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21. 发明申请

WO02062308A3 PRIMARY INTERMEDIATES FOR OXIDATIVE COLORATION OF HAIR 审中-公开
标题翻译：主要用于氧化染发的中间体
公开(公告)号：WO02062308A3
公开(公告)日：2002-09-19
申请号：PCT/US0201581
申请日：2002-01-18
申请人： CLAIROL INC
发明人： LIM MU-III , PAN YUH-GUO
IPC分类号： C07D295/12 , A61K8/00 , A61K8/34 , A61K8/41 , A61K8/49 , A61Q5/10 , C07C213/02 , C07C215/14 , C07C215/76 , C07C215/80 , C07C217/58 , C07C217/84 , C07D211/56 , C07D295/135 , D06P3/08 , A61K7/13
CPC分类号： C07D295/135 , A61K8/347 , A61K8/415 , A61K8/4926 , A61K8/4953 , A61Q5/10 , C07C215/14 , C07C215/76 , C07C217/58 , C07C217/84
摘要： Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): where R1, and R2 are each individually selected from a hydrogen atom, a C1 to C3 alkyl group, a C1 to C5 mono or dihydroxyalkyl group; phenyl or benzyl optionally substituted with an alkoxy group, or R1, and R2 together with the nitrogen atom to which they are attached form a piperazine, piperidine, imidazole, or morpholine ring.
摘要翻译：用于头发氧化染色的染发组合物的主要中间体是式（1）的化合物：其中R1和R2各自独立地选自氢原子，C1至C3烷基，C1至C5单或二羟基烷基; 任选被烷氧基取代的苯基或苄基，或R 1和R 2与它们所连接的氮原子一起形成哌嗪，哌啶，咪唑或吗啉环。

22. 发明申请

WO02002507A1 2-HYDROXY-5-AMINO-BIPHENYL-DERIVATIVES AND OXIDATIVE HAIR COLOURING AGENTS CONTAINING SAID COMPOUNDS 审中-公开
标题翻译： 2-羟基-5-氨基联苯衍生物和含有它们的氧化头发
公开(公告)号：WO02002507A1
公开(公告)日：2002-01-10
申请号：PCT/EP2001/002704
申请日：2001-03-10
IPC分类号： A61K8/00 , A61K8/41 , A61Q5/10 , C07C215/76 , C07C215/78 , C07C215/80 , C07C217/80 , C07C217/84 , C07C225/22 , C07C255/59 , C07C323/31 , C07C323/32 , C07D209/08 , C07D317/58 , D06P3/08 , A61K7/13 , D06P1/32
CPC分类号： C07D317/58 , A61K8/415 , A61Q5/10 , C07C215/76 , C07C215/78 , C07C215/80 , C07C217/80 , C07C225/22 , C07C255/59 , C07C323/31 , C07D209/08
摘要： The invention relates to an oxidative colouring agent for keratin fibres, in particular hair, based on a developing agent-coupling agent combination, which contains as a developing agent, at least one 2-hydroxy-5-amino-biphenyl derivative of general formula (I), in addition to novel 2-hydroxy-5-amino-biphenyl derivatives.
摘要翻译：本发明涉及对氧化着色剂用于角蛋白纤维，特别是头发，基于显影剂的偶联剂组合，其中至少一种含有作为展开剂，（通式2-羟基-5-氨基联苯衍生物 I）中，除了新的2-羟基-5-氨基联苯衍生物。

23. 发明申请

WO2013016263A3 AMINE-INITIATED POLYOLS FROM RENWABLE RESOURCES AND PROCESSES FOR THEIR PRODUCTION AND USE 审中-公开
公开(公告)号：WO2013016263A3
公开(公告)日：2013-01-31
申请号：PCT/US2012/047808
申请日：2012-07-23
申请人： BAYER MATERIALSCIENCE LLC , WARDIUS, Don S. , SCHILLING, Steven L.
发明人： WARDIUS, Don S. , SCHILLING, Steven L.
IPC分类号： C07C215/80 , C07C215/12 , B01J23/04 , B01J31/12 , C08G18/28 , C08J9/00
摘要： Amine-initiated polyether polyols are made by reacting an amine adduct with a triglyceride in the presence of an alkylene oxide to obtain a polyol having a total renewables content of at least 20%. The polyols produced in this manner are particularly useful for the production of polyurethane and a polyisocyanurate foams.

