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31. 发明申请

WO2007101163A3 SYSTEM AND METHOD FOR SPECTRAL UNMIXING IN A FIBER ARRAY SPECTRAL TRANSLATOR BASED POLYMORPH SCREENING SYSTEM 审中-公开
公开(公告)号：WO2007101163A3
公开(公告)日：2007-09-07
申请号：PCT/US2007/062822
申请日：2007-02-26
申请人： CHEMIMAGE CORPORATION , NEISS, Jason, H. , TREADO, Patrick, J. , SCHWEITZER, Robert
发明人： NEISS, Jason, H. , TREADO, Patrick, J. , SCHWEITZER, Robert
IPC分类号： G01D18/00 , G01J3/00 , G01C19/00
摘要： The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based ("FAST") spectroscopic system for performing spectral unmixing of a mixture containing multiple polymorphs. In an embodiment, a first spectrum of a mixture containing polymorphs of a compound is obtained using a photon detector and a fiber array spectral translator having plural fibers. A set of second spectra is provided where each spectrum of the set of second spectra may be representative of a different polymorph of the compound. The first spectrum and the set of second spectra may be compared, and based on the comparison, the presence of one or more polymorphs in the mixture may be determined.

32. 发明申请

WO2007087315A2 METHOD AND SYSTEM FOR COMBINED RAMAN AND LIBS DETECTION 审中-公开
标题翻译：用于组合拉曼和LIBS检测的方法和系统
公开(公告)号：WO2007087315A2
公开(公告)日：2007-08-02
申请号：PCT/US2007/001799
申请日：2007-01-23
申请人： CHEMIMAGE CORPORATION , BECKSTEAD, Jeffrey , TREADO, Patrick, J. , NELSON, Matthew , HUBBLE, Hugh, W., II , NEISS, Jason
发明人： BECKSTEAD, Jeffrey , TREADO, Patrick, J. , NELSON, Matthew , HUBBLE, Hugh, W., II , NEISS, Jason
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/28 , G01J3/443 , G01N21/65 , G01N21/718 , G01N2201/0221
摘要： In one embodiment, the disclosure relates to a method for interrogating a sample by: illuminating a first region of the sample with a first illumination pattern to obtain a plurality of first sample photons; illuminating a second region of the sample with a second illumination pattern to obtain a plurality of second sample photons; processing the plurality of first sample photons to obtain a characteristic atomic emission of the first region and processing the plurality of second sample photons to obtain a Raman spectrum; and identifying the sample through at least one of the characteristic atomic emission of the first region or the Raman spectrum of the second region of the sample.
摘要翻译：在一个实施例中，本公开涉及一种用于询问样本的方法，其中：用第一照明图案照射样品的第一区域以获得多个第一样品光子; 用第二照明图案照射样品的第二区域以获得多个第二样品光子; 处理多个第一样品光子以获得第一区域的特征原子发射并处理多个第二样品光子以获得拉曼光谱; 以及通过样品的第二区域的第一区域的特征性原子发射或拉曼光谱中的至少一个来识别样品。

33. 发明申请

WO2007075426A2 METHOD AND APPARATUS FOR AUTOMATED SPECTRAL CALIBRATION 审中-公开
标题翻译：自动光谱校准的方法和装置
公开(公告)号：WO2007075426A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/047933
申请日：2006-12-18
申请人： CHEMIMAGE CORPORATION , NELSON, Matthew, P. , WOLFE, Julianne , TREADO, Patrick, J. , KEITZER, Scott , IZYDORE, Earl
发明人： NELSON, Matthew, P. , WOLFE, Julianne , TREADO, Patrick, J. , KEITZER, Scott , IZYDORE, Earl
IPC分类号： G01D18/00
CPC分类号： G01J3/28 , A61B5/0059 , A61B2560/0223 , G01J2003/2866
摘要： The disclosure generally relates to a method and apparatus for automated spectral calibration of a spectroscopy device. In one embodiment, the disclosure relates to a method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a plurality of illuminating photons; receiving, at the spectrometer, a first plurality of photons collected from the sample and a second plurality of photons collected from the calibrant; forming a calibrant spectrum from the first plurality of collected photons and a sample spectrum from the second plurality of collected photons; comparing the calibrant spectrum with a reference spectrum of the calibrant to determine a wavelength-shift in the calibrant spectrum; applying the wavelength-shift to the sample spectrum to obtain a calibrated sample spectrum.
摘要翻译：本发明一般涉及一种用于光谱设备的自动光谱校准的方法和装置。在一个实施方案中，本公开涉及通过以下步骤同时校准和光谱成像的方法：同时用多个照明光子照射样品和校准物; 在光谱仪处接收从样品收集的第一组多个光子和从校准物收集的第二组多个光子; 从所述第一多个收集的光子形成校准谱，以及来自所述第二多个收集的光子的样品光谱; 将校准谱与校准物的参考光谱进行比较，以确定校准谱中的波长漂移; 将波长偏移应用于样本光谱以获得校准的样本光谱。

