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31. 发明申请

WO1996035430A1 REMEDY AND PREVENTIVE FOR DISEASES CAUSED BY NF-'kappa'B 审中-公开
标题翻译： NF-κB引起的疾病的补救和预防
公开(公告)号：WO1996035430A1
公开(公告)日：1996-11-14
申请号：PCT/JP1996001234
申请日：1996-05-10
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , MORISHITA, Ryuichi , OGIWARA, Toshio , SUGIMOTO, Toshiko , MAEDA, Kazuhiro , KAWAMURA, Ikuo , CHIBA, Toshiyuki
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K31/70
CPC分类号： A61K31/00 , A61K38/00 , A61K48/005 , C12N15/113 , C12N2310/13 , C12N2310/315
摘要： The administration of a compound as a decoy specifically antagonizing the nucleic acid site to which a transcription regulator NF- kappa B binds in order to effectively treat and prevent diseases caused by NF- kappa B such as ischemic diseases, inflammatory diseases, autoimmune diseases, infiltrating metastasis of cancer, cachexia, etc.
摘要翻译：施用化合物作为特异性拮抗转录调节因子NF-κB结合的核酸位点的诱饵，以有效治疗和预防由NF-κB引起的疾病如缺血性疾病，炎症性疾病，自身免疫性疾病，浸润性癌转移，恶病质等

32. 发明申请

WO1996031238A1 AGENT FOR CIRCULATORY ORGANS 审中-公开
标题翻译：循环机器代理
公开(公告)号：WO1996031238A1
公开(公告)日：1996-10-10
申请号：PCT/JP1996000775
申请日：1996-03-26
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , YAMAGUCHI, Isamu , MATSUOKA, Nobuya
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K45/00
CPC分类号： A61K45/00
摘要： An agent for circulatory organs which contains as the active ingredient a psychotropic drug comprising a dopamine (D1) receptor antagonist or an NMDA receptor antagonist. The agent is useful as a remedy and preventive for stress-induced cardiomyopathy, myocarditis, cardiac failure, irregular pulse, ischemic cardiac diseases, valvular diseases, cardiac hypertrophy or sudden death caused thereby.
摘要翻译：作为活性成分含有多巴胺（D1）受体拮抗剂或NMDA受体拮抗剂的精神药物的循环器官的药剂。该药物可用作压力诱发的心肌病，心肌炎，心力衰竭，不规则脉搏，缺血性心脏病，瓣膜疾病，心脏肥大或由此引起的猝死的补救和预防。

33. 发明申请

WO1996030399A1 CYCLIC PEPTIDE NUCLEI AND DERIVATIVES THEREOF 审中-公开
标题翻译：循环肽核及其衍生物
公开(公告)号：WO1996030399A1
公开(公告)日：1996-10-03
申请号：PCT/JP1996000774
申请日：1996-03-26
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , HASHIMOTO, Michizane , SHIGEMATSU, Nobuharu , HASHIMOTO, Seiji
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07K07/08
CPC分类号： C07K7/08 , A61K38/00 , C07K7/56 , Y02P20/55
摘要： New peptide compounds of formula (I), wherein R is alkyl or aralkyl, R is amino(lower)alkyl or protected amino(lower)alkyl, R is hydroxy, protected hydroxy, amino or protected amino, R is hydroxy, or R and R are linked together to form -Z- (in which -Z- is -O- or -NH-), and R is hydrogen or an amino protective group, R is hydroxy, or R and R are linked together to form bond, with proviso that when R is hydroxy, protected hydroxy, amino or protected amino and R is hydroxy, then R and R are linked together to form bond, and a pharmaceutically acceptable salt thereof, which is useful as a medicament.
摘要翻译：式（I）的新肽化合物，其中R 1是烷基或芳烷基，R 2是氨基（低级）烷基或被保护的氨基（低级）烷基，R 3是羟基，保护的羟基，氨基或被保护的氨基，R 4是羟基，或R 3和R 4连接在一起形成-Z-（其中-Z-是-O-或-NH-），R 5是氢或氨基保护基，R 6为羟基，或R 5和R 6连接在一起形成键，条件是当R 3为羟基时，被保护的羟基，氨基或被保护的氨基和R <4>是羟基，则R 5和R 6连接在一起形成键，以及其药学上可接受的盐，其可用作药物。

