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1. 发明申请

WO2018033515A1 SYSTEMS AND METHODS FOR OPTIMIZATION OF BOLUS TIMING RELATIVE TO MEAL EVENTS 审中-公开
标题翻译：用于优化与餐饮事件相关的波洛斯时间的系统和方法
公开(公告)号：WO2018033515A1
公开(公告)日：2018-02-22
申请号：PCT/EP2017/070587
申请日：2017-08-14
申请人： NOVO NORDISK A/S
发明人： ARADÓTTIR, Tinna, Björk , BENGTSSON, Henrik , BROCKMEIER, Pete , PEDERSEN, Jonas, Kildegård
IPC分类号： G06F19/00
摘要： Systems and methods are provided for optimizing short acting insulin medicament dosage timing relative to a meal event for a subject. Glucose measurements of the subject over a time course and the timing of the measurements are obtained. Meal events in the time course and information regarding when dosages were injected into the subject relative to the meal events is obtained. Bins, each for a different time range for when a dosage is injected relative to a meal event, are constructed. Each bin is assigned glucose measurements in one or more periods within the time course in which the subject injected the dosage within the time range associated with the bin. A glycaemic risk measure is determined for each bin with the assigned measurements and used to identify an optimal relative time range for the subject. This is communicated to a health care practitioner or to the subject.
摘要翻译：系统和方法被提供用于优化短效胰岛素药剂剂量正时相对于受试者的进餐事件。获得在时间过程中对象的葡萄糖测量结果和测量的时间。获得时间进程中的用餐事件和关于何时向对象注射剂量的相对于进餐事件的信息。构建了每个时间范围内的剂量，以便相对于膳食事件注射剂量时。每个仓在时间进程内的一个或多个时间段内被分配葡萄糖测量，其中受试者在与仓相关的时间范围内注射剂量。使用分配的测量为每个仓确定血糖风险度量，并用于确定对象的最佳相对时间范围。这是传达给医疗从业人员或主题。

2. 发明申请

WO2018060036A1 SYSTEMS AND METHODS FOR COMMUNICATING A DOSE HISTORY REPRESENTING AN AVERAGE AND A VARIABILITY OF A DISTRIBUTION OF MEDICAMENT INJECTIONS 审中-公开
标题翻译：用于传达表示药物注射剂分布的平均值和变量的剂量历史的系统和方法
公开(公告)号：WO2018060036A1
公开(公告)日：2018-04-05
申请号：PCT/EP2017/073850
申请日：2017-09-21
申请人： NOVO NORDISK A/S
发明人： BROCKMEIER, Pete , BENGTSSON, Henrik , ARADÓTTIR, Tinna, Björk
IPC分类号： G06F19/00
摘要： Systems and methods for communicating a dose history configured for representing an average and a variability of a distribution of injections with a blood glucose regulating medicament applied by a subject with a treatment regimen. Past records are obtained from insulin pens applying the treatment regimen. Each record specifies an amount and type of medicament injected, the type being one of a blood glucose regulating medicament, and a timestamp. Assigning single-shape polygons (231) to each record, wherein single-shape polygons (231) is configured for visualizing a polygon (261) with a two-dimensional shape, in a displayed mode. The single-shape polygons are used to create a set of multi-shape data structures comprising corresponding multi-shape polygons (244), configured for visualizing a polygon (265) with a two-dimensional shape, in the displayed mode (260). The multi- shape polygons are configured to be displayed with an increasing intensity, depending on the number of overlapping single-shape polygons used to define the multi-shape polygon. The method also comprises communicating display data (247), comprising (i) the plurality of sets of medicament records, and (ii) the set of multi-shape data structures (240).
摘要翻译：传递剂量历史的系统和方法，所述剂量历史被配置用于表示由具有治疗方案的受试者应用的血糖调节药物的注射分布的平均值和变化性。过去的记录是从使用治疗方案的胰岛素笔中获得的。每个记录指定注射的药物的量和类型，该类型是血糖调节药物中的一种，以及时间戳。为每个记录分配单一形状的多边形（231），其中单一形状的多边形（231）被配置用于在显示的模式下可视化具有二维形状的多边形（261）。单一形状的多边形被用来创建一组包含对应的多形状多边形（244）的多形状数据结构，其被配置用于在显示模式（260）中以二维形状可视化多边形（265）。根据用于定义多形状多边形的重叠单形多边形的数量，多形状多边形被配置为以增加的强度显示。该方法还包括传送包括（i）多组药物记录和（ii）多组形状数据结构（240）的显示数据（247）。

