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31. 发明申请

WO2016144615A1 SYSTEMS, DEVICES, AND METHODS FOR ELECTRICAL STIMULATION USING A CHEMICAL BIOMARKER FOR FEEDBACK TO ADJUST STIMULATION PARAMETERS 审中-公开
标题翻译：使用化学生物标记进行电刺激的系统，设备和方法进行反馈以调整刺激参数
公开(公告)号：WO2016144615A1
公开(公告)日：2016-09-15
申请号：PCT/US2016/020266
申请日：2016-03-01
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： PARRAMON, Jordi
IPC分类号： A61N1/36 , A61B5/04
CPC分类号： A61N1/36139 , A61B5/14546 , A61B5/4824 , A61N1/36021 , A61N1/36071
摘要： An electrical stimulation system includes a chemical biomarker sensor to monitor, measure, or observe a chemical biomarker in a body of a patient; a control module to use stimulation parameters to provide electrical stimulation signals to an electrical stimulation lead coupled to the control module for stimulation of patient tissue; and a processor to communicate with the chemical biomarker sensor to generate an adjustment to one or more of the stimulation parameters based on the monitoring, measurement, or observation of the chemical biomarker by the chemical biomarker sensor. One example of a chemical biomarker sensor is an adenosine sensor.
摘要翻译：电刺激系统包括用于监测，测量或观察患者体内的化学生物标志物的化学生物标志物传感器; 控制模块，其使用刺激参数来向耦合到控制模块的电刺激引线提供电刺激信号，以刺激患者组织; 以及处理器，用于与化学生物标志物传感器通信，以基于由化学生物标志物传感器监测，测量或观察化学生物标志物来产生对一个或多个刺激参数的调整。化学生物标志物传感器的一个实例是腺苷传感器。

32. 发明申请

WO2016048967A1 PERCEPTION CALIBRATION OF NEURAL TISSUE USING FIELD TROLL 审中-公开
标题翻译：使用现场手册对神经组织的认知校准
公开(公告)号：WO2016048967A1
公开(公告)日：2016-03-31
申请号：PCT/US2015/051365
申请日：2015-09-22
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： MOFFITT, Michael A. , HERSHEY, Bradley Lawrence , ZHU, Changfang , PARRAMON, Jordi , KOTHANDARAMAN, Sridhar
IPC分类号： A61N1/372 , A61N1/36
CPC分类号： A61N1/36132 , A61N1/0551 , A61N1/36071 , A61N1/36185 , A61N1/37247
摘要： An example of a system may include an electrode arrangement, a neural modulation generator configured to use electrodes in the electrode arrangement to generate a modulation field, a communication module configured to receive commands, a memory configured to store modulation field parameter data, and a controller configured to control the neural modulation generator to generate the modulation field. The controller may be configured to implement a trolling routine to troll the modulation field through neural tissue positions, and implement a marking routine multiple times as the modulation field is trolled through the neural tissue positions to identify when the modulation field provides patient-perceived modulation. The marking procedure implemented by the controller may receive a marking command that indicates that a modulation intensity achieved the patient-perceived modulation, and store in the memory the modulation field parameter data that affects the modulation intensity in response to receiving the marking command.
摘要翻译：系统的示例可以包括电极装置，被配置为在电极装置中使用电极以产生调制场的神经调制发生器，被配置为接收命令的通信模块，被配置为存储调制场参数数据的存储器和控制器被配置为控制神经调制发生器以产生调制场。控制器可以被配置为实现拖曳程序以通过神经组织位置来拖动调制场，并且当调制域被牵引穿过神经组织位置时，多次执行标记程序，以识别调制域何时提供患者感知的调制。由控制器执行的标记过程可以接收指示调制强度达到患者感知调制的标记指令，并且响应于接收到标记命令而将影响调制强度的调制场参数数据存储在存储器中。

