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21. 发明申请

WO2004010852A3 TISSUE COMPOSITIONS AND METHODS FOR PRODUCING SAME 审中-公开
标题翻译：组织组合物和生产该组合物的方法
公开(公告)号：WO2004010852A3
公开(公告)日：2004-09-23
申请号：PCT/US0324173
申请日：2003-07-31
申请人： KROPP BRADLEY P , CHENG EARL Y , ZHANG YUAN YUAN , LIN H K , COWAN RICK
发明人： KROPP BRADLEY P , CHENG EARL Y , ZHANG YUAN YUAN , LIN H K , COWAN RICK
IPC分类号： A61F2/02 , A61K35/12 , C12N5/071 , A01N63/00 , A61F2/04 , A61F2/08 , A61K35/37 , C12N5/00 , C12N5/08
CPC分类号： A61F2/02 , A61K35/12 , C12N5/0685 , C12N5/0697 , C12N2502/02 , C12N2502/1347 , C12N2502/1358 , C12N2502/253 , C12N2506/02 , C12N2506/1353 , C12N2533/92
摘要： A method for providing a urinary tract tissue graft composition includes providing a segment of small intestinal submucosa and positioning the segment of small intestinal submucosa in a tissue culture frame such that the segment of small intestinal submucosa is suspended and held in a taut position by the tissue culture frame. At least one multipotent cell type is isolated from a tissue specimen of a subject and cultured, and then seeded upon a surface of the segment of small intestinal submucosa, thereby forming a urinary tract tissue graft. Methods for repairing a damaged urinary tract tissue of a subject are also disclosed.
摘要翻译：提供尿道组织移植物组合物的方法包括提供一段小肠粘膜下层并将小肠粘膜下层段定位在组织培养框架中，使得小肠粘膜下层的段被组织悬挂并保持在拉紧位置文化框架。从受试者的组织标本中分离出至少一种多潜能细胞类型并进行培养，然后将其接种在小肠粘膜下层部分的表面上，从而形成尿道组织移植物。还公开了修复受试者的受损尿路组织的方法。

22. 发明申请

WO02014469A3 REPROGRAMMING CELLS FOR ENHANCED DIFFERENTIATION CAPACITY USING PLURIPOTENT STEM CELLS 审中-公开
标题翻译：使用PLUIPOTETI STEM细胞增强分化能力的重组细胞
公开(公告)号：WO02014469A3
公开(公告)日：2002-06-13
申请号：PCT/US2001/025493
申请日：2001-08-14
IPC分类号： C12N5/071 , C12N5/0793 , C12N5/00 , C12N5/08
CPC分类号： C12N5/0619 , C12N5/067 , C12N2502/02 , C12N2506/1353
摘要： Described in this disclosure is a new process whereby cells of one tissue type can be reprogrammed to produce cells of a different tissue type. Cells from a human donor are reprogrammed by culturing adjacent to primate pluripotent stem cells (in an undifferentiated or newly differentiated state) or in an environment supplemented by components taken from pPS cells. Simultaneously or in a subsequent step, the donor cells can be treated in a manner that enhances differentiation towards a different tissue type. In this manner, patients in need of tissue regeneration can be treated with cells differentiated and reprogrammed from their own autologous cell donation.
摘要翻译：在本公开中描述的是一种新方法，其中一种组织类型的细胞可以被重新编程以产生不同组织类型的细胞。通过与灵长类多能干细胞（未分化或新分化状态）相邻的环境或在补充有从pPS细胞的组分补充的环境中培养来重新编程来自人供体的细胞。同时或在随后的步骤中，供体细胞可以以增强朝不同组织类型分化的方式进行治疗。以这种方式，需要组织再生的患者可以用从其自身的自体细胞捐献分化和重新编程的细胞来治疗。

