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31. 发明申请

WO2010147653A1 OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OPSIN-BINDING LIGANDS，COMPOSITIONS AND METHODS OF USE
公开(公告)号：WO2010147653A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/001739
申请日：2010-06-16
申请人： BIKAM PHARMACEUTICALS, INC. , GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, Robert , BREWER, Mark, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
发明人： GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, Robert , BREWER, Mark, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
IPC分类号： A01N35/00 , A61K31/11
CPC分类号： C07D295/215 , C07B59/002 , C07B2200/05 , C07C233/10 , C07C275/14 , C07C2601/16 , C07D205/04 , C07D207/12 , C07D207/14 , C07D211/38 , C07D241/04 , C07D241/08 , C07D243/08 , C07D295/182 , C07D295/185 , C07D295/194 , C07D295/205 , C07D295/26 , C07D491/10 , C07D493/08
摘要： Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.
摘要翻译：公开了所述化合物的化合物和组合物以及化合物的使用方法，用于治疗与视蛋白蛋白质错位定位相关的眼科疾病，突变视蛋白蛋白质的错误折叠以及积聚在眼睛中的毒性视觉循环产物的产生。还描述了可用于这些方法中的单独或与其它治疗剂组合的化合物和组合物。

32. 发明申请

WO2007075542A3 NITRIC OXIDE ENHANCING PYRUVATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：氮氧化物增强吡咯化合物，组合物和使用方法
公开(公告)号：WO2007075542A3
公开(公告)日：2009-04-16
申请号：PCT/US2006048194
申请日：2006-12-19
申请人： NITROMED INC , GARVEY DAVID S
发明人： GARVEY DAVID S
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： A61K31/421 , A61K31/537
摘要： The invention provides novel compositions and kits comprising at least one nitric oxide enhancing pyruvate compound, or a pharmaceutically acceptable salt thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (1) treating peripheral vascular diseases; (m) treating portal hypertension; (n) treating reperfusion injury following ischemia; and/or (m) preserving tissues, organs, organ parts and/or limbs. The nitric oxide enhancing pyruvate compounds comprise at least one heterocyclic nitric oxide donor group and/or at least one nitroxide group.
摘要翻译：本发明提供了包含至少一种一氧化氮增强丙酮酸化合物或其药学上可接受的盐，和任选的至少一种一氧化氮增强化合物和/或至少一种治疗剂的新型组合物和试剂盒。本发明还提供了（a）治疗心血管疾病的方法; （b）治疗血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; （k）治疗肾病; （1）治疗外周血管疾病; （m）治疗门静脉高压; （n）局部缺血后再灌注损伤; 和/或（m）保存组织，器官，器官部分和/或肢体。一氧化氮增强丙酮酸化合物包含至少一种杂环一氧化氮供体基团和/或至少一种氮氧化物基团。

33. 发明申请

WO2007086884A2 ORGANIC NITRIC OXIDE DONOR SALTS OF ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：有机氮氧化物的抗菌化合物，组合物和使用方法
公开(公告)号：WO2007086884A2
公开(公告)日：2007-08-02
申请号：PCT/US2006005416
申请日：2006-02-16
申请人： NITROMED INC , ELLIS JAMES L , GARVEY DAVID S , LIN CHIA-EN
发明人： ELLIS JAMES L , GARVEY DAVID S , LIN CHIA-EN
IPC分类号： A61K31/7034
CPC分类号： C07H5/04 , C07H5/06 , C07H15/00 , C07H17/00
摘要： The invention describes novel organic nitric oxide donor salts of a antimicrobial . compounds, and novel compositions and kits comprising at least one organic nitric oxide donor salt of an antimicrobial compound, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating bacterial infections; (b) treating viral infections; (c) treating fungal infections; and (d) treating lesions. In one embodiment the antimicrobial compounds of the invention are aztreonam, ciprofloxacin, doripenam, duramycin and tobramycin. The organic nitric oxide donors that form salts are preferably organic nitrates, organic nitrites, nitrosothiols, thionitrites and heterocyclic nitric oxide donors. The heterocyclic nitric oxide donors are preferably furoxans, sydnonimines, oxatriazole-5-ones and/or oxatriazole-5-imines. The methods of the invention are preferably for the treatment of bacterial infections associated with pulmonary diseases such as cystic fibrosis and for treating Bacillus anthracis<
摘要翻译：本发明描述了抗微生物剂的新型有机一氧化氮供体盐。化合物和包含抗微生物化合物的至少一种有机一氧化氮供体盐，和任选的至少一种一氧化氮增强化合物和/或至少一种治疗剂的新型组合物和试剂盒。本发明还提供了（a）治疗细菌感染的方法; （b）治疗病毒感染; （c）治疗真菌感染; 和（d）治疗病变。在一个实施方案中，本发明的抗微生物化合物是氨曲南，环丙沙星，多瑞培南，杜氏霉素和妥布霉素。形成盐的有机一氧化氮供体优选为有机硝酸盐，有机亚硝酸盐，亚硝基硫醇，硫堇啶和杂环一氧化氮供体。杂环一氧化氮供体优选呋喃香糖，苏氨酸亚胺，氧杂三唑-5-酮和/或氧杂三唑-5-亚胺。本发明的方法优选用于治疗与肺部疾病如囊性纤维化相关的细菌感染和用于治疗炭疽芽孢杆菌

