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1. 发明申请

WO2018089438A8 MULTIPLEXED IMAGING USING MERFISH, EXPANSION MICROSCOPY, AND RELATED TECHNOLOGIES 审中-公开
公开(公告)号：WO2018089438A8
公开(公告)日：2018-05-17
申请号：PCT/US2017/060558
申请日：2017-11-08
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： ZHUANG, Xiaowei , MOFFITT, Jeffrey, R. , WANG, Guiping
IPC分类号： G01N1/36 , C12Q1/68
摘要： The present invention generally relates to microscopy, and to systems and methods for imaging or determining nucleic acids or other desired targets, for instance, within cells. In certain aspects, a sample is contained within an expandable material, which is expanded and imaged in some fashion. Expansion of the material improves the effective resolution of the subsequent image. This may be combined, for example, with other super-resolution techniques, such as STORM, and/or with techniques such as MERFISH for determining nucleic acids such as mRNA within the sample, for example, by binding nucleic acid probes to the sample. Other aspects are generally directed to compositions or devices for use in such methods, kits for use in such methods, or the like.

2. 发明申请

WO2018089438A1 MULTIPLEXED IMAGING USING MERFISH, EXPANSION MICROSCOPY, AND RELATED TECHNOLOGIES 审中-公开
标题翻译：使用MERFISH，扩展显微镜和相关技术的复合成像
公开(公告)号：WO2018089438A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060558
申请日：2017-11-08
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： MOFFITT, Jeffrey, R. , WANG, Guiping , ZHUANG, Xiaowei
IPC分类号： G01N1/36 , C12Q1/68
摘要： The present invention generally relates to microscopy, and to systems and methods for imaging or determining nucleic acids or other desired targets, for instance, within cells. In certain aspects, a sample is contained within an expandable material, which is expanded and imaged in some fashion. Expansion of the material improves the effective resolution of the subsequent image. This may be combined, for example, with other super-resolution techniques, such as STORM, and/or with techniques such as MERFISH for determining nucleic acids such as mRNA within the sample, for example, by binding nucleic acid probes to the sample. Other aspects are generally directed to compositions or devices for use in such methods, kits for use in such methods, or the like.
摘要翻译：本发明总体上涉及显微术，并且涉及例如在细胞内成像或确定核酸或其他期望靶标的系统和方法。在某些方面，样品被包含在可膨胀材料内，其以某种方式膨胀和成像。材料的扩展提高了后续图像的有效分辨率。例如，通过将核酸探针与样品结合，这可以与例如诸如STORM的其他超分辨技术和/或诸如MERFISH的技术组合以用于确定样品内的核酸例如mRNA。其他方面通常涉及用于这种方法的组合物或装置，用于这种方法的试剂盒等。

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