3. 发明申请

WO2018001855A1 SYSTEMS AND METHODS FOR ANALYSIS OF INSULIN REGIMEN ADHERENCE DATA 审中-公开
标题翻译：用于分析胰岛素方案依从性数据的系统和方法
公开(公告)号：WO2018001855A1
公开(公告)日：2018-01-04
申请号：PCT/EP2017/065385
申请日：2017-06-22
申请人： NOVO NORDISK A/S
发明人： BENGTSSON, Henrik , ARADÓTTIR, Tinna, Björk , BROCKMEIER, Pete
IPC分类号： G06F19/00
摘要： System and methods are disclosed for monitoring adherence to a prescribed insulin regimen for a subject. A data set comprising a plurality of metabolic events the subject engaged is obtained. Each metabolic event comprises a timestamp of the event and a first classification that is one of insulin regimen adherent and nonadherent. Each respective metabolic event is then further classified using a second classification, based upon the timestamp of the metabolic event. The second classification has a temporal periodicity represented by a plurality of periodic elements. Metabolic events are binned on the basis of the second classification thereby obtaining a plurality of subsets of the metabolic events, each subset for a different periodic element. For each respective subset, a respective representation of adherence to the insulin regimen is communicated, the representation of adherence being collectively based upon the first classification of metabolic events in the respective subset.
摘要翻译：公开了系统和方法用于监测对于对象的规定胰岛素方案的依从性。获得包含受试者参与的多个代谢事件的数据集。每个代谢事件包括事件的时间戳和第一分类，其是胰岛素方案粘附和非粘附之一。然后基于代谢事件的时间戳，使用第二分类来进一步分类各个代谢事件。第二分类具有由多个周期性元素表示的时间周期性。基于第二分类对代谢事件进行分类，从而获得代谢事件的多个子集，每个子集用于不同的周期性元素。对于每个相应的子集，传达对胰岛素方案的依从性的相应表示，依从性的表示是基于相应子集中的代谢事件的第一分类来集体进行的。

4. 发明申请

WO2018077835A1 SYSTEMS AND METHODS FOR ESTIMATING THE RISK OF A FUTURE HYPOGLYCEMIC EVENT 审中-公开
标题翻译：用于估计未来低血糖事件风险的系统和方法
公开(公告)号：WO2018077835A1
公开(公告)日：2018-05-03
申请号：PCT/EP2017/077077
申请日：2017-10-24
申请人： NOVO NORDISK A/S
发明人： ORDEN, Brad, Van , ARADÓTTIR, Tinna, Björk , BROCKMEIER, Pete , BENGTSSON, Henrik
IPC分类号： G06F19/00
CPC分类号： G16H50/70
摘要： A device (250) for estimating the risk of a future hypoglycemic event for a subject with a standing insulin regimen (206), wherein the standing insulin regimen comprises one or more types of insulin medicament dosage regimen (208), wherein each of the one or more types of insulin medicament dosage regimen (208) comprises a type of insulin medicament (210) defining one or more types of insulin medicaments. Using the evaluation of a glucose concentration, a first time derivative and an insulin on board for the subject in a current metabolic state, and the evaluation of a glucose concentration, a first derivative and a historical insulin on board to estimate a hypoglycemic risk measure.
摘要翻译：（250），其用于估计具有常设胰岛素方案的受试者将来的低血糖事件的风险（206），其中所述常备胰岛素方案包括一种或多种类型的胰岛素药物剂量方案（ 208），其中所述一种或多种类型的胰岛素药物剂量方案（208）中的每一种包括定义一种或多种类型的胰岛素药物的一种类型的胰岛素药物（210）。使用对当前代谢状态下的受试者的葡萄糖浓度，一阶导数和胰岛素的评估以及评估葡萄糖浓度，一阶导数和机载历史胰岛素以估计低血糖风险度量。

5. 发明申请

WO2018033513A1 SYSTEMS AND METHODS FOR OPTIMIZATION OF A BOLUS INSULIN MEDICAMENT DOSAGE FOR A MEAL EVENT 审中-公开
标题翻译：系统和方法优化用于膳食事件的波斯胰岛素药物剂量
公开(公告)号：WO2018033513A1
公开(公告)日：2018-02-22
申请号：PCT/EP2017/070583
申请日：2017-08-14
申请人： NOVO NORDISK A/S
发明人： ARADÓTTIR, Tinna, Björk , BENGTSSON, Henrik , BROCKMEIER, Pete , PEDERSEN, Jonas, Kildegård
IPC分类号： G06F19/00
摘要： Systems and methods for adjusting a short acting dosage for a prospective meal for a subject with a standing regimen are provided. The standing regimen comprises short acting and long acting regimens. Past records are obtained from insulin pens applying the standing regimen. Each record specifies an amount and type of medicament injected, the type being one of short and long acting, and a timestamp. Responsive to the prospective meal at time (t 0 ), total insulin on board (IOB total ) is calculated as the sum of IOB bolus and IOB basal , with IOB bolus being the total amount of short acting medicament injected, indicated by records having timestamps within a duration of the short acting medicament to t 0 , and IOB basal being the total amount of long acting medicament injected, indicated by records having timestamps within the duration of the long acting medicament to t 0 . IOB total serves to calculate the short acting dosage for the meal.
摘要翻译：提供了用于调整具有静止疗法的对象的预期膳食的短效剂量的系统和方法。常规疗法包括短效和长效疗法。过去的记录是从应用常规方案的胰岛素笔中获得的。每个记录指定注射药物的量和类型，该类型是短期和长期作用之一，以及时间戳。响应于在时间点（t 0 0）的预期用餐，船上的总胰岛素（IOB总数）被计算为IOB快餐团的总数和 IOB _{，其中IOB 是注射的短效药物的总量，由在短效药物的持续时间内具有时间戳的记录指示为t _{0 < 并且IOB基础是注射的长效药物的总量，由在长效药物的持续时间内具有时间戳的记录指示为t0。 IOB 用于计算膳食的短效剂量。}}