23. 发明申请

WO2014186394A1 HUMAN PLURIPOTENT STEM CELLS PRODUCED BY SOMATIC CELL NUCLEAR TRANSFER 审中-公开
标题翻译：人类细胞核转运生产的人类细胞干细胞
公开(公告)号：WO2014186394A1
公开(公告)日：2014-11-20
申请号：PCT/US2014/037897
申请日：2014-05-13
申请人： OREGON HEALTH & SCIENCE UNIVERSITY
发明人： MITALIPOV, Shoukhrat , TACHIBANA, Masahito
IPC分类号： C12N5/074 , C12N5/02
CPC分类号： C12N5/0606 , C12N5/0603 , C12N5/0609 , C12N5/0611 , C12N5/16 , C12N15/873 , C12N15/8776 , C12N2500/44 , C12N2500/70 , C12N2500/84 , C12N2502/02 , C12N2506/02 , C12N2517/04
摘要： Human pluripotent embryonic stem cells produced by somatic cell nuclear transfer as well as methods of making and using said human pluripotent embryonic stem cells are disclosed.
摘要翻译：公开了通过体细胞核转移产生的人多能胚胎干细胞以及制备和使用所述人多能胚胎干细胞的方法。

24. 发明申请

WO2012112576A1 TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS USING UMBILICAL DERIVED CELLS 审中-公开
标题翻译：使用脐带血细胞治疗间质性侧凸性肉芽肿
公开(公告)号：WO2012112576A1
公开(公告)日：2012-08-23
申请号：PCT/US2012/025086
申请日：2012-02-14
申请人： ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC , GOSIEWSKA, Anna , HARMON, Alexander M. , KIHM, Anthony J. , FANG, Carrie H. , DHANARAJ, Sridevi
发明人： GOSIEWSKA, Anna , HARMON, Alexander M. , KIHM, Anthony J. , FANG, Carrie H. , DHANARAJ, Sridevi
IPC分类号： A61K35/16 , C12N5/0775
CPC分类号： C12N5/0605 , A61K35/12 , C12N5/0607 , C12N5/0622 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/12 , C12N2501/13 , C12N2501/21 , C12N2501/23 , C12N2501/385 , C12N2501/41 , C12N2502/02 , C12N2502/03 , C12N2506/02 , C12N2506/025 , C12N2506/03 , C12N2509/00 , C12N2533/50
摘要： This invention relates to methods of treating amyotrophic lateral sclerosis. In particular, the invention provides for methods of treating amyotrophic lateral sclerosis by administering umbilical cord tissue-derived cells, an effective amount of a substantially homogenous population of umbilical cord tissue-derived cells or a pharmaceutical composition comprising umbilical cord tissue-derived cells to a patient.
摘要翻译：本发明涉及治疗肌萎缩性侧索硬化症的方法。特别地，本发明提供了通过施用脐带组织来源的细胞，有效量的基本上均匀的脐带组织来源的细胞群或包含脐带组织来源的细胞的药物组合物来治疗肌萎缩性侧索硬化的方法患者。