34. 发明申请

WO2006091716A3 NITRIC OXIDE ENHANCING DIURETIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：硝酸氧化物增强化学复合物，组合物和使用方法
公开(公告)号：WO2006091716A3
公开(公告)日：2007-07-12
申请号：PCT/US2006006375
申请日：2006-02-24
申请人： NITROMED INC , GARVEY DAVID S , LETTS GORDON L , EARL RICHARD A , EZAWA MAIKO , FANG XINQIN , GASTON RICKY D , KHANAPURE SUBHASH P , LIN CHIA-EN , RANATUNGE RAMANI R , STEVENSON CHERI A , WEY SHIOW-JYI
发明人： GARVEY DAVID S , LETTS GORDON L , EARL RICHARD A , EZAWA MAIKO , FANG XINQIN , GASTON RICKY D , KHANAPURE SUBHASH P , LIN CHIA-EN , RANATUNGE RAMANI R , STEVENSON CHERI A , WEY SHIOW-JYI
IPC分类号： A61K31/549 , C07D417/02
CPC分类号： C07D285/30 , C07D285/28 , C07D285/32 , C07D417/04 , C07D417/06 , C07D513/10
摘要： The invention describes novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or pharmaceutically acceptable salts thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating conditions resulting from excessive water and/or electrolyte retention; (b) treating cardiovascular diseases; (c) treating renovascular diseases; (d) treating diabetes; (e) treating diseases resulting from oxidative stress; (f) treating endothelial dysfunctions; (g) treating diseases caused by endothelial dysfunctions; (h) treating cirrhosis; (j) treating pre-eclampsia; (k) treating osteoporosis; (1) treating nephropathy; (m) treating peripheral vascular diseases; (n) treating portal hypertension; (o) treating central nervous system disorders; (p) treating metabolic syndrome; (q) treating sexual dysfunctions; and (r) hyperlipidemia. The nitric oxide enhancing diuretic compounds comprise at least one nitric oxide enhancing group linked to the diuretic compound through one or more sites such as carbon, oxygen and/or nitrogen via a bond or moiety that cannot be hydrolyzed.
摘要翻译：本发明描述了包含至少一种一氧化氮增强利尿剂或其药学上可接受的盐，和任选的至少一种一氧化氮增强化合物和/或至少一种治疗剂的新型组合物和试剂盒。本发明还提供了（a）处理由过量水和/或电解质滞留导致的条件的方法; （二）治疗心血管疾病; （c）治疗血管性疾病; （d）治疗糖尿病; （e）治疗由氧化应激引起的疾病; （f）治疗内皮功能障碍; （g）治疗由内皮功能障碍引起的疾病; （h）治疗肝硬化; （j）治疗先兆子痫; （k）治疗骨质疏松症; （1）治疗肾病; （m）治疗外周血管疾病; （n）治疗门静脉高压; （o）治疗中枢神经系统疾病; （p）治疗代谢综合征; （q）治疗性功能障碍; 和（r）高脂血症。一氧化氮增强利尿化合物包含通过一个或多个位点如碳，氧和/或氮通过不能水解的键或部分与利尿剂化合物连接的至少一个一氧化氮增强基团。

