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31. 发明申请

WO2015160699A1 NOVEL HYDROGEL TISSUE EXPANDERS 审中-公开
标题翻译：新型HYDROGEL TISSUE扩展器
公开(公告)号：WO2015160699A1
公开(公告)日：2015-10-22
申请号：PCT/US2015/025556
申请日：2015-04-13
申请人： AKINA, INC. (AN INDIANA (US) CORP) , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS , BARCO, Clark, Tobias
发明人： BARCO, Clark, Tobias , PARK, Kinam , PARK, Haesun , FU, Yourong , GARNER, John, Solomon
IPC分类号： C08G81/00
CPC分类号： C08J3/075 , A61B17/8858 , A61B90/02 , A61B2017/00004 , A61B2017/00898 , A61B2017/681 , A61C8/0006 , A61F2/2803 , A61F2310/00383 , A61K47/34 , C08F299/024 , C08G81/00 , C08J2353/00
摘要： The present invention provides tissue expanders comprising biodegradable, chemically cross-linked hydrogels which are elastic in the dry state. These biocompatible tissue expanders are self-inflating and membrane-free. They swell slowly and elicit minimal negative tissue responses, while allowing for rapid and easy manipulation by the surgeon at the time of emplacement.
摘要翻译：本发明提供了包含在干燥状态下是弹性的可生物降解的，化学交联的水凝胶的组织扩张器。这些生物相容的组织扩张器是自膨胀和无膜的。它们缓慢膨胀并引起最小的负面组织反应，同时允许外科医生在放置时快速和容易地操作。

32. 发明申请

WO2015089087A1 COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY INJURY OR DISEASE 审中-公开
标题翻译：用于治疗呼吸道损伤或疾病的组合物和方法
公开(公告)号：WO2015089087A1
公开(公告)日：2015-06-18
申请号：PCT/US2014/069368
申请日：2014-12-09
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： CHEN, Beibei , MALLAMPALLI, Rama
IPC分类号： A61K31/505 , A61K31/137 , A61P11/00 , A61P29/00
CPC分类号： A61K31/137 , A61K9/007 , A61K31/341 , A61K31/381 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/427 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K45/06 , C07C211/27 , C07D295/135 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D417/12
摘要： A method for treating a respiratory injury or disease comprising: administering to a patient in need of treatment a pharmaceutical composition comprising a compound of general Formula I: or salt, ester, solvate, hydrate, or prodrug thereof; wherein: x is an integer from 1 to 10; A and B are each, independently, C 3-7 cycloalkyl, C 3-7 cycloalkyl-Ci-6alkyl, C 3-7 heterocycloalkyl, C 3-7 heterocycloalkyl-C 1-6 alkyl, C 6-1 oaryl, C 6-1 oaryl-C 1-6 alkyl, C 3-9 heteroaryl, or C 3-9 heteroaryl-C 1-6 alkyl; and n and p are each, independently, integers from 1 to 10; and a pharmaceutically acceptable carrier, excipient, or diluent.
摘要翻译：一种治疗呼吸道损伤或疾病的方法，包括：向需要治疗的患者施用包含通式I化合物或其盐，酯，溶剂合物，水合物或前药的药物组合物; 其中：x是1至10的整数; A和B各自独立地为C 3-7环烷基，C 3-7环烷基-C 1-6烷基，C 3-7杂环烷基，C 3-7杂环烷基-C 1-6烷基，C 6-8芳基，C 6-8芳基-C 1-6烷基，C 3 -9杂芳基或C 3-9杂芳基-C 1-6烷基; n和p各自独立地为1至10的整数; 和药学上可接受的载体，赋形剂或稀释剂。

33. 发明申请

WO2014178931A1 SOBETIROME IN THE TREATMENT OF MYELINATION DISEASES 审中-公开
标题翻译：治疗放血疾病中的SOBETIROME
公开(公告)号：WO2014178931A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/014943
申请日：2014-02-05
申请人： SCANLAN, Thomas, S. , HARTLEY, Meredith , PLACZEK, Andrew , RIGHI, Marco , BOURDETTE, Dennis , MARRACCI, Gail , CHAUDHARY, Priya , OREGON HEALTH & SCIENCE UNIVERSITY , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： HARTLEY, Meredith , PLACZEK, Andrew , RIGHI, Marco , BOURDETTE, Dennis , MARRACCI, Gail , CHAUDHARY, Priya
IPC分类号： A61K38/24 , A61P25/00 , A61P25/28 , C07C59/48
CPC分类号： A61K31/192 , A61K9/0053 , A61K9/0095
摘要： Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath are described. The methods include administration of a therapeutically effective amount of sobetirome, or a pharmaceutically acceptable salt thereof.
摘要翻译：描述了治疗患有或具有发展与脱髓鞘有关的神经变性疾病或病症的风险的受试者的方法，髓鞘脱髓鞘或髓鞘的不发达。所述方法包括施用治疗有效量的sobetirome或其药学上可接受的盐。

