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21. 发明申请

WO2020004904A1 RNA 은 제자리 혼성화 방법을 통한 AIMP2-DX2 신호 자동화 검출 방법 审中-公开
公开(公告)号：WO2020004904A1
公开(公告)日：2020-01-02
申请号：PCT/KR2019/007660
申请日：2019-06-25
申请人： 재단법인 의약바이오컨버젼스연구단 , 서울대학교병원
发明人： 고영일 , 김유식 , 김성훈 , 권남훈
IPC分类号： C12Q1/6813 , C12Q1/6886 , G01N1/36 , G06T7/11
摘要： 본 발명은 RNA 은 제자리 혼성화 방법을 통한 AIMP2-DX2 신호 자동화 검출 방법에 관한 것으로, 보다 상세하게는 RNA 은 제자리 혼성화 방법을 이용하여 피검체로부터 수득한 생물학적 시료에서 AIMP2의 플라이싱 변이체(splicing variant)인 AIMP2-DX2 신호의 비율을 자동으로 검출하는 방법에 관한 것이다. 본 발명의 방법에 따르면 동일 시료 내에서 AIMP2-DX2의 비율을 정량적으로 검출할 수 있고 자동화가 가능하며, 진단결과의 정확도가 우수할 뿐만 아니라 FFPE 시료를 사용하여 임상에 적용 가능하기 때문에, 암의 구분진단, 예후 예측 등에 매우 유용하게 활용될 수 있다.

22. 发明申请

WO2019104438A1 COATED GLASS SLIDE FOR ENHANCED THIN TISSUE SECTION ADHESION 审中-公开
公开(公告)号：WO2019104438A1
公开(公告)日：2019-06-06
申请号：PCT/CA2018/051527
申请日：2018-11-30
申请人： VALORISATION-RECHERCHE, LIMITED PARTNERSHIP , VAL-CHUM, LIMITED PARTNERSHIP
发明人： DUFRESNE, Martin , CHAURAND, Pierre , TRUDEL, Dominique , MASSON, Jean-françois
IPC分类号： G01N1/00 , G01N1/04 , G01N1/36 , G02B21/34
摘要： It is provided a substrate such as a microscopic slide coated with a layer of metal, such as chrome, titanium or aluminum, particularly a layer of less than 5 nm, or between 3 nm and 1 nm for adhering a sample, such as a tissue sample.

23. 发明申请

WO2019090290A1 BIOPSY SAMPLE MANIPULATION AND IMAGING SYSTEM AND METHODS FOR USE 审中-公开
公开(公告)号：WO2019090290A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/059344
申请日：2018-11-06
申请人： UNIVERSITY OF WASHINGTON
发明人： FAUVER, Mark E. , SEIBEL, Eric J.
IPC分类号： G01N1/36 , A61B10/02 , A61B10/04 , A61M39/00 , G01N1/28 , G01N33/483
CPC分类号： G01N1/36 , A61M39/00 , B01L3/502 , B01L2200/16 , B01L2300/0832 , B01L2300/123 , G01N1/30 , G02B21/34
摘要： An example fluidic device includes an elastic tube, a first actuator coupled to an outer surface of the elastic tube between a first end and a second end of the elastic tube, and a second actuator coupled to the outer surface of the elastic tube between the first actuator and the second end of the elastic tube. The first actuator and the second actuator are configured to move apart from one another to transition a portion of the elastic tube positioned between the first actuator and the second actuator from a first condition to a second condition. A diameter of the elastic tube is greater in the first condition than in the second condition. The fluidic device also includes one or more rotatable components coupled to the first actuator and the second actuator which are configured to rotate the portion of the elastic tube positioned between the first actuator and the second actuator.

