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21. 发明申请

WO2010014468A3 SUBCUTANEOUSLY IMPLANTABLE LEAD INCLUDING DISTAL FIXATION MECHANISM 审中-公开
标题翻译：皮下可植入导线，包括远端固定机制
公开(公告)号：WO2010014468A3
公开(公告)日：2010-05-06
申请号：PCT/US2009051368
申请日：2009-07-22
申请人： MEDTRONIC INC , RUTTEN JEAN JOSEPH GERARDUS , SMITS KAREL F A A , LAZEROMS MARKUS J
发明人： RUTTEN JEAN JOSEPH GERARDUS , SMITS KAREL F A A , LAZEROMS MARKUS J
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0504
摘要： A subcutaneously implantable lead includes a coil disposed along a portion of the lead, and a lead tip coupled to a distal end of the lead. The lead tip includes at least one component that is movable relative to the distal end of the lead and configured to anchor the lead tip in subcutaneous tissue.
摘要翻译：皮下植入式引线包括沿着引线的一部分设置的线圈以及联接到引线的远端的引线尖端。引线尖端包括至少一个相对于引线的远端可移动的部件，并被配置为将引线尖端锚定在皮下组织中。

22. 发明申请

WO2010014469A2 SUBCUTANEOUS IMPLANTABLE LEAD 审中-公开
标题翻译：不可替代的领先
公开(公告)号：WO2010014469A2
公开(公告)日：2010-02-04
申请号：PCT/US2009/051371
申请日：2009-07-22
申请人： MEDTRONIC, INC. , HAVEL, William, J. , LAZEROMS, Markus, J. , RUTTEN, Jean Joseph, Gerardus , SMITS, Karel, F.A.A.
发明人： HAVEL, William, J. , LAZEROMS, Markus, J. , RUTTEN, Jean Joseph, Gerardus , SMITS, Karel, F.A.A.
IPC分类号： A61N1/39 , A61N1/05
CPC分类号： A61N1/0504 , A61N1/3962
摘要： A subcutaneous implantable device is provided that includes a defibrillation electrode disposed along a portion of a lead, and a lead tip connected to the lead. The lead tip includes a trailing end coupled to a distal end of the lead, and first and second non-parallel sides extending from the trailing end that converge to a leading end that is configured to wedge between tissue layers as the lead is advanced subcutaneously.
摘要翻译：提供了一种皮下可植入装置，其包括沿引线的一部分设置的除颤电极和连接到引线的引线头。引导尖端包括联接到引线的远端的尾端以及从后端延伸的第一和第二非平行侧，所述后端会聚到前端，当引导皮下进行时，构造成在组织层之间楔入。

23. 发明申请

WO2010014374A1 APPARATUS FOR GUIDING THE PLACEMENT OF A SUBCUTANEOUS DEVICE 审中-公开
标题翻译：用于指导设备的布置的装置
公开(公告)号：WO2010014374A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/050185
申请日：2009-07-10
申请人： MEDTRONIC, INC. , WHITMAN, Teresa, A. , HAVEL, William, J. , FOERSTER, Laurice, D. , MARSHALL, Mark, T
发明人： WHITMAN, Teresa, A. , HAVEL, William, J. , FOERSTER, Laurice, D. , MARSHALL, Mark, T
IPC分类号： A61B17/34
CPC分类号： A61B17/3468 , A61B17/3462 , A61B17/3472 , A61B2017/00026 , A61B2017/0003 , A61B2017/00561 , A61B2017/306 , A61B2017/320044 , A61B2017/320056 , A61M5/425 , A61M5/427 , A61M2005/1586 , A61N1/046 , A61N1/0504
摘要： An apparatus (100) or guiding the placement of a subcutaneous device such as a coil electrode for an implantable cardioverter-defibrillator (ICD).The apparatus includes a strap (102) having an indentation (104) configured for a fold of skin and fat layer to be positioned within the indentation as the subcutaneous device is advanced to a desired implantation site.
摘要翻译：一种装置（100）或引导诸如用于可植入心律转复除颤器（ICD）的线圈电极的皮下装置的放置。该装置包括带子（102），其具有构造成用于皮肤和脂肪的折叠的凹陷（104）层，当皮下装置前进到期望的植入位置时，其定位在凹陷内。