33. 发明申请

WO2014145222A3 SYSTEMS FOR DELIVERING SUBTHRESHOLD THERAPY TO A PATIENT 审中-公开
公开(公告)号：WO2014145222A3
公开(公告)日：2014-09-18
申请号：PCT/US2014/029945
申请日：2014-03-15
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： VANSICKLE, Dennis, Allen , LEE, Dongchul , KOTHANDARAMAN, Sridhar , DOAN, Que, T. , ZHU, Changfang , PARRAMON, Jordi , HOLLEY, Justin , HERSHEY, Bradley, L. , GILLESPIE, Christopher, E. , CARBUNARU, Rafael , WAHAB, Nazim
IPC分类号： A61N1/36 , A61N1/372 , A61B5/055
摘要： An external control device for programming an implantable neuromodulator coupled to an electrode array is provided. The external control device comprises a user interface including a programming selection control element configured for allowing a user to select one of a first programming mode (e.g., a semi- automated programming mode) having a first limit on a modulation parameter and a second programming mode (e.g., a semi-automated programming mode) having a second limit on the modulation parameter different from the first limit. In one embodiment, the modulation parameter is a pulse rate, in which case, the first limit may be, e.g., an upper limit value less than 1500 Hz, and the second limit may be, e.g., a lower limit value greater than 1500 Hz. In another embodiment, the modulation parameter is a pulse width, in which case, the first limit may be, e.g., a lower limit value greater than 100 [micro]s, and the second limit may be, e.g., an upper limit value less than 100 ps. In still another embodiment, the modulation parameter is an electrode combination (e.g., a fractionalized electrode combination), in which case, the first limit may be, e.g., a range of electrode combinations having only anodic electrodes as primary modulating electrodes, and the second limit may be, e.g., a range of electrode combinations having only cathodic electrodes as primary modulating electrodes, or the first limit may be, e.g., a range of monopolar electrode combinations, and the second limit may be, e.g., a range of multipolar electrode combinations.

34. 发明申请

WO2018075791A1 NEUROMODULATION SYSTEM AND METHOD FOR PRODUCING MULTI-PHASIC FIELDS 审中-公开
标题翻译：用于产生多相场的神经调节系统和方法
公开(公告)号：WO2018075791A1
公开(公告)日：2018-04-26
申请号：PCT/US2017/057426
申请日：2017-10-19
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： PARRAMON, Jordi , ZHANG, Tianhe , CARBUNARU, Rafael
IPC分类号： A61N1/36
CPC分类号： A61N1/36189 , A61N1/0551 , A61N1/36062 , A61N1/36071 , A61N1/36146 , A61N1/36164 , A61N1/36167 , A61N1/37247
摘要： Multi-phasic fields (2206) are to be produced at a neuromodulation site using electrodes. A first phase (2202) is to be directed at a target region in order to inject a first-polarity electrical charge into the target region and a second phase (2204) is to be directed at portions of the neuromodulation site other than the target region in order to inject a second-polarity electrical charge, opposite the first-polarity electrical charge, into those portions of the neuromodulation site to essentially neutralize the first-polarity charge injected at the neuromodulation site while maintaining at least a portion of the first-polarity charge at the target region. In some cases, each electrode used as an anode to produce the first phase is to be used as a cathode to produce the second phase and each electrode used as a cathode to produce the first phase is to be used as an anode to produce the second phase.
摘要翻译：使用电极将在神经调节位点产生多阶段场（2206）。第一阶段（2202）将被引导到目标区域以便将第一极性电荷注入到目标区域中，并且第二阶段（2204）将被指引到除了目标区域之外的神经调节位点的部分为了将与第一极性电荷相反的第二极性电荷注入神经调节位点的那些部分中以基本中和在神经调节位点处注入的第一极性电荷，同时保持第一极性的至少一部分在目标区域收费。在一些情况下，将用作阳极以产生第一相的每个电极用作阴极以产生第二相，并且将用作阴极以产生第一相的每个电极用作阳极以产生第二相相。

