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31. 发明申请

WO2012115608A2 POLYAMINE INHIBITORS FOR THE TREATMENT AND PREVENTION OF PARKINSON'S DISEASE 审中-公开
标题翻译：用于治疗和预防帕金森病的多胺抑制剂
公开(公告)号：WO2012115608A2
公开(公告)日：2012-08-30
申请号：PCT/US2011000386
申请日：2011-02-26
申请人： UNIV COLUMBIA , SMALL SCOTT A , LEWANDOWSKI NICOLE , LANDRY DONALD W , DENG SHI-XIANG
发明人： SMALL SCOTT A , LEWANDOWSKI NICOLE , LANDRY DONALD W , DENG SHI-XIANG
IPC分类号： A61K31/197 , A61K31/132 , A61P25/16 , C07C229/26 , C07D241/08 , C07D243/04
CPC分类号： C07D243/04 , A61K31/132 , A61K31/197 , C07C229/26 , C07C271/22 , C07D241/08
摘要： Disclosed herein are methods for treating a disease involving a-synucleic aggregation using (1) a compound which reduces the amount of polyamines in an amount effective to reduce a-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce a-synucleic aggregation; or (3) a compound which inhibits a- synucleic aggregation in an amount effective to reduce a-synucleic aggregation. Also disclosed are methods for reducing the amount of a-synucleic aggregation in a brain cell using (1) a compound which reduces the amount of polyamines in an amount effective to reduce a-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce a-synucleic aggregation; or (3) a compound which inhibits a- synucleic aggregation in an amount effective to reduce a-synucleic aggregation. Disclosed herein are also compounds which can be used in the above described methods.
摘要翻译：本文公开了使用以下方法治疗涉及α-鸟氨酸聚集的疾病的方法：（1）以有效减少α-鸟氨酸聚集的量减少多胺的量的化合物; （2）以有效降低α-鸟氨酸聚集的量抑制多胺合成的化合物; 或（3）以有效减少α-鸟氨酸聚集的量抑制聚集度的化合物。还公开了使用（1）以有效减少α-鸟氨酸聚集的量减少多胺的量的化合物来减少脑细胞中α-突触聚集的量的方法; （2）以有效降低α-鸟氨酸聚集的量抑制多胺合成的化合物; 或（3）以有效减少α-鸟氨酸聚集的量抑制聚集度的化合物。本文公开的也是可以用于上述方法的化合物。

32. 发明申请

WO2012088420A1 HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF 审中-公开
标题翻译：乙酰胆碱酯酶调节剂及其用途
公开(公告)号：WO2012088420A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/066851
申请日：2011-12-22
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , FRANCIS, Yitshak , FA, Mauro , ARANCIO, Ottavio , FIORITO, Jole , DENG, Shixian , LANDRY, Donald, W. , LUZAC, Michal , FENG, Yan
发明人： FRANCIS, Yitshak , FA, Mauro , ARANCIO, Ottavio , FIORITO, Jole , DENG, Shixian , LANDRY, Donald, W. , LUZAC, Michal , FENG, Yan
IPC分类号： A01N55/02
CPC分类号： C07C217/22 , C07C217/58 , C07C235/60 , C07C235/64 , C07C251/24 , C07D209/48 , C07D265/14 , C07D265/36 , C07D295/088
摘要： The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
摘要翻译：本发明提供了包含调节组蛋白酰基转移酶（HAT）的化合物的化合物和组合物。本发明进一步提供了通过向受试者施用调节HAT的化合物来治疗神经变性疾病，与累积的淀粉样蛋白β肽沉积物相关的病症，Tau蛋白水平和/或α-突触核蛋白的积累以及癌症的方法。

