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    • 31. 发明申请
    • METHOD FOR TRANSMITTING A CONTROL INFORMATION ITEM FROM A CONTROL DEVICE TO A LAMP UNIT AND A LIGHTING SYSTEM SUITABLE THEREFOR, AND A LAMP UNIT AND A CONTROL DEVICE
    • 将控制信息项目从控制装置发送到灯单元和适用于其的照明系统的方法,以及灯单元和控制装置
    • WO2011054552A1
    • 2011-05-12
    • PCT/EP2010/061474
    • 2010-08-06
    • OSRAM GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNGINSTA ELEKTRO GMBHENDRES, HelmutFISCHER, KlausHOLTZ, FriedhelmKRAUSE, Karl-HeinzKREITTMAYR, JosefWEHLMANN, Friedhelm
    • ENDRES, HelmutFISCHER, KlausHOLTZ, FriedhelmKRAUSE, Karl-HeinzKREITTMAYR, JosefWEHLMANN, Friedhelm
    • H05B37/02
    • H05B37/0263
    • A method for driving at least one lamp unit (7), which is connected to an AC voltage power supply system, comprises the following steps: modulation of a control information item for the operation of the lamp unit (7) onto this supplied AC voltage, decoding of the modulation received on the lamp unit side for reading the control information item and driving the light- emitting means (6) in accordance with the control information item. In this case, provision is made for a shunt to be produced in the line (3) used for transmitting the control information item prior to or at the beginning of the modulation of the control information item. The invention also describes a lamp unit (7) and a control device (1) for implementing the method. The invention also describes a lighting system. This lighting system comprises a control device (1), which is connected to an AC voltage power supply system, with a modulator for generating a modulation on the system voltage, which modulation encodes a control information item for a light-emitting means (6), which control device is connected to the at least one light-emitting means (6) via a supply line (3) for transmitting the modulation and the electrical power. A transformer (4) for operating the light-emitting means (6) and a decoder (11), which applies its output signals to the transformer (4), for decoding the modulation of the AC voltage for determining the control information item are assigned to the light-emitting means (6). This system is characterized by the fact that a switchable constant current source (9, 10) for producing a shunt is assigned to the lamp unit (7), which comprises the transformer (4), the decoder (11) and the light-emitting means (6).
    • 一种用于驱动连接到AC电压电源系统的至少一个灯单元(7)的方法包括以下步骤:将用于灯单元(7)的操作的控制信息项调制到所提供的AC电压 对在灯单元侧接收的用于读取控制信息项的调制进行解码,并根据控制信息项驱动发光装置(6)。 在这种情况下,为控制信息项的调制之前或开始时用于发送控制信息项的行(3)中的分路进行设定。 本发明还描述了一种用于实现该方法的灯单元(7)和控制装置(1)。 本发明还描述了一种照明系统。 该照明系统包括连接到AC电压电源系统的控制装置(1),其具有用于产生对系统电压的调制的调制器,该调制编码用于发光装置(6)的控制信息项, ,所述控制装置经由用于发送调制和电力的供应线(3)连接到所述至少一个发光装置(6)。 分配用于操作发光装置(6)的变压器(4)和将其输出信号施加到变压器(4)以解码用于确定控制信息项目的AC电压的调制的解码器(11) 到发光装置(6)。 该系统的特征在于,用于产生分路的可切换恒流源(9,10)被分配给灯单元(7),灯单元(7)包括变压器(4),解码器(11)和发光 手段(6)。
    • 32. 发明申请
    • MEANS AND METHODS FOR THE TREATMENT OF CATARACT AND PRESBYOPIA
    • WO2009044294A3
    • 2009-04-09
    • PCT/IB2008/003602
    • 2008-06-12
    • UNIVERSITÉ DE GENEVEHOPITAUX UNIVERSITAIRES DE GENEVEKRAUSE, Karl-HeinzSERRANDER, Lena
    • KRAUSE, Karl-HeinzSERRANDER, Lena
    • C12N9/02C12N15/11A61K31/713C12Q1/26A61P27/10A61P27/12
