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31. 发明申请

WO2018228932A1 BASAL TITRATION WITH ADAPTIVE TARGET GLUCOSE LEVEL 审中-公开
公开(公告)号：WO2018228932A1
公开(公告)日：2018-12-20
申请号：PCT/EP2018/065126
申请日：2018-06-08
申请人： NOVO NORDISK A/S
发明人： BJÖRK, ARADÓTTIR, Tinna , BENGTSSON, Henrik , LIND, JENSEN, Morten , BROCKMEIER, Pete
IPC分类号： G16H20/17 , A61B5/145 , G16H50/20
CPC分类号： G16H20/17 , A61B5/0004 , A61B5/14532 , A61B5/4839 , A61M5/1723 , A61M2005/1726 , A61M2205/3306 , A61M2205/3507 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/50 , A61M2205/52 , A61M2205/8206 , G16H50/20
摘要： Systems and methods are provided for adjusting long acting insulin medicament dosages for a subject. A plurality of timestamped glucose measurements of the subject is obtained. A titration glucose level (246) is computed as a measure of central tendency (244, 268, 274) of a titration subset of small glucose measurements (240, 269, 273) identified within the timestamped glucose measurements, wherein the measure of central tendency represents a measure of small glucose measurements for the primary time window. A long acting insulin medicament dosage (216) is adjusted or maintained based upon the obtained titration glucose level (246).

32. 发明申请

WO2018210919A1 GLP-1 COMPOSITIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2018210919A1
公开(公告)日：2018-11-22
申请号：PCT/EP2018/062698
申请日：2018-05-16
申请人： NOVO NORDISK A/S
发明人： STABY, Arne , EVA HORN, Møller , NORDFANG, Ole
IPC分类号： A61K9/00 , A61K38/26 , A61K47/18 , A61K47/20
CPC分类号： A61K9/0019 , A61K38/26 , A61K47/183 , A61K47/20
摘要： The present invention relates to compositions comprising the GLP-1 peptide liraglutide and a thiol-containing excipient.

33. 发明申请

WO2018167194A1 BICYCLIC COMPOUNDS CAPABLE OF BINDING TO MELANOCORTIN 4 RECEPTOR 审中-公开
公开(公告)号：WO2018167194A1
公开(公告)日：2018-09-20
申请号：PCT/EP2018/056482
申请日：2018-03-15
申请人： NOVO NORDISK A/S
发明人： FRIEBOES, Kilian,Waldemar,Conde , TORNØE, Christian,Wenzel , NIELSEN, Line,Marie
IPC分类号： C07K7/64 , A61K38/00 , C07K14/685
摘要： The present invention relates to novel peptide compounds which are effective as melanocortin 4 receptor agonists, to the use of the compounds in medicine, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds for the manufacture of 5 medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity or overweight as well as a variety of diseases or conditions associated with obesity.

34. 发明申请

WO2018167154A1 DOSE CAPTURING ASSEMBLY WITH SECONDARY IMAGE ANALYSIS FEATURE 审中-公开
公开(公告)号：WO2018167154A1
公开(公告)日：2018-09-20
申请号：PCT/EP2018/056407
申请日：2018-03-14
申请人： NOVO NORDISK A/S
发明人： PEDERSEN, Bennie, Peder, Smiszek
IPC分类号： A61M5/20 , A61M5/315
摘要： An add-on device for a drug delivery device comprises a camera for capturing an image of a scale drum, and a processor for determining the value of a captured image using a first image analysis process, the value corresponding to a set dose amount. If the determined value belongs to a pre-defined group of values, the determined value is confirmed using a second image analysis process in which for a given value from the pre-defined group of values one or more partial image areas and an associated nominal content thereof are pre-defined. If the captured content for each image area corresponds to the nominal content, the determined value is confirmed.