33. 发明申请

WO2012009553A1 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF 审中-公开
标题翻译： ALDOSE还原抑制剂及其用途
公开(公告)号：WO2012009553A1
公开(公告)日：2012-01-19
申请号：PCT/US2011/044038
申请日：2011-07-14
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , WASMUTH, Andrew , LANDRY, Donald, W. , DENG, Shi, Xian , RAMASAMY, Ravichandran , SCHMIDT, Ann Marie , MYLARI, Banavara, L.
发明人： WASMUTH, Andrew , LANDRY, Donald, W. , DENG, Shi, Xian , RAMASAMY, Ravichandran , SCHMIDT, Ann Marie , MYLARI, Banavara, L.
IPC分类号： C07D487/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.
摘要翻译：本发明涉及新颖的化合物及其药物组合物，以及用于促进皮肤健康老化，皮肤病症治疗，心血管疾病治疗，肾脏疾病治疗，血管生成障碍如癌症治疗的治疗方法的组织损伤，例如非心脏组织损伤，进展性心肌梗死的治疗，以及治疗各种其它疾病，例如由本发明的化合物和组合物引起的糖尿病并发症。其它障碍可以包括但不限于动脉粥样硬化，冠状动脉疾病，糖尿病性肾病，糖尿病性神经病，糖尿病性视网膜病，皮肤感染，外周血管疾病，中风等。

34. 发明申请

WO2007079392A3 REAL-TIME ASSAYS OF NEURO-HUMORAL TO ASSESS CARDIOVASCULAR STRESS 审中-公开
标题翻译：实时评估神经心理学评估心血管应激
公开(公告)号：WO2007079392A3
公开(公告)日：2007-09-20
申请号：PCT/US2006062665
申请日：2006-12-28
申请人： UNIV COLUMBIA , LANDRY DONALD W , OLIVER JUAN , STOJANOVIC MILAN N
发明人： LANDRY DONALD W , OLIVER JUAN , STOJANOVIC MILAN N
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： G01N33/6893 , C12N15/115 , C12N2310/16 , C12N2320/10 , G01N2800/321
摘要： The present invention relates to rapid assays for neuro-humoral factors modulated in response to cardiovascular stress and integration of data obtained from such assays to provide profiles of response to cardiovascular stress that can guide therapy.
摘要翻译：本发明涉及响应于心血管应激而调节的神经体液因子的快速分析，以及从这些分析获得的数据的整合，以提供可指导治疗的心血管应激反应曲线。

35. 发明申请

WO2007024717A2 AGENTS FOR PREVENTING AND TREATING DISORDERS INVOLVING MODULATION OF THE RYR RECEPTORS 审中-公开
标题翻译：涉及RYR受体调节的预防和治疗疾病的药剂
公开(公告)号：WO2007024717A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/032405
申请日：2006-08-17
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , MARKS, Andrew, Robert , LANDRY, Donald, W. , DENG, Shixian , CHENG, Zhen, Zhuang , LEHNART, Stephan, E.
发明人： MARKS, Andrew, Robert , LANDRY, Donald, W. , DENG, Shixian , CHENG, Zhen, Zhuang , LEHNART, Stephan, E.
IPC分类号： C07D291/08 , A61K31/554
CPC分类号： C07D281/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds of Formula I, (I) and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells.
摘要翻译：本发明提供式I，（I）的化合物及其盐，水合物，溶剂化物，络合物和前药。本发明还提供了合成式I化合物的方法。本发明另外提供包含式I化合物的药物组合物和使用式I药物组合物的方法，以治疗和预防与调节钙的RyR受体相关的疾病和疾病通道在单元格中起作用。