6. 发明申请

WO2018007160A1 SYSTEMS AND METHODS FOR THE DETERMINATION OF INSULIN SENSITIVITY 审中-公开
标题翻译：确定胰岛素敏感性的系统和方法
公开(公告)号：WO2018007160A1
公开(公告)日：2018-01-11
申请号：PCT/EP2017/065378
申请日：2017-06-22
申请人： NOVO NORDISK A/S
发明人： BENGTSSON, Henrik , ARADÓTTIR, Tinna, Björk , BROCKMEIER, Pete
IPC分类号： G06F19/00
摘要： A subject is prescribed short and long acting insulin medicament regimens. When a qualified fasting event occurs, the basal insulin sensitivity estimate of the subject is updated using (i) an expected fasting blood glucose level based upon the long acting insulin medicament dosing specified by the long acting regimen during the fasting event, (ii) glucose measurements contemporaneous with the fasting event and (iii) a prior insulin sensitivity factor. A basal insulin sensitivity factor curve is calculated from the updated basal insulin sensitivity estimate. A bolus insulin sensitivity estimate of the subject is updated upon occurrence of a correction bolus with a short acting insulin medicament using (i) an expected blood glucose level based upon the correction bolus, (ii) glucose measurements after occurrence of the correction bolus, and (iii) a prior insulin sensitivity factor. A bolus insulin sensitivity factor curve is calculated from the updated bolus insulin sensitivity estimate.
摘要翻译：一个对象被规定为短效和长效胰岛素药物治疗方案。当发生合格的禁食事件时，使用（i）基于在禁食事件期间由长效方案指定的长效胰岛素药物剂量的预期空腹血糖水平，（ii）葡萄糖与禁食事件同时进行的测量和（iii）先前的胰岛素敏感因子。根据更新的基础胰岛素敏感性估计计算基础胰岛素敏感性因子曲线。使用（i）基于校正推注的预期血糖水平，（ii）在发生校正推注后的葡萄糖测量，以及（ii）基于校正推注的预期血糖水平，利用短效胰岛素药物发生校正推注时更新对象的推注胰岛素敏感性估计（iii）之前的胰岛素敏感因子。根据更新的推注胰岛素敏感性估计计算推注胰岛素敏感性因子曲线。

7. 发明申请

WO2022234030A1 INSULIN ON BOARD FOR GLUCOSE SENSITIVE INSULIN 审中-公开
公开(公告)号：WO2022234030A1
公开(公告)日：2022-11-10
申请号：PCT/EP2022/062181
申请日：2022-05-05
申请人： NOVO NORDISK A/S
发明人： BENGTSSON, Henrik , ARADÓTTIR, Tinna, Björk , ENGELL, Sarah, Ellinor , RYDE, Thomas, Emil
IPC分类号： G16H20/10 , G16H20/17 , G16H50/20 , G16H50/50
摘要： A method of estimating insulin on board (IOB) for a given glucose sensitive insulin (GSI) in a subject is provided. The method comprises the steps (i) for the given GSI, providing at least one rate constant (rc) as function of glucose concentration (rc(G)), (ii) providing for a period of time a continuous blood glucose log G(t) from the subject, (iii) providing for the period of time 5 an insulin dose log I(t) from the subject, (iv) based on rc(G) and G(t), calculating for each rc a rate constant as function of time (rc(t)), and (v) based on the at least one rc(t) and I(t) and using an estimating algorithm, calculating an estimated IOB for the subject.