34. 发明申请

WO2013185010A1 HUMAN BISPECIFIC EGFRvIII ANTIBODY ENGAGING MOLECULES 审中-公开
标题翻译：人类BISPECIFIC EGFRvIII抗体联合分子
公开(公告)号：WO2013185010A1
公开(公告)日：2013-12-12
申请号：PCT/US2013/044672
申请日：2013-06-07
申请人： DUKE UNIVERSITY , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： BIGNER, Darell , KUAN, Chien-Tsun , SAMPSON, John , CHOI, Bryan , PASTAN, Ira H.
IPC分类号： C07K16/18 , C12N15/13 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/92 , C12N15/11
摘要： We have constructed bispecific antibody engaging molecules which have one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The engaging moleculess are highly cytotoxic and antigen-specific. These are promising therapeutic agents.
摘要翻译：我们已经构建了双特异性抗体接合分子，其具有特异性接合在其表面上表达人EGFRvIII突变蛋白的肿瘤细胞的一个臂，以及特异性结合T细胞激活配体CD3的第二个臂。接合分子是高度细胞毒性和抗原特异性的。这些是有希望的治疗剂。

35. 发明申请

WO2013184202A1 FBXO3 INHIBITORS 审中-公开
标题翻译： FBXO3抑制剂
公开(公告)号：WO2013184202A1
公开(公告)日：2013-12-12
申请号：PCT/US2013/030995
申请日：2013-03-13
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： CHEN, Beibel , MALLAMPALLI, Rama, K.
IPC分类号： C07D213/36 , C07D295/135 , C07D277/28 , C07D333/20 , C07D307/52 , C07D233/60 , C07D231/10 , C07D239/26 , C07D471/04 , C07D471/10 , C07D413/12 , A61K31/137 , A61K31/5375 , A61P3/10 , A61P11/06 , A61P19/00 , A61P25/00 , A61P35/00 , C07C15/12 , C07C13/10 , A61K31/402 , A61K31/4418 , A61K31/4155 , A61K31/427 , A61K31/381 , A61K31/341 , A61K31/506
CPC分类号： A61K31/506 , A61K31/137 , A61K31/341 , A61K31/381 , A61K31/402 , A61K31/4155 , A61K31/4178 , A61K31/427 , A61K31/435 , A61K31/4418 , A61K31/444 , A61K31/5375 , C07C211/01 , C07C211/53 , C07C229/38 , C07D207/06 , C07D211/14 , C07D213/06 , C07D213/36 , C07D213/38 , C07D231/12 , C07D233/61 , C07D233/64 , C07D239/26 , C07D265/30 , C07D277/28 , C07D295/135 , C07D401/12 , C07D403/12 , Y02A50/411 , Y02A50/473
摘要： The present application discloses benzathine and related compounds and their use as FBXO-3 inhibitors.
摘要翻译：本申请公开了苄星青霉素及其相关化合物及其作为FBXO-3抑制剂的用途。

36. 发明申请

WO2013106847A1 COMPOUNDS, COMPOSITIONS AND ASSOCIATED METHODS COMPRISING 3-ARYL QUINOLINES 审中-公开
标题翻译：化合物，组合物和包含3-芳基喹啉的相关方法
公开(公告)号：WO2013106847A1
公开(公告)日：2013-07-18
申请号：PCT/US2013/021472
申请日：2013-01-14
申请人： OREGON HEALTH & SCIENCE UNIVERSITY , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： RISCOE, Michael K. , WINTER, Rolf W. , POU, Sovitj , HINRICHS, David J. , KELLY, Jane Xu , LI, Yuexin , NILSEN, Aaron
IPC分类号： C07D215/40 , A61K31/47 , A61P33/06
CPC分类号： C07D215/46 , A61K31/47 , C07D401/12 , Y02A50/411
摘要： Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed.
摘要翻译：提供了可用于治疗感染性疾病的化合物，组合物和方法。特别地，公开了3-芳基喹啉化合物，其合成，其药物组合物和治疗感染性疾病如疟疾的方法。

37. 发明申请

WO2011139633A2 HIGHLY POROUS CERAMIC OXIDE AEROGELS HAVING IMPROVED FLEXIBILITY 审中-公开
标题翻译：具有改进灵活性的高分子陶瓷氧化物气凝胶
公开(公告)号：WO2011139633A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/033774
申请日：2011-04-25
申请人： OHIO AEROSPACE INSTITUTE , UNITED STATES GOVERNMENT, AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION , MEADOR, Mary Ann B. , NGUYEN, Baochau N. , GUO, Haiquan
发明人： MEADOR, Mary Ann B. , NGUYEN, Baochau N. , GUO, Haiquan
IPC分类号： C07F7/08 , C07F7/04 , C07F7/18 , C08G77/04
CPC分类号： C07F7/21 , C08G77/26
摘要： Ceramic oxide aerogels having improved flexibility are disclosed. Preferred embodiments exhibit high modulus and other strength properties despite their improved flexibility. The gels may be polymer cross-linked via organic polymer chains to further improve strength properties, without substantially detracting from the improved flexibility. Methods of making such aerogels are also disclosed.
摘要翻译：公开了具有改进的柔性的陶瓷氧化物气凝胶。优选的实施方案尽管具有改进的柔性，但表现出高模量和其它强度性能。凝胶可以通过有机聚合物链进行聚合物交联，以进一步提高强度性能，而不会显着降低改进的柔韧性。还公开了制造这种气凝胶的方法。

