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21. 发明申请

WO2004092201A3 ENHANCED HIV-1 VACCINES AND METHODS FOR THEIR USE 审中-公开
标题翻译：增强的HIV-1疫苗及其使用方法
公开(公告)号：WO2004092201A3
公开(公告)日：2004-12-02
申请号：PCT/US2004009617
申请日：2004-03-29
申请人： US GOV HEALTH & HUMAN SERV , BERZOFSKY JAY A , OKAZAKI TAKAHIRO
发明人： BERZOFSKY JAY A , OKAZAKI TAKAHIRO
IPC分类号： A61K39/21 , A61K39/385 , C07K20060101 , C07K14/16
CPC分类号： C12N9/1276 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/385 , A61K2039/5158 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/55566 , A61K2039/57 , A61K2039/6018 , A61K2039/645 , C07K14/005 , C12N7/00 , C12N2740/16222 , C12N2740/16234
摘要： ENHANCED HIV-1 VACCINES AND METHODS FOR THEIR USE ABSTRACT The present invention provides peptides and proteins for use in second generation HIV vaccines and as diagnostic tools in the treatment and control of HIV infection. The antiviral protection shown by compositions of the present invention has not been previously achieved with an HLA epitope-enhanced vaccine. These findings define a critical balance between MHC affinity and receptor crossreactivity required for effective epitope enhancement and also demonstrate construction and efficacy of such a component of a new generation vaccine.
摘要翻译：增强的HIV-1疫苗及其使用方法摘要本发明提供了用于第二代HIV疫苗的肽和蛋白质，并作为治疗和控制HIV感染的诊断工具。用本发明的组合物显示的抗病毒保护以前没有用HLA表位增强的疫苗实现。这些发现确定了有效表位增强所需的MHC亲和力与受体交叉反应性之间的关键平衡，并且还证明了新一代疫苗的这种组分的构建和功效。

22. 发明申请

WO02036160A2 METHOD FOR OBTAINING ANTIGENIC STRUCTURES ENHANCING SPECIFIC CROSS REACTIVITY 审中-公开
标题翻译：获得具有特异性交叉反应性的抗原结构的方法
公开(公告)号：WO02036160A2
公开(公告)日：2002-05-10
申请号：PCT/CU2001/000007
申请日：2001-11-01
IPC分类号： C12P21/02 , A61K20060101 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/29 , A61K39/385 , A61K47/48 , A61P31/00 , A61P31/18 , A61P35/00 , C07K7/08 , C07K14/00 , C07K14/16 , C08G83/00
CPC分类号： A61K39/12 , A61K39/21 , A61K39/29 , A61K39/292 , A61K39/385 , A61K47/646 , A61K2039/545 , A61K2039/6031 , A61K2039/6075 , A61K2039/645 , C07K7/08 , C08G83/003 , C12N2730/10134 , C12N2740/16034 , C12N2770/24234 , Y02A50/386
摘要： The invention relates to a method for obtaining high cross reactivity antigenic structures that are capable of enhancing an immune response to peptidic antigens administered systemically and/or mucosally and to the chemical structures obtained with said method and the formulations obtained from said structures and their utilization. The method describes the obtention of new dendrimeric structures from the selection and synthesis of dendrimers that are subsequently coupled to carrier molecules. The resulting structures can be used conveniently adjuvated or in a formulation in which several antigens of this type can be introduced, a synergistic effect taking place between these components in relation to the cross reactivity and the immunogenicity of the response obtained. The preparation may also contain stabilizers and preserving agents. The resulting antigenic structures can be used in the pharmaceutical industry as vaccine formulations for human and veterinary use and as part of diagnostic systems.
摘要翻译：本发明涉及一种获得高交叉反应性抗原结构的方法，该交叉反应性抗原结构能够增强对全身和/或粘膜施用的肽抗原的免疫应答以及由所述方法获得的化学结构以及从所述结构及其利用获得的制剂。该方法描述了从随后与载体分子偶联的树枝状大分子的选择和合成中获得新的树枝状聚合物结构。所得到的结构可以方便地用于佐剂或在其中可以引入这种类型的几种抗原的制剂中，这些组分之间发生相互交叉反应性和所得反应的免疫原性相协调的作用。制剂还可以含有稳定剂和防腐剂。所得到的抗原结构可用于制药工业中作为用于人类和兽医用途的疫苗制剂，并且作为诊断系统的一部分。