34. 发明申请

WO1996017850A1 CEPHEM COMPOUNDS AND PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译： CEPHEM化合物及其药物用途
公开(公告)号：WO1996017850A1
公开(公告)日：1996-06-13
申请号：PCT/JP1995002505
申请日：1995-12-06
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , YOSHIDA, Yoshiki , SASAKI, Hiroshi , MATSUDA, Keiji , TAKASUGI, Hisashi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D501/36
CPC分类号： C07D501/00
摘要： This invention relates to a new use of a cephem compound of formula (I), wherein R is aryl(lower)alkyl which may have one or more suitable substituent(s), arylthio(lower)alkyl, lower alkenylthio(lower)alkyl which may have one or more suitable substituent(s), or a group of the formula: R -A- or R -S-A- in which R is heterocyclic group which may have one or more suitable substituent(s), and A is lower alkylene which may have one or more suitable substituent(s) or lower alkenylene, R is heterocyclic group which may have one or more suitable substituent(s), or heterocyclic(lower)-alkyl and R is carboxy or protected carboxy, and a pharmaceutically acceptable salt thereof, which have antimicrobial activity against Helicobacter pylori, and are useful as anti-Helicobacter pylori agents, anti-gastritis agents, antiulcer agents and anticancer agents.
摘要翻译：本发明涉及式（I）的头孢烯化合物的新用途，其中R 1为可具有一个或多个合适取代基的芳基（低级）烷基，芳硫基（低级）烷基，低级链烯硫基（低级））烷基，其可以具有一个或多个合适的取代基，或下式的基团：R 4 -A或R 4 -SA-，其中R 4是杂环基，其可以具有一个或多个更合适的取代基，并且A是可以具有一个或多个合适的取代基或低级亚烯基的低级亚烷基，R 2是可以具有一个或多个合适的取代基的杂环基或杂环（低级） - 烷基和R 3是对幽门螺杆菌具有抗微生物活性的羧基或被保护的羧基及其药学上可接受的盐，并且可用作抗幽门螺杆菌药，抗胃炎剂，抗溃疡剂和抗癌剂。

35. 发明申请

WO1996013485A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS 审中-公开
标题翻译：吡咯烷酮，喹啉和熔融N-酰基转移酶作为BRADYKININ拮抗剂
公开(公告)号：WO1996013485A1
公开(公告)日：1996-05-09
申请号：PCT/JP1995002192
申请日：1995-10-25
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , OKU, Teruo , KAYAKIRI, Hiroshi , SATOH, Shigeki , ABE, Yoshito , SAWADA, Yuki , INOUE, Takayuki , TANAKA, Hirokazu
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D215/16
CPC分类号： C07D401/12 , C07D215/26 , C07D215/40 , C07D215/42 , C07D215/48 , C07D241/40 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The invention relates to Pyridopyrimidones, Quinolines and fused N-heterocyclic compounds of formula (I) wherein Z is a group of the formula (a) or (b) in which X is N or C-R , X is N or C-R , X is N or C-R , R is lower alkyl, R is hydrogen, lower alkyl, etc., R is hydrogen or lower alkyl, R is halogen, etc., R is halogen, etc., R is a group of formula (c), etc., A is lower alkylene, and Y is O, etc., and pharmaceutically acceptable salts thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods of using the same therapeutically in the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.
摘要翻译：本发明涉及式（I）的吡啶并嘧啶酮，喹啉和稠合的N-杂环化合物，其中Z是式（a）或（b）的基团，其中X 1是N或CR 1，X 2 >为N或CR 9，X 3为N或CR 2，R 1为低级烷基，R 2为氢，低级烷基等，R 9为氢或低级烷基，R 3为卤素等，R 4为卤素等，R 5为式（c）等基团，A为低级亚烷基，Y为O等。及其药学上可接受的盐，其制备方法，涉及含有该组合物的药物组合物，以及在预防和/或治疗缓激肽或其类似物介导的人或动物疾病中的治疗方法。