35. 发明申请

WO2018039117A1 NEUROMODULATION SYSTEM FOR PROVIDING PARESTHESIA AND ANALGESIA AND A SYSTEM WITH LEADS AND WITH ELECTRODES 审中-公开
标题翻译：神经调节系统用于提供包皮和镇痛药以及带引线和带电极的系统
公开(公告)号：WO2018039117A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/047784
申请日：2017-08-21
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： PARRAMON, Jordi , DOAN, Que T.
IPC分类号： A61N1/36
CPC分类号： A61N1/36062 , A61N1/0551 , A61N1/36071 , A61N1/36171 , A61N1/372
摘要： Systems and methods are disclosed for providing a paresthesia therapy to a patient, wherein providing the paresthesia therapy may include delivering to the patient an electrical waveform (900) having a duration and having a distribution of frequencies in the range of 0.001 kHz to 20 kHz and wherein the distribution of frequencies includes a first frequency group of one or more frequencies and a second frequency group of one or more frequencies.
摘要翻译：公开了用于向患者提供感觉异常疗法的系统和方法，其中提供感觉异常疗法可以包括向患者递送具有持续时间并具有在患者中的频率分布的电波形（900）范围为0.001kHz至20kHz，并且其中频率分布包括一个或多个频率的第一频率组和一个或多个频率的第二频率组。

36. 发明申请

WO2016048976A1 SUB-PERCEPTION MODULATION RESPONSIVE TO PATIENT INPUT 审中-公开
标题翻译：对患者输入的子感觉调节
公开(公告)号：WO2016048976A1
公开(公告)日：2016-03-31
申请号：PCT/US2015/051378
申请日：2015-09-22
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： PARRAMON, Jordi , HERSHEY, Bradley Lawrence , MOFFITT, Michael A. , ZHU, Changfang
IPC分类号： A61N1/36 , A61N1/05 , A61N1/372
CPC分类号： A61N1/36132 , A61N1/0551 , A61N1/36071 , A61N1/36139 , A61N1/36142 , A61N1/37247
摘要： An example of a system may include electrodes on at least one lead configured to be operationally positioned for use in modulating neural tissue. The neural tissue may include at least one of dorsal horn tissue, dorsal root tissue or dorsal column tissue. The system may include an implantable device including a neural modulation device and a controller. The neural modulation device may be configured to use at least some of the electrodes to generate a modulation field to deliver sub-perception modulation to the neural tissue. The sub-perception modulation may have an intensity below a patient-perception threshold. The patient-perception threshold may be a boundary below which a patient does not sense generation of the modulation field. The controller may be configured to control the neural modulation device to generate the modulation field, and automatically adjust the modulation field in response to a patient input.
摘要翻译：系统的示例可以包括至少一个引线上的电极，其被配置为可操作地定位以用于调节神经组织。神经组织可以包括背角组织，背根组织或背侧组织中的至少一个。该系统可以包括包括神经调制装置和控制器的可植入装置。神经调制装置可以被配置为使用至少一些电极来产生调制场，以将子感知调制传递给神经组织。子感知调制可能具有低于患者感知阈值的强度。患者感知阈值可以是边界，在该边界下，患者不会感测到调制场的产生。控制器可以被配置为控制神经调制装置以产生调制场，并且响应于患者输入自动调整调制场。