23. 发明申请

WO1995026365A1 SYNTHETIC PEPTIDE BASED IMMUNOGENS FOR THE TREATMENT OF ALLERGY 审中-公开
标题翻译：用于治疗过敏症的基于合成肽的免疫原
公开(公告)号：WO1995026365A1
公开(公告)日：1995-10-05
申请号：PCT/US1995003741
申请日：1995-03-24
申请人： UNITED BIOMEDICAL, INC. , WANG, Chang, Yi
发明人： UNITED BIOMEDICAL, INC.
IPC分类号： C07K19/00
CPC分类号： C07K16/00 , A61K39/0005 , A61K2039/645 , C07K16/4291 , C07K19/00
摘要： The present invention relates to a method for eliciting the production in healthy mammals, including humans, of high titer antibodies to an effector site in human IgE heavy chain, i.e. a site in the CH4 domain of the ELEMENT -chain, by the use of compositions of synthetic peptide immunogens in either a radially branching multimeric form (such as branching octameric or hexadecameric peptides) or a linearly arranged monomeric form, to inhibit mast cell activation and reduce allergen-induced IgE production. It also relates to the use of such "optimally" designer, carrier protein free, IgE ELEMENT -chain related immunogens as key components in a synthetic vaccine to provide an immunotherapy for the treatment of allergy. The subject peptides contain immune stimulator sequences, including a built-in helper T cell epitope tandemly linked in a specific orientation, to aid in stimulating the immune response towards the IgE CH4 domain.
摘要翻译：本发明涉及一种在健康哺乳动物（包括人）中产生人类IgE重链中效应位点的高滴度抗体的方法，即ELEMENT链的CH4结构域中的位点，通过使用组合物的合成肽免疫原以径向分支的多聚体形式（例如支化八聚体或十六聚体肽）或线性排列的单体形式，以抑制肥大细胞活化并降低变应原诱导的IgE产生。它还涉及使用这种“最佳”设计者，无载体蛋白质，IgE ELEMENT-链相关免疫原作为合成疫苗中的关键组分，以提供用于治疗过敏的免疫治疗。主题肽含有免疫刺激剂序列，包括以特定方向串联连接的内在辅助T细胞表位，以帮助刺激针对IgE CH4结构域的免疫应答。

24. 发明申请

WO1993022343A1 MULTIPLE ANTIGEN PEPTIDE SYSTEM HAVING ADJUVANT PROPERTIES AND VACCINES PREPARED THEREFROM 审中-公开
标题翻译：具有调节性能的多种抗原肽系统及其制备的疫苗
公开(公告)号：WO1993022343A1
公开(公告)日：1993-11-11
申请号：PCT/US1993004179
申请日：1993-05-03
申请人： THE ROCKFELLER UNIVERSITY , TAM, James, P.
发明人： THE ROCKFELLER UNIVERSITY
IPC分类号： C07K13/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/385 , A61K2039/55555 , A61K2039/645 , C07K19/00 , C12N2740/16122 , Y02A50/412 , Y10S424/16 , Y10S977/754 , Y10S977/917
摘要： A multiple antigenic peptide system is disclosed that comprises a dendritic core and peptide and a lipophilic anchoring moiety. This particular combination has as an advantage that it eliminates the need for the inclusion of adjuvants found to be toxic to humans, and facilitates the exponential amplification of the antigenic potential of a vaccine prepared therefrom, as noncovalent amplification by a liposome or micellar form is possible. Further, multiple different antigenic peptides may be attached so that the system may be prepared for administration to concurrently treat diverse ailments, such as for example, AIDS and influenza. The present multiple antigen peptide system is capable of eliciting an immune response when injected into a mammal, and accordingly, vaccines prepared from the system and methods of use including therapeutic protocols are included.
摘要翻译：公开了包含树突核心和肽和亲脂性锚定部分的多重抗原肽系统。这种特殊的组合具有这样的优点：它消除了对发现对人有毒性的佐剂的需要，并且有助于由其制备的疫苗的抗原性潜力的指数扩增，因为通过脂质体或胶束形式的非共价扩增是可能的。此外，可以连接多种不同的抗原肽，使得该系统可以被制备用于施用以同时治疗多种疾病，例如AIDS和流感。本发明的多抗原肽系统能够在注射到哺乳动物中时引发免疫应答，因此，包括从系统制备的疫苗和包括治疗方案的使用方法。