34. 发明申请

WO2006135806A2 FORENSIC INTEGRATED SEARCH TECHNOLOGY 审中-公开
标题翻译：威信集成搜索技术
公开(公告)号：WO2006135806A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022618
申请日：2006-06-09
申请人： CHEMIMAGE CORPORATION , TREADO, Patrick, J. , SCHWEITZER, Robert , NEISS, Jason
发明人： TREADO, Patrick, J. , SCHWEITZER, Robert , NEISS, Jason
IPC分类号： G06F7/00
CPC分类号： G06F17/30536 , G06F19/703 , G06F19/709
摘要： A system and method to search spectra databases and to identify unknown materials. A library having a plurality of sublibraries is provided wherein each sublibrary contains a plurality of reference data sets generated by a corresponding one of a plurality of spectroscopic data generating instruments associated with the sublibrary. Each reference data set characterizes a corresponding known material. A plurality of test data sets is provided that is characteristic of an unknown material, wherein each test data set is generated by one or more of the plurality of spectroscopic data generating instruments. For each test data set, each sublibrary is searched where the sublibrary is associated with the spectroscopic data generating instrument used to generate the test data set. A corresponding set of scores for each searched sublibrary is produced, wherein each score in the set of scores indicates a likelihood of a match between one of the plurality of reference data sets in the searched sublibrary and the test data set. A set of relative probability values is calculated for each searched sublibrary based on the set of scores for each searched sublibrary. All relative probability values for each searched sublibrary are fused producing a set of final probability values that are used in determining whether the unknown material is represented through a known material characterized in the library. A highest final probability value is selected from the set of final probability values and compared to a minimum confidence value. The known material represented in the libraries having the highest final probability value is reported, if the highest final probability value is greater than or equal to the minimum confidence value.
摘要翻译：搜索光谱数据库并识别未知材料的系统和方法。提供具有多个子图库的库，其中每个子图库包含由与该子图书馆相关联的多个光谱数据生成装置中的相应一个生成的多个参考数据集。每个参考数据集表征相应的已知材料。提供了许多测试数据集，其是未知材料的特征，其中每个测试数据集由多个光谱数据产生装置中的一个或多个产生。对于每个测试数据集，搜索每个子图书馆，其中子图书馆与用于生成测试数据集的光谱数据生成工具相关联。产生每个搜索的子图库的相应的一组分数，其中该分数集中的每个分数表示搜索的子图库中的多个参考数据集之一与测试数据集之间的匹配的可能性。基于每个搜索的子图库的分数集合，针对每个搜索的子图书馆计算一组相对概率值。每个搜索的子图库的所有相对概率值被融合，产生用于确定未知材料是否通过库中表征的已知材料表示的一组最终概率值。从最终概率值的集合中选择最高的最终概率值并与最小置信度值进行比较。如果最大最终概率值大于或等于最小置信度值，则报告具有最高最终概率值的库中表示的已知材料。

35. 发明申请

WO2006083715A2 METHOD AND APPARATUS FOR VARIABLE-FIELD ILLUMINATION 审中-公开
标题翻译：用于可变场照明的方法和装置
公开(公告)号：WO2006083715A2
公开(公告)日：2006-08-10
申请号：PCT/US2006/002975
申请日：2006-01-30
申请人： CHEMIMAGE CORPORATION , VOIGHT, Thomas , ZHANG, Jingyun , TREADO, Patrick, J. , TUSCHEL, David
发明人： VOIGHT, Thomas , ZHANG, Jingyun , TREADO, Patrick, J. , TUSCHEL, David
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0208 , G01J3/0224 , G01N21/65
摘要： The disclosure relates to identifying one or more regions of interest within a broader field of view of a dynamic sample using one or more optical components and illuminating photons. Once the region of interest is identified within a section of the broader field of view, chemical information in the form of Raman spectrum is obtained from the region of interest by focusing the illuminating photons or the optical components on the region of interest.
摘要翻译：本公开涉及使用一个或多个光学组件和照射光子来识别动态样本的更宽视野内的一个或多个感兴趣区域。一旦在较宽视场的一部分内识别出感兴趣区域，则通过将照射光子或光学部件聚焦在感兴趣区域上，从感兴趣的区域获得拉曼光谱形式的化学信息。