24. 发明申请

WO2011084789A3 INTEGRATED PROCESSES FOR THE PREPARATION OF POLYBENZIMIDAZOLE PRECURSORS 审中-公开
标题翻译：一种制备聚苯并咪唑前体的综合方法
公开(公告)号：WO2011084789A3
公开(公告)日：2011-11-10
申请号：PCT/US2010061536
申请日：2010-12-21
申请人： DU PONT , DHAWAN RAJIV , RITTER JOACHIM C
发明人： DHAWAN RAJIV , RITTER JOACHIM C
IPC分类号： C07C213/02 , C07C51/097 , C07C57/34 , C07C59/68 , C07C215/80
CPC分类号： C07C213/08 , C07C51/412 , Y02P20/125 , C07C65/05 , C07C63/26 , C07C63/38 , C07C215/80
摘要： An integrated process is provided for efficiently preparing 2,4,5-triaminophenol, starting with nitration of 2,6-dihalobenzene; high purity salts thereof; and complexes of 2,4,5-triaminophenol aromatic diacids, which are precursors for making polybenzimidazole polymer for high performance fibers. The process design eliminates several costly intermediate drying and recrystallization steps. The handling of solid materials with possible skin sensitizing properties and toxicity is avoided, thereby eliminating human and environmental exposure.
摘要翻译：从2,6-二卤代苯的硝化开始，提供了一种有效制备2,4,5-三氨基苯酚的综合方法; 其高纯度盐; 以及2,4,5-三氨基苯酚芳族二酸的配合物，它们是用于制备用于高性能纤维的聚苯并咪唑聚合物的前体。工艺设计消除了几个昂贵的中间干燥和重结晶步骤。避免处理具有可能的皮肤致敏性和毒性的固体材料，从而消除人和环境的暴露。

25. 发明申请

WO2008117704A1 ３，３’－ジアミノ－５，５’－ジフェニル－４，４’－ビフェニルジオール及びその原料、並びにポリベンゾオキサゾール审中-公开
标题翻译： 3,3'-二氨基-5,5'-二苯基-4,4'-联苯胺，其原料及聚苯并噻唑
公开(公告)号：WO2008117704A1
公开(公告)日：2008-10-02
申请号：PCT/JP2008/055011
申请日：2008-03-18
申请人：日本化薬株式会社 , 国方賢治 , 高本大平 , 関根健二
发明人：国方賢治 , 高本大平 , 関根健二
IPC分类号： C07C215/80 , C07C205/23 , C08G73/22
CPC分类号： C08G73/22 , C07C215/74
摘要：　本発明は、高性能ポリマー、特にポリベンゾオキサゾールやポリイミド等の半導体分野での高度な性能要求を満たすポリマーのモノマーとして有用な３，３’－ジアミノ－５，５’－ジフェニル－４，４’－ビフェニルジオールと、その原料である３，３’－ジニトロ－５，５’－ジフェニル－４，４’－ビフェニルジオールとを提供するものである。また、本発明は、下記式（１）：（式中、Ｒは２価のジカルボン酸残基である）で表される繰り返し単位を有するポリベンゾオキサゾールを提供するものである。
摘要翻译： 3,3'-二氨基-5,5'-二苯基-4,4'-联苯二醇，其可用作高性能聚合物的单体，特别是在半导体领域满足高度性能要求的单体，例如聚苯并恶唑和聚酰亚胺。还提供了作为该二醇的原料的3,3'-二硝基-5,5'-二苯基-4,4'-联苯二醇。此外还提供了具有由下式（1）表示的重复单元的聚苯并恶唑：（1）（其中R是二羧酸的二价残基）。

26. 发明申请

WO01030743A1 AMINOPHENOL DERIVATIVES AND THE USE THEREOF IN OXIDATIVE HAIR DYES 审中-公开
标题翻译：氨基酚衍生物和它们在氧化染发剂
公开(公告)号：WO01030743A1
公开(公告)日：2001-05-03
申请号：PCT/EP2000/010073
申请日：2000-10-13
IPC分类号： A61K8/00 , A61K8/41 , A61Q5/10 , C07C215/80 , A61K7/13 , C07C217/84 , C07C229/44
CPC分类号： A61Q5/10 , A61K8/415 , C07C215/80
摘要： The invention relates to aminophenol derivatives of the general formula (I) with the substituent X of the general formula (II), wherein at least one of the groups R and R and at least one of the groups R and R is not hydrogen, and in which -A- represents one of the groups -(CH2)x-, -CH2-c(CH3)c-, -O-(CH2)y-O-, -O-(CnH2n-z(OH)z)-O-, -O-(C2H4-O)u- or -O-(C3H6-O)v-, or to the water-soluble salts of the above-mentioned compounds. The inventive compounds are particularly suitable for use as developers in oxidative dyes for dyeing keratin fibers.
摘要翻译：通式（I）与通式中的取代基X（II）的氨基苯酚衍生物，其中两个基团中的至少一个R <1>和R <2>和两个基团中的至少一个R <3>和R <4> 不代表Wasserstpff，并且其中-A-代表的基团之一 - （CH 2）x - ，-CH 2 -C（CH 3）C-，-O-（CH 2）yO-，-O-（为CnH2n-Z （OH）z的）-O - ， - O-（C 2 H 4 O）U形或-O-（C 3 H 6-O）V-，或水溶性盐，所述的化合物是特别适合作为在用于着色角蛋白纤维的着色剂的氧化显色剂组分。

