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1. 发明申请

WO2006019685A3 COMPOUNDS AND THEIR PREPARATION FOR THE TREATMENT OF ALZHEIMER'S DISEASE BY INHIBITING BETA-AMYLOID PEPTIDE PRODUCTION 审中-公开
公开(公告)号：WO2006019685A3
公开(公告)日：2006-02-23
申请号：PCT/US2005/024533
申请日：2005-07-11
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , LANDRY, Donald W. , DENG, Shixian , KIM, Tae-Wan , PARK, Jeong Hill
发明人： LANDRY, Donald W. , DENG, Shixian , KIM, Tae-Wan , PARK, Jeong Hill
IPC分类号： C07J9/00 , C07J17/00 , A61K31/575 , A61K31/58
摘要： The present invention provides novel ginsenoside compounds, compositions (e.g. pharmaceutical compositions) comprising the ginsenoside compounds, and methods for the synthesis of these ginsenoside compounds. Additionally, the present invention provides methods for inhibiting beta-amyloid peptide production and methods for treating or preventing a pathological condition, particularly, neurodegeneration diseases (e.g. Alzheimer's disease), using these ginsenoside compounds.

2. 发明申请

WO1995023604A1 CELL GROWTH STIMULATING COMPOSITIONS CONTAINING ALOESIN 审中-公开
标题翻译：含有ALOESIN的细胞生长刺激组合物
公开(公告)号：WO1995023604A1
公开(公告)日：1995-09-08
申请号：PCT/KR1995000016
申请日：1995-03-02
申请人： NAMYANG ALOE CO., LTD. , KIM, Kyeong, Ho , PARK, Jeong, Hill , SUNG, Chung, Ki , KIM, Jin, Woong , CHOI, Jae, Sue , LEE, Seung, Ki , KIM, Yeong, Shik , SON, Byeong, Hwa , CHUNG, Myung, Hee , PARK, Young, In , KIM, Kyu, Won , LEE, Chong, Kil
发明人： NAMYANG ALOE CO., LTD.
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , A61K8/602 , A61Q19/00
摘要： The present invention relates to a cell growth stimulating composition containing aloesin as an active ingredient. More specifically, the present invention relates to a composition for stimulating cell growth, especially for stimulating epidermal cells and hepatic cells, which contains aloesin as an active ingredient. Aloesin is a component of Aloe vera, for which an effect for blocking ultraviolet ray from skin and an activity as mushroom tyrosinase inhibitor have been disclosed in the prior art. However, accordint to the present invention, it has now been identified that aloesin has the novel pharmacological use as a cell growth stimulating agent which has never been disclosed in the prior art.
摘要翻译：本发明涉及含有芦荟素作为活性成分的细胞生长刺激组合物。更具体地，本发明涉及用于刺激细胞生长的组合物，特别是用于刺激含有芦荟素作为活性成分的表皮细胞和肝细胞。芦荟是芦荟的成分，现有技术已经公开了从皮肤阻断紫外线的效果和作为蘑菇酪氨酸酶抑制剂的活性。然而，根据本发明，现在已经确定，芦荟素具有新的药理学用途作为细胞生长刺激剂，其从未在现有技术中公开。

3. 发明申请

WO1998000389A1 2-HYDROXYPROPIONIC ACID DERIVATIVE AND ITS MANUFACTURING METHOD 审中-公开
标题翻译： 2-羟基丙酸衍生物及其制备方法
公开(公告)号：WO1998000389A1
公开(公告)日：1998-01-08
申请号：PCT/KR1997000133
申请日：1997-07-02
申请人： JEW, Sang, Sup , KO, Kwang, Ho , KIM, Bak, Kwang , KANG, Suk, Ku , KIM, Deuk, Joon , KIM, Won, Ki , KIM, Hwa, Jung , MOON, Chang, Kiu , PARK, Jeong, Hill , SUH, Young, Ger , LEE, Bong, Jin , LEE, Jee, Woo , JUNG, Ki, Hwa , CHUN, Moon, Woo , HUH, Hoon , LEE, Eung, Seok , KIM, Hyung, Ook , KIM, Eun, Kyung , KIM, Sung, Jin , CHEONG, Jae, Hoon
IPC分类号： C07C69/712
CPC分类号： C07D231/12 , C07C69/708 , C07D233/56 , C07D249/08 , C07D307/42 , C07D333/16 , C07D333/26 , C07D333/32
摘要： This invention relates to a novel 2-hydroxypropionic acid derivative and its manufacturing method. Based on its mechanism to inhibit the CPT I, 2-hydroxypropionic acid derivative of this invention has blood glucose lowering effects so that the derivative may be effectively used as an antidiabetic agent having remarkable antidiabetic activity and fewer side effects.
摘要翻译：本发明涉及一种新的2-羟基丙酸衍生物及其制备方法。基于其抑制CPT I的机制，本发明的2-羟基丙酸衍生物具有降血糖作用，因此该衍生物可有效用作具有显着抗糖尿病活性和较少副作用的抗糖尿病药。