37. 发明申请

WO2015108814A1 CIRCUITRY FOR CHARGING A BATTERY IN AN IMPLANTABLE MEDICAL DEVICE IN ACCORDANCE WITH HISTORICAL PARAMETERS IMPACTING BATTERY CAPACITY 审中-公开
标题翻译：根据影响电池容量的历史参数，在可植入医疗设备中为电池充电的电路
公开(公告)号：WO2015108814A1
公开(公告)日：2015-07-23
申请号：PCT/US2015/011005
申请日：2015-01-12
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： MARNFELDT, Goran, N. , CARBUNARU, Rafael , PARRAMON, Jordi
IPC分类号： A61N1/378 , H02J7/00 , A61N1/36
CPC分类号： A61N1/36128 , A61N1/36025 , A61N1/3605 , A61N1/36125 , A61N1/3708 , A61N1/378 , A61N1/3787 , A61N2001/36039 , H02J7/0057
摘要： An algorithm programmed into the control circuitry of a rechargeable-battery Implantable Medical Device (IMD) is disclosed that can adjust the charging current (Ibat) provided to the rechargeable battery over time (e.g., the life of the IMD) in accordance with one or more of the parameters having an effect on rechargeable battery capacity, such as number of charging cycles, charging current, discharge depth, load current, and battery calendar age. The algorithm consults such parameters as stored over the history of the operation of the IMD in a parameter log, and in conjunction with a battery capacity database reflective of the effect of these parameters on battery capacity, estimates a change in the capacity of the battery, and adjust the charging current in one or both of trickle and active charging paths to slow the loss of battery capacity and extend the life of the IMD.
摘要翻译：公开了一种编程到可充电电池植入式医疗装置（IMD）的控制电路中的算法，其可以根据一个或多个可调节医疗装置（IMD）随时间调整提供给可再充电电池的充电电流（例如，IMD的寿命）更多的参数对充电电池容量有影响，例如充电次数，充电电流，放电深度，负载电流和电池日历时间。该算法参考存储在参数日志中的IMD操作历史的参数，并结合反映这些参数对电池容量的影响的电池容量数据库，估计电池容量的变化，并且在涓流和有源充电路径中的一个或两个中调整充电电流以减慢电池容量的损失并延长IMD的寿命。

38. 发明申请

WO2015031136A1 SYSTEMS FOR ADJUSTING THE COMPLIANCE VOLTAGE IN A NEUROMODULATION DEVICE 审中-公开
标题翻译：用于调节神经修正装置中的合格电压的系统
公开(公告)号：WO2015031136A1
公开(公告)日：2015-03-05
申请号：PCT/US2014/051941
申请日：2014-08-20
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： SHI, Jess Weiqian , PARRAMON, Jordi , MARNFELDT, Goran N.
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36153 , A61N1/0534 , A61N1/36125 , A61N1/36128 , A61N1/36139 , A61N1/36178
摘要： A therapeutic neuromodulation system configured for providing therapy to a patient. The therapeutic neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to a plurality of electrodes implanted within tissue, analog output circuitry configured for delivering therapeutic electrical energy between the plurality of electrical terminals in accordance with a set of modulation parameters that includes a defined current value, a voltage regulator configured for supplying an adjustable compliance voltage to the analog output circuitry, and control/processing circuitry configured for automatically performing a compliance voltage calibration process at a compliance voltage adjustment interval by periodically computing an adjusted compliance voltage value as a function of a compliance voltage margin. The control/processing circuitry may also be configured for automatically adjusting at least one of the compliance voltage adjustment interval and the compliance voltage margin during the compliance voltage calibration process.
摘要翻译：被配置为向患者提供治疗的治疗性神经调节系统。治疗性神经调节系统包括被配置为分别耦合到植入组织内的多个电极的多个电端子，模拟输出电路被配置为根据一组调制参数在多个电端子之间递送治疗电能，所述调制参数包括定义的电流值，被配置为向模拟输出电路提供可调整的顺应性电压的电压调节器，以及被配置为通过周期性地将调整的顺应性电压值周期性地计算为顺应性电压调整间隔来自动执行遵从电压校准过程的控制/处理电路，符合电压裕度的功能。控制/处理电路还可以被配置为在顺应性电压校准过程期间自动调整顺应性电压调节间隔和顺应性电压裕度中的至少一个。