24. 发明申请

WO2008042468A2 SYSTEM FOR NEURALLY-MEDIATED ANTI-ARRHYTHMIC THERAPY 审中-公开
标题翻译：用于神经介导的抗精神病治疗的系统
公开(公告)号：WO2008042468A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/069010
申请日：2007-05-16
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad , PASTORE, Joseph M.
发明人： LIBBUS, Imad , PASTORE, Joseph M.
IPC分类号： A61N1/39 , A61N1/36
CPC分类号： A61N1/36114 , A61N1/0504 , A61N1/3956
摘要： According to an embodiment of a method, a predetermined cardiac activity indicated for an antitachycardia shock is detected. Neural stimulation is applied to lower a defibrillation threshold in preparation for the shock, and the shock is subcutaneously delivered. According to one embodiment, neural stimulation is applied as part of a prophylactic therapy. A predetermined cardiac activity indicated for an antitachycardia shock is detected, and the shock is subcutaneously delivered. Other aspects and embodiments are provided herein.
摘要翻译：根据方法的一个实施方案，检测到针对抗心动过速休克指示的预定心脏活动。应用神经刺激来降低除颤阈值以准备休克，并且皮下递送休克。根据一个实施例，神经刺激作为预防性治疗的一部分被应用。检测到针对抗心动过速休克的预定心脏活动，并且皮下递送休克。本文提供了其它方面和实施例。

25. 发明申请

WO2006115772A2 SUBCUTANEOUS CARDIOVERTER-DEFIBRILLATOR 审中-公开
公开(公告)号：WO2006115772A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/013569
申请日：2006-04-11
申请人： MEDTRONIC, INC. , OLSON, Walter, H. , STILWELL, Gary, J. , MOY, King, Y. , NAKAYAMA, Joey, G. , PROKOP, Gary, F.
发明人： OLSON, Walter, H. , STILWELL, Gary, J. , MOY, King, Y. , NAKAYAMA, Joey, G. , PROKOP, Gary, F.
IPC分类号： A61N1/39
CPC分类号： A61N1/3968 , A61N1/0504 , A61N1/375 , A61N1/3756
摘要： SubQ ICDs are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion-defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. Configurations include one hermetically sealed housing with 1 or, optionally, 2 subcutaneous sensing and cardioversion-defibrillation therapy delivery leads or alternatively, 2 hermetically sealed housings interconnected by a power/signal cable. The housings are generally dynamically configurable to adjust to varying rib structure and associated articulation of the thoracic cavity and muscles. Further the housings may optionally be flexibly adjusted for ease of implant and patient comfort.
摘要翻译：公开了SubQ ICD，其完全可植入皮下，以最小的手术侵入患者身体，并提供分布式心脏复律除颤感和刺激电极，用于在需要时在整个心脏中递送心脏复律除颤电击和起搏治疗。配置包括一个密封的外壳，具有1个或任选地2个皮下感测和心脏复律除颤治疗输送引线，或者备选地，通过电力/信号电缆互连的2个气密密封外壳。这些外壳通常是可动态配置的，可调整到胸腔和肌肉的不同肋骨结构和相关关节。此外，为了便于植入和患者舒适，还可以灵活地调整这些外壳。