35. 发明申请

WO2007075542A2 NITRIC OXIDE ENHANCING PYRUVATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：氮氧化物增强吡咯化合物，组合物和使用方法
公开(公告)号：WO2007075542A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048194
申请日：2006-12-19
申请人： NITROMED, INC. , GARVEY, David, S.
发明人： GARVEY, David, S.
IPC分类号： A61K31/537 , A61K31/421
CPC分类号： A61K31/421 , A61K31/537
摘要： The invention provides novel compositions and kits comprising at least one nitric oxide enhancing pyruvate compound, or a pharmaceutically acceptable salt thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (1) treating peripheral vascular diseases; (m) treating portal hypertension; (n) treating reperfusion injury following ischemia; and/or (m) preserving tissues, organs, organ parts and/or limbs. The nitric oxide enhancing pyruvate compounds comprise at least one heterocyclic nitric oxide donor group and/or at least one nitroxide group.
摘要翻译：本发明提供了包含至少一种一氧化氮增强丙酮酸化合物或其药学上可接受的盐，和任选的至少一种一氧化氮增强化合物和/或至少一种治疗剂的新型组合物和试剂盒。本发明还提供了（a）治疗心血管疾病的方法; （b）治疗血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; （k）治疗肾病; （1）治疗外周血管疾病; （m）治疗门静脉高压; （n）局部缺血后再灌注损伤; 和/或（m）保存组织，器官，器官部分和/或肢体。一氧化氮增强丙酮酸化合物包含至少一种杂环一氧化氮供体基团和/或至少一种氮氧化物基团。

36. 发明申请

WO2007019448A2 NITRIC OXIDE ENHANCING ANGIOTENSIN II ANTAGONIST COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：硝酸氧化物增强ANGONTENSIN II拮抗剂化合物，组合物和使用方法
公开(公告)号：WO2007019448A2
公开(公告)日：2007-02-15
申请号：PCT/US2006030733
申请日：2006-08-07
申请人： NITROMED INC , GARVEY DAVID S , CAI XIONG , FANG XINQIN , RANATUNGE RAMANI R , WEY SHIOW-JYI , ZHAI HAI-XIAO
发明人： GARVEY DAVID S , CAI XIONG , FANG XINQIN , RANATUNGE RAMANI R , WEY SHIOW-JYI , ZHAI HAI-XIAO
IPC分类号： A61K31/4245 , A61K31/42 , A61K31/433
CPC分类号： C07D257/04 , C07D401/12 , C07D403/10 , C07D403/12 , C07D471/04
摘要： The invention describes compositions and kits comprising at least one nitric oxide enhancing angiotensin II antagonist compound, or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitric oxide enhancing angiotensin II antagonist compound, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (1) treating peripheral vascular diseases; (m) treating portal hypertension (o) treating central nervous system disorders; (p) treating metabolic syndrome; and (q) treating hyperlipidemia. The nitric oxide enhancing angiotensin II antagonist compounds comprise at least one nitric oxide enhancing group linked to the angiotensin II antagonist compound through one or more sites such as carbon, oxygen and/or nitrogen via a bond or moiety that cannot be hydrolyzed.
摘要翻译：本发明描述了包含至少一种氧化氮增强型血管紧张素II拮抗剂化合物或其药学上可接受的盐的组合物和试剂盒，以及包含至少一种一氧化氮增强型血管紧张素II拮抗剂化合物和任选地至少一种一氧化氮增强化合物和/或至少一种治疗剂。本发明还提供了（a）治疗心血管疾病的方法; （b）治疗血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; （k）治疗肾病; （1）治疗外周血管疾病; （m）治疗门静脉高压（o）治疗中枢神经系统疾病; （p）治疗代谢综合征; 和（q）治疗高脂血症。一氧化氮增强型血管紧张素II拮抗剂化合物包含通过一个或多个位点如碳，氧和/或氮通过不能水解的键或部分与血管紧张素II拮抗剂化合物连接的至少一个一氧化氮增强基团。