36. 发明申请

WO1996005187A1 (4-(3-AMINOMETHYLPHENYL)THIAZOL-2-YL)-GUANIDINES AS H2-RECEPTOR ANTAGONISTS 审中-公开
标题翻译：（4-（3-氨基乙基）噻唑-2-基） - 胍作为H 2受体拮抗剂
公开(公告)号：WO1996005187A1
公开(公告)日：1996-02-22
申请号：PCT/JP1995001596
申请日：1995-08-09
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , KATSURA, Yousuke , TOMISHI, Tetsuo , NISHINO, Shigetaka , OHNO, Mitsuko
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D277/48
CPC分类号： C07D277/48
摘要： New compounds of formula (I), wherein R is lower alkoxy, lower alkoxy(lower)alkyl, cyano(lower)alkyl, phenyl, phenyl(lower)alkyl, [2-(lower)alkoxyphenyl] (lower)alkyl, diphenyl(lower)alkyl, phenoxy(lower)alkyl, phenyl(lower)alkoxy(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, protected amino(lower)alkyl or adamantyloxy(lower)alkyl, and R is hydrogen, lower alkanoyl or carbamoyl, and a pharmaceutically acceptable salt thereof which are useful as a medicament.
摘要翻译：新的式（I）化合物，其中R 1是低级烷氧基，低级烷氧基（低级）烷基，氰基（低级）烷基，苯基，苯基（低级）烷基，[2-（低级）烷氧基苯基] （低级）烷基，苯氧基（低级）烷基，苯基（低级）烷氧基（低级）烷基，环（低级）烯基（低级）烷基，被保护的氨基（低级）烷基或金刚烷基氧基 >是可用作药物的氢，低级烷酰基或氨基甲酰基及其药学上可接受的盐。

37. 发明申请

WO1995027694A1 PROCESS FOR PRODUCING 'alpha','beta'-DISUBSTITUTED ALCOHOL DERIVATIVE 审中-公开
标题翻译：生产α，β - 衍生的醇醇衍生物的方法
公开(公告)号：WO1995027694A1
公开(公告)日：1995-10-19
申请号：PCT/JP1995000656
申请日：1995-04-05
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , MURATA, Masayoshi , TSUTSUMI, Hideo , OHTAKE, Hiroaki , YONISHI, Satoshi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07C69/16
CPC分类号： C07D209/18 , C07B53/00 , C07C67/31 , C07C231/12 , C07C235/30 , C07C235/34 , C07C2601/14 , C07D307/54 , C07D333/24
摘要： A process for producing an alpha , beta -disubstituted alcohol derivative according to the reaction scheme, which is more excellent than the conventional reduction process in the selectivity for an anti -form, thus being industrially advantageous. In (1), R represents hydrogen or an organic group; R represents optionally substituted carbamoyl; R represents an organic group; and A and Q represent each lower alkylene or a single bond.
摘要翻译：根据反应方案制备α，β-二取代醇衍生物的方法，其比在常规还原方法中对于反式选择性更优异，因此在工业上是有利的。在（1）中，R 1表示氢或有机基团; R 2表示任选取代的氨基甲酰基; R 3表示有机基团; A和Q表示低级亚烷基或单键。