26. 发明申请

WO1992017240A1 SUBCUTANEOUS MULTI-ELECTRODE SENSING SYSTEM 审中-公开
标题翻译： SUBCUTANEOUS多电极感应系统
公开(公告)号：WO1992017240A1
公开(公告)日：1992-10-15
申请号：PCT/US1992000981
申请日：1992-02-04
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , BENNETT, Tom, D. , COMBS, William, J. , KALLOK, Michael, J. , LEE, Brian, B. , MEHRA, Rahul
IPC分类号： A61N01/365
CPC分类号： A61N1/3686 , A61N1/0504 , A61N1/36185 , A61N1/3622 , A61N1/3756 , Y10S128/903
摘要： A method and apparatus for providing an enhanced capability of detecting and gathering electrical cardiac signals via an array of relatively closely spaced subcutaneous electrodes (located on the body of an implanted device) which may be employed with suitable switching circuits, signal processors, and memory to process the electrical cardiac signals between any selected pair or pairs of the electrode array in order to provide a leadless, orientation insensitive means for receiving the electrical signal from the heart. This far-field EGM may be used to provide storage and analysis of arrhythmic events and to provide control signals for the delivery of various therapies including pacing, cardioversion and defibrillation therapies as well as the delivery of antiarrhythmic drugs, and, in the pacing context, to effect capture detection and automatic stimulation threshold adaptation, recording of PMT episodes, measurement of refractory periods in order to set timing windows for antitachy pacing therapies, and as a control signal for use in adjusting pacing rate to physiologic demand. The housing or case of the subcutaneously implanted medical device is modified to provide an array of electrodes which may be selectively or sequentially coupled in one or more pairs to the terminals of one or more sense amplifiers to pick up, amplify and process the electrical cardiac signals across each electrode pair. In one embodiment, the signals from the selected electrode pairs may be stored and compared to one another in order to determine the sensing vector which provides the largest cardiac signal (in a test mode). Following completion of the test mode, the system may employ the selected subcutaneous ECG signal vector for a number of applications. The implanted device possesses analog-to-digital conversion circuitry for sampling and converting the selected subcutaneous ECG signal to digital data which is stored in a recirculating buffer, the contents of which are transferred to RAM for later data retrieval either periodically or upon the occurrence of an event of interest. In another embodiment, the selected subcutaneous ECG signal is used to confirm capture in conjunction with an algorithm for determining the stimulation threshold of the heart and set stimulation pulse energy at a level exceeding the threshold by a desired safety margin. Further embodiments include replacing the switching approach with parallel linear and nonlinear combinational processing of the signals from the orthogonal electrode pairs of the electrode array, to develop and employ continuous signals insensitive to the orientation variations of the electrode array. These linear and nonlinear embodiments would be used for improving the data storage and autocapture embodiments by providing an optimal signal at all times, while avoiding the switching process.
摘要翻译：一种用于提供通过相对紧密间隔的皮下电极（位于植入装置的主体上）的阵列来检测和收集电心电信号的增强能力的方法和装置，其可以与合适的开关电路，信号处理器和存储器一起使用处理任何所选择的一对或一对电极阵列之间的电心脏信号，以便提供用于从心脏接收电信号的无引导方向不敏感的装置。这种远场EGM可用于提供心律失常事件的存储和分析，并提供用于递送各种疗法的控制信号，包括起搏，心脏复律和除颤疗法以及递送抗心律失常药物，并且在起搏背景下，实现捕获检测和自动刺激阈值适应，记录PMT发作，测量不良期以设置反向起搏治疗的时间窗口，以及用于调整生理需求起搏速度的控制信号。修改皮下植入的医疗装置的壳体或壳体以提供电极阵列，其可以以一对或多对选择性或顺序耦合到一个或多个感测放大器的端子，以拾取，放大和处理电心脏信号穿过每个电极对。在一个实施例中，来自所选择的电极对的信号可以彼此存储和比较，以便确定提供最大心脏信号（在测试模式中）的感测向量。在完成测试模式之后，系统可以使用选择的皮下ECG信号向量进行多种应用。植入的装置具有模数转换电路，用于对所选择的皮下ECG信号进行取样并将其转换成存储在再循环缓冲器中的数字数据，其内容被传送到RAM以便稍后数据检索感兴趣的事件在另一个实施例中，所选择的皮下ECG信号用于结合用于确定心脏的刺激阈值的算法来确认捕获，并将刺激脉冲能量设置在超过阈值的水平所需安全余量。另外的实施例包括用来自电极阵列的正交电极对的信号的并行线性和非线性组合处理替换开关方法，以开发和采用对电极阵列的取向变化不敏感的连续信号。这些线性和非线性实施例将用于通过在避免切换过程的同时始终提供最佳信号来改进数据存储和自动捕获实施例。

27. 发明申请

WO2018200723A1 RESORBABLE IMPLANT FOR STIMULATING TISSUE, SYSTEMS INCLUDING SUCH IMPLANT, AND METHODS OF USING 审中-公开
公开(公告)号：WO2018200723A1
公开(公告)日：2018-11-01
申请号：PCT/US2018/029437
申请日：2018-04-25
申请人： WASHINGTON UNIVERSITY , NORTHWESTERN UNIVERSITY
发明人： RAY, Wilson Z. , MACEWAN, Matthew R. , ZOHNY, Zohny , ROGERS, John A.
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0504 , A61N1/05 , A61N1/205 , A61N1/326
摘要： A system for stimulating tissue generally comprises a resorbable implant. The resorbable implant includes a substrate, at least one contact, and a transceiver, wherein the substrate, the at least one contact, and the transceiver are resorbable. The system also includes a controller configured to communicate with the transceiver of the resorbable implant and a power supply connected to the controller. The controller delivers power to the resorbable implant from the power supply. The resorbable implant delivers electrical stimulation to tissue when the resorbable implant receives power.