35. 发明申请

WO2018122394A1 PLUNGER SUB-ASSEMBLY FOR A PREFILLED MEDICAMENT INJECTOR, A PREFILLED MEDICAMENT INJECTOR AND METHOD FOR ASSEMBLING A PREFILLED MEDICAL INJECTOR 审中-公开
公开(公告)号：WO2018122394A1
公开(公告)日：2018-07-05
申请号：PCT/EP2017/084856
申请日：2017-12-29
申请人： NOVO NORDISK A/S
发明人： EILAND, Jacob , HOLTEN-TINGLEFF, Frederik , BJERRUM, Peter , MØRKEBERG TORRY-SMITH, Jonas
IPC分类号： A61M5/20 , A61M5/315
摘要： A plunger sub-assembly (40, 60, 70; 80) for a pre-filled medicament injector for expelling a dose of a medicament, comprising: a) a container (60) holding a medicament, the container (60) comprising a body (61) with a proximally facing rim surface (64), and a distally slideable piston (63); b) a plunger (40); and c) a tolerance compensating element (70; 80) configured to cooperate with the plunger (40) and to cooperate with either the proximally facing rim surface (64) or the piston (63), the tolerance compensating element (70; 80) being rotatable relative to the plunger (40) to adjust the piston (63) end of dose position. The plunger sub- assembly (40, 60, 70; 80) is formed so that end of dose state occurs by the plunger (40) cooperating with the proximally facing rim surface (64). Pre-filled medicament injectors and methods of assembling a pre-filled medicament injector are further described.

36. 发明申请

WO2018122295A1 A NEEDLE CANNULA, AN INJECTION NEEDLE ASSEMBLY FOR AN INJECTION DEVICE AND AN INJECTION DEVICE COMPRISING SUCH ASSEMBLY 审中-公开
公开(公告)号：WO2018122295A1
公开(公告)日：2018-07-05
申请号：PCT/EP2017/084696
申请日：2017-12-28
申请人： NOVO NORDISK A/S
发明人： TØNNESEN, Lene, Westergaard , PEDERSEN, Erik
IPC分类号： A61M5/32 , A61M5/20
摘要： A needle cannula for an injection device, extends along a central axis and comprises: a) a skin piercing distal end (133b), b) a proximal end (133a) configured for penetrating a seal structure (102b) of a medicament container (102), and c) a sidewall extending between the skin piercing distal end (133b) and the proximal end (133a), wherein the proximal end (133a) is defined by an angled surface (134) pointing proximally, the angled surface (134) defining a leading portion (134.1) and a heel portion (134.2), and wherein the angled surface (134) comprises a surface portion (134a, 134b) at the heel portion (134.2) forming an angle (α 1 ) between 50 to 75 degrees with respect to the central axis, and further comprises a surface portion (134c) at the leading portion (134.1) forming an angle (α 2 ) between 60 to 85 degrees with respect to the central axis. An injection needle assembly for an injection device and an injection device comprising such assembly are further described.

37. 发明申请

WO2018083111A1 TOLEROGENIC DNA VACCINE 审中-公开
公开(公告)号：WO2018083111A1
公开(公告)日：2018-05-11
申请号：PCT/EP2017/077949
申请日：2017-11-01
申请人： NOVO NORDISK A/S
发明人： CHAPLIN, Jay , WIJARANAKULA, Michael
IPC分类号： A61K39/00 , A61P3/10
摘要： The present invention relates to plasmids encoding insulin antigens and cytokines for use in tolerizing immunization, in particular for the prevention and/or delay of e.g. type 1 diabetes.
摘要翻译：本发明涉及编码胰岛素抗原和细胞因子的质粒，用于耐受免疫接种，特别是用于预防和/或延迟例如胰岛素抵抗。 1型糖尿病。

38. 发明申请

WO2018078161A1 IMAGE CAPTURE DEVICE WITH VIEWING FUNCTIONALITY 审中-公开
标题翻译：具有查看功能的图像捕获设备
公开(公告)号：WO2018078161A1
公开(公告)日：2018-05-03
申请号：PCT/EP2017/077788
申请日：2017-10-30
申请人： NOVO NORDISK A/S
发明人： JOHST CHRISTENSEN, Martin
IPC分类号： A61M5/315
摘要： An image capture device with a housing comprising a capture opening and a viewing opening arranged opposed to the capture opening. The image capture device comprises a camera for capturing an image of at least a portion of an object arranged in register with the capture opening, as well as a beam-splitter arranged to cover the capture opening, the beam-splitter allowing a first portion of light reflected from an observed object to pass through the beam-splitter, this allowing a user to effectively watch the object during image capture.
摘要翻译：具有外壳的图像捕获装置，所述外壳包括捕获开口和与所述捕获开口相对布置的观察开口。图像捕获装置包括用于捕获布置成与捕获开口对准的物体的至少一部分的图像的照相机，以及布置成覆盖捕获开口的分束器，分束器允许第一部分的从被观察物体反射的光穿过分束器，这允许用户在图像捕获期间有效地观察物体。

