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31. 发明申请

WO2008069938A2 METHOD OF FORMING A TABLET 审中-公开
标题翻译：形成片剂的方法
公开(公告)号：WO2008069938A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/024489
申请日：2007-11-28
申请人： SCOLR PHARMA, INC. , HITE, Michael , FEDERICI, Cathy , BRUNELLE, Alan , TURNER, Stephen
发明人： HITE, Michael , FEDERICI, Cathy , BRUNELLE, Alan , TURNER, Stephen
IPC分类号： A61K9/16 , A61K9/22 , A61K31/192
CPC分类号： A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K31/192
摘要： A method of forming a tablet includes the steps of pre-blending an active pharmaceutical ingredient susceptible to tackiness and a blending additive with a first mixing effort to form a pre-blend mixture, wherein the first mixing effort and a second mixing effort, resulting from mixing at least one excipient with the pre-blend mixture, form a blend suitable for direct compression and compressing the blend to form the tablet. One way of achieving the first mixing effort is to pre-blend for an extended period of time. The method allows for directly compressing the blend without the need for a granulation step or roller compression. One such active pharmaceutical ingredient susceptible to tackiness is ibuprofen.
摘要翻译：形成片剂的方法包括以下步骤：将具有粘性的活性药物成分和混合添加剂预先混合以形成预混物混合物，其中第一混合力和第二混合力由将至少一种赋形剂与预混物混合物混合，形成适于直接压缩和压缩混合物以形成片剂的共混物。实现第一次混合努力的一种方式是预混合一段较长的时间。该方法允许直接压缩共混物，而不需要造粒步骤或辊压缩。易于粘性的一种这样的活性药物成分是布洛芬。

32. 发明申请

WO2007075873A3 PROTEIN ENGINEERING STRATEGIES TO OPTIMIZE ACTIVITY OF SURFACE ATTACHED PROTEINS 审中-公开
标题翻译：蛋白质工程策略优化表面附着蛋白的活性
公开(公告)号：WO2007075873A3
公开(公告)日：2007-11-29
申请号：PCT/US2006048764
申请日：2006-12-21
申请人： PACIFIC BIOSCIENCES CALIFORNIA , HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFF , PHAM THANG , RANK DAVID , TURNER STEPHEN
发明人： HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFF , PHAM THANG , RANK DAVID , TURNER STEPHEN
IPC分类号： C12N11/00 , C12N11/16 , G01N33/53
CPC分类号： C12N9/22 , C07K2319/21 , Y10T428/2991 , Y10T428/2993 , Y10T428/2996 , Y10T428/31663 , Y10T428/31768
摘要： Isolated and/or recombinant enzymes that include surface binding domains, surfaces with active enzymes bound to them and methods of coupling enzymes to surfaces are provided. Enzymes can include large and/or multiple surface coupling domains for surface coupling.
摘要翻译：提供了包括表面结合结构域，具有与其结合的活性酶的表面和将酶偶联到表面的方法的分离和/或重组酶。酶可以包括用于表面偶联的大和/或多个表面偶联域。

33. 发明申请

WO2007123763A2 ARTICLES HAVING LOCALIZED MOLECULES DISPOSED THEREON AND METHODS OF PRODUCING SAME 审中-公开
标题翻译：具有本地化分子的制品及其生产方法
公开(公告)号：WO2007123763A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/008019
申请日：2007-03-29
申请人： PACIFIC BIOSCIENCES OF CALIFORNIA, INC. , RANK, David, R. , WEGENER, Jeffery , KORLACH, Jonas , ROITMAN, Daniel , XU, Yue , LYLE, John , TURNER, Stephen , PELUSO, Paul , OTTO, Geoff
发明人： RANK, David, R. , WEGENER, Jeffery , KORLACH, Jonas , ROITMAN, Daniel , XU, Yue , LYLE, John , TURNER, Stephen , PELUSO, Paul , OTTO, Geoff
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , B01J19/0046 , B01J2219/00427 , B01J2219/0045 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y20/00 , B82Y30/00 , C12Q1/6837 , Y10T29/49002 , C12Q2565/629 , C12Q2527/127
摘要： Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
摘要翻译：通过使用底物的元素来辅助活性化学基团在基底的所需区域中的定位来制备具有选定的活性化学区域的基底的方法。所述方法可以包括用于沉积，去除，激活和/或去活衬底的选定区域中的化学基团的光学，化学和/或机械方法，以提供衬底的选择性活性区域。