28. 发明申请

WO2017015366A3 SUBSTERNAL PLACEMENT OF A PACING AND/OR DEFIBRILLATING ELECTRODE 审中-公开
标题翻译：电镀和/或断开电极的后置放置
公开(公告)号：WO2017015366A3
公开(公告)日：2017-03-02
申请号：PCT/US2016043128
申请日：2016-07-20
申请人： CAMERON HEALTH INC
发明人： REDDY G SHANTANU , TOCKMAN BRUCE A
IPC分类号： A61B17/34 , A61B17/32 , A61N1/05 , A61N1/362
CPC分类号： A61N1/05 , A61B17/0401 , A61B17/3468 , A61B90/361 , A61B2017/0409 , A61B2017/0417 , A61B2017/320056 , A61N1/0504 , A61N1/059 , A61N1/362
摘要： New methods for implanting a cardiac therapy system include implanting a lead of the system substernally anterior of the heart without attaching to the myocardium or pericardium. An illustration includes placement of an anchor beneath the sternum in the vicinity of one of the sternal angle, a location superior of the ventricles, the area bounded by the 2nd or 3rd ribs, and level with the aortic arch. A tension element or tether is attached to the anchor and a lead is introduced over the tension element or tether and secured in a desired position relative to the anchor. Other examples also include implantation, substernally, of a lead without the use of a pre-tunneling tool or sheath over the lead itself, for example by using an advancing tool for pushing the lead into position.
摘要翻译：植入心脏治疗系统的新方法包括在心脏前方植入系统的铅，而不附着于心肌或心包。插图包括在胸骨下方的胸骨角度附近放置锚固体，在心室上方的位置，由第二或第三肋限定的区域和与主动脉弓水平的位置。张紧元件或系绳附接到锚固件，并且引线被引导到张力元件或系绳上并且相对于锚固件固定在期望的位置。其他示例还包括在铅的本体上植入，即不使用预引线工具或护套的引线本身，例如通过使用用于将引线推入位置的前进工具。

29. 发明申请

WO2016037144A3 CARDIAC PACING LEAD DELIVERY SYSTEM 审中-公开
标题翻译： CARDIAC PACING铅交货系统
公开(公告)号：WO2016037144A3
公开(公告)日：2016-09-15
申请号：PCT/US2015048712
申请日：2015-09-04
申请人： ATACOR MEDICAL INC
发明人： MARCOVECCHIO ALAN , SANGHERA RICK , MCGEEHAN SEAN
IPC分类号： A61N1/18 , A61N1/05
CPC分类号： A61N1/0592 , A61N1/0504 , A61N1/0587 , A61N1/059 , A61N1/362 , A61N1/365 , A61N1/36542 , A61N1/3655 , A61N1/36564 , A61N1/37211 , A61N1/3752
摘要： A lead delivery system having a base for securing a lead delivery device to one or more anatomical structures of a patient and a lead advancer configured to incrementally advance a lead into a patient by a predefined amount.
摘要翻译：一种引线输送系统，其具有用于将引线输送装置固定到患者的一个或多个解剖结构的基部，以及引导推进器，其构造成将引线递增地推进到患者预定量。

30. 发明申请

WO2016100798A1 COLLAPSIBLE EXTRAVASCULAR LEAD 审中-公开
标题翻译：不可思议的超导铅
公开(公告)号：WO2016100798A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/066628
申请日：2015-12-18
申请人： MEDTRONIC, INC.
发明人： MARSHALL, Mark T. , NIKOLSKI, Vladimir P. , OLSON, Nathan L.
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0504 , A61N1/0563
摘要： An implantable medical electrical lead having an elongate lead body having a proximal end and a distal portion. A plurality of defibrillation electrodes coupled to the distal portion is included, the plurality of electrodes being transitionable from a first configuration in which the defibrillation electrodes are biased in an expanded configuration to a second configuration in which the defibrillation electrodes are in a collapsed configuration. A joint slideably disposed around a portion of the lead body is included, at least a portion of the plurality of defibrillation electrodes being coupled to the joint
摘要翻译：一种具有细长引线主体的可植入医疗电线，其具有近端和远端部分。包括耦合到远端部分的多个除颤电极，所述多个电极可从其中除颤电极以扩张构型偏置到其中除颤电极处于折叠构型的第二配置的第一配置转变。包括可滑动地设置在引线主体的一部分周围的接头，多个除颤电极的至少一部分耦合到接头

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