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31. 发明申请

WO1998010797A2 MARKER COMPOSITIONS 审中-公开
标题翻译：标记组成
公开(公告)号：WO1998010797A2
公开(公告)日：1998-03-19
申请号：PCT/GB1997002509
申请日：1997-09-12
申请人： NYCOMED IMAGING AS , COCKBAIN, Julian , BRILEY-SÆBO, Karen, Catherin , KELLAR, Kenneth, Edmund , LADD, David, Lee , HOLLISTER, Kenneth, Robert , BJORNERUD, Atle
发明人： NYCOMED IMAGING AS , COCKBAIN, Julian
IPC分类号： A61K49/00
CPC分类号： A61K49/128 , A61K49/18 , A61K49/1803
摘要： This invention relates to a set of aqueous marker compositions, each composition having a selected 1/Ti value which is substantially invariant over an at least 10 DEG C temperature range between 15 and 40 DEG C and preferably over an at least +/- 2 % magnetic field strength range about a selected field strength value between 0.01 and 5T and comprising an aqueous matrix material having a non-zero 1/Ti temperature dependence within said temperature range with distributed therein a first paramagnetic material having a Ti relaxivity which is substantially invariant within said range(s) and/or a second paramagnetic material having within said range(s) a Ti relaxivity which has a non-zero temperature dependence of opposite polarity to the temperature dependence of 1/Ti of said matrix material, said set containing a plurality of said compositions with different selected 1/Ti values preferably encompassing at least the range 1.0 to 2.5 s , said set preferably comprising at least one said composition containing said second paramagnetic material and at least one said composition containing said first paramagnetic material, where i in Ti is 1 or 2.
摘要翻译：本发明涉及一组水性标记组合物，每种组合物具有选择的1 / Ti值，其在15至40℃之间的至少10℃温度范围内基本上不变，优选至少为+/- 2％磁场强度范围大约在0.01和5T之间的选定的场强值，并且包括在所述温度范围内具有非零1 / Ti温度依赖性的水基质材料，其中分布有第一顺磁性材料，其具有基本上不变的Ti弛豫度所述范围和/或第二顺磁材料具有在所述范围内的Ti弛豫度，其具有与所述基体材料的1 / Ti的温度依赖性相反极性的非零温度依赖性，所述组包含具有不同选择的1 / Ti值的多个所述组合物优选包含至少1.0至2.5s -1的范围，所述组优选包含至少一个所述共包含所述第二顺磁性材料和至少一种含有所述第一顺磁性材料的组合物，其中i在Ti中为1或2。

32. 发明申请

WO1998008747A1 CONTAINER CONTAINING CONTRAST AGENTS 审中-公开
标题翻译：含有对比剂的容器
公开(公告)号：WO1998008747A1
公开(公告)日：1998-03-05
申请号：PCT/GB1997002310
申请日：1997-08-27
申请人： MARSDEN, John , NYCOMED IMAGING AS , SNOW, Robert
发明人： MARSDEN, John , NYCOMED IMAGING AS
IPC分类号： B65D51/00
CPC分类号： A61K49/223 , A61B2090/3925 , A61J1/06 , A61J1/10 , A61J1/14 , A61M5/007 , A61M2207/00 , B65D51/005 , B65D51/30 , Y10T428/1352 , Y10T428/1376 , Y10T428/1386 , Y10T428/214
摘要： Plastics material-containing closed containers (e.g. elastomer-stoppered vials) for contrast agents and contrast agent precursors which incorporate or are adapted to incorporate a volatile substance (e.g. a gaseous halocarbon such as a perfluorocarbon), where the plastics material is pretreated by exposure to the volatile substance. Such containers may enhance the storage stability of the contrast agent or precursor content.
摘要翻译：用于造影剂和造影剂前体的含塑料材料的密封容器（例如弹性体塞子小瓶），其包含或适于掺入挥发性物质（例如气态卤化碳，例如全氟化碳）），其中塑料材料通过暴露于挥发性物质。这样的容器可以增强造影剂或前体物质的储存稳定性。

33. 发明申请

WO1996007434A1 IMPROVEMENTS IN OR RELATING TO CONTRAST AGENTS 审中-公开
标题翻译：改进或与对比剂相关
公开(公告)号：WO1996007434A1
公开(公告)日：1996-03-14
申请号：PCT/GB1995002109
申请日：1995-09-06
申请人： MARSDEN, John, Christopher , NYCOMED IMAGING AS , KLAVENESS, Jo , RONGVED, Pål , STRANDE, Per
发明人： MARSDEN, John, Christopher , NYCOMED IMAGING AS
IPC分类号： A61K49/00
CPC分类号： A61B8/481 , A61F2210/0004 , A61K49/0002 , A61K49/22 , A61L15/62 , A61L27/58
摘要： Contrast agents comprising gas-containing polymer microparticles and/or microballoons in which the polymer is a biodegradable polymer comprising repeating units of formula (II) (where a is an integer of 9-19 and b is an integer of 1-8) may be used in diagnostic applications such as ultrasound and MR imaging. The polymers are novel and are also claimed per se.
摘要翻译：包含含气体的聚合物微粒和/或微球的造影剂可以是其中聚合物是包含式（II）的重复单元（其中a为9-19的整数，b为1-8的整数）的可生物降解的聚合物用于诊断应用，如超声和MR成像。聚合物是新颖的，并且本身也是要求的。