34. 发明申请

WO2007115205A2 IMPROVED METHODS, SYSTEMS AND COMPOSITIONS FOR MONITORING ENZYME ACTIVITY AND APPLICATIONS THEREOF 审中-公开
标题翻译：用于监测酶活性的改进方法，系统和组合物及其应用
公开(公告)号：WO2007115205A2
公开(公告)日：2007-10-11
申请号：PCT/US2007065687
申请日：2007-03-30
申请人： PACIFIC BIOSCIENCES CALIFORNIA , KORLACH JONAS , TURNER STEPHEN
发明人： KORLACH JONAS , TURNER STEPHEN
IPC分类号： G01C21/32
CPC分类号： C12Q1/66 , C12Q1/42 , G01N33/573
摘要： Methods of monitoring enzyme mediated reactions, and particularly nucleic acid synthesis reactions such as pyrosequencing methods that employ enzymatic reporter systems. The methods and systems provide elevated signal levels as compared to conventional pyrosequencing processes, and/or mediate de-phasing of sequencing analyses employing pyrosequencing or other "sequencing by synthesis" methods.
摘要翻译：监测酶介导的反应的方法，特别是核酸合成反应，例如采用酶报告系统的焦磷酸测序方法。与常规焦磷酸测序方法相比，该方法和系统提供升高的信号水平，和/或介导使用焦磷酸测序或其他“合成测序”方法进行测序分析的脱相。

35. 发明申请

WO2007075987A2 ACTIVE SURFACE COUPLED POLYMERASES 审中-公开
标题翻译：活性表面偶联聚合物
公开(公告)号：WO2007075987A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048973
申请日：2006-12-21
申请人： PACIFIC BIOSCIENCES OF CALIFORNIA, INC. , HANZEL, David , KORLACH, Jonas , PELUSO, Paul , OTTO, Geoffrey , PHAM, Thang , RANK, David , TURNER, Stephen
发明人： HANZEL, David , KORLACH, Jonas , PELUSO, Paul , OTTO, Geoffrey , PHAM, Thang , RANK, David , TURNER, Stephen
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： C12Q1/6837 , C07K2319/23 , C12N9/1252 , C12Q1/6844 , C12Q2521/101 , C12Q2565/531
摘要： Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
摘要翻译：提供活性表面偶联的聚合酶，包括这种聚合酶的表面，以及制备和使用表面连接的聚合酶的方法。

36. 发明申请

WO2007019582A2 METHODS AND SYSTEMS FOR MONITORING MULTIPLE OPTICAL SIGNALS FROM A SINGLE SOURCE 审中-公开
标题翻译：用于从单个源监视多个光信号的方法和系统
公开(公告)号：WO2007019582A2
公开(公告)日：2007-02-15
申请号：PCT/US2006/031387
申请日：2006-08-10
申请人： PACIFIC BIOSCIENCES FOR CALIFORNIA, INC. , LUNDQUIST, Paul , TURNER, Stephen , ZACCARIN, Denis
发明人： LUNDQUIST, Paul , TURNER, Stephen , ZACCARIN, Denis
IPC分类号： G02B6/00
CPC分类号： G01N21/6452 , G01J3/2803 , G01J3/36 , G01N21/6428
摘要： Methods and systems for monitoring a plurality of different optical signals from a single source of such signals, where each such different optical signal is spatially separated from other such signals and directed to different detectors or locations upon a single detector, which direction is generally accomplished through the use of a small number of optical components and/or manipulations.
摘要翻译：用于从这种信号的单个源监测多个不同光信号的方法和系统，其中每个这样的不同光信号在单个检测器上与其他这样的信号在空间上分离并被引导到不同的检测器或位置，该方向通常通过使用少量的光学部件和/或操纵。

37. 发明申请

WO2006044078A2 APPARATUS AND METHOD FOR ANALYSIS OF MOLECULES 审中-公开
标题翻译：用于分析分子的装置和方法
公开(公告)号：WO2006044078A2
公开(公告)日：2006-04-27
申请号：PCT/US2005/033052
申请日：2005-09-16
申请人： PACIFIC BIOSCIENCES OF CALIFORNIA, INC. , TURNER, Stephen , KORLACH, Jonas
发明人： TURNER, Stephen , KORLACH, Jonas
IPC分类号： H05H3/04
CPC分类号： G01N21/6452 , B01L3/5085 , B01L2200/0668 , B01L2300/0654 , B01L2300/0896 , B82Y20/00 , B82Y30/00 , G02B6/13 , Y10T436/10
摘要： The present invention relates to optical confinements, method of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.
摘要翻译：本发明涉及光学限制，其制备方法和使用它们分析分子和/或监测化学反应的方法。本发明中体现的装置和方法对于高通量和低成本的单分子分析特别有用。