36. 发明申请

WO2005094457A3 NOVEL ANTI-ARRHYTHMIC AND HEART FAILURE DRUGS THAT TARGET THE LEAK IN THE RYANODINE RECEPTOR (RYR2) AND USES THEREOF 审中-公开
标题翻译：目标靶向受体（RYR2）中的漏出的新型抗精神病药和心脏衰竭药物及其用途
公开(公告)号：WO2005094457A3
公开(公告)日：2006-04-27
申请号：PCT/US2005009495
申请日：2005-03-22
申请人： UNIV COLUMBIA , MARKS ANDREW R , LANDRY DONALD W , DENG SHIXIAN , CHENG ZHEN ZHUANG
发明人： MARKS ANDREW R , LANDRY DONALD W , DENG SHIXIAN , CHENG ZHEN ZHUANG
IPC分类号： A61K31/553 , A61K31/554
CPC分类号： A61K31/554
摘要： The present invention provides methods for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject. The present invention further provides methods for treating and preventing atrial and ventricular cardiac arrhythmias, heart failure, and exercise-induced sudden cardiac death in a subject. Additionally, the present invention provides use of JTV-519 in a method for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject who has, or is a candidate for, atrial fibrillation. Also provided are uses of 1,4-benzothiazepine derivatives in methods for treating and preventing atrial and ventricular cardiac arrhythmias and heart failure in a subject, and for preventing exercise-induced sudden cardiac death. The present invention also provides methods for identifying agents for use in treating and preventing atrial fibrillation and heart failure, and agents identified by these methods.
摘要翻译：本发明提供限制或预防受试者中RyR2结合的FKBP12.6水平降低的方法。本发明还提供了治疗和预防受试者心房心室心律失常心力衰竭和运动性心源性猝死的方法。另外，本发明提供了用于限制或预防具有或已经是心房颤动候选者的受试者中RyR2结合的FKBP12.6的水平降低的方法中的JTV-519的用途。还提供了1,4-苯并硫氮杂衍生物在治疗和预防受试者的心房心室心律失常和心力衰竭以及用于预防运动性心源性猝死的方法中的用途。本发明还提供了用于鉴定用于治疗和预防心房颤动和心力衰竭的药剂的方法，以及通过这些方法鉴定的药剂。

37. 发明申请

WO2006019685A3 COMPOUNDS AND THEIR PREPARATION FOR THE TREATMENT OF ALZHEIMER'S DISEASE BY INHIBITING BETA-AMYLOID PEPTIDE PRODUCTION 审中-公开
公开(公告)号：WO2006019685A3
公开(公告)日：2006-02-23
申请号：PCT/US2005/024533
申请日：2005-07-11
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , LANDRY, Donald W. , DENG, Shixian , KIM, Tae-Wan , PARK, Jeong Hill
发明人： LANDRY, Donald W. , DENG, Shixian , KIM, Tae-Wan , PARK, Jeong Hill
IPC分类号： C07J9/00 , C07J17/00 , A61K31/575 , A61K31/58
摘要： The present invention provides novel ginsenoside compounds, compositions (e.g. pharmaceutical compositions) comprising the ginsenoside compounds, and methods for the synthesis of these ginsenoside compounds. Additionally, the present invention provides methods for inhibiting beta-amyloid peptide production and methods for treating or preventing a pathological condition, particularly, neurodegeneration diseases (e.g. Alzheimer's disease), using these ginsenoside compounds.

38. 发明申请

WO2004052918A3 PEPTIDES AND METHODS FOR DEACTIVATION OF ORGANOPHOSPHORUS-BASED NERVE AGENTS AND INSECTICIDES 审中-公开
标题翻译：用于去除基于有机磷的神经病毒和杀虫剂的肽和方法
公开(公告)号：WO2004052918A3
公开(公告)日：2005-06-02
申请号：PCT/US0339207
申请日：2003-12-08
申请人： UNIV COLUMBIA , LANDRY DONALD W , DENG SHI-XIAN
发明人： LANDRY DONALD W , DENG SHI-XIAN
IPC分类号： C07K20060101 , C12Q1/00 , C12Q1/37 , C12Q1/42 , G01N33/53
CPC分类号： C07K7/06 , C12Q1/46 , G01N33/5308
摘要： This invention provides methods and peptides for the inactivation of organophosphorus-based insecticides and chemical warfare agents. The instant methods include peptide screening methods, peptides and peptide libraries, related compositions of matter, articles of manufacture, and methods for prophylaxis, treatment, decontamination and detection.
摘要翻译：本发明提供用于灭活有机磷杀虫剂和化学战剂的方法和肽。本方法包括肽筛选方法，肽和肽文库，物质的相关组合物，制品，以及预防，处理，去污和检测方法。