34. 发明申请

WO1993018070A1 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO1993018070A1
公开(公告)日：1993-09-16
申请号：PCT/GB1993000469
申请日：1993-03-05
申请人： NYCOMED IMAGING AS , KLAVENESS, Jo , REDFORD, Keith , SOLBERG, Jan , STRANDE, Per
发明人： NYCOMED IMAGING AS
IPC分类号： C08F08/14
CPC分类号： A61K49/1857 , A61K49/223
摘要： Non-crosslinked non-polypeptide polymers containing biodegradable lipophilic side chains incorporating methylene diester units of the formula -[-CO-O-C(R R )-O-CO-]- (where R and R each represents a hydrogen atom or a carbon-attached monovalent organic group or R and R together form a carbon-attached divalent organic group) whereby the lipophilic moieties are biodegradatively cleavable to yield a water-soluble polymer.
摘要翻译：含有具有式 - [ - CO-OC（R 1 R 2）-O-CO - ] - （其中R 1和R 2）的亚甲基二酯单元的可生物降解的亲脂侧链的非交联非多肽聚合物 <2>各自表示氢原子或连碳的一价有机基团，或者R 1和R 2一起形成碳键的二价有机基团），由此亲油部分可生物降解地切割，得到水溶性聚合物。

35. 发明申请

WO1993013808A2 IMPROVEMENTS IN OR RELATING TO CONTRAST AGENTS 审中-公开
标题翻译：改进或与对比剂相关
公开(公告)号：WO1993013808A2
公开(公告)日：1993-07-22
申请号：PCT/EP1993000027
申请日：1993-01-08
申请人： HOLMES, Michael, John , NYCOMED IMAGING AS , KLAVENESS, Jo , RONGVED, Pål , STUBBERUD, Lars
发明人： HOLMES, Michael, John , NYCOMED IMAGING AS
IPC分类号： A61K49/00
CPC分类号： A61K49/1818 , A61K49/1821 , A61K49/223 , A61K49/225
摘要： Contrast agents comprising microbubble-generating carbohydrate microparticles having a surfactant admixed within the microparticulate structure (with the proviso that the surfactant is not a saturated C10-20 fatty acid when the microparticulate carbohydrate is galactose) exhibit useful levels of contrast efficiency and/or stability and may be used in diagnostic applications such as ultrasound and MR imaging.
摘要翻译：造粒剂包含产生微泡的碳水化合物微粒，其具有在微粒结构内混合的表面活性剂（条件是当微粒碳水化合物为半乳糖时表面活性剂不是饱和的C10-20脂肪酸）表现出对比度效率和/或稳定性的有用水平，可用于诊断应用，如超声和MR成像。

36. 发明申请

WO1993013802A1 CONTRAST AGENTS CONSISTING OF GALACTOSE PARTICLES AND AN AMPHIPHILIC CARBOXYLIC ACID 审中-公开
标题翻译：含有胶体糖浆和AMPHIPHILIC羧酸的对照试剂
公开(公告)号：WO1993013802A1
公开(公告)日：1993-07-22
申请号：PCT/EP1993000026
申请日：1993-01-08
申请人： HOLMES, Michael, John , NYCOMED IMAGING AS , KLAVENESS, Jo , RONGVED, Pål , STUBBERUD, Lars
发明人： HOLMES, Michael, John , NYCOMED IMAGING AS
IPC分类号： A61K49/00
CPC分类号： A61K49/223 , A61K49/226
摘要： Contrast agents comprising microbubble-generating carbohydrate microparticles in admixture with an amphiphilic organic acid containing in excess of 20 carbon atoms exhibit good stability and/or enhanced contrast effect and may be used in diagnostic applications such as ultrasound and MR imaging.
摘要翻译：包含产生微泡的碳水化合物微粒与含有超过20个碳原子的两亲性有机酸的造影剂表现出良好的稳定性和/或增强的对比度效果，并可用于诸如超声和MR成像的诊断应用中。