    • The present invention relates to an inhibitor of a protein, wherein said protein (i) comprises or consists of the amino acid sequence of SEQ ID NOs: 2 or 4, or is encoded by a nucleic acid comprising or consisting of the sequence of SEQ ID NOs: 1 or 3; (ii) comprises or consists of the amino acid sequence of SEQ ID NO: 26, or is encoded by a nucleic acid comprising or consisting of the sequence of SEQ ID NO: 25; (iii) is a fragment of the protein according to (i), or has a sequence at least 75% identical with the protein according to (i) or with said fragment of the protein according to (i), and exhibits NADPH oxidase activity; or (iv) is a fragment of the protein according to (ii) or has a sequence at least 75% identical with the protein according to (ii) or with said fragment of the protein according to (ii) and stabilizes said protein exhibiting NADPH oxidase activity; and/or an inhibitor of a nucleic acid, wherein said nucleic (v) comprises or consists of the nucleic acid sequence of SEQ ID NO: 1 or 3, or encodes a protein comprising or consisting of the sequence of SEQ ID NO: 2 or 4; (vi) comprises or consists of the nucleic acid sequence of SEQ ID NO: 25, or encodes a protein comprising or consisting of the sequence of SEQ ID NO: 26; (vii) is a fragment of the nucleic acid according to (v), or has a sequence at least 75% identical with the nucleic acid according to (v) or with said fragment of the nucleic acid according to (v), and encodes a protein exhibiting NADPH oxidase activity; or (viii) is a fragment of the nucleic acid according to (vi), or has a sequence at least 75% identical with the nucleic acid according to (vi) or with said fragment of the nucleic acid according to (vi), and encodes a protein stabilizing said protein exhibiting NADPH oxidase activity; for treatment and/or prevention of cataract and/or presbyopia. The sequences define NADPH oxidases or a subunit of an NADPH oxidase, respectively. A preferred inhibitor is a siRNA. Also provided are a method of treating cataract and presbyopia, pharmaceutical compositions, medical uses and diagnostic uses of compounds of the invention.
    • 33. 发明申请
    • NOVEL MEANS AND METHODS FOR THE TREATMENT OF HEARING LOSS AND PHANTOM HEARING
    • 治疗听力损失和听觉听觉的新手段和方法
    • WO2005119251A3
    • 2006-05-26
    • PCT/EP2005006061
    • 2005-06-06
    • UNIV GENEVEKRAUSE KARL-HEINZBANFI BOTOND
    • KRAUSE KARL-HEINZBANFI BOTOND
    • G01N33/50A61K49/00C07K14/47
    • C12N15/1137A61K31/713A61K45/06A61K49/0008C12N2310/11C12N2320/31G01N33/5088G01N2333/90209G01N2800/14
    • This invention relates to a method of identifying a modulator of an NADPH oxidase, whereby said modulator is suitable as a lead compound and/or as a medicament for the treatment and/or prevention of hearing loss and/or phantom hearing, the method comprising the steps of (a) contacting a test compound with a protein, wherein said protein (i) comprises or consists of the amino acid sequence of any one of SEQ ID NO: 1, 3 or 5, or (ii) is encoded by a nucleic acid comprising or consisting of the sequence of any one of SEQ ID NO: 2, 4, 6, 23 or 24, or (iii) is a fragment of the protein according to (i) or (ii) and exhibits NADPH oxidase activity, or (iv) has a sequence at least 75% identical with the protein according to (i) or (ii) or with the fragment according to (iii) and exhibits NADPH oxidase activity, and optionally with one or more NADPH oxidase subunits, under conditions allowing binding of said test compound to said protein or, if present, said subunit(s); (b) optionally determining whether said test compound binds to said protein or, if present, said subunit(s); and (c) determining whether (ca) said test compound, upon contacting in step (a); or (cb) said test compound, upon binding in step (b) modulates the expression and/or activity of said protein or, if present, said subunit(s). Also provided are pharmaceutical compositions, medical uses and diagnostic uses of compounds of the invention.