39. 发明申请

WO2018077835A1 SYSTEMS AND METHODS FOR ESTIMATING THE RISK OF A FUTURE HYPOGLYCEMIC EVENT 审中-公开
标题翻译：用于估计未来低血糖事件风险的系统和方法
公开(公告)号：WO2018077835A1
公开(公告)日：2018-05-03
申请号：PCT/EP2017/077077
申请日：2017-10-24
申请人： NOVO NORDISK A/S
发明人： ORDEN, Brad, Van , ARADÓTTIR, Tinna, Björk , BROCKMEIER, Pete , BENGTSSON, Henrik
IPC分类号： G06F19/00
CPC分类号： G16H50/70
摘要： A device (250) for estimating the risk of a future hypoglycemic event for a subject with a standing insulin regimen (206), wherein the standing insulin regimen comprises one or more types of insulin medicament dosage regimen (208), wherein each of the one or more types of insulin medicament dosage regimen (208) comprises a type of insulin medicament (210) defining one or more types of insulin medicaments. Using the evaluation of a glucose concentration, a first time derivative and an insulin on board for the subject in a current metabolic state, and the evaluation of a glucose concentration, a first derivative and a historical insulin on board to estimate a hypoglycemic risk measure.
摘要翻译：（250），其用于估计具有常设胰岛素方案的受试者将来的低血糖事件的风险（206），其中所述常备胰岛素方案包括一种或多种类型的胰岛素药物剂量方案（ 208），其中所述一种或多种类型的胰岛素药物剂量方案（208）中的每一种包括定义一种或多种类型的胰岛素药物的一种类型的胰岛素药物（210）。使用对当前代谢状态下的受试者的葡萄糖浓度，一阶导数和胰岛素的评估以及评估葡萄糖浓度，一阶导数和机载历史胰岛素以估计低血糖风险度量。

40. 发明申请

WO2018041899A1 DRUG DELIVERY DEVICE WITH OVER-TORQUE PROTECTION MECHANISM 审中-公开
标题翻译：具有过转矩保护机制的药物递送装置
公开(公告)号：WO2018041899A1
公开(公告)日：2018-03-08
申请号：PCT/EP2017/071774
申请日：2017-08-30
申请人： NOVO NORDISK A/S
发明人： KIILERICH, Ebbe
IPC分类号： A61M5/315
摘要： Drug delivery device adapted to expel a set dose, comprising an expelling mechanism with a drive spring, a dose setting mechanism with first and second dose setting ratchet parts, a bias spring as well as control means. The control means is adapted to rotate the second ratchet part in a first direction to thereby set a dose when rotating the dose setting member in the first direction, and move the ratchet parts axially out of engagement with each other when the dose setting member is rotated in the opposite direction. When the first and second ratchet parts have been axially disengaged, the drive spring will rotate the second ratchet part in the second direction to thereby reduce the set dose, the bias spring moving the ratchet parts axially into engagement with each other again, this resulting in the set dose being reduced corresponding to one tooth of the ratchet mechanism.
摘要翻译：适于排出设定剂量的药物输送装置，其包括具有驱动弹簧的排出机构，具有第一和第二剂量设定棘轮部分的剂量设定机构，偏置弹簧以及控制装置。控制装置适于在第一方向上旋转第二棘轮部件，从而当在第一方向上旋转剂量设定构件时设定剂量，并且当剂量设定构件旋转时使棘轮部件沿轴向移动脱离接合在相反的方向。当第一棘轮部件和第二棘轮部件已经轴向脱离时，驱动弹簧将使第二棘轮部件沿第二方向旋转，从而减小设定剂量，偏置弹簧使棘轮部件再次轴向移动而彼此接合，这导致设定剂量相应于棘轮机构的一个齿减小。

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