4. 发明申请

WO2008140178A1 COMPOSITION COMPRISING AN EXTRACT OF PROCESSED GINSENG FOR PREVENTING AND TREATING OBESITY AND THE USE THEREOF 审中-公开
标题翻译：包含加工金山提取物及其治疗用药的组合物及其用途
公开(公告)号：WO2008140178A1
公开(公告)日：2008-11-20
申请号：PCT/KR2008/001076
申请日：2008-02-25
申请人： GINSENG SCIENCE INC. , HWANG, Gwi Seo , JUNG, Sung Jae , LEE, Han Shin , KIM, Hyun Young , KIM, Bok Deuk , PARK, Jeong Hill , LEE, Hyang Jin
发明人： HWANG, Gwi Seo , JUNG, Sung Jae , LEE, Han Shin , KIM, Hyun Young , KIM, Bok Deuk , PARK, Jeong Hill , LEE, Hyang Jin
IPC分类号： A61K36/258
CPC分类号： A61K36/258
摘要： The present invention relates to compositions comprising an inventive extract of processed Panax genus of the present invention and the inventive extract reduced body weight, the level of total cholesterol, LDL and triglyceride in blood, increased the level of blood HDL as well as inhibited the lipid accumulation of Caenorhabditis elegans (C. elegans) . Therefore, it can be used as the therapeutics or health food for treating and preventing obesity without adverse action.
摘要翻译：本发明涉及组合物，其包含本发明的加工的Panax属的本发明提取物和本发明的提取物减少的体重，血液中总胆固醇，LDL和甘油三酯的水平，增加了血液HDL的水平以及抑制了脂质秀丽隐杆线虫（秀丽隐杆线虫）的积累。因此，它可以用作治疗或保健食品，用于治疗和预防肥胖而不产生不利影响。

5. 发明申请

WO2006019685A2 COMPOUNDS AND THEIR PREPARATION FOR THE TREATMENT OF ALZHEIMER'S DISEASE BY INHIBITING BETA-AMYLOID PEPTIDE PRODUCTION 审中-公开
标题翻译：通过抑制β-淀粉样蛋白肽生产来治疗阿尔茨海默病的化合物及其制备方法
公开(公告)号：WO2006019685A2
公开(公告)日：2006-02-23
申请号：PCT/US2005024533
申请日：2005-07-11
申请人： UNIV COLUMBIA , LANDRY DONALD W , DENG SHIXIAN , KIM TAE-WAN , PARK JEONG HILL
发明人： LANDRY DONALD W , DENG SHIXIAN , KIM TAE-WAN , PARK JEONG HILL
IPC分类号： C07J17/00 , A61K31/704
CPC分类号： C07J17/00
摘要： The present invention provides novel ginsenoside compounds, compositions (e.g. pharmaceutical compositions) comprising the ginsenoside compounds, and methods for the synthesis of these ginsenoside compounds. Additionally, the present invention provides methods for inhibiting beta-amyloid peptide production and methods for treating or preventing a pathological condition, particularly, neurodegeneration diseases (e.g. Alzheimer's disease), using these ginsenoside compounds.
摘要翻译：本发明提供了新型人参皂苷化合物，包含人参皂苷化合物的组合物（例如药物组合物），以及合成这些人参皂苷化合物的方法。此外，本发明提供了用于抑制β-淀粉样肽产生的方法以及使用这些人参皂苷化合物治疗或预防病理状态，特别是神经变性疾病（例如阿尔茨海默氏病）的方法。