    • 本发明涉及一种鉴定NADPH氧化酶调节剂的方法,其中所述调节剂适合作为用于治疗和/或预防听力损失和/或幻影听觉的铅化合物和/或药物,该方法包括 (a)使测试化合物与蛋白质接触的步骤,其中所述蛋白质(i)包含SEQ ID NO:1,3或5中任一个的氨基酸序列或由其组成,或(ii)由核酸编码 包含SEQ ID NO:2,4,6,23或24中任一项的序列或由其组成的酸,或(iii)是根据(i)或(ii)的蛋白质的片段,并且表现出NADPH氧化酶活性, 或(iv)具有与根据(i)或(ii)的蛋白质或根据(iii)的片段至少75%相同的序列并显示NADPH氧化酶活性的序列,并且任选地含有一个或多个NADPH氧化酶亚基, 允许所述测试化合物结合所述蛋白质或如果存在的话,所述亚基的条件; (b)任选地确定所述测试化合物是否结合所述蛋白质,或者如果存在,则是所述亚基; 和(c)在步骤(a)中确定(ca)所述测试化合物在接触时是否存在。 或(cb)所述测试化合物在步骤(b)中结合时调节所述蛋白质的表达和/或活性,或如果存在,则调节所述亚基。 还提供了本发明化合物的药物组合物,医疗用途和诊断用途。
    • 36. 发明申请
    • HYBRID MEMBRANE POLYMER ELECTROLYTE FUEL CELL
    • 复合式膜聚合物电解质燃料电池
    • WO02082562A3
    • 2003-06-26
    • PCT/DE0200648
    • 2002-02-22
    • INTECH THUERINGEN GMBHSCHMAUDER HANS-PETERSCHUNK WERNERBRUDER MICHAELHEIBER UWEKRAUSE KARL-HEINZMERKMANN GERHARD
    • SCHMAUDER HANS-PETERSCHUNK WERNERBRUDER MICHAELHEIBER UWEKRAUSE KARL-HEINZMERKMANN GERHARD
    • H01M8/10
    • H01M8/1016
    • The invention relates to a fuel cell (1) comprising at least the following parts: a proton-conducting membrane (2) serving as an electrolyte; catalyst layers (3), which cover the membrane (2) on both sides; gas permeable electrodes provided in the form an anode (4) and cathode (5), which rest on the outwardly pointing surface of the catalyst layers (3); electrically conductive plates (6), which contact the electrodes in an electrically conductive manner while being located at small distances from one another, and which, together with the electrodes, delimit gas-conducting channels, and; gas connections for supplying hydrogen (H2) on one side and oxygen (O2) on the other. The inventive fuel cell (1) is characterized in that the membrane (2) is a hybrid membrane comprising a matrix into which a channel-forming protein is mixed. The invention also relates to advantageous variants of the membrane (2) in which the matrix, for example, contains a molecular sieve/protein adduct.