24. 发明申请

WO2018176060A1 AEROSOL AND VAPOR ENHANCED SAMPLE MODULE 审中-公开
公开(公告)号：WO2018176060A1
公开(公告)日：2018-09-27
申请号：PCT/US2018/024687
申请日：2018-03-27
申请人： SIGNATURE SCIENCE, LLC
发明人： DICKINSON, Danielle , CARLSON, Micah
IPC分类号： G01N1/18 , G01N1/22 , G01N1/36 , G01N1/44
CPC分类号： G01N1/2208 , G01N1/2214 , G01N1/405 , G01N2001/2223
摘要： A sampling system is disclosed which comprises a collection chamber equipped with an inlet and first and second outlets; a pump which creates a flow of fluid into said inlet from the ambient environment, wherein said collection chamber divides the flow of fluid into a first major flow of fluid along which flows along a first flow path between said inlet and said first outlet, and a second minor flow of fluid which flows along a second flow path between said inlet and said second outlet; a collection surface disposed within said collection chamber and within the second flow path such that particles in the flow of fluid into said inlet impinge on said collection surface; a heater which vaporizes particles that collect on said collection surface; and an analyzer which analyzes the composition of the fluidic flow through said second outlet.

25. 发明申请

WO2018150986A1 包埋装置审中-公开
公开(公告)号：WO2018150986A1
公开(公告)日：2018-08-23
申请号：PCT/JP2018/004299
申请日：2018-02-08
申请人：サクラ精機株式会社 , サクラファインテックジャパン株式会社
发明人：中澤　良昭
IPC分类号： G01N1/36 , G01N1/06
摘要：包埋用のカセットの蓋を片手で開けることが可能な包埋装置を提供することを課題とする。　解決手段として、本発明に係る包埋装置（１）は、本体（２Ｂ）と前記本体（２Ｂ）に対して開閉可能に設けられた蓋（２Ａ）とを有して試料を収容するカセット（２）を載置する載置機構（４０）と、前記カセット（２）の前記蓋（２Ａ）を開ける蓋開け機構（３０）と、を備え、前記蓋開け機構（３０）は、前記蓋（２Ａ）が閉められた前記カセット（２）が前記載置機構（４０）の所定位置に載置された状態において前記蓋（２Ａ）の下面（２ａ）よりも高さが低い位置に設けられる一端部（３１）と、前記一端部（３１）から前記蓋（２Ａ）の下面（２ａ）よりも高さが高い位置まで延びる傾斜面（３２）と、を有する。

26. 发明申请

WO2018089438A8 MULTIPLEXED IMAGING USING MERFISH, EXPANSION MICROSCOPY, AND RELATED TECHNOLOGIES 审中-公开
公开(公告)号：WO2018089438A8
公开(公告)日：2018-05-17
申请号：PCT/US2017/060558
申请日：2017-11-08
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： ZHUANG, Xiaowei , MOFFITT, Jeffrey, R. , WANG, Guiping
IPC分类号： G01N1/36 , C12Q1/68
摘要： The present invention generally relates to microscopy, and to systems and methods for imaging or determining nucleic acids or other desired targets, for instance, within cells. In certain aspects, a sample is contained within an expandable material, which is expanded and imaged in some fashion. Expansion of the material improves the effective resolution of the subsequent image. This may be combined, for example, with other super-resolution techniques, such as STORM, and/or with techniques such as MERFISH for determining nucleic acids such as mRNA within the sample, for example, by binding nucleic acid probes to the sample. Other aspects are generally directed to compositions or devices for use in such methods, kits for use in such methods, or the like.