27. 发明申请

WO01014319A1 4,6-BIS(SUBSTITUTED)PHENYLAZORESORCINOL AND PROCESS FOR PRODUCING 4,6-DIAMINORESORCINOL 审中-公开
标题翻译： 4,6-BIS（取代的）苯并三唑和生产4,6-DIAMINORESORCINOL的方法
公开(公告)号：WO01014319A1
公开(公告)日：2001-03-01
申请号：PCT/JP2000/005767
申请日：2000-08-25
IPC分类号： B01J23/02 , C07C245/08 , C09B33/04 , C09B41/00 , C09B67/54 , B01J23/44 , C07C213/02 , C07C215/80
CPC分类号： C07C245/08 , B01J23/02 , C09B33/04 , C09B41/001 , C09B67/0096
摘要： A process for producing a 4,6-bis(substituted)phenylazoresorcinol represented by formula (2) which comprises mixing a solution of a (substituted) benzenediazonium salt represented by formula (1) with a solution or suspension of the hydroxide of an alkali metal or alkaline earth metal to obtain an alkaline mixture, mixing and reacting this mixture with an aqueous solution of resorcinol and/or of an alkali metal salt or alkaline earth metal salt thereof, and mixing the resultant reaction mixture with an acid liquid to make the mixture acid and thereby crystallize the target compound, characterized in that the acidification of the reaction mixture is conducted by adding the reaction mixture to the acid liquid and mixing them. The process is effective in reducing the time required for filtration for collecting the reaction product to thereby heighten production efficiency. (In the formulae, R represents halogeno, etc.; n is an integer of 0 to 5; and X represents chlorine, etc.).
摘要翻译：一种制备由式（2）表示的4,6-双（取代的）苯基氮杂间半乳糖醇的方法，其包括将由式（1）表示的（取代的）重氮盐的溶液与碱金属氢氧化物的溶液或悬浮液或碱土金属，以获得碱性混合物，将该混合物与间苯二酚和/或其碱金属盐或碱土金属盐的水溶液混合和反应，并将所得反应混合物与酸性液体混合以制备混合物酸，从而使目标化合物结晶，其特征在于反应混合物的酸化通过将反应混合物加入到酸性液体中并混合来进行。该方法有效地减少用于收集反应产物的过滤所需的时间，从而提高生产效率。（式中，R表示卤代等，n表示0〜5的整数，X表示氯等）。

28. 发明申请

WO00043349A1 NOVEL TRIPHENYL COMPOUNDS 审中-公开
标题翻译：新型三苯乙烯化合物
公开(公告)号：WO00043349A1
公开(公告)日：2000-07-27
申请号：PCT/JP2000/000191
申请日：2000-01-18
IPC分类号： C07D251/24 , C08K5/3492 , C07C215/80
CPC分类号： C07D251/24 , C08K5/3492 , C08L21/00
摘要： Triphenyl compounds represented by general formula (I) or salts thereof, wherein X , X and X are each independently hydroxyl, mercapto, or amino; Y is amino; and R is a C1-C12 trivalent hydrocarbon group which may be fluorinated or contain an etheric oxygen atom, or a triazine residue, with the proviso that either each of X , X and X or Y is bonded at the meta position and the other at the para position. The compounds are useful as crosslinking agents for elastomers and give crosslinked products excellent in heat resistance.
摘要翻译：由通式（I）表示的三苯基化合物或其盐，其中X 1，X 2和X 3各自独立地为羟基，巯基或氨基; Y为氨基; 并且R 4是可以被氟化或含有醚性氧原子的C1-C12三价烃基或三嗪残基，条件是X 1，X 2和X 3中的每一个，或Y在间位结合，另一个在对位结合。这些化合物可用作弹性体的交联剂，并产生耐热性优异的交联产物。

