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31. 发明申请

WO9858633A3 MICRODOSE THERAPY OF VASCULAR CONDITIONS BY NO DONORS 审中-公开
标题翻译：血管病变的微阵列治疗
公开(公告)号：WO9858633A3
公开(公告)日：1999-08-12
申请号：PCT/CA9800603
申请日：1998-06-22
申请人： UNIV KINGSTON , ADAMS MICHAEL A , HEATON JEREMY P W , BANTING JAMES D
发明人： ADAMS MICHAEL A , HEATON JEREMY P W , BANTING JAMES D
IPC分类号： A61K45/00 , A61K31/04 , A61K31/16 , A61K31/198 , A61K31/21 , A61K31/295 , A61K31/34 , A61K31/5377 , A61K38/06 , A61P15/00 , A61P15/10 , A61P43/00
CPC分类号： A61K38/063 , A61K31/04 , A61K31/16 , A61K31/198 , A61K31/21 , A61K31/295 , A61K31/34 , A61K31/5377
摘要： Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET), are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (1/2 to 1/20) of those known to induce vasodilation in "normal" circulations. The low doses of these agents effectively alleviate vascular conditions associated with a reduction in NO production or an attenuation of NO effect, by restoring balance in vascular tone while exerting almost no systemic effect in normal vasculature.
摘要翻译：提供了用于治疗血管紧张度局部不平衡相关血管病变的方法，这些假说主要是内皮素升高（ET）引起的。所述方法包括给予一氧化氮（NO），能够提供NO的试剂，例如NO供体，活化脯氨酸环化酶的试剂，例如YC-1，或延长内源性NO或环鸟苷酸单磷酸的作用的试剂 cGMP;第二信使分子），例如磷酸二酯酶（PDE）抑制剂。根据本发明，通过本领域已知的任何途径，以最小剂量或微量剂量施用这些试剂，以提供已知诱导的剂量的约一半至约二十分之一（1/2至1/20）的剂量 “正常”循环中的血管舒张。低剂量的这些药物通过恢复血管紧张度的平衡，同时在正常脉管系统中几乎没有全身作用，有效缓解与NO产生减少或NO作用减弱相关的血管病变。

32. 发明申请

WO9840055A3 ANTI-EPILEPTOGENIC AGENTS 审中-公开
标题翻译：抗血小板药物
公开(公告)号：WO9840055A3
公开(公告)日：1999-02-18
申请号：PCT/CA9800244
申请日：1998-03-12
申请人： UNIV KINGSTON , WEAVER DONALD F , MILNE PAUL H , TAN CHRISTOPHER Y K , CARRAN JOHN R
发明人： WEAVER DONALD F , MILNE PAUL H , TAN CHRISTOPHER Y K , CARRAN JOHN R
IPC分类号： A61K31/197 , A61K31/216 , A61K31/495 , A61K31/505 , A61K38/00 , A61K45/00 , A61P25/08 , C07C229/28 , C07C229/34 , C07C229/42 , C07C233/54 , C07D239/54 , C07D241/08 , C07D241/18 , A61K31/00
CPC分类号： C07D241/18 , A61K31/197 , A61K31/495 , C07C229/28 , C07C229/34 , C07C229/42 , C07C233/54 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2601/20
摘要： Methods and compounds useful for the inhibition of convulsive disorders, including epilepsy, are disclosed. The methods and compounds of the invention inhibit or prevent ictogenesis and epileptogenesis. Methods for preparing the compounds of the invention are also described.

33. 发明申请

WO9007111A3 METHOD FOR PREDICTING BIOLOGICAL ACTIVITY OF ANTIBIOTICS, AND NOVEL NON BETA-LACTAM ANTIBACTERIAL AGENTS DERIVED THEREFROM 审中-公开
标题翻译：用于预测抗生素生物活性的方法，以及衍生自其的新型非BETA-LACTAM抗生素代谢物
公开(公告)号：WO9007111A3
公开(公告)日：1990-07-12
申请号：PCT/GB8901493
申请日：1989-12-13
申请人： HICKS RICHARD , UNIV KINGSTON
发明人： WOLFE SAUL , BRUDER STEPHEN
IPC分类号： G01N33/00 , A61K31/535 , A61K31/5375 , A61K31/545 , A61K31/546 , A61K31/55 , A61K31/554 , A61P31/04 , C07B61/00 , C07D223/06 , C07D241/06 , C07D265/30 , C07D267/08 , C07D273/06 , C07D279/12 , C07D285/36 , C07D501/00 , C07K1/00 , C07K7/06 , G01N33/15 , C07D501/60 , G01N33/68
CPC分类号： G01N33/15
摘要： A molecular model of the interaction of various non β-lactam antibiotics with the active site of a penicillin receptor has been developed so that it is now possible to predict the ''fit'' and ''reactivity'' of potential antibacterial compounds with this receptor. Novel structural types and compounds are defined.