6. 发明申请

WO1997031933A1 NOVEL GINSENG SAPONIN COMPOUNDS, PROCESS FOR PREPARATION THEREOF AND ANTI-TUMOR AGENT COMPRISING THE SAME AS AN ACTIVE COMPONENT 审中-公开
标题翻译：新型金山曙光化合物，其制备方法和包含其的抗肿瘤剂作为活性成分
公开(公告)号：WO1997031933A1
公开(公告)日：1997-09-04
申请号：PCT/KR1996000123
申请日：1996-07-29
申请人： CHEIL JE DANG CO. , PARK, Man, Ki , LEE, Seung, Ki , PARK, Jeong, Hill , KIM, Jong, Moon , LEE, Kwang, Youl , HAN, Sang, Beom
发明人： CHEIL JE DANG CO.
IPC分类号： C07J17/00
CPC分类号： C07J17/005
摘要： The present invention relates to novel ginseng saponin compounds having a potent anti-tumor activity, which are represented by formulae (I) and (II). The compounds (I) and (II) above are novel and can be produced by heating plants of ginseng genus for 0.5 to 20 hours at a high temperature of 110 to 180 DEG C, or can be synthesized by acetylating ginsenoside Rg3 and DELTA -ginsenoside Rg3 which are known ginseng saponin compounds, respectively. The present invention also relates to an anti-tumor composition comprising these compounds (I) and/or (II) as an active ingredient.
摘要翻译：本发明涉及由式（I）和（II）表示的具有有效抗肿瘤活性的新人参皂苷化合物。上述化合物（I）和（II）是新颖的，可以通过在110〜180℃的高温下加热人参属植物0.5〜20小时来制造，或者可以通过将人参皂甙Rg3和DELTA <20 （22）> - 人参皂苷化合物的人参皂甙Rg3。本发明还涉及包含这些化合物（I）和/或（II）作为活性成分的抗肿瘤组合物。

7. 发明申请

WO2007061182A1 A METHOD FOR PREVENTING AND TREATING THE DISEASE CAUSED BY VASCULAR DAMAGE AND THE USE THEREOF 审中-公开
标题翻译：用于预防和治疗由血管损伤引起的疾病及其使用的方法
公开(公告)号：WO2007061182A1
公开(公告)日：2007-05-31
申请号：PCT/KR2006/003699
申请日：2006-09-15
申请人： GINSENG SCIENCE INC. , PARK, Jeong Hill , KIM, Hyun Young , KWON, Young Guen , KIM, Jeong Hun , KIM, Bok Deuk , MAENG, Young Sun
发明人： PARK, Jeong Hill , KIM, Hyun Young , KWON, Young Guen , KIM, Jeong Hun , KIM, Bok Deuk , MAENG, Young Sun
IPC分类号： A61K31/704
CPC分类号： A61K36/258
摘要： The present invention relates to compositions containing an extract of processed Panax genus plant and saponin compounds isolated therefrom for treat the diseases caused by vascular injury in human or mammal, the method for treating said diseases using thereby and the use thereof. The extractof processed Panax genus plant and saponin compounds isolated therefrom shows suppressive effect on endothelial dysfunction and damage of blood-retinal on HUVEC and retinal vascular endothelial cell. Therefore, it can be used as the therapeutics or functional health food for treating and preventing the diseases caused by vascular injury.
摘要翻译：本发明涉及含有加工的Panax属植物的提取物和从其分离的皂苷化合物的组合物，用于治疗由人或哺乳动物的血管损伤引起的疾病，使用其治疗所述疾病的方法及其用途。从其中分离出的经加工的Panax属植物和皂苷化合物的提取显示对HUVEC和视网膜血管内皮细胞的内皮功能障碍和血液 - 视网膜损伤的抑制作用。因此，它可以用作治疗和预防由血管损伤引起的疾病的治疗剂或功能保健食品。

8. 发明申请

WO1998000422A1 OXIRANE CARBOXYLIC ACID DERIVATIVE AND ITS MANUFACTURING METHOD 审中-公开
标题翻译：氧化羧酸衍生物及其制备方法
公开(公告)号：WO1998000422A1
公开(公告)日：1998-01-08
申请号：PCT/KR1997000132
申请日：1997-07-02
申请人： JEW, Sang, Sup , KO, Kwang, Ho , KIM, Bak, Kwang , KANG, Suk, Ku , KIM, Deuk, Joon , KIM, Won, Ki , KIM, Hwa, Jung , MOON, Chang, Kiu , PARK, Jeong, Hill , SUH, Young, Ger , LEE, Bong, Jin , LEE, Jee, Woo , JUNG, Ki, Hwa , CHUN, Moon, Woo , HUH, Hoon , LEE, Eung, Seok , KIM, Hyung, Ook , KIM, Eun, Kyung , KIM, Sung, Jin , CHEONG, Jae, Hoon
IPC分类号： C07D405/04
CPC分类号： C07D405/12 , C07D303/48 , C07D407/12 , C07D409/12
摘要： This invention relates to a novel oxirane carboxylic acid derivative and thereof manufacturing method. Based on thereof mechanism to inhibit the CPT I, oxirane carboxylic acid derivative of this invention has blood glucose lowering effects so that the derivative may be effectively used as an antidiabetic agent having remarkable antidiabetic activity and less side effects.
摘要翻译：本发明涉及一种新型环氧乙烷羧酸衍生物及其制备方法。基于抑制CPT I的机制，本发明的环氧乙烷羧酸衍生物具有降血糖作用，使得该衍生物可有效用作具有显着抗糖尿病活性和较少副作用的抗糖尿病药。

