. The combinations and compositions of this invention are useful as methods for treating metabolic disorders including diabetes, particularly Type I and Type II diabetes, as well as diseases and disorders associated with diabetes, including but not limited to atherosclerosis, cardiovascular disease, inflammatory disorders, nephropathy, neuropathy, retinopathy, β-cell dysfunction, dyslipidemia, LADA, metabolic syndrome, hyperglycemia, insulin resistance, and/or chronic obstructive pulmonary disease in a mammal, particularly a diabetic mammal, and specifically a human patient. This invention is particularly directed to pharmaceutical compositions comprising an lipoic acid, one or more anti-inflammatories selected from the group consisting of diflunisal, diclofenac, dexibuprofen, dexketoprofen, naproxen, and salicylate, and optionally one or more pharmaceutically acceptable carriers. The compositions of this invention are useful as methods for treating metabolic disorders including type II diabetes, insulin resistance, beta-cell dysfunction, and hyperglycemia in a patient, particularly a diabetic patient.
摘要翻译：本发明涉及包含抗氧化剂，抗炎剂和任选的至少一种其它用于治疗代谢紊乱的其它抗糖尿病药物的药物组合。本发明还包括药学上可接受的组合物，其包含抗氧化剂，抗炎剂，任选的至少一种其它抗糖尿病药物和至少一种药学上可接受的吸收剂。本发明的组合和组合物可用作治疗代谢紊乱的方法，包括糖尿病，特别是I型和II型糖尿病，以及与糖尿病相关的疾病和病症，包括但不限于动脉粥样硬化，心血管疾病，炎症性疾病，肾病，神经病，视网膜病变，β细胞功能障碍，血脂异常，LADA，代谢综合征，高血糖症，胰岛素抵抗和/或慢性阻塞性肺疾病，特别是糖尿病哺乳动物，特别是人类患者。本发明特别涉及药物组合物，其包含硫辛酸，一种或多种选自二氟尼柳，双氯芬酸，右布洛芬，右克洛芬，萘普生和水杨酸酯的抗炎剂，以及任选的一种或多种药学上可接受的载体。本发明的组合物可用作治疗患者，特别是糖尿病患者中的II型糖尿病，胰岛素抵抗，β细胞功能障碍和高血糖症的代谢疾病的方法。

40. 发明申请

WO2010065069A3 COMPOSITIONS COMPRISING RENIN-ANGIOTENSIN ALDOSTERONE SYSTEM INHIBITORS AND LIPOIC ACID COMPOUNDS, AND THE USE THEREOF FOR THE TREATMENT OF RENIN-ANGIOTENSIN ALDOSTERONE SYSTEM RELATED DISORDERS 审中-公开
标题翻译：包含肾素 - 血管紧张素醛固酮系统抑制剂和硫酸酯化合物的组合物及其用于治疗肾素 - 血管紧张素醛固酮系统相关疾病的用途
公开(公告)号：WO2010065069A3
公开(公告)日：2010-09-23
申请号：PCT/US2009006247
申请日：2009-11-23
申请人： IN VASC THERAPEUTICS INC , KHAN BOBBY V , PARTHASARATHY SAM
发明人： KHAN BOBBY V , PARTHASARATHY SAM
IPC分类号： A61K31/382 , A61K9/22 , A61K31/195 , A61K31/385 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61P3/10 , A61P9/12
CPC分类号： A61K31/385 , A61K31/435 , A61K2300/00
摘要： Compositions are provided which can be useful in treating a renin-angiotensin aldosterone system-related disorder. These compositions include renin-angiotensin aldosterone system inhibitors and lipoic acid compounds, as well as other therapeutic agents, and are useful in treating hypertension, stroke, metabolic syndrome, or other renin-angiotensin aldosterone system-related disorders in a subject. The compositions are also useful in improving vasodilation, reducing proteinuria, and reducing insulin resistance in a subject. Pharmaceutical compositions and methods of treatment using the compositions are further provided.
摘要翻译：提供了可用于治疗肾素 - 血管紧张素醛固酮系统相关病症的组合物。这些组合物包括肾素 - 血管紧张素醛固酮系统抑制剂和硫辛酸化合物以及其他治疗剂，并且可用于治疗受试者的高血压，中风，代谢综合征或其他肾素 - 血管紧张素醛固酮系统相关病症。该组合物还可用于改善受试者的血管舒张，减少蛋白尿和降低胰岛素抵抗。进一步提供了药物组合物和使用该组合物的治疗方法。

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