38. 发明申请

WO2005049876A3 HIGH-PURITY TITANIUM-NICKEL ALLOYS WITH SHAPE MEMORY 审中-公开
标题翻译：具有形状记忆的高纯钛镍合金
公开(公告)号：WO2005049876A3
公开(公告)日：2005-08-04
申请号：PCT/US2004034972
申请日：2004-10-22
申请人： HONEYWELL INT INC , LOVE DAVID B , TURNER STEPHEN P , XU YUN
发明人： LOVE DAVID B , TURNER STEPHEN P , XU YUN
IPC分类号： C22C14/00 , C22C19/03
CPC分类号： C22C19/03 , C22F1/006
摘要： The invention includes an alloy containing equivalent amounts of nickel and titanium. The alloy has shape memory and a metallic purity of at least about 99.995%, and comprises less than about 200 ppm of gases. The invention also includes an alloy comprising titanium and nickel where the titanium and nickel amounts are non-equivalent. The alloy has shape memory and has a metallic purity of at least 99.995%, and contains less than about 200 ppm of gases. The invention further includes a method of producing a shape memory alloy. Titanium is provided having a metallic purity of at least 99.999% and nickel is provided having a metallic purity of at least 99.99%. The titanium and nickel are combined utilizing at least one melting event independently selected from e-beam melting, vacuum arc melting, vacuum induction melting, induction skull melting and plasma melting.
摘要翻译：本发明包括含有等量的镍和钛的合金。该合金具有形状记忆和至少约99.995％的金属纯度，并且包含小于约200ppm的气体。本发明还包括含有钛和镍的合金，其中钛和镍的量是不等价的。该合金具有形状记忆并具有至少99.995％的金属纯度，并且含有小于约200ppm的气体。本发明还包括一种生产形状记忆合金的方法。提供具有至少99.999％的金属纯度的钛和提供具有至少99.99％的金属纯度的镍。利用独立选自电子束熔化，真空电弧熔化，真空感应熔化，感应头骨熔化和等离子熔化的至少一个熔化事件来合并钛和镍。

39. 发明申请

WO2004032184B1 LOW TEMPERATURE SALICIDE FORMING MATERIALS AND SPUTTERING TARGETS FORMED THEREFROM 审中-公开
标题翻译：低温杀菌剂形成材料和溅射目标
公开(公告)号：WO2004032184B1
公开(公告)日：2005-01-27
申请号：PCT/US0324968
申请日：2003-08-06
申请人： HONEYWELL INT INC , THOMAS MICHAEL A , DANIELS BRIAN , TURNER STEPHEN P , LEE EAL H
发明人： THOMAS MICHAEL A , DANIELS BRIAN , TURNER STEPHEN P , LEE EAL H
IPC分类号： C23C14/14 , C23C14/34 , C22C19/03 , C22C19/07 , C22C22/00
CPC分类号： C23C14/3414 , C23C14/14
摘要： Metal-based precursor materials as described herein have an overall Curie temperature and include: a) a first material constituent having a first Curie temperature component; and b) at least one additional material constituent having a second Curie temperature component, wherein the overall Curie temperature is lower than the first Curie temperature component. Methods are also described of forming a metal-based salicide precursor material having an overall Curie temperature including: a) providing a first material constituent having a first Curie temperature component; b) providing at least one additional material constituent having a second Curie temperature component; and c) combining the first material constituent and the at least one additional material constituent such that the overall Curie temperature is lower than the first Curie temperature.
摘要翻译：本文所述的基于金属的前体材料具有总体居里温度，并且包括：a）具有第一居里温度分量的第一材料成分; 和b）具有第二居里温度分量的至少一种另外的材料成分，其中总居里温度低于第一居里温度分量。还描述了形成总体居里温度的基于金属的自对准硅化物前体材料的方法，包括：a）提供具有第一居里温度分量的第一材料成分; b）提供具有第二居里温度分量的至少一种另外的材料成分; 以及c）将所述第一材料成分和所述至少一种另外的材料成分相结合，使得总的居里温度低于第一居里温度。

40. 发明申请

WO2003049689A3 ISOFLAVONE COMPOSITION FOR ORAL DELIVERY 审中-公开
公开(公告)号：WO2003049689A3
公开(公告)日：2003-06-19
申请号：PCT/US2002/039032
申请日：2002-12-06
申请人： NUTRACEUTIX, INC. , HITE, Michael, P. , FEDERICI, Catherine , TURNER, Stephen, J.
发明人： HITE, Michael, P. , FEDERICI, Catherine , TURNER, Stephen, J.
IPC分类号： A61K35/78
摘要： A controlled release delivery system composition and method for oral administration of an isoflavone is disclosed.

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