38. 发明申请

WO1995023220A1 PROCESS FOR PRODUCING 2-KETO-L-GULONIC ACID 审中-公开
标题翻译： 2-KETO-L-GULONIC酸的生产方法
公开(公告)号：WO1995023220A1
公开(公告)日：1995-08-31
申请号：PCT/JP1995000285
申请日：1995-02-24
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , NIWA, Mineo , SAITO, Yoshimasa , ISHII, Yoshinori , YOSHIDA, Masaru , HAYASHI, Hiromi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C12N09/04
CPC分类号： C12N9/0008 , C12N9/0006 , C12P7/60 , Y10S435/822
摘要： An expression vector containing both of a DNA coding for L-sorbose dehydrogenase and a DNA coding for L-sorbosone dehydrogenase; a transformant capable of producing 2-keto-L-gulonic acid (2KLGA) from D-sorbitol in a high yield and prepared by transforming with the above vector a microorganism which produces L-sorbose from D-sorbitol in a high yield and which has no or little activity of decomposing 2KLGA, or such a microorganism which has, in addition, no or little activity of producing L-idonic acid; and a process for producing 2KLGA by culturing the transformant in a medium containing D-sorbitol. The invention process enables 2KLGA useful for producing L-ascorbic acid to be produced readily in a large amount at a good efficiency by single culture.
摘要翻译：含有编码L-山梨糖脱氢酶的DNA和编码L-山梨糖酮脱氢酶的DNA的表达载体; 能够以高产率从D-山梨糖醇生产2-酮-L-古洛糖酸（2KLGA）的转化体，并通过用上述载体以高产率从D-山梨糖醇转化产生L-山梨糖的微生物制备，没有或很少分解2KLGA的活性，或者这样的微生物，另外没有或很少生产L-吉非糖酸的活性; 以及通过在含有D-山梨糖醇的培养基中培养转化体来生产2KLGA的方法。本发明方法使得2KLGA可用于通过单一培养以高效率大量容易地生产L-抗坏血酸。

39. 发明申请

WO1995019959A1 AMINO ACID DERIVATIVES AND THEIR USE AS PHOSPHOLIPASE A2 INHIBITORS 审中-公开
标题翻译：氨基酸衍生物及其作为磷脂酶A2抑制剂的用途
公开(公告)号：WO1995019959A1
公开(公告)日：1995-07-27
申请号：PCT/JP1995000068
申请日：1995-01-23
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , TAKASE, Shigehiro , SHIGEMATSU, Nobuharu , YOSHIMURA, Seiji , OKADA, Satoshi , HEMMI, Keiji , TANAKA, Hirokazu , OTSUKA, Takanao , TSURUMI, Yasuhisa , OKAMOTO, Masanori , OKUHARA, Masakuni , FUKAMI, Naoki
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07C271/22
CPC分类号： C07D213/40 , C07C235/08 , C07C235/12 , C07C271/22 , C07C271/54 , C07C275/16 , C07C311/42 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/36 , C07D215/38 , C07D215/44 , C07D215/48 , C07D217/06 , C07D217/26 , C07D233/64 , C07D241/24 , C07D241/44 , C07D263/58 , C07D277/82 , C07D295/215 , C07D295/32 , C07D317/58 , C07D471/04
摘要： The present invention relates to a novel fatty acid derivative of formula (I) wherein R is acyl group, etc.; R is acyl(lower)alkyl; R is lower alkyl, etc.; R is hydrogen, etc.; and X is -O-, etc.; and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.
摘要翻译：本发明涉及式（I）的新型脂肪酸衍生物，其中R 1为酰基等; R 2是酰基（低级）烷基; R 3是低级烷基等; R 4是氢等; X为-O-等。和其药学上可接受的盐，其可用作药物; 所述脂肪酸衍生物或其盐的制备方法; 包含所述脂肪酸衍生物或其药学上可接受的盐的药物组合物; 等等

40. 发明申请

WO1995018142A1 WF15604 SUBSTANCES 审中-公开
标题翻译： WF15604物质
公开(公告)号：WO1995018142A1
公开(公告)日：1995-07-06
申请号：PCT/JP1994002192
申请日：1994-12-22
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , SHIBATA, Toshihiro , NISHIKAWA, Motoaki , SATO, Tomoko , TAKASE, Shigehiro , YAMASHITA, Michio , HASHIMOTO, Seiji
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07J53/00
CPC分类号： C12R1/645 , C07J53/004 , C12P33/00
摘要： The invention relates to new compounds, WF15604 substances or salts thereof, having antifungal activity and inhibitory activity on cholesterol biosynthesis, to a process for the preparation thereof and to a pharmaceutical composition comprising the same, said compounds having formula (I).
摘要翻译：本发明涉及具有抗真菌活性和对胆固醇生物合成的抑制活性的新化合物WF15604物质或其盐，其制备方法和含有该化合物的药物组合物，所述具有式（I）的化合物。

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