39. 发明申请

WO2014004557A1 NEUROSTIMULATION SYSTEM FOR ENABLING MAGNETIC FIELD SENSING WITH A SHUT-DOWN HALL SENSOR 审中-公开
标题翻译：用于使用下降霍尔传感器实现磁场感应的神经网络系统
公开(公告)号：WO2014004557A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/047684
申请日：2013-06-25
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： FELDMAN, Emanuel , PARRAMON, Jordi , BOCEK, Joseph M. , GURURAJ, Kiran
IPC分类号： A61N1/362 , A61N1/39 , A61N1/37 , A61N1/36
CPC分类号： A61N1/36128 , A61N1/36003 , A61N1/36007 , A61N1/3605 , A61N1/36082 , A61N1/36142 , A61N1/362 , A61N1/3718 , A61N1/3925 , A61N1/3956
摘要： An implantable medical device capable of being placed between a first operational mode and a second operational mode. The medical device comprises a magnetic field sensing device configured for outputting a signal in response to sensing a magnetic field. The medical device further comprises a logic circuit configured for continuously asserting the signal during a time period when the neurostimulation device is in the first operational mode, and intermittently asserting the signal during at least one time period when the neurostimulation device is in the second operational mode. The medical device further comprises a delay circuit configured for introducing a time delay into the asserted signal, the time delay being less than the time period, but greater than each of the at least one time period. The medical device further comprises control circuitry configured for performing a function in response to receiving the delayed signal at a first input terminal.
摘要翻译：一种能够放置在第一操作模式和第二操作模式之间的可植入医疗装置。医疗装置包括被配置为响应于感测磁场而输出信号的磁场感测装置。该医疗装置还包括逻辑电路，该逻辑电路被配置为在神经刺激装置处于第一操作模式的时间周期期间连续断言信号，并且在神经刺激装置处于第二操作模式的至少一个时间段内间歇地断言该信号。该医疗装置还包括延迟电路，该延迟电路被配置为将时间延迟引入所述被确定的信号中，所述时间延迟小于所述时间段，但大于所述至少一个时间段中的每一个。医疗装置还包括被配置为响应于在第一输入端接收延迟信号而执行功能的控制电路。

40. 发明申请

WO2013138511A1 NEUROSTIMULATION SYSTEM FOR PREVENTING MAGNETICALLY INDUCED CURRENTS IN ELECTRONIC CIRCUITRY 审中-公开
标题翻译：用于防止电子电路中的磁感应电流的神经网络系统
公开(公告)号：WO2013138511A1
公开(公告)日：2013-09-19
申请号：PCT/US2013/031015
申请日：2013-03-13
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
发明人： GURURAJ, Kiran , WEERAKOON, Pujitha , MARNFELDT, Goran N. , PARRAMON, Jordi , MURTONEN, Salomo , FELDMAN, Emanuel
IPC分类号： A61N1/08
CPC分类号： A61N1/36142 , A61N1/08 , A61N1/086 , A61N1/36 , A61N1/3605
摘要： A neurostimulation device capable of being placed between an active stimulation state and an inactive stimulation state and method of using same. The neurostimulation device comprises a plurality of electrical terminals configured for being respectively coupled to a plurality of stimulation electrodes, a first solid-state switching device coupled to a first one of the electrical terminals, a variable power source coupled to the first switching device, and a controller configured for, when the neurostimulation device is in the inactive stimulation state, prompting the variable power source to selectively output a relatively low voltage to place the first switching device into a first open state and a relatively high voltage to place the first switching device into a second open state.
摘要翻译：能够置于主动刺激状态和非活动刺激状态之间的神经刺激装置及其使用方法。神经刺激装置包括被配置为分别耦合到多个刺激电极的多个电端子，耦合到电端子中的第一个的第一固态开关装置，耦合到第一开关装置的可变电源，以及控制器，被配置为当所述神经刺激装置处于非激活刺激状态时，促使所述可变电源选择性地输出相对低的电压以将所述第一开关装置置于第一开启状态和相对高的电压以将所述第一开关装置进入第二个开放状态。

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