34. 发明申请

WO2007098611A1 COMPOSITIONS FOR TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的组合物
公开(公告)号：WO2007098611A1
公开(公告)日：2007-09-07
申请号：PCT/CA2007000352
申请日：2007-03-05
申请人： UNIV KINGSTON , JIA ZONGCHAO , SINGH VINAY K
发明人： JIA ZONGCHAO , SINGH VINAY K
IPC分类号： C07K14/435 , A61K9/127 , A61K38/08 , A61K38/10 , A61K38/17 , A61K47/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/46
CPC分类号： A61K9/127 , A61K38/00 , C07K14/47 , C07K2319/70 , C12N15/62
摘要： Synthetic peptides containing an ankyrin repeat-like motif or portion thereof and mimetics thereof which interact with synuclein-gamma (SNCG) and reduce SNCG- mediated resistance of SNCG-expressing cancer cells to treatment with anticancer drugs or inhibit tumorigenesis and cancer cell proliferation are provided. Compositions containing these peptides, portions thereof or mimetics thereof are also provided. Methods for use of these peptides or portions thereof, compositions, and mimetics thereof in potentiating efficacy of anticancer drugs, in particular microtubule inhibitors and hormonal cancer therapies, and in treating cancer are also provided.
摘要翻译：提供了含有锚蛋白重复样基序或其部分的合成肽和其与突触核蛋白-γ（SNCG）相互作用并且将SNCG介导的表达SNCG的癌细胞对抗癌药物治疗或抑制肿瘤发生和癌细胞增殖的抗性相互作用的模拟物。还提供了含有这些肽，其部分或其模拟物的组合物。还提供了使用这些肽或其部分，组合物和其模拟物在抗癌药物，特别是微管抑制剂和激素治疗方法以及治疗癌症方面的功效的方法。

35. 发明申请

WO2007068102A2 OIL DISPERSIBLE POLYMER NANOPARTICLES 审中-公开
标题翻译：油分散聚合物纳米粒子
公开(公告)号：WO2007068102A2
公开(公告)日：2007-06-21
申请号：PCT/CA2006002020
申请日：2006-12-12
申请人： UNIV KINGSTON , LIU GUOJUN
发明人： LIU GUOJUN
IPC分类号： C10M171/06
CPC分类号： C10M171/06 , B82Y30/00 , C10N2220/082 , Y10T428/2998
摘要： There is disclosed an oil-dispersible nanoparticle comprising metal-binding functional groups on its surface. Preferably, the nanoparticle is derived from substantially spherical polymer micelles of (A 1-y C y ) n B m diblocks or (A 1-y C y ) n B m (A 1-y C y ) n , triblocks. A method for producing the nanoparticles is also described. The nanoparticles are particularly useful as lubricant additives.
摘要翻译：公开了在其表面上包含金属结合官能团的油分散性纳米粒子。优选地，纳米颗粒衍生自基本上球形的（A 1-y C _{y ）n B _{m >二嵌段或（A _{1-y _{y ）_{n B _{m （A _{1-y C _{y ）_{n ，triplelocks。还描述了用于制造纳米颗粒的方法。纳米颗粒特别适用作润滑剂添加剂。}}}}}}}}}