25. 发明申请

WO2011140441A2 METHODS AND SYSTEMS FOR CONVERTING PRECURSOR CELLS INTO INTESTINAL TISSUES THROUGH DIRECTED DIFFERENTIATION 审中-公开
标题翻译：通过指导性差异将前列腺细胞转化为细胞组织的方法和系统
公开(公告)号：WO2011140441A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/035518
申请日：2011-05-06
申请人： CHILDREN'S HOSPITAL MEDICAL CENTER , WELLS, James, M. , ZORN, Aaron, M. , SPENCE, Jason, R. , SHROYER, Noah, F.
发明人： WELLS, James, M. , ZORN, Aaron, M. , SPENCE, Jason, R. , SHROYER, Noah, F.
IPC分类号： C12N5/071 , C12N5/02 , C07K14/47 , C07K14/50
CPC分类号： C12N5/0679 , C12N5/0661 , C12N2501/119 , C12N2501/155 , C12N2501/16 , C12N2501/385 , C12N2501/415 , C12N2502/02 , C12N2502/45
摘要： The generation of complex organ tissues from human embryonic and pluripotent stem cells (PSCs) remains a major challenge for translational studies. It is shown that PSCs can be directed to differentiate into intestinal tissue in vitro by modulating the combinatorial activities of several signaling pathways in a step-wise fashion, effectively recapitulating in vivo fetal intestinal development. The resulting intestinal "organoids" were three-dimensional structures consisting of a polarized, columnar epithelium surrounded by mesenchyme that included a smooth muscle-like layer. The epithelium was patterned into crypt-like SOX9-positive proliferative zones and villus-like structures with all of the major functional cell types of the intestine. The culture system is used to demonstrate that expression of NEUROG3, a pro-endocrine transcription factor mutated in enteric anendocrinosis is sufficient to promote differentiation towards the enteroendocrine cell lineage. In conclusion, PSC-derived human intestinal tissue should allow for unprecedented studies of human intestinal development, homeostasis and disease.
摘要翻译：来自人胚胎和多能干细胞（PSCs）的复杂器官组织的产生仍然是翻译研究的主要挑战。显示PSC可以通过以逐步方式调节多种信号传导途径的组合活性而被引导以在体外分化成肠组织，有效地重现体内胎儿肠发育。所得到的肠“有机体”是由包含平滑肌层的间质包围的极化柱状上皮组成的三维结构。将上皮图案化为具有肠的所有主要功能性细胞类型的隐窝样SOX9阳性增殖区和绒毛状结构。培养系统用于证明在肠内分泌异常症中突变的前内分泌转录因子的NEUROG3的表达足以促进对肠内分泌细胞谱系的分化。总之，PSC衍生的人肠组织应该允许对人肠发育，体内平衡和疾病进行前所未有的研究。

26. 发明申请

WO2011030915A1 METHOD FOR PRODUCING MAST CELLS FROM PLURIPOTENT STEM CELLS 审中-公开
标题翻译：从细胞干细胞生产细胞的方法
公开(公告)号：WO2011030915A1
公开(公告)日：2011-03-17
申请号：PCT/JP2010/065893
申请日：2010-09-08
申请人： KYOTO UNIVERSITY , NAKAHATA, Tatsutoshi , TSUJI, Kohichiro , MA, Feng
发明人： NAKAHATA, Tatsutoshi , TSUJI, Kohichiro , MA, Feng
IPC分类号： C12N5/0787 , C12N5/071 , C12N5/10
CPC分类号： C12N5/0642 , C12N2501/125 , C12N2501/145 , C12N2501/165 , C12N2501/23 , C12N2501/26 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2506/45
摘要： The present invention relates to a method for producing human mast cells from human pluripotent stem cells. More particularly, the present invention provides a method for producing human mast cells from human pluripotent stem cells, comprising the steps of: (a) culturing human pluripotent stem cells under a condition suitable for promoting differentiation of the human pluripotent stem cells into hematopoietic progenitor cells expressing CD34; and (b) culturing the cells obtained in step (a) in the presence of hematopoietic factors comprising thrombopoietin (TPO) and Flt3 ligand.
摘要翻译：本发明涉及从人多能干细胞生产人肥大细胞的方法。更具体地，本发明提供了一种从人多能干细胞产生人肥大细胞的方法，包括以下步骤：（a）在适合于促进人多能干细胞分化成造血祖细胞的条件下培养人多能干细胞表达CD34; 和（b）在造血因子存在下培养在步骤（a）中获得的细胞，所述造血因子包括血小板生成素（TPO）和Flt3配体。