8. 发明申请

WO2018037080A1 STARTER KIT FOR BASAL INSULIN TITRATION 审中-公开
标题翻译：入门套件基础胰岛素滴注
公开(公告)号：WO2018037080A1
公开(公告)日：2018-03-01
申请号：PCT/EP2017/071332
申请日：2017-08-24
申请人： NOVO NORDISK A/S
发明人： ORDEN, Brad, Van , WIELANDT, Jakob, Oest , MILLER, Thomas, Dedenroth , ARADÓTTIR, Tinna, Björk , BROCKMEIER, Pete , BENGTSSON, Henrik
IPC分类号： G06F19/00
摘要： Systems and methods for treating a subject are provided. A first dataset comprising timestamped autonomous glucose measurements of the subject over a first time course is obtained. A second dataset, associated with a standing insulin regimen for the subject over the first time course and comprising insulin medicament records, is also obtained. Each record comprises a timestamped injection event including an amount and type of insulin medicament injected into the subject by an insulin pen. The first and second datasets serve to calculate a glycaemic risk measure and an insulin sensitivity factor of the subject during the first time course, which are used to obtain a basal titration schedule and a fasting blood glucose profile model over a subsequent second time course for the subject. The model predicts the fasting blood glucose level of the subject based upon amounts of basal insulin medicament injected into the subject.
摘要翻译：提供了用于治疗受试者的系统和方法。获得第一数据集，其包括在第一时间进程上的对象的时间戳自主葡萄糖测量。还获得第二数据集，其与在第一时间过程中用于受试者的常规胰岛素方案相关并且包含胰岛素药物记录。每个记录包括时间戳注射事件，包括通过胰岛素笔向对象注射的胰岛素药物的量和类型。第一和第二数据集用于计算第一时间过程期间受试者的血糖风险测量和胰岛素敏感因子，所述第一和第二数据用于在随后的第二时间过程中获得基础滴定时间表和空腹血糖曲线模型，学科。该模型基于注入受试者的基础胰岛素药物的量来预测受试者的空腹血糖水平。

9. 发明申请

WO2018001856A1 SYSTEMS AND METHODS FOR ANALYSIS OF INSULIN REGIMEN ADHERENCE DATA 审中-公开
标题翻译：用于分析胰岛素方案依从性数据的系统和方法
公开(公告)号：WO2018001856A1
公开(公告)日：2018-01-04
申请号：PCT/EP2017/065387
申请日：2017-06-22
申请人： NOVO NORDISK A/S
发明人： BENGTSSON, Henrik , ARADÓTTIR, Tinna, Björk , BROCKMEIER, Pete
IPC分类号： G06F19/00
摘要： Systems and methods for evaluating insulin medicament dosage regimen adherence by a subject are provided. A description of metabolic events the subject engaged in is obtained. Each event comprises a timestamp and a classification that is one of insulin regimen adherent and insulin regimen nonadherent. Events are binned 5 into consecutive time windows on the basis of time to obtain a plurality of subsets. Adherence values are computed. Each adherence value is for a subset and is computed by dividing the insulin regimen adherent events by the total number of events in the subset. Adherence values are combined into a composite value by a process that comprises downweighting a first adherence value, representing a first time window, 10 with respect to a second adherence value, representing a second time window, when the first time window occurs in time before the second time window. The composite value is communicated as a single representation. 15
摘要翻译：提供了用于评估受试者胰岛素药物剂量方案依从性的系统和方法。获得主体参与的代谢事件的描述。每个事件包括时间戳和分类，其是胰岛素方案粘附和胰岛素方案非粘附之一。根据时间将事件分成5个连续的时间窗口以获得多个子集。计算粘附值。每个依从性值是针对一个子集的，并且通过将胰岛素治疗方案粘附事件除以子集中事件的总数来计算。通过以下过程将附着值组合成复合值，该过程包括下列过程：当第一时间窗出现在第一时间窗之前的时间内时，第一时间窗出现在第一时间窗10内，相对于表示第二时间窗的第二附着值，第二时间窗口。复合值作为单个表示进行通信。 15

10. 发明申请

WO2021110823A1 SELF-BENCHMARKING FOR DOSE GUIDANCE ALGORITHMS 审中-公开
公开(公告)号：WO2021110823A1
公开(公告)日：2021-06-10
申请号：PCT/EP2020/084440
申请日：2020-12-03
申请人： NOVO NORDISK A/S
发明人： BENGTSSON, Henrik , ARADÓTTIR, Tinna, Björk , MAHMOUDI, Zeinab , MOHEBBI, Ali , THORPE, Julia Rosemary
IPC分类号： G16H10/60 , G16H20/17
摘要： A benchmarking approach is employed that compares advice output from one or more alternative treatment guidance algorithms with a current actual treatment in terms of treatment outcomes. Treatment outcome for the current strategy is reflected in an actual BG outcome or profiled. Treatment outcome for an alternative algorithm-generated dose advice is based on a patient-specific model. The two sets of outcomes can be compared directly or using performance scores as a weighted combination that penalises or rewards certain outcomes. A statistical test may be applied to the accumulated results (paired outcomes or scores) to determine whether the algorithm is superior to the user's current dosing strategy, or alternative strategies.

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