36. 发明申请

WO2005076695A3 METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY 审中-公开
标题翻译：调节神经营养介导活性的方法
公开(公告)号：WO2005076695A3
公开(公告)日：2005-10-13
申请号：PCT/IB2005001050
申请日：2005-02-11
申请人： PAINCEPTOR PHARMA CORP , UNIV KINGSTON , ROSS GREGORY M , SZAREK WALTER A , VOHRA RAHUL
发明人： ROSS GREGORY M , SZAREK WALTER A , VOHRA RAHUL
IPC分类号： A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/513 , A61P29/00
CPC分类号： A61K31/42 , A61K31/513
摘要： Disclosed are compositions which modulate the interaction of nerve growth factor and brain-derived neurotrophic factor with neurotrophic receptors, comprising contacting cells expressing a neurotrophin receptor with an effective amount of a compound of Formulas 1-6. Also disclosed are methods of using the compositions of the invention for the treatment of pain, inflammatory disorder and neurological disorder in subject in need.
摘要翻译：公开了调节神经生长因子和脑源性神经营养因子与神经营养受体的相互作用的组合物，包括使表达神经营养因子受体的细胞与有效量的式1-6化合物接触。还公开了使用本发明的组合物治疗需要的受试者的疼痛，炎性疾病和神经障碍的方法。

37. 发明申请

WO0180890A3 FORMULATIONS AND METHODS OF USING NITRIC OXIDE MIMETICS AGAINST A MALIGNANT CELL PHENOTYPE 审中-公开
标题翻译：使用硝化氧化物对抗恶性细胞溶液的制剂和方法
公开(公告)号：WO0180890A3
公开(公告)日：2002-08-08
申请号：PCT/CA0100566
申请日：2001-04-26
申请人： UNIV KINGSTON , ADAMS MICHAEL A , GRAHAM CHARLES H , HEATON JEREMY P W , POSTOVIT LYNNE-MARIE
发明人： ADAMS MICHAEL A , GRAHAM CHARLES H , HEATON JEREMY P W , POSTOVIT LYNNE-MARIE
IPC分类号： G01N33/48 , A61K31/00 , A61K31/198 , A61K31/21 , A61K33/00 , A61K45/00 , A61K45/06 , A61P13/08 , A61P35/00 , A61P35/04 , G01N33/53 , A61K33/26
CPC分类号： A61K45/06 , A61K31/00 , A61K31/198 , A61K31/21 , A61K33/00 , Y10S514/908 , Y10S514/929 , A61K2300/00
摘要： Methods and formulations for inhibiting and preventing a malignant cell phenotype by administering to cells a low dose of a nitric oxide mimetic are provided.
摘要翻译：提供了通过向细胞施用低剂量的一氧化氮模拟物来抑制和预防恶性细胞表型的方法和制剂。

38. 发明申请

WO0012110A3 USE OF ANTI(W)PRESSOR AGENTS FOR VASCULAR REMODELING IN GENITAL DYSFUNCTION 审中-公开
标题翻译： ANTI（W）压力器用于血管重建的遗传性功能障碍
公开(公告)号：WO0012110A3
公开(公告)日：2000-08-03
申请号：PCT/CA9900787
申请日：1999-08-25
申请人： UNIV KINGSTON , ADAMS MICHAEL A , HEATON JEREMY P W
发明人： ADAMS MICHAEL A , HEATON JEREMY P W
IPC分类号： A61K31/00 , A61K31/502 , A61K31/513 , A61K31/519 , A61K31/5575 , A61K45/06 , A61P15/10
CPC分类号： A61K31/519 , A61K31/00 , A61K31/502 , A61K31/513 , A61K31/5575 , A61K45/06
摘要： The present invention provides a method of administration of an agent which acts to remodel neuronal or vascular pathways for the long term management of sexual dysfunction in both males and females. In a preferred embodiment, the invention provides a method of ameliorating or reversing pathogenic vascular degradative modeling in the ilio-hypogastric-pudental arterial bed and genitalia comprising administering to a human patient in need of such treatment a therapeutically effective amount of an anti-pressor agent. The anti-pressor agent comprises one or more compounds selected from the therapeutic classes of direct vasodilators such as hydralazine and NO donors, ACE inhibitors, angiotensin-II receptor antagonists, alpha 1-adrenergic receptor antagonists, beta -adrenergic receptor antagonists, calcium channel blockers, and phosphodiesterase inhibitors. The anti-pressor agent may be co-administered with a diuretic compound, and is administered either chronically at low dose, or for short periods of time at doses higher than are typically used for the treatment of hypertension. In certain embodiments of the method of the invention, the anti-pressor agent is co-administered with a diuretic agent and/or prostaglandin-E1.
摘要翻译：本发明提供了一种用于改变神经元或血管途径以在男性和女性中长期治疗性功能障碍的药剂的给药方法。在一个优选的实施方案中，本发明提供了一种改善或逆转髂下腹部 - 动脉血管床和生殖器中的病原性血管降解模型的方法，包括向需要这种治疗的人类患者施用治疗有效量的抗压力剂。抗压剂包含一种或多种选自直接血管扩张剂如肼屈嗪和NO供体的治疗类别的化合物，ACE抑制剂，血管紧张素-II受体拮抗剂，α1-肾上腺素能受体拮抗剂，β-肾上腺素能受体拮抗剂，钙通道阻滞剂，和磷酸二酯酶抑制剂。抗压剂可以与利尿剂共同施用，并且以低于通常用于治疗高血压的剂量以低剂量或长时间给药。在本发明方法的某些实施方案中，抗压剂与利尿剂和/或前列腺素-E1共同施用。