39. 发明申请

WO1997049800A1 ANTI-COCAINE CATALYTIC ANTIBODY 审中-公开
标题翻译：抗COCAINE催化抗体
公开(公告)号：WO1997049800A1
公开(公告)日：1997-12-31
申请号：PCT/US1997010965
申请日：1997-06-25
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , LANDRY, Donald, W.
发明人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
IPC分类号： C12N09/00
CPC分类号： C12N9/0002 , A61K38/00
摘要： Disclosed are catalytic antibodies and polypeptides capable of degrading cocaine. Said catalytic antibodies and polypeptides are characterized by the amino acid sequence of their complementarity determining regions and framework regions. The present invention also discloses a pharmaceutical composition and a method for decreasing the concentration of cocaine in a subject. Finally, the invention discloses pharmaceutical compositions and methods for treating cocaine overdose and addiction in subjects.
摘要翻译：公开了能够降解可卡因的催化抗体和多肽。所述催化抗体和多肽的特征在于其互补决定区和框架区的氨基酸序列。本发明还公开了一种降低受试者中可卡因浓度的药物组合物和方法。最后，本发明公开了治疗可卡因过量和成瘾的药物组合物和方法。

40. 发明申请

WO1997007236A1 DETECTION OF ORGANIC COMPOUNDS THROUGH REGULATION OF ANTIBODY-CATALYZED REACTIONS 审中-公开
标题翻译：通过调节抗体反应来检测有机化合物
公开(公告)号：WO1997007236A1
公开(公告)日：1997-02-27
申请号：PCT/US1996013182
申请日：1996-08-16
申请人： LANDRY, Donald, W.
IPC分类号： C12Q01/25
CPC分类号： G01N33/5308 , G01N33/577 , G01N33/68 , G01N2333/901
摘要： The present invention provides a method for determining the presence of a target organic molecule in a sample which comprises either: (A) first, adding a substrate molecule to the sample, the substrate molecule being a conjugate of the target organic molecule and a reporter molecule; second, adding a catalytic monoclonal antidoby to the sample which: (1) recognizes and binds the target organic molecule when the target organic molecule is present in the sample and (2) recognizes and binds the substrate molecule when the target organic molecule is not present in the sample; and third detecting a change in the sample signifying the absence of the target organic molecule, the change being the product of an antibody-catalyzed reaction and thereby determining the presence of an organic molecule in the sample; or (B) first adding a substrate molecule to the sample, the substrate molecule being a conjugate of a molecule complementary to the target molecule and a reporter molecule; second adding a catalytic monoclonal antibody to the sample which: (1) recognizes and binds the target organic molecule when the target molecule is present in the sample and (2) recognizes and binds the substrate molecule only if the target molecule is present in the sample; and third detecting a change in the sample signifying the presence of the target molecule, the change being the product of an antibody-catalyzed reaction and thereby determining the presence of the target organic molecule in the sample.
摘要翻译：本发明提供了一种用于确定样品中目标有机分子的存在的方法，其包括：（A）首先，向样品中加入底物分子，底物分子是靶有机分子和报告分子的缀合物 ; 第二，向样品中加入催化单克隆抗体，其中：（1）当目标有机分子存在于样品中时识别和结合目标有机分子，和（2）当目标有机分子不存在时识别和结合底物分子在样品中第三次检测样品中不存在目标有机分子的变化，该变化是抗体催化反应的产物，从而确定样品中有机分子的存在; 或（B）首先向所述样品添加底物分子，所述底物分子是与所述靶分子互补的分子和报告分子的缀合物; 第二次向样品中加入催化单克隆抗体：（1）当靶分子存在于样品中时识别和结合目标有机分子，（2）仅当靶分子存在于样品中时识别和结合底物分子 ; 并且第三次检测表明靶分子存在的样品的变化，该变化是抗体催化反应的产物，从而确定样品中目标有机分子的存在。

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