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31. 发明申请

WO2006121991A3 COMPOSITIONS AND METHODS FOR DETECTION, PROGNOSIS AND TREATMENT OF BREAST CANCER 审中-公开
标题翻译：用于乳腺癌检测，预防和治疗的组合物和方法
公开(公告)号：WO2006121991A3
公开(公告)日：2007-04-05
申请号：PCT/US2006017653
申请日：2006-05-08
申请人： DIADEXUS INC , MACINA ROBERTO A
发明人： MACINA ROBERTO A
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： The present invention relates to methods of detection, prognosis and treatment of breast cancer using a plurality genes or gene products present in normal and neoplastic cells, tissues and bodily fluids. Gene products relate to compositions comprising the nucleic acids, polypeptides, antibodies, post translational modifications (PTMs), variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. Additional uses include identifying, monitoring, staging, imaging and treating cancer and non-cancerous disease states in breast as well as determining the effectiveness of therapies alone or in combination for an individual. Therapies include gene therapy, therapeutic molecules including but not limited to antibodies, small molecules and antisense molecules.
摘要翻译：本发明涉及使用存在于正常和肿瘤细胞，组织和体液中的多个基因或基因产物来检测，预测和治疗乳腺癌的方法。基因产物涉及包含本发明的核酸，多肽，抗体，翻译后修饰（PTM），变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。其他用途包括识别，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，以及确定单独或组合使用个体的疗法的有效性。治疗方法包括基因治疗，治疗分子，包括但不限于抗体，小分子和反义分子。

32. 发明申请

WO2004053081A3 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组合物，SPLICE变体和与前列腺特异性基因和蛋白相关的方法
公开(公告)号：WO2004053081A3
公开(公告)日：2006-07-27
申请号：PCT/US0338877
申请日：2003-12-08
申请人： DIADEXUS INC , MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING
发明人： MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING
IPC分类号： C07H21/04 , C07K14/47 , C12N9/00 , C12N15/63 , C12N15/85 , C12N15/86 , C12P21/00 , C12Q1/68
CPC分类号： C07K14/47
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗前列腺中的前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程前列腺组织的生产。

33. 发明申请

WO2004089301A3 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO COLON SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组成特征基因和蛋白质的差异变异和方法
公开(公告)号：WO2004089301A3
公开(公告)日：2006-01-05
申请号：PCT/US2004010531
申请日：2004-04-02
申请人： DIADEXUS INC , MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING
发明人： MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING
IPC分类号： A61K20060101 , C07K14/47 , C12N15/12 , C07H21/04 , C12N15/00 , C12N15/63 , C12P21/06
CPC分类号： C07K14/47 , A61K2039/53
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性结肠细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗结肠中的结肠癌和非癌性疾病状态，鉴定结肠组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程结肠组织的生产。

34. 发明申请

WO2005027713A3 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO COLON SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组成特征基因和蛋白质的差异变异和方法
公开(公告)号：WO2005027713A3
公开(公告)日：2005-10-13
申请号：PCT/US2004020223
申请日：2004-06-25
申请人： DIADEXUS INC , TURNER LEAH R , CHEN HUEI-MEI , MACINA ROBERTO A
发明人： TURNER LEAH R , CHEN HUEI-MEI , MACINA ROBERTO A
IPC分类号： A61B20060101 , C12Q1/68 , C12Q1/70 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/136
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性结肠细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定诊断，监测，分期，成像和治疗结肠中的结肠癌和非癌性疾病状态，鉴定结肠组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程结肠组织的生产。

35. 发明申请

WO2004074430A3 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组成，裂解变异体和与肺特异性基因和蛋白质相关的方法
公开(公告)号：WO2004074430A3
公开(公告)日：2004-12-16
申请号：PCT/US0338896
申请日：2003-12-08
申请人： DIADEXUS INC , MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING , LIU SHU-HUI
发明人： MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING , LIU SHU-HUI
IPC分类号： C07K14/47 , C12N15/12 , C12Q1/68 , A61K31/7088 , A61K31/711 , C12N15/00 , C12N15/11 , C12P21/02
CPC分类号： C07K14/47
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤肺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂的组合物和使用这些组合物的方法。这些包括鉴别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，鉴定肺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。这些用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