25. 发明申请

WO1993010816A1 COMPOSITIONS FOR ELICITING CYTOTOXIC T-LYMPHOCYTE RESPONSES AGAINST VIRUSES 审中-公开
标题翻译：针对病毒的细胞毒性T淋巴细胞反应的组合物
公开(公告)号：WO1993010816A1
公开(公告)日：1993-06-10
申请号：PCT/US1992010378
申请日：1992-12-02
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , SASTRY, Jagannadha, K. , ARLINGHAUS, Ralph, B. , PLATSOUCAS, Chris, D. , NEHETE, Pramod, N.
IPC分类号： A61K39/21
CPC分类号： G01N33/5088 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K2039/55566 , A61K2039/57 , A61K2039/645 , A61K2039/70 , C07K14/005 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2760/16022 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134 , C12N2760/18822 , C12N2760/18834 , G01N33/505 , G01N2333/16
摘要： The present invention provides compositions and methods for the prevention and treatment of viral infections. The identification of distinct classes of peptides for use in both anti-viral vaccines and therapeutic formulations is reported. Peptide formulations are disclosed which enhance the systemic distribution, activity, and longevity of anti-viral cytotoxic T cells, and/or which protect human cells from HIV infection. A novel method for the rapid screening of cytotoxic T lymphocyte- (CTL-) inducing compounds, for use in CTL vaccines and in the preparation of specifically primed CTLs, is also disclosed.
摘要翻译：本发明提供了用于预防和治疗病毒感染的组合物和方法。报道了用于抗病毒疫苗和治疗制剂的不同类型的肽的鉴定。公开了增强抗病毒细胞毒性T细胞的全身分布，活性和寿命和/或保护人类细胞免受HIV感染的肽制剂。还公开了用于快速筛选细胞毒性T淋巴细胞（CTL））诱导化合物，用于CTL疫苗和制备特异性引发的CTL的新方法。

26. 发明申请

WO2018055370A1 NOVEL ADJUVANTS 审中-公开
标题翻译：新的助剂
公开(公告)号：WO2018055370A1
公开(公告)日：2018-03-29
申请号：PCT/GB2017/052805
申请日：2017-09-20
申请人： UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS
发明人： CONNARIS, Helen , TAYLOR, Garry , RANDALL, Richard E.
IPC分类号： A61K39/39 , C07K14/28 , C07K14/315
CPC分类号： A61K39/39 , A61K9/0043 , A61K9/006 , A61K47/646 , A61K2039/541 , A61K2039/55516 , A61K2039/6068 , A61K2039/645 , A61P37/04 , C07K14/28 , C07K14/3156 , C07K2319/735 , C12N9/2417 , C12Y302/01018
摘要： The present disclosure provides novel adjuvants which may be used in combination with one or more antigens to augment, modulate or enhance a host immune response to the one or more antigens. The adjuvants are based on sialic acid binding molecules and may be combined with any type of antigen. The adjuvants may be formulated for mucosal and/or intranasal administration.
摘要翻译：本公开内容提供了可与一种或多种抗原组合使用以增强，调节或增强对一种或多种抗原的宿主免疫应答的新佐剂。佐剂基于唾液酸结合分子，并可与任何类型的抗原组合。佐剂可以配制用于粘膜和/或鼻内给药。