37. 发明申请

WO2005023182A3 NITROSATED AND NITROSYLATED CARDIOVASCULAR COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：硝酸和硝基化血管化合物，组合物和使用方法
公开(公告)号：WO2005023182A3
公开(公告)日：2006-10-19
申请号：PCT/US2004026910
申请日：2004-08-20
申请人： NITROMED INC , GARVEY DAVID S , LETTS GORDON L , WORCEL MANUEL
发明人： GARVEY DAVID S , LETTS GORDON L , WORCEL MANUEL
IPC分类号： A61K31/4523 , A61K20060101 , A61K31/517 , A61K31/5415 , A61K31/549 , C07D211/00 , C07D285/22 , C07D295/00 , C07D307/00 , C07D417/12 , C07D417/14
CPC分类号： C07D403/10 , C07C205/40 , C07D233/68 , C07D235/18 , C07D257/04 , C07D307/52 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要： The invention describes novel nitrosated and/or nitrosylated cardiovascular compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated cardiovascular compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at least one cardiovascular compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; and (k) treating nephropathy. The nitrosated and/or nitrosylated cardiovascular compounds are preferably nitrosated and/or nitrosylated aldosterone antagonists, nitrosated and/or nitrosylated angiotensin II antagonists, nitrosated and/or nitrosylated calcium channel blockers, nitrosated and/or nitrosylated endothelin antagonists, nitrosated and/or nitrosylated hydralazine compounds, nitrosated and/or nitrosylated neutral endopeptidase inhibitors and nitrosated and/or nitrosylated renin inhibitors.
摘要翻译：本发明描述了新的亚硝化和/或亚硝基化的心血管化合物或其药学上可接受的盐，以及包含至少一种亚硝化和/或亚硝基化的心血管化合物和任选的至少一种一氧化氮供体和/或至少一种治疗剂的新组合物。本发明还提供了包含至少一种本发明的心血管化合物，其任选被亚硝化和/或亚硝基化的新组合物和试剂盒，以及任选的至少一种一氧化氮供体化合物和/或至少一种治疗剂。本发明还提供了（a）治疗心血管疾病的方法; （b）治疗血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; 和（k）治疗肾病。亚硝化和/或亚硝基化的心血管化合物优选为亚硝化和/或亚硝基化的醛固酮拮抗剂，亚硝化和/或亚硝酰化的血管紧张素II拮抗剂，亚硝化和/或亚硝酰化的钙通道阻断剂，亚硝化和/或亚硝基化的内皮素拮抗剂，亚硝化和/ 化合物，亚硝化和/或亚硝基化的中性内肽酶抑制剂和亚硝化和/或亚硝基化的肾素抑制剂。

38. 发明申请

WO2006078995A1 CARDIOVASCULAR COMPOUNDS COMPRISING HETEROCYCLIC NITRIC OXIDE DONOR GROUP COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：包含杂环氧化物二氧化碳基团组合物的心血管化合物及其使用方法
公开(公告)号：WO2006078995A1
公开(公告)日：2006-07-27
申请号：PCT/US2006/002199
申请日：2006-01-23
申请人： NITROMED, INC. , GARVEY, David, S.
发明人： GARVEY, David, S.
IPC分类号： C07D271/08
CPC分类号： C07D285/10 , C07C217/30 , C07C233/30 , C07C233/65 , C07C255/54 , C07C275/34 , C07D207/16 , C07D209/08 , C07D209/16 , C07D209/52 , C07D209/88 , C07D217/26 , C07D223/16 , C07D233/38 , C07D271/08 , C07D273/00 , C07D281/06 , C07D311/18 , C07D413/12 , C07D413/14 , C07D487/04 , C07D495/10
摘要： The invention describes compositions and kits comprising at least one cardiovascular compound comprising at least one heterocyclic nitric oxide donor group, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (1) treating peripheral vascular diseases; (m) treating portal hypertension and (n) treating ophthalmic disorders. The cardiovascular compounds are preferably β-adrenergic antagonists, angiotensin- converting enzyme (ACE) inhibitors, anti-hyperlipidemic compounds, and antithrombotic and vasodilator compounds. The heterocyclic nitric oxide donor groups are preferably furoxans, sydnonimines, oxatriazole-5-ones and/or oxatriazole-5-imines.
摘要翻译：本发明描述了包含至少一种包含至少一种杂环一氧化氮供体基团的心血管化合物和任选的至少一种一氧化氮增强化合物和/或至少一种治疗剂的组合物和试剂盒。本发明还提供了（a）治疗心血管疾病的方法; （b）治疗血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; （k）治疗肾病; （1）治疗外周血管疾病; （m）治疗门静脉高压和（n）治疗眼科疾病。心血管化合物优选是β-肾上腺素能拮抗剂，血管紧张素转换酶（ACE）抑制剂，抗高脂血症化合物和抗血栓形成和血管扩张剂化合物。杂环一氧化氮供体基团优选为呋喃糖，苏氨酸，氧杂三唑-5-酮和/或氧杂三唑-5-亚胺。