29. 发明申请

WO99037294A2 MITOCHONDRIA PROTECTING AGENTS FOR TREATING MITOCHONDRIA ASSOCIATED DISEASES 审中-公开
标题翻译：用于治疗麻醉相关疾病的麻醉保护剂
公开(公告)号：WO99037294A2
公开(公告)日：1999-07-29
申请号：PCT/US1999/001718
申请日：1999-01-26
IPC分类号： C07D215/08 , A61K31/00 , A61K31/047 , A61K31/05 , A61K31/06 , A61K31/085 , A61K31/12 , A61K31/136 , A61K31/155 , A61K31/235 , A61K31/352 , A61K31/353 , A61K31/47 , A61K47/48 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/00 , A61P43/00 , C07C39/08 , C07C39/11 , C07C39/19 , C07C69/017 , C07C215/78 , C07C215/80 , C07C217/84 , C07C279/18 , C07D215/20 , C07D311/72
CPC分类号： A61K31/155 , A61K31/00 , A61K31/05 , A61K31/06 , A61K31/136 , C07C39/08 , C07C39/11 , C07C39/19 , C07C69/017 , C07C215/78 , C07C215/80 , C07C217/84 , C07C279/18 , C07D215/20 , C07D311/72
摘要： The present invention relates generally to mitochondria protecting agents for treating diseases in which mitochondrial dysfunction leads to tissue degeneration and, more specifically, to compounds, compositions and methods related to the same. The methods of this invention involve administration of a pharmaceutically effective amount of a mitochondria protecting agent to a warm-blooded animal in need thereof, and composition of this invention contains a mitochondria protecting agent in combination with a pharmaceutically acceptable carrier or diluent. Mitochondrial associated diseases which may be treated by the present invention include (but are not limited to) Alzheimer's Disease, diabetes mellitus, Parkinsons's Disease, neuronal and cardiac ischemia, Huntington's disease and stroke.
摘要翻译：本发明一般涉及用于治疗线粒体功能障碍导致组织变性的线粒体保护剂，更具体地涉及与其相关的化合物，组合物和方法。本发明的方法包括向有需要的温血动物施用药学有效量的线粒体保护剂，本发明的组合物含有与药学上可接受的载体或稀释剂组合的线粒体保护剂。可以通过本发明治疗的线粒体相关疾病包括（但不限于）阿尔茨海默氏病，糖尿病，帕金森氏病，神经元和心脏缺血，亨廷顿病和中风。

30. 发明申请

WO98043942A1 NOVEL COMPOUNDS, THEIR USE AND PREPARATION 审中-公开
标题翻译：新化合物，其使用和制备
公开(公告)号：WO98043942A1
公开(公告)日：1998-10-08
申请号：PCT/SE1998/000556
申请日：1998-03-26
IPC分类号： C07D233/64 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/216 , A61K31/275 , A61K31/33 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/4164 , A61K31/421 , A61K31/426 , A61K31/4406 , A61K31/4535 , A61P13/00 , A61P43/00 , C07C209/08 , C07C209/24 , C07C209/70 , C07C209/88 , C07C211/06 , C07C211/29 , C07C211/49 , C07C213/00 , C07C215/30 , C07C215/48 , C07C215/54 , C07C215/80 , C07C217/08 , C07C217/48 , C07C217/62 , C07C221/00 , C07C223/02 , C07C225/16 , C07C227/16 , C07C229/34 , C07C229/38 , C07C233/36 , C07C237/20 , C07C237/30 , C07C247/16 , C07C255/33 , C07C255/43 , C07D207/32 , C07D207/335 , C07D213/38 , C07D233/54 , C07D263/32 , C07D263/56 , C07D277/28 , C07D307/52 , C07D333/20
CPC分类号： C07D207/335 , A61K31/137 , A61K31/381 , C07C211/29 , C07C211/49 , C07C215/30 , C07C215/54 , C07C215/80 , C07C217/08 , C07C217/48 , C07C223/02 , C07C225/16 , C07C229/34 , C07C229/38 , C07C233/36 , C07C237/20 , C07C247/16 , C07C255/43 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07D213/38 , C07D233/64 , C07D263/32 , C07D263/56 , C07D277/28 , C07D307/52 , C07D333/20
摘要： The invention relates to novel compounds of Formula (I) wherein R , R , R , R , R , R , R and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, when the compounds can be in the form of optical isomers, the racemic mixture and the individual enantiomers. The compounds have anticholinergic activity, and the invention also relates to the compounds of Formula (I) for use as therapeutically active substances, pharmaceutical compositions containing compounds of Formula (I), the use of the compounds of Formula (I) for preparing anticholinergic drugs, the use of the compounds of Formula (I) for treating urinary incontinence, and methods for preparing the compounds of Formula (I).
摘要翻译：本发明涉及新的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和Ar分别为权利要求1所述的盐，其与生理上可接受的酸的盐，当化合物可以是旋光异构体形式时，外消旋混合物和单独的对映异构体。该化合物具有抗胆碱能活性，本发明还涉及用作治疗活性物质的式（I）化合物，含有式（I）化合物的药物组合物，式（I）化合物用于制备抗胆碱能药物，式（I）化合物用于治疗尿失禁的用途，以及制备式（I）化合物的方法。

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