36. 发明申请

WO2005008199A2 METHOD AND APPARATUS FOR COMPACT FABRY-PEROT IMAGING SPECTROMETER 审中-公开
标题翻译：用于紧凑型手绘成像光谱仪的方法和装置
公开(公告)号：WO2005008199A2
公开(公告)日：2005-01-27
申请号：PCT/US2004/023073
申请日：2004-07-19
申请人： CHEMIMAGE CORPORATION , TREADO, Patrick, J. , VANNI, G., Steven
发明人： TREADO, Patrick, J. , VANNI, G., Steven
IPC分类号： G01J
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/10 , G01J3/44 , G01J3/4406 , G01N21/6456 , G01N2021/6417 , G01N2021/6423 , G01N2021/6471 , G01N2201/0221 , G01N2201/0627 , G02F1/133371 , G02F1/1347
摘要： The disclosure generally relates to a method and apparatus for compact FabryPerot imaging spectrometer. More specifically, in one embodiment, the disclosure concerns a tunable Fabry-Perot optical filter for providing a spatially accurate wavelength-resolved image of a sample having two spatial dimensions. The optical filter may include plural filter elements having an initial predetermined spacing between adjacent filter elements; and a micro electro-mechanical system ("MEMS") actuator. One of the plural filter elements may be attached to the MEMS actuator so that the actuator is capable of moving said one filter element relative to another of said plural filter elements to thereby tune said Fabry-Perot optical filter.
摘要翻译：本发明一般涉及用于紧凑FabryPerot成像光谱仪的方法和装置。更具体地说，在一个实施例中，本发明涉及一种可调谐法布里 - 珀罗滤光器，用于提供具有两个空间维度的样品的空间上准确的波长分辨图像。滤光器可以包括在相邻的滤光元件之间具有初始预定间隔的多个滤光元件; 和微机电系统（“MEMS”）致动器。多个滤波器元件中的一个可以附接到MEMS致动器，使得致动器能够相对于所述多个滤波器元件中的另一个移动所述一个滤波器元件，从而调谐所述法布里 - 珀罗滤光器。

37. 发明申请

WO2006019991A3 METHOD AND APPARATUS FOR MULTIMODAL DETECTION 审中-公开
公开(公告)号：WO2006019991A3
公开(公告)日：2006-02-23
申请号：PCT/US2005/025112
申请日：2005-07-14
申请人： CHEMINAGE CORPORATION , NEISS, Jason, H. , SCHWEITZER, Robert , TREADO, Patrick, J.
发明人： NEISS, Jason, H. , SCHWEITZER, Robert , TREADO, Patrick, J.
IPC分类号： G01J3/44
摘要： In one embodiment, the disclosure relates to a method for detecting and classifying an unknown substance in a sample. The method including the steps of (a) providing a spectrum for each of a predetermined number of reference substances; (b) detecting an area of interest on said unknown substance; (c) targeting said area of interest; (d) determining a spectrum from said area of interest; (e) comparing the determined spectrum with the spectrum of one of the reference substances; and (f) classifying said unknown substance based on the comparison of spectra.

38. 发明申请

WO2022016156A1 SYSTEMS AND METHODS OF CONFORMAL SPECTRAL LIBRARY TRAINING 审中-公开
公开(公告)号：WO2022016156A1
公开(公告)日：2022-01-20
申请号：PCT/US2021/042232
申请日：2021-07-19
申请人： CHEMIMAGE CORPORATION
发明人： TREADO, Patrick, J. , NELSON, Matthew, P. , TAZIK, Shawna , SCHWEITZER, Robert, C.
IPC分类号： G01J3/28 , G01J3/30 , G01J3/36 , G01N21/25 , G01N21/31 , G02F1/347 , G01J2003/2826 , G01J2003/2833 , G01J2003/2836 , G01J3/2823
摘要： The conformal spectral library training method (CSLTM) of the disclosure allows sets of voltages for an optical filter to be calculated by way of a direct calculation. Methods, optical devices, and software are disclosed.

39. 发明申请

WO2020159682A2 SYSTEMS AND METHODS OF COVERT IDENTIFICATION 审中-公开
公开(公告)号：WO2020159682A2
公开(公告)日：2020-08-06
申请号：PCT/US2020/012769
申请日：2020-01-08
申请人： CHEMIMAGE CORPORATION
发明人： TREADO, Patrick, J. , CAUDLE, David, W. , NELSON, Matthew, P. , TAZIK, Shawna
IPC分类号： G01N21/27
摘要： In order to avoid friendly fire incidents in the combat theater, novel covert identification systems and methods of identifying friendly forces are provided. The systems include at least a spectroscopic imaging device and a marker that interact with each other by using a synchronized, predetermined filter tuning sequence. The filter tuning sequence enables interacted photons to wavelength hop according to the predetermined tuning sequence. As a result, the covert identification system allows friendly forces to clearly identify each while avoiding detection by enemy forces that employ conventional broadband and night vision sensors.

40. 发明申请

WO2020163338A1 QUANTIFICATION OF HEART FAILURE USING MOLECULAR CHEMICAL IMAGING 审中-公开
公开(公告)号：WO2020163338A1
公开(公告)日：2020-08-13
申请号：PCT/US2020/016589
申请日：2020-02-04
申请人： CHEMIMAGE CORPORATION
发明人： COHEN, Jeffrey, K. , POST, J. Christopher , STEWART, Shona , TREADO, Patrick, J. , GOMER, Heather , SMITH, Aaron
IPC分类号： A61B5/1455 , G01N21/17 , G02F1/1335 , A61B5/05 , A61B5/00 , G01J3/28
摘要： Systems and methods of detecting and monitoring edema in a subject are described. The systems and methods include light sources, image detectors, filters, and processors that determine whether a subject has edema and the degree of severity. In some embodiments, the processor fuses data from more than one imaging modality.

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