9. 发明申请

WO1997018824A1 VASODILATING COMPOSITION 审中-公开
公开(公告)号：WO1997018824A1
公开(公告)日：1997-05-29
申请号：PCT/KR1996000207
申请日：1996-11-20
申请人： CHEIL JE DANG CO. , PARK, Man, Ki , KIM, Nak, Doo , PARK, Jeong, Hill , KIM, Jong, Moon , KANG, Su, Yeon , KIM, Wang, You
发明人： CHEIL JE DANG CO.
IPC分类号： A61K35/78
CPC分类号： A61K31/704
摘要： The present invention relates to a vasodilating composition comprising ginsenoside Rg3 and/or Rg5, one of the saponin components of ginseng, as an active ingredient. Since ginsenoside Rg3 and Rg5, the active ingredient of the composition according to the present invention, exhibit an endothelium-dependent vasodilation and do not destroy endothelium cells contrary to the ordinary saponins, they can be used safely without any side effect such as hemolysis or toxicity against fishes. Ginsenoside Rg3 and Rg5 are hardly contained in ginseng plants such as fresh ginseng, white ginseng, etc., and contained in a minor amount in red ginseng. The contents of ginsenoside Rg3 and Rg5 are increased greatly by heating ginseng plant for 0.5 to 20 hours at a high temperature of 110 to 180 DEG C.
摘要翻译：本发明涉及作为活性成分的人参皂苷成分中的人参皂甙Rg3和/或Rg5的血管舒张组合物。由于根据本发明的组合物的活性成分的人参皂甙Rg3和Rg5表现出内皮依赖性血管舒张，并且不破坏与普通皂苷相反的内皮细胞，所以可以安全使用，没有任何副作用，如溶血或毒性反对鱼在人参，白参等人参植物中几乎不含有人参皂甙Rg3和Rg5，在人参中含有少量的人参。通过在110〜180℃的高温下将人参植物加热0.5〜20小时，人参皂苷Rg3和Rg5的含量大大增加。

10. 发明申请

WO1996040181A1 PROCESSED GINSENG HAVING ENHANCED PHARMACOLOGICAL EFFECT 审中-公开
标题翻译：加工金山有增强药理作用
公开(公告)号：WO1996040181A1
公开(公告)日：1996-12-19
申请号：PCT/KR1996000087
申请日：1996-06-05
申请人： CHEIL JE DANG CO. , PARK, Man, Ki , KIM, Nak, Doo , LEE, Seung, Ki , PARK, Jeong, Hill , KIM, Jong, Moon
发明人： CHEIL JE DANG CO.
IPC分类号： A61K35/78
CPC分类号： A61K36/258 , A61K36/69 , A61K2300/00
摘要： The present invention relates to a processed ginseng having an enhanced pharmacological effect by heating ginseng at a high temperature. More specifically, the present invention relates to a processed ginseng produced by heating ginseng for 0.5 to 20 hours at 120 to 180 DEG C, of which the ratio of ginsenoside (Rg3+Rg5)/(Rc+Rd+Rb1+Rb2) is above 1.0 and thus exhibits an enhanced pharmacological activity, and to a beverage composition comprising said processed ginseng. The processed ginseng heat-treated according to the present invention provides an enhanced pharmacological effect since it contains greatly increased amount of the existing pharmacologically active components as well as newly formed pharmacologically active components in comparison with white ginseng, fresh ginseng and the like which are utilized until now.
摘要翻译：本发明涉及通过在高温下加热人参而具有增强的药理作用的加工人参。更具体地说，本发明涉及通过在120〜180℃下加热人参0.5〜20小时制成的加工人参，其中人参皂甙（Rg3 + Rg5）/（Rc + Rd + Rb1 + Rb2）的比例高于 1.0，因此表现出增强的药理活性，以及包含所述加工的人参的饮料组合物。根据本发明加热处理的人参提供了增强的药理作用，因为与使用的白参，新鲜人参等相比，其含有大量增加的现有药理活性成分以及新形成的药理活性成分到现在。

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