27. 发明申请

WO2017123652A1 MICRONEEDLE COMPOSITIONS AND METHODS OF USING SAME 审中-公开
标题翻译： MICRONEEDLE组合物及其使用方法
公开(公告)号：WO2017123652A1
公开(公告)日：2017-07-20
申请号：PCT/US2017/013043
申请日：2017-01-11
申请人： VERNDARI, INC.
发明人： HENDERSON, Daniel R.
IPC分类号： A61M5/00 , C07K14/005 , C12N15/79
CPC分类号： A61K39/145 , A61K9/0021 , A61K9/5146 , A61K39/12 , A61K48/005 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/645 , A61K2039/70 , C12N7/00 , C12N15/89 , C12N2760/16134 , C12N2760/16234 , C12N2770/36143 , Y02A50/466
摘要： Described herein, are microneedle devices comprising a recombinant alphavirus replicon encoding an exogenous polypeptide, wherein the recombinant alphavirus replicon is coated onto or embedded into a plurality of microneedles. Also described herein are methods of preparing a microneedle device comprising a recombinant alphavirus replicon encoding an exogenous polypeptide. Also disclosed herein are methods of inducing an immune response in an individual comprising contacting the individual with a microneedle device comprising a recombinant alphavirus replicon encoding an exogenous polypeptide.
摘要翻译：本文描述了包含编码外源多肽的重组α病毒复制子的微针装置，其中重组α病毒复制子被包被或包埋到多个微针中。本文还描述了制备包含编码外源多肽的重组α病毒复制子的微针设备的方法。本文还公开了在个体中诱导免疫应答的方法，包括使所述个体与包含编码外源多肽的重组α病毒复制子的微针装置接触。

28. 发明申请

WO2017024292A1 HYBRID FLAGELLIN AS A T CELL INDEPENDENT VACCINE SCAFFOLD 审中-公开
标题翻译：混合FLAGELLIN作为一个独立的细胞疫苗
公开(公告)号：WO2017024292A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/045929
申请日：2016-08-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： LO, David, D. , BENNETT, Kaila, M.
IPC分类号： A61K39/02 , A61K39/12 , A61K39/39 , C07K2/00
CPC分类号： A61K39/02 , A61K39/12 , A61K39/39 , A61K2039/54 , A61K2039/545 , A61K2039/55516 , A61K2039/575 , A61K2039/6068 , A61K2039/645 , A61K2039/70 , C07K2/00 , C12N2770/24134
摘要： A method of immunizing a subject. The method includes administering to the subject an immunogenic amount of a filament including one or more hybrid flagellin proteins, each hybrid protein including a heterologous polypeptide antigen and a portion of a FliC flagellin protein. As a result of the administration, a TI immune response to the polypeptide antigen can be produced in the subject.
摘要翻译：免疫受试者的方法。该方法包括对受试者施用免疫原性量的包含一种或多种杂交鞭毛蛋白的细丝，每种杂合蛋白包括异源多肽抗原和FliC鞭毛蛋白的一部分。作为施用的结果，可以在受试者中产生对多肽抗原的TI免疫应答。