36. 发明申请

WO2004053075A3 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组合物，与乳腺特异性基因和蛋白相关的差异变异和方法
公开(公告)号：WO2004053075A3
公开(公告)日：2004-11-04
申请号：PCT/US0338739
申请日：2003-12-05
申请人： DIADEXUS INC , MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING
发明人： MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING
IPC分类号： C07K14/47 , C12N15/12 , C12Q1/68 , A61K31/7088 , A61K31/711 , C12N15/00 , C12N15/11 , C12P21/02
CPC分类号： C12Q1/6886 , A61K39/00 , A61K48/00 , C07K14/47 , C12Q2600/112 , G01N33/57415
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

37. 发明申请

WO0242463A3 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与前列腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO0242463A3
公开(公告)日：2003-07-10
申请号：PCT/US0145009
申请日：2001-11-20
申请人： DIADEXUS INC , SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA
发明人： SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA
IPC分类号： C07K14/47 , C12N1/21 , C12N15/12 , A61K39/395 , C07K16/18 , C12N5/10 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/47 , A61K2039/505 , A61K2039/53
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate ells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗前列腺组织中的前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程前列腺组织的生产。

38. 发明申请

WO0218576A3 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES 审中-公开
标题翻译：与肺特异性基因有关的组合物和方法
公开(公告)号：WO0218576A3
公开(公告)日：2003-04-17
申请号：PCT/US0126684
申请日：2001-08-27
申请人： DIADEXUS INC , CHEN SEI-YU , MACINA ROBERTO A , SUN YONGMING , RECIPON HERVE
发明人： CHEN SEI-YU , MACINA ROBERTO A , SUN YONGMING , RECIPON HERVE
IPC分类号： G21H5/02 , A61K39/00 , A61K45/00 , A61K49/00 , A61K51/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07K14/47 , C07K16/32 , C12N15/09 , C12N15/12 , C12Q1/68 , G01T1/161 , A61K38/17 , A61K39/395 , C07K16/18 , G01N33/50 , G01N33/547
CPC分类号： C07K14/47 , A61K39/00
摘要： The invention relates to LSG polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及LSG多肽，编码所述多肽的多核苷酸，产生所述多肽的方法，特别是通过表达所述多核苷酸，以及所述多肽的激动剂和拮抗剂。本发明还涉及用于应用的这种多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床技术。

39. 发明申请

WO02068633A3 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与肺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO02068633A3
公开(公告)日：2003-03-27
申请号：PCT/US0143612
申请日：2001-11-21
申请人： DIADEXUS INC , MACINA ROBERTO A , RECIPON HERVE , CHEN SEI-YU , SUN YONGMING , LIU CHENGHUA
发明人： MACINA ROBERTO A , RECIPON HERVE , CHEN SEI-YU , SUN YONGMING , LIU CHENGHUA
IPC分类号： A61K48/00 , C07K14/47 , C12Q1/68 , G01N33/574 , G01N33/68 , C12N15/09
CPC分类号： C07K14/4748 , A61K48/00 , C12Q1/6886 , C12Q2600/158 , G01N33/57423 , G01N33/6884 , G01N2800/12
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing and antagonists of polypeptide of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，鉴定肺组织，监测和鉴定和/或本发明多肽的设计和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

40. 发明申请

WO0208278A3 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES 审中-公开
标题翻译：与肺特异性基因相关的组合物和方法
公开(公告)号：WO0208278A3
公开(公告)日：2003-03-13
申请号：PCT/US0122949
申请日：2001-07-20
申请人： DIADEXUS INC , MACINA ROBERTO A , NAIR MANOJ , CHEN SEIYU
发明人： MACINA ROBERTO A , NAIR MANOJ , CHEN SEIYU
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , A61K38/04 , C07K16/18 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention relates to LSG polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及LSG多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

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