39. 发明申请

WO9806048A3 Molecular modelling of neurotrophin-receptor binding 审中-公开
标题翻译：神经营养因子受体结合的分子建模
公开(公告)号：WO9806048A3
公开(公告)日：1998-08-06
申请号：PCT/CA9700539
申请日：1997-07-31
申请人： UNIV KINGSTON , SHAMOVSKY IGOR L , ROSS GREGORY M , RIOPELLE RICHARD J , WEAVER DONALD F
发明人： SHAMOVSKY IGOR L , ROSS GREGORY M , RIOPELLE RICHARD J , WEAVER DONALD F
IPC分类号： C07K14/475 , G06F17/50 , G06F19/16 , C07K1/00 , G01N33/68
CPC分类号： G06F19/16 , C07K14/475
摘要： The present invention relates to a computational method for identifying the bioactive conformations of peptide domains, in particular, the geometries of complexes of neurotrophins and their receptors. The bioactive conformation of the Nerve Growth Factor (NGF) amino and carboxyl termini (Trk binding domain) was determined. The complex of the NGF termini splits into two distinct regions: a rigid region (residues 9-11 and 112'-118') and a flexible loop (residues 1-8). The geometry of the rigid region, which is maintained by electrostatic interaction between Glu11 and Arg118', is conserved in active molecules only. The separation of the flexible loop from the rigid region is necessary in order to eliminate an influence of the loop on the biologically active conformation of the rigid region. The present invention also relates to a method for identifying and theoretically modelling specific receptor binding sites for Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) on their receptors, TrkA and TrkB, respectively. The present invention also relates to a method for identifying and theoretically modelling a receptor binding site for neurotrophins, such as NGF, BDNF, NT-3, and NT-4/5, of the common neurotrophin receptor p75NTR.

40. 发明申请

WO9827969A2 ANTIMICROBIAL PHENAZINE COMPOUNDS 审中-公开
标题翻译：抗微生物化合物
公开(公告)号：WO9827969A2
公开(公告)日：1998-07-02
申请号：PCT/CA9700978
申请日：1997-12-24
申请人： UNIV KINGSTON , ZOUTMAN DICK , NAKATSU KANJI , VUKOMANOVIC DRAGIC , MARKS GERALD , BRIEN JAMES
发明人： ZOUTMAN DICK , NAKATSU KANJI , VUKOMANOVIC DRAGIC , MARKS GERALD , BRIEN JAMES
IPC分类号： A61K31/498 , A61K31/00
CPC分类号： A61K31/498
摘要： Phenazine compounds having antimicrobial activity are described. The phenazine compounds can be phenazine N-oxides, including phenazine-5,10-dioxides, which may optionally be substituted at one or more positions, preferably the 7- and/or 8-positions of the phenazine nucleus. Also described are methods for treating microbial infections, and methods for inhibiting the growth of a microbial cell. The microbes treated or inhibited can be multidrug resistant.
摘要翻译：描述了具有抗微生物活性的吩嗪化合物。吩嗪化合物可以是吩嗪N-氧化物，包括吩嗪-5,10-二氧化物，其可任选在吩嗪核的一个或多个位置，优选7-和/或8-位取代。还描述了用于治疗微生物感染的方法，以及抑制微生物细胞生长的方法。处理或抑制的微生物可以是多重耐药性的。

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