39. 发明申请

WO2006041855A2 COMPOSITIONS AND METHODS USING APOCYNIN COMPOUNDS AND NITRIC OXIDE DONORS 审中-公开
标题翻译：使用APOCYNIN化合物和一氧化氮供体的组合物和方法
公开(公告)号：WO2006041855A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/035715
申请日：2005-10-03
申请人： NITROMED, INC. , GARVEY, David, S.
发明人： GARVEY, David, S.
IPC分类号： A61K31/198 , A61K31/12
CPC分类号： A61K31/12 , A61K31/198 , A61K2300/00
摘要： The invention describes novel compositions comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The invention also provides novel kits comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor compound, and, optionally, at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating gastrointestinal disorders; (h) treating inflammatory disorders; (j) treating respiratory disorders; and (k) treating peripheral vascular diseases. The apocynin compound may be apocynin. The nitric oxide donor compound may be isosorbide dinitrate and/or isosorbide mononitrate.
摘要翻译：本发明描述了包含至少一种夹竹桃麻素化合物或其药学上可接受的盐和至少一种一氧化氮供体以及任选地至少一种治疗剂的新型组合物。本发明还提供了包含至少一种夹竹桃麻素化合物或其药学上可接受的盐和至少一种一氧化氮供体化合物以及任选地至少一种治疗剂的新药盒。本发明还提供了用于（a）治疗心血管疾病的方法; （b）治疗肾血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗胃肠疾病; （h）治疗炎性疾病; （j）治疗呼吸系统疾病; 和（k）治疗外周血管疾病。罗布麻宁化合物可以是夹竹桃麻素。一氧化氮供体化合物可以是硝酸异山梨酯和/或单硝酸异山梨酯。

40. 发明申请

WO2005030135A3 NITROSATED GLUTAMIC ACID COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：硝酸谷氨酸化合物，组合物和使用方法
公开(公告)号：WO2005030135A3
公开(公告)日：2005-06-16
申请号：PCT/US2004031372
申请日：2004-09-27
申请人： NITROMED INC , GARVEY DAVID S , EARL RICHARD A , EZAWA MAIKO , FANG XINQIN , GASTON RICKY D , KHANAPURE SUBHASH P , LIN CHIA-EN , RANATUNGE RAMANI R , STEVENSON CHERI A , WEY SHIOW-JYI
发明人： GARVEY DAVID S , EARL RICHARD A , EZAWA MAIKO , FANG XINQIN , GASTON RICKY D , KHANAPURE SUBHASH P , LIN CHIA-EN , RANATUNGE RAMANI R , STEVENSON CHERI A , WEY SHIOW-JYI
IPC分类号： A61K20060101 , C07C229/24 , C07C237/12 , C07C271/22 , C07D295/185 , C07K5/06
CPC分类号： C07C271/22 , C07C229/24 , C07C237/12 , C07D295/185
摘要： The invention describes novel nitrosated glutamic acid compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated glutamic acid compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated glutamic acid compound, and, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (1) treating diseases resulting from elevated levels of gamma-glutamyl transpeptidase and (m) the targeted delivery of compounds and nitric oxide to organs, cells or tissues containing the enzyme gamma-glutamyl transpeptidase.
摘要翻译：本发明描述了新的亚硝酸化谷氨酸化合物及其药学上可接受的盐，以及包含至少一种亚硝酸化谷氨酸化合物和任选的至少一种一氧化氮供体和/或至少一种治疗剂的新型组合物。本发明还提供了包含至少一种亚硝酸化谷氨酸化合物和任选的至少一种一氧化氮供体化合物和/或至少一种治疗剂的新型试剂盒。本发明还提供了（a）治疗心血管疾病的方法; （b）治疗血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; （k）治疗肾病; （1）治疗由γ-谷氨酰转肽酶水平升高引起的疾病和（m）将化合物和一氧化氮靶向递送至含有γ-谷氨酰转肽酶的器官，细胞或组织。

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