38. 发明申请

WO2008008370A2 ADAPTIVE SPACED TEACHING METHOD AND SYSTEM 审中-公开
标题翻译：自适应间隔教学方法和系统
公开(公告)号：WO2008008370A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/015779
申请日：2007-07-11
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF VETERANS AFFAIRS , KERFOOT, Branch, Price, III
发明人： KERFOOT, Branch, Price, III
IPC分类号： G06F19/00
CPC分类号： G09B7/00
摘要： The system of the present invention provides interactive spaced education and combines the pedagogical merits of the spacing effect and the testing effect to improve a learner's ability to learn and retain conceptual items. A test item, such as a question or educational material regarding a concept, is delivered, a learner's response is recorded, and the correct answer to the test item is provided. Future delivery of additional test items is customized with regard to its content, difficulty, and time interval based on information from the learner's response(s). The electronic delivery includes a structured repetition over spaced intervals of time as well as retesting the learner with subsequent test items based on new levels of difficulty, new delivery intervals, and new content areas. The present invention, by combining spaced education with adaptive learning, improves the learner's ability to learn, recall, and retain items of information.
摘要翻译：本发明的系统提供交互式间隔教育并结合间隔效应和测试效果的教学优点，以提高学习者学习和保留概念项目的能力。一个测试项目，例如关于一个概念的问题或教育材料被交付，一个学习者的回答被记录下来，并且提供了测试项目的正确答案。根据学习者的回答提供的信息，可以根据其内容，难度和时间间隔定制未来的额外测试项目。电子交付包括间隔时间间隔的结构化重复，以及根据新难度水平，新交付间隔和新内容区域对学习者重新测试随后的测试项目。本发明通过将间隔教育与自适应学习相结合，提高了学习者学习，回忆和保留信息项目的能力。

39. 发明申请

WO2002083069A2 TRUNCATED RECOMBINANT MAJOR OUTER MEMBRANE PROTEIN ANTIGEN (R56) OF ORIENTA TSUTSUGAMUSHI STRAINS KARP, KATO AND GILLIAM AND ITS USE IN ANTIBODY BASED DETECTION ASSAYS AND VACCINES. 审中-公开
标题翻译： TS HI HI HI HI HI HI HI HI HI STR EN EN AN AN AN AN AN（（。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。
公开(公告)号：WO2002083069A2
公开(公告)日：2002-10-24
申请号：PCT/US2002/011379
申请日：2002-04-12
申请人： UNITED STATES GOVERNMENT as represented by THE UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES , CHING, Wei-Mei , KELLY, Daryl, J. , DASCH, Gregory, A.
发明人： CHING, Wei-Mei , KELLY, Daryl, J. , DASCH, Gregory, A.
IPC分类号： A61K
CPC分类号： C07K14/29 , A61K39/00 , A61K2039/53 , Y02A50/403
摘要： A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orienta tsutsugamushi or the karp, kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulations and production of immune globulins for passive prophylaxis and immunity in subjects.
摘要翻译：已经产生了由恙虫病恙虫病ts the the the the the ushi ushi k k from from from from from polypeptide polypeptide polypeptide polypeptide。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。本发明可用于检测先前暴露于斑疹伤寒症，筛选和/或鉴定至少一种感染性菌株相似性（即，卡普样，加藤样或吉利安样菌株），其基于其对截短的反应强度蛋白质和作为疫苗制剂中的组分和免疫球蛋白的产生，用于受试者的被动预防和免疫。

40. 发明申请

WO1991004051A1 PEPTIDES INCLUDING CTL EPITOPES OF HIV PROTEINS AND USE THEREOF 审中-公开
标题翻译：包括HIV蛋白的CTL外显子及其用途的肽
公开(公告)号：WO1991004051A1
公开(公告)日：1991-04-04
申请号：PCT/US1990005343
申请日：1990-09-19
申请人： MEDIMMUNE, INC. , UNITED STATES GOVERNMENT as represented by THE ... , FUERST, Thomas , KOENIG, Scott
发明人： MEDIMMUNE, INC. , UNITED STATES GOVERNMENT as represented by THE ...
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： Peptide fragments of HIV proteins such as NEF protein, GAG protein, and ENV protein, which include a CTL epitope. Such peptide fragments containing CTL epitopes may be used to induce or augment cellular immune responses against HIV virus to treat or prevent infection of the animal with HIV virus.
摘要翻译： HIV蛋白质的肽片段，例如NEF蛋白质，GAG蛋白质和ENV蛋白质，其包括CTL表位。含有CTL表位的这些肽片段可用于诱导或增加针对HIV病毒的细胞免疫应答，以治疗或预防用HIV病毒感染动物。

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