    • 本发明涉及一种燃料电池1,包括至少以下部件:质子导电膜2作为电解质,催化剂层3上的膜2覆盖气体可渗透电极的两侧的阳极4和阴极5,其抵靠所述催化剂层3的面向外的表面的形式进行电 导电板6,其导电地接触在紧密间隔的时间间隔的电极和与电极,和氢H¿2的供给气体连接一起限定气体传导频道? 一方面和氧O¿2其他。 本发明的燃料电池1的特征在于,该膜2是包括在其中的通道形成蛋白掺合基质的混合膜。 膜片2的另外的有利的变体中,例如,所述基质包含分子筛/蛋白质加合物。
    • 38. 发明申请
    • N-NITROSAMINARMER GUMMIWERKSTOFF
    • N-硝基SAMI LOW橡胶材料
    • WO2003002647A1
    • 2003-01-09
    • PCT/DE2002/002113
    • 2002-06-10
    • INTECH THÜRINGEN GMBHSCHMAUDER, Hans-PeterSCHUNK, WernerALBRACHT, FrankKRAUSE, Karl-HeinzKRELL, ElviraMERKMANN, Gerhard
    • SCHMAUDER, Hans-PeterSCHUNK, WernerALBRACHT, FrankKRAUSE, Karl-HeinzKRELL, ElviraMERKMANN, Gerhard
    • C08K9/04
    • C08K9/04C08L23/16
    • Die Erfindung betrifft einen Gummiwerkstoff (2) mit N-nitrosaminarmen Eigenschaften für dynamisch-mechanisch und thermisch hoch beanspruchte Gummiartikel (1); umfassend eine vulkanisierte Kautschukmischung, insbesondere auf der Basis von Ethylen-Propylen-Dien-Terpolymer, unter Beimischung üblicher Mischungsingredienzien; wobei nun erfindungsgemäss der Kautschukmischung zusätzlich ein Molekularsieb mit oder ohne Kristallwasser beigemischt ist, das mit einem Radikalfänger (Z) beladen ist, und zwar unter Bildung eines Molekularsieb/Radikalfänger-Adduktes (3), wobei der Radikalfänger Stickoxide (X 1 ) und/oder sekundäre Amine (X 2 ) und/oder N-Nitrosamine (X 3 ) bindet. Nach einer besonders vorteilhaften Ausgestaltung der Erfindung zeichnet sich der Gummiwerkstoff (2) dadurch aus, dass das Molekularsieb/Radikalfänger-Addukt (3) zusätzlich Kristallwasser enthält, und zwar derart, dass in Bezug auf eine ausreichende Grundmolmenge (m) an Kristallwasser das Molekularsieb partiell dehydratisiert ist, wobei das Molekularsieb mit der reduzierten Molmenge (m') an Kristallwasser mit dem Radikalfänger (Z) beladen ist, so dass bei Adsorption von Wasser unter Zunahme des Kristallwassergehaltes des Molekularsiebes eine Desorption des Radikalfängers stattfindet, wobei der Radikalfänger Stickoxide (X 1 ) und/oder sekundäre Amine (X 2 ) und/oder N-Nitrosamine (X 3 ) bindet.
    • 本发明涉及一种橡胶材料(2)具有用于动态力学热和高应力的橡胶制品(1)N-亚硝胺差性能; 包括与通常的混合物的成分的硫化橡胶混合物,特别是基于乙烯 - 丙烯 - 二烯三元共聚物,在混合物; 根据本发明的橡胶混合物的加入,其中现在,分子筛混有或没有结晶,其加载有自由基捕捉剂(Z)的水,在形成的分子筛/自由基清除剂加合物(3),其中,所述自由基清除剂的氮氧化物(X1)和/或次级的 胺(X2)和/或N-亚硝胺(X3)结合。 根据本发明的一个特别有利的实施方案中,橡胶材料(2),即相对于一个足够基本摩尔量(m)的特征在于,所述分子筛/自由基清除剂加合物(3)还含有结晶水,在结晶的这样的水,分子筛部分 脱水,其中,与具有所述自由基清除剂(Z)结晶水的减少摩尔量(M“)的分子筛被加载,使得当水下在自由基清除剂的分子筛脱附的结晶水含量的增加,吸附发生,其中,所述自由基清除剂的氮氧化物(X1) 和/或仲胺(X2)和/或N-亚硝胺(X3)结合。
    • 39. 发明申请
    • MEANS AND METHODS FOR THE TREATMENT OF CATARACT AND PRESBYOPIA
    • 用于治疗感染和预后的手段和方法
    • WO2009044294A2
    • 2009-04-09
    • PCT/IB2008003602
    • 2008-06-12
    • UNIV GENEVEHOPITAUX UNIVERSITAIRES DE GENKRAUSE KARL-HEINZSERRANDER LENA
    • KRAUSE KARL-HEINZSERRANDER LENA
    • C12N9/02A61K31/713A61P27/10A61P27/12C12N15/11C12Q1/26
    • C12N9/0036A61K38/005