37. 发明申请

WO1993005818A1 DIAGNOSTIC AGENTS 审中-公开
标题翻译：诊断代理
公开(公告)号：WO1993005818A1
公开(公告)日：1993-04-01
申请号：PCT/EP1992002254
申请日：1992-09-26
申请人： COCKBAIN, Julian, Roderick, Michaelson , NYCOMED IMAGING AS , KLAVENESS, Jo , EGE, Thorfinn , ROCKLAGE, Scott, M.
发明人： COCKBAIN, Julian, Roderick, Michaelson , NYCOMED IMAGING AS
IPC分类号： A61K49/00
CPC分类号： A61K49/1887 , A61K49/18 , A61K49/1857 , Y10T436/24
摘要： The invention provides the use of a physiologically tolerable, particulate, free or matrix-borne, ferrimagnetic or ferromagnetic material for the manufacture of a diagnostic agent for administration into the gastrointestinal tract, the reproductive tract, the urinary tract, a closed body cavity (e.g. into the synovial fluid or the vasculature) or the musculature for magnetometric imaging of the human or non-human animal body.
摘要翻译：本发明提供了生理上可耐受的，颗粒状的，游离的或基质载体的铁磁性或铁磁材料用于制造用于施用于胃肠道，生殖道，尿道，闭合体腔（例如，进入滑液或脉管系统）或用于人或非人动物体的磁力计成像的肌肉组织。

38. 发明申请

WO1999021587A1 COMPLEXING AGENTS AND TARGETING IMMUNOREAGENTS 审中-公开
标题翻译：复合药剂和靶向免疫接种
公开(公告)号：WO1999021587A1
公开(公告)日：1999-05-06
申请号：PCT/GB1998003102
申请日：1998-10-15
申请人： NYCOMED IMAGING AS , MATTHEWS, Derek, Peter , WOLFE, Henry , DELECKI, Daniel, Joseph , YU, Shi-Bao
发明人： NYCOMED IMAGING AS , MATTHEWS, Derek, Peter
IPC分类号： A61K47/48
CPC分类号： A61K51/088 , A61K47/62
摘要： A targeting immunoreagent comprising a metal ion, a complexing agent and an immunoreactive group of covalently bonded to said complexing agent, said complexing agent having structure (I), said immunoreactive group is an ST binding receptor moiety.
摘要翻译：包含与所述络合剂共价结合的金属离子，络合剂和免疫反应性基团的靶向免疫原，所述络合剂具有结构（I），所述免疫反应性基团是ST结合受体部分。

39. 发明申请

WO1998023297A2 PARTICULATE COMPOSITIONS 审中-公开
标题翻译：颗粒组合物
公开(公告)号：WO1998023297A2
公开(公告)日：1998-06-04
申请号：PCT/GB1997003283
申请日：1997-11-28
申请人： NYCOMED IMAGING AS , COCKBAIN, Julian , ODEGÅRDSTUEN, Liv, Ingrid , DYVIK, Kari , BJERKNES, Kathrin , FAHLVIK, Anne, Kjersti
发明人： NYCOMED IMAGING AS , COCKBAIN, Julian
IPC分类号： A61K49/04
CPC分类号： A61K49/0466
摘要： The invention provides a contrast agent composition, preferably an X-ray contrast medium, comprising vesicles in suspension in an aqueous medium, said vesicles and optionally also said aqueous medium containing an iodinated X-ray contrast agent, characterised in that a dose of said composition containing 100 mgI entrapped in said vesicles contains no more than 8x10 vesicles.
摘要翻译：本发明提供造影剂组合物，优选X射线造影剂，其包含在水性介质中的悬浮液中的囊泡，所述囊泡和任选地还包含含有碘化X射线造影剂的水性介质，其特征在于所述组合物的剂量含有100mg的所述囊泡含有不超过8×10 12个囊泡。

40. 发明申请

WO1998018498A2 IMPROVEMENTS IN OR RELATING TO DIAGNOSTIC/THERAPEUTIC AGENTS 审中-公开
标题翻译：诊断/治疗药物的改善或相关
公开(公告)号：WO1998018498A2
公开(公告)日：1998-05-07
申请号：PCT/GB1997002958
申请日：1997-10-28
申请人： MARSDEN, John, Christopher , NYCOMED IMAGING AS , KLAVENESS, Jo , RONGVED, Pål , HOGSET, Anders , TOLLESHAUG, Helge , GODAL, Aslak , CUTHBERTSON, Alan , LOVHAUG, Dagfinn , SOLBAKKEN, Magne
发明人： MARSDEN, John, Christopher , NYCOMED IMAGING AS
IPC分类号： A61K49/00
CPC分类号： A61K49/0058 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0043 , A61K49/0091 , A61K49/223 , A61K51/0497 , A61K51/088
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generated material, in which the reporter is coupled or linked to one or more non-bioactive vectors.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体生成材料的报道分子的含水载体液体中的悬浮液，其中所述报告物偶联或连接至一种或多种非生物活性载体。

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