27. 发明申请

WO2009027654A1 REGIONALISED ENDODERM CELLS AND USES THEREOF 审中-公开
标题翻译：区域性内胚层细胞及其用途
公开(公告)号：WO2009027654A1
公开(公告)日：2009-03-05
申请号：PCT/GB2008002875
申请日：2008-08-25
申请人： UNIV EDINBURGH , MORRISONM GILLIAN MARY , BRICKMAN JOSHUA MARK , OIKONOMOPOULOU IFIGENIA
发明人： MORRISONM GILLIAN MARY , BRICKMAN JOSHUA MARK , OIKONOMOPOULOU IFIGENIA
IPC分类号： A61K35/12 , C12N5/073
CPC分类号： C12N5/0603 , A61K35/54 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/155 , C12N2501/16 , C12N2501/165 , C12N2501/385 , C12N2501/40 , C12N2501/41 , C12N2501/999 , C12N2502/02 , C12N2506/02 , C12N2510/00 , C12Q1/6881
摘要： The present invention relates to the generation of anterior definitive endoderm (ADE) cells from embryonic stem cells and the differentiation of such cells to, for example, pancreatic or liver cells. The invention also relates to cell lines, cell culture methods, cells markers and the like and their potential uses in a variety of applications.
摘要翻译：本发明涉及从胚胎干细胞产生前定形内胚层（ADE）细胞并将这些细胞分化成例如胰腺细胞或肝细胞。本发明还涉及细胞系，细胞培养方法，细胞标记等及其在各种应用中的潜在用途。

28. 发明申请

WO2008075378A3 XENO-FREE CULTURE CONDITIONS FOR HUMAN EMBRYONIC STEM CELLS AND METHODS THEREOF 审中-公开
标题翻译：人胚胎干细胞的XENO-FREE文化条件及其方法
公开(公告)号：WO2008075378A3
公开(公告)日：2009-01-22
申请号：PCT/IN2007000594
申请日：2007-12-17
申请人： STEMPEUTICS RES PRIVATE LTD , TOTEY SATISH , KULKARNI KUMAR UDAY , SAXENA SHOBHIT
发明人： TOTEY SATISH , KULKARNI KUMAR UDAY , SAXENA SHOBHIT
IPC分类号： C12N5/0735
CPC分类号： C12N5/0606 , C12N2500/25 , C12N2500/90 , C12N2501/105 , C12N2501/11 , C12N2501/117 , C12N2501/12 , C12N2501/125 , C12N2501/13 , C12N2501/135 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2502/02 , C12N2506/02
摘要： The present disclosure provides novel culture system and methods for culturing and propagating hESCs in a substantially undifferentiated state for several passages. The ability to grow such cells without differentiation has important applications for therapeutic uses of ES cells for treating human disorders using tissue transplantation and/or gene therapy techniques. In particular, the disclosure further relates to conditioned medium obtained from human germ lineage derived feeder cells (GLDF). The hESC lines are derived, cultured and propagated in substantially undifferentiated state using the conditioned media from GLDF cells of the disclosure. In particular, the disclosure relates to the xeno-free derivation, culture and propagation of hESCs using conditioned medium of GLDF cells obtained thereof.
摘要翻译：本公开提供了用于培养和繁殖基本上未分化状态的hESC几代的新型培养系统和方法。在不分化的情况下生长这种细胞的能力对于ES细胞用于使用组织移植和/或基因治疗技术治疗人类疾病的治疗用途具有重要的应用。特别地，本发明还涉及从人类胚系谱系饲养细胞（GLDF）获得的条件培养基。使用本公开的GLDF细胞的条件培养基，基本上未分化状态导出，培养和繁殖hESC系。特别地，本公开涉及使用其获得的GLDF细胞的条件培养基的hESC的无异种素衍生，培养和繁殖。