    • The present invention relates to an inhibitor of a protein, wherein said protein (i) comprises or consists of the amino acid sequence of SEQ ID NOs: 2 or 4, or is encoded by a nucleic acid comprising or consisting of the sequence of SEQ ID NOs: 1 or 3; (ii) comprises or consists of the amino acid sequence of SEQ ID NO: 26, or is encoded by a nucleic acid comprising or consisting of the sequence of SEQ ID NO: 25; (iii) is a fragment of the protein according to (i), or has a sequence at least 75% identical with the protein according to (i) or with said fragment of the protein according to (i), and exhibits NADPH oxidase activity; or (iv) is a fragment of the protein according to (ii) or has a sequence at least 75% identical with the protein according to (ii) or with said fragment of the protein according to (ii) and stabilizes said protein exhibiting NADPH oxidase activity; and/or an inhibitor of a nucleic acid, wherein said nucleic (v) comprises or consists of the nucleic acid sequence of SEQ ID NO: 1 or 3, or encodes a protein comprising or consisting of the sequence of SEQ ID NO: 2 or 4; (vi) comprises or consists of the nucleic acid sequence of SEQ ID NO: 25, or encodes a protein comprising or consisting of the sequence of SEQ ID NO: 26; (vii) is a fragment of the nucleic acid according to (v), or has a sequence at least 75% identical with the nucleic acid according to (v) or with said fragment of the nucleic acid according to (v), and encodes a protein exhibiting NADPH oxidase activity; or (viii) is a fragment of the nucleic acid according to (vi), or has a sequence at least 75% identical with the nucleic acid according to (vi) or with said fragment of the nucleic acid according to (vi), and encodes a protein stabilizing said protein exhibiting NADPH oxidase activity; for treatment and/or prevention of cataract and/or presbyopia. The sequences define NADPH oxidases or a subunit of an NADPH oxidase, respectively. A preferred inhibitor is a siRNA. Also provided are a method of treating cataract and presbyopia, pharmaceutical compositions, medical uses and diagnostic uses of compounds of the invention.
    • 本发明涉及蛋白质的抑制剂,其中所述蛋白质(i)包含SEQ ID NO:2或4的氨基酸序列或由SEQ ID NO:2或4的氨基酸序列组成,或由包含SEQ ID NO: NO:1或3; (ii)包含SEQ ID NO:26的氨基酸序列或由SEQ ID NO:26的氨基酸序列组成,或由包含或由SEQ ID NO:25的序列组成的核酸编码; (iii)是根据(i)的蛋白质的片段,或具有与根据(i)的蛋白质或根据(i)的蛋白质的所述片段至少75%相同的序列,并且表现出NADPH氧化酶活性 ; 或(iv)是根据(ii)的蛋白质的片段或具有与根据(ii)的蛋白质或根据(ii)的蛋白质的所述片段至少75%相同的序列,并稳定所述表达NADPH的蛋白质 氧化酶活性; 和/或核酸的抑制剂,其中所述核酸(v)包含SEQ ID NO:1或3的核酸序列或由SEQ ID NO:1或3的核酸序列组成,或编码包含SEQ ID NO:2或SEQ ID NO:2的序列或由SEQ ID NO: 4; (vi)包含SEQ ID NO:25的核酸序列或由SEQ ID NO:25的核酸序列组成,或编码包含SEQ ID NO:26的序列或由SEQ ID NO:26的序列组成的蛋白质。 (vii)是根据(v)的核酸的片段,或具有与根据(v)的核酸或根据(v)的核酸的所述片段至少75%相同的序列,并编码 表现出NADPH氧化酶活性的蛋白质; 或(viii)是根据(vi)的核酸的片段,或具有与根据(vi)的核酸或根据(vi)的核酸的所述片段至少75%相同的序列,和 编码稳定表达NADPH氧化酶活性的所述蛋白质的蛋白质; 用于治疗和/或预防白内障和/或老花眼。 序列分别定义NADPH氧化酶或NADPH氧化酶的亚基。 优选的抑制剂是siRNA。 还提供了治疗本发明化合物的白内障和老花眼的方法,药物组合物,医学用途和诊断用途。