29. 发明申请

WO2014118201A1 MULTIVALENT GLYCOCONJUGATE VACCINES 审中-公开
标题翻译：多发性糖尿病疫苗
公开(公告)号：WO2014118201A1
公开(公告)日：2014-08-07
申请号：PCT/EP2014/051670
申请日：2014-01-29
申请人： BIOSYNTH S.R.L.
发明人： PORRO, Massimo
IPC分类号： A61K39/095 , A61K39/09
CPC分类号： A61K39/385 , A61K39/092 , A61K39/095 , A61K39/102 , A61K2039/55505 , A61K2039/6037 , A61K2039/645 , A61K2039/70
摘要： The present invention refers to conjugate antigens expressing built-in multiple epitopes and to polyvalent glycoconjugate vaccines and formulations containing the same. In addition, the present invention concerns the use of these vaccines in particular for the protection of the human population, and in particular for the protection of the paediatric population from pulmonary and systemic infections due to S.pneumoniae, N.meningitidis, H.influenzae, K. pneumoniae, M. tuberculosis, S. aureus, or from intestinal infections due to S. typhi, V. cholerae and E. coli. The present invention additionally refers to polyvalent glycoconjugate vaccines for the protection from C. albicans and E. coli systemic and genitourinary infections or for the protection from M. bovis infections in veterinary medicine.
摘要翻译：本发明涉及表达内在多表位的缀合物抗原和涉及多价糖缀合物的疫苗和含有这些表位的制剂。此外，本发明涉及这些疫苗的用途，特别是用于保护人群，特别是为了保护儿科人群免受肺炎支原体，脑膜炎奈瑟氏球菌，流感嗜血杆菌的肺部和全身感染，肺炎克雷伯杆菌，结核分枝杆菌，金黄色葡萄球菌，或由于伤寒沙门氏菌，霍乱弧菌和大肠杆菌引起的肠道感染。本发明还涉及用于保护白色念珠菌和大肠杆菌系统性和泌尿生殖系统感染或在兽医学中保护牛枝原体感染的多价糖缀合物疫苗。

30. 发明申请

WO2013149974A1 PEPTIDE VACCINES FOR THE PREVENTION OF FOOT-AND-MOUTH DISEASE 审中-公开
标题翻译：用于防治食源性疾病的肽类疫苗
公开(公告)号：WO2013149974A1
公开(公告)日：2013-10-10
申请号：PCT/EP2013/056843
申请日：2013-04-01
申请人： UNIVERSITAT POMPEU FABRA , CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS , INSTITUTO NACIONAL DE INVESTIGACIÓN Y TECNOLOGÍA AGRARIA Y ALIMENTARIA INIA
发明人： ANDREU MARTÍNEZ, David , BÁRCENA DEL RIEGO, Juan , BLANCO LAVILLA, Esther , CUBILLOS ZAPATA, Carolina , GARCÍA DE LA TORRE, Beatriz , MONSÓ OLIVARES, Marta , SOBRINO CASTELLÓ, Francisco
IPC分类号： A61K47/48 , A61K39/135
CPC分类号： A61K39/12 , A61K47/641 , A61K2039/552 , A61K2039/55566 , A61K2039/645 , C12N2770/32134
摘要： The invention relates to a dendrimeric peptide construct of formula (I) wherein: T is a T epitope of the FMDV, bound to the lysine core by its N-terminal end, B is a B epitope of the FMDV, W is a linker group, Z is Cys bound to the linker group W through its sulphur atom or Lys bound to the linker group W through its ε amino group, X is absent when B is bound to the α-carboxylic group of Z by its N-terminal end or is an acyl group when B is bound to the α-amino group of Z by its C-terminal end. The invention also refers to the use of said constructs as an immunogen for the prevention of foot-and-mouth disease in an animal.
摘要翻译：本发明涉及式（I）的树状多肽构建体，其中：T是FMDV的T表位，其N-末端与赖氨酸核心结合，B是FMDV的B表位，W是连接基团 Z是通过其硫原子与连接基团W结合的Cys或通过其ε氨基与连接基团W结合的Lys结合，当B通过其N末端与Z的α-羧基键合时，X不存在当B通过C末端与Z的α-氨基结合时，是酰基。本发明还涉及所述构建体作为免疫原用于预防动物口蹄疫的用途。

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