27. 发明申请

WO2018067407A1 MODULE FOR FREEZING AND STORAGE OF FROZEN TISSUE 审中-公开
标题翻译：冻结和储存冷冻组织的模块
公开(公告)号：WO2018067407A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/054531
申请日：2017-09-29
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , OSHETSKI, Michael
发明人： OSHETSKI, Michael , HEWITT, Stephen, M. , HANSON, Jeffrey, C. , YLAYA, Kris, R.
IPC分类号： G01N1/36 , G01N1/42 , B01L3/00 , G01N1/31
CPC分类号： G01N1/36 , B01L3/508 , B01L2300/041 , B01L2300/0609 , G01N1/42 , G01N2001/315 , G01N2001/366
摘要： An article (21) comprising: a planar base (6) having a first surface (7) and an opposing second surface (8) and an outer peripheral edge (9), wherein the second surface includes an area comprising a plurality of protuberances (10) and configured to attach and maintain orientation of a frozen tissue specimen block; and a removable lid (22) having a first side (23) and a second side (24), wherein the first side (23) defines a continuous planar surface and the second side (24) defines a recessed portion (25) configured to cover a frozen tissue specimen block and an outer rim (28) configured to engage with the outer peripheral edge (9) of the base (6), wherein the outer rim (28) does not form part of the recessed portion (25), wherein the area of the base (6) and the recessed portion (25) of the lid (22) are aligned.
摘要翻译：一种物品（21），包括：具有第一表面（7）和相对的第二表面（8）以及外周边缘（9）的平面基部（6），其中所述第二表面包括包括多个突起（10）并且被配置成附着并保持冷冻组织样本块的取向的区域; 和具有第一侧面（23）和第二侧面（24）的可移除的盖子（22），其中所述第一侧面（23）限定连续的平坦表面并且所述第二侧面（24）限定凹陷部分（25），所述凹入部分覆盖冷冻组织样本块和配置成与基部（6）的外周缘（9）接合的外缘（28），其中外缘（28）不形成凹部（25）的一部分，其中底座（6）的区域和盖（22）的凹入部分（25）对齐。

28. 发明申请

WO2018034437A1 박막 물성측정 및 분석용 시료 제작 방법 및 이에 의해 제작된 시료 审中-公开
标题翻译：样品制备方法，用于测量和分析薄膜和样品的物理性质
公开(公告)号：WO2018034437A1
公开(公告)日：2018-02-22
申请号：PCT/KR2017/007879
申请日：2017-07-21
申请人： 서울대학교산학협력단
发明人： 김기범 , 김민식 , 김현미 , 김기주
IPC分类号： G01N1/28 , G01N1/36 , H01L21/306 , H01L29/16 , H01L21/205 , H01L21/66 , H01L21/033
摘要： 본 발명은 박막 물성측정 및 분석용 시료 제작 방법 및 이에 의해 제작된 시료에 관한 것으로, 보다 상세하게는 하나의 시료에서 여러 가지 물성을 측정하거나 분석할 수 있는 시료를 제작하는 방법 및 이에 의해 제작된 시료에 관한 것이다. 본 발명에 따른 박막 물성측정 및 분석용 시료 제작 방법은 기판의 전면에 절연 물질로 이루어진 제1층을 형성하고, 기판의 후면에 제2층을 형성하고, 제2층을 패터닝하고, 패터닝된 제2층을 마스크로 이용하여 기판의 후면을 식각하여 기판의 전면과 후면을 관통하는 관통공을 형성함으로써 제1층의 기판과 대향하는 면의 일부를 하나 이상 노출시키고, 기판의 후면을 통하여 제1층의 노출된 부분을 일부 식각하고, 그리고 제1층의 기판과 대향하는 면의 반대면 상에 대상 박막을 형성한다.
摘要翻译：本发明涉及用于测量和分析薄膜的物理性质的样品制备方法和由此制备的样品，并且更具体地涉及能够测量或分析一个样品中的各种物理性质的样品制备方法并通过该方法生成一个样本。根据本发明的用于制造用于物理性质测量和分析的样品的方法包括：在衬底的前表面上形成第一绝缘材料层;在衬底的后表面上形成第二层;图案化第二层; 第二层用作掩模以蚀刻基板的后表面以形成贯穿基板的前表面和后表面的通孔，以暴露第一层的面向基板的表面的至少一部分，对该层的暴露部分进行部分蚀刻，并且在第一层的与衬底相对的衬底的相对侧上形成目标薄膜。