29. 发明申请

WO2007096115A3 COLLECTION AND SELECTION METHODS OF AN EMBRYONIC- LIKE STEM CELL POPULATION FROM HUMAN ADULT PERIODONTAL FOLLICULAR TISSUES 审中-公开
标题翻译：成人牙周组织中胚胎样干细胞种群的筛选及筛选方法
公开(公告)号：WO2007096115A3
公开(公告)日：2007-11-22
申请号：PCT/EP2007001416
申请日：2007-02-19
申请人： LAINO GREGORIO , PAPACCIO GIANPAOLO , DE ROSA ALFREDO , D AQUINO RICCARDO , GRAZIANO ANTONIO
发明人： LAINO GREGORIO , PAPACCIO GIANPAOLO , DE ROSA ALFREDO , D AQUINO RICCARDO , GRAZIANO ANTONIO
IPC分类号： C12N5/077
CPC分类号： C12N5/0664 , C12N2501/115 , C12N2501/15 , C12N2502/02
摘要： Methods for the isolation, expansion and storage of a population of stem cells belonging to human dental follicles, called FENC (Follicle-derived Embryonic Neural Crest stem cells,) including: a) Collection of the follicular sack in sterile conditions, digestion and primary culture growth and expansion; b) Optional amplification; c) FACsorting.
摘要翻译：一种称为FENC（Follicle-derived Embryonic Neural Crest干细胞）的人类牙囊干细胞群的分离，扩增和储存方法，包括：a）在无菌条件下收集滤泡袋，消化和原代培养增长和扩张; b）可选扩增; c）FACsorting。

30. 发明申请

WO2006061717A3 MATERIALS AND METHODS RELATED TO DICKKOPFS (DKK) AND NEUROGENESIS 审中-公开
标题翻译：材料与DICKKOPFS（DKK）和神经发生相关的方法
公开(公告)号：WO2006061717A3
公开(公告)日：2007-07-05
申请号：PCT/IB2005003996
申请日：2005-12-09
申请人： NEURO THERAPEUTICS AB , ARENAS ERNESTO , CASTELO BRANCO GONCALO , SOUSA KYLE
发明人： ARENAS ERNESTO , CASTELO BRANCO GONCALO , SOUSA KYLE
IPC分类号： A61K38/00 , C12N5/079 , C12N5/0793
CPC分类号： A61K38/1709 , C12N5/0619 , C12N5/0622 , C12N2502/02 , C12N2506/02 , G01N33/5058 , G01N33/5073 , G01N2800/2835
摘要： Materials and Methods related to Dickkopfs and Neurogenesis Abstract Methods for promoting dopaminergic neuronal development and producing neural cells having a dopaminergic phenotype. Dopaminergic neural cells may be used for treating individuals having a neurodegenerative disease such as Parkinson's disease. Dopaminergic cells may be implanted into the brain of the individual, and/or dopaminergic neural development may be induced or enhanced in the brain of the individual. Methods comprise treating the cell with a Dkk ligand, such as any one of Dkk1 to Dkk4 or a fragment thereof comprising a cysteine rich domain, or a Dkk receptor such as LRP5 or LRP6, thereby producing or enhancing proliferation, self-renewal, survival and/or dopaminergic induction, differentiation, survival or acquisition of a neuronal dopaminergic phenotype. The cell may be co-cultured with astrocytes or glial cells and may be contacted with an FGF growth factor. Dopaminergic neurons may also be useful in drug/toxicology testing and for target development or drug discovery.
摘要翻译：与Dickkopfs和神经发生有关的材料和方法Abstract Abstract促进多巴胺能神经元发育和产生具有多巴胺能表型的神经细胞的方法。多巴胺能神经细胞可用于治疗患有神经变性疾病如帕金森病的个体。可以将多巴胺能细胞植入个体的脑中，和/或多巴胺能神经发育可以在个体的大脑中被诱导或增强。方法包括用Dkk配体，例如Dkk1至Dkk4中的任一种或其包含富含半胱氨酸的结构域或Dkk受体如LRP5或LRP6的片段处理细胞，从而产生或增强增殖，自我更新，存活和 /或多巴胺能诱导，分化，存活或获得神经元多巴胺能表型。细胞可与星形胶质细胞或神经胶质细胞共培养，并可与FGF生长因子接触。多巴胺能神经元也可用于药物/毒理学测试和目标开发或药物发现。

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