29. 发明申请

WO2017223070A1 SYSTEM AND METHOD FOR LABELING AND MONITORING CEMENTITIOUS COMPOSITES 审中-公开
标题翻译：用于标记和监测水泥复合材料的系统和方法
公开(公告)号：WO2017223070A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/038303
申请日：2017-06-20
申请人： THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY
发明人： LEY, Matthew Tyler , LEFLORE, Kristopher Jacob
IPC分类号： B28B23/00 , B28B7/00 , G01N1/28 , G01N1/36 , G01N33/00 , G01N33/38
CPC分类号： B28B23/0031 , B28B7/0094 , G01N33/383
摘要： This system includes a concrete identification technology that is used in taking, testing, monitoring, and labeling concrete samples or members using custom labels called a tag. This tag comprises a series of corresponding labels, one for the outside of the form, and on for the inside of the form that becomes part of the concrete sample. These tags are physically bonded to the concrete specimen with only minimal impact on its shape and properties. In some embodiments the tags will contain a hook-and-loop or fiber type surface texture (protrusions) which is placed in the form with the protrusions facing the fresh concrete. The tag can also contain electronic circuitry to gather and track information about the concrete and the surrounding environment. This will eliminate the need to relabel the samples after demolding while also measuring a number of other parameters about the concrete and its performance.
摘要翻译：
该系统包括一个具体的识别技术，该技术用于使用称为标签的自定义标签对具体样本或成员进行采集，测试，监控和标注。该标签包含一系列相应的标签，一个用于表单的外部，另一个用于表单的内部，成为混凝土样本的一部分。这些标签物理结合到混凝土试样上，对其形状和性能影响很小。在一些实施方案中，标签将包含钩状和环状或纤维类型的表面纹理（突起），其以突起面向新鲜混凝土的形式放置。标签还可以包含电子电路来收集和追踪有关混凝土和周围环境的信息。这样就不需要在脱模后对样品进行重新贴标签，同时还可以测量许多其他有关混凝土及其性能的参数。

30. 发明申请

WO2017202729A1 MIKROFLUIDISCHE VORRICHTUNG UND VERFAHREN ZUR PROBENAUFBEREITUNG VON PARAFFIN-EIGEBETTETEM GEWEBE 审中-公开
标题翻译：用于加工石蜡 - 特种织物织物的微流体装置和方法
公开(公告)号：WO2017202729A1
公开(公告)日：2017-11-30
申请号：PCT/EP2017/062156
申请日：2017-05-19
申请人： ROBERT BOSCH GMBH
发明人： HOFFMANN, Jochen
IPC分类号： G01N1/34 , G01N1/36
摘要： Die Erfindung betrifft ein Verfahren (500) zur Probenaufbereitung von Paraffin-eingebettetem Gewebe mit einer mikrofluidischen Vorrichtung (100), umfassend die Schritte: • Einbringen einer Paraffin-eingebetteten Gewebeprobe (1) in eine erste Kammer (110) der mikrofluidischen Vorrichtung (100) • Einleiten von Öl in die erste Kammer (110), insbesondere durch ein Pumpen des Öls aus einem ersten Reservoir (120) der mikrofluidischen Vorrichtung (100) in die erste Kammer (110) • Extrahierung von Paraffin aus der Paraffin-eingebetteten Gewebeprobe (1) durch Kontaktierung der Gewebeprobe (1) mit dem Öl, wobei das Öl durch eine Heizeinrichtung (130) der mikrofluidischen Vorrichtung (100) auf eine erste Temperatur gebracht und vorzugsweise auf der ersten Temperatur gehalten wird.
摘要翻译：
本发明涉及用于石蜡包埋的组织的样品制备与微流体装置（100）的方法（500），包括以下步骤：•引入石蜡包埋的组织样本（1）为第一室（ 110）中的微流体装置（100）•引入＆Ouml的;通过从所述微流体装置（100的第一贮存器120）泵送＆Ouml（LS）（在第一腔室升（在第一腔室110），特别是110） •由组织样品（1）与所述＆Ouml接触从石蜡包埋的组织样本（1）石蜡的提取;升，其中，所述＆Ouml;升由所述微流体装置（100）的加热装置（130）带到第一温度，并且优选保持在第一温度。

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