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1. 发明申请

WO2017123652A1 MICRONEEDLE COMPOSITIONS AND METHODS OF USING SAME 审中-公开
标题翻译： MICRONEEDLE组合物及其使用方法
公开(公告)号：WO2017123652A1
公开(公告)日：2017-07-20
申请号：PCT/US2017/013043
申请日：2017-01-11
申请人： VERNDARI, INC.
发明人： HENDERSON, Daniel R.
IPC分类号： A61M5/00 , C07K14/005 , C12N15/79
CPC分类号： A61K39/145 , A61K9/0021 , A61K9/5146 , A61K39/12 , A61K48/005 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/645 , A61K2039/70 , C12N7/00 , C12N15/89 , C12N2760/16134 , C12N2760/16234 , C12N2770/36143 , Y02A50/466
摘要： Described herein, are microneedle devices comprising a recombinant alphavirus replicon encoding an exogenous polypeptide, wherein the recombinant alphavirus replicon is coated onto or embedded into a plurality of microneedles. Also described herein are methods of preparing a microneedle device comprising a recombinant alphavirus replicon encoding an exogenous polypeptide. Also disclosed herein are methods of inducing an immune response in an individual comprising contacting the individual with a microneedle device comprising a recombinant alphavirus replicon encoding an exogenous polypeptide.
摘要翻译：本文描述了包含编码外源多肽的重组α病毒复制子的微针装置，其中重组α病毒复制子被包被或包埋到多个微针中。本文还描述了制备包含编码外源多肽的重组α病毒复制子的微针设备的方法。本文还公开了在个体中诱导免疫应答的方法，包括使所述个体与包含编码外源多肽的重组α病毒复制子的微针装置接触。

2. 发明申请

WO2021022008A1 VIRUS-LIKE PARTICLE VACCINES 审中-公开
公开(公告)号：WO2021022008A1
公开(公告)日：2021-02-04
申请号：PCT/US2020/044196
申请日：2020-07-30
申请人： VERNDARI, INC.
发明人： HENDERSON, Daniel R. , ELLISON, Thomas J. , TALBOTT, George C. , SONG, Yeonju
IPC分类号： C07K16/08 , C07K16/10 , C07K16/12 , C07K16/14 , C07K16/18
摘要： Provided, herein, in certain embodiments are virus-like particles such as synthetic enveloped VLPs or synthetic membrane VLPs. In some embodiments, the VLPs comprise a lipid bilayer. In some embodiments, the VLPs comprise a purified antigen anchored to the lipid bilayer. Some embodiments relate to vaccines comprising the VLP, methods of using the vaccine, and methods of making the vaccine or VLP.

3. 发明申请

WO2018026955A1 MICROARRAYS AND METHODS 审中-公开
标题翻译：微阵列和方法
公开(公告)号：WO2018026955A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/045161
申请日：2017-08-02
申请人： VERNDARI, INC.
发明人： HENDERSON, Daniel R.
IPC分类号： A61M37/00 , A61K9/00
摘要： The present disclosure describes microtips, MicroArrays, MicroArray Patches comprising MicroArrays, delivery devices, and methods of manufacturing and methods of using same. In some embodiments, a substance-loaded MicroArray is prepared by photochemically etching MicroArray outlines in a substrate sheet, the MicroArrays comprising a plurality of microtips, configuring reservoirs in each microtip such as by photochemical half etching, filling each reservoir with a substance to be delivered, and then bending each of the microtips out of planarity such that each microtip comprises a substance-loaded projection disposed an angle relative to the generally planar substrate sheet.
摘要翻译：本公开描述了微尖端，微阵列，包含微阵列的微阵列贴片，递送装置，以及制造方法和使用它们的方法。在一些实施方案中，通过在衬底片中光化学蚀刻MicroArray轮廓来制备物质加载的微阵列，所述微阵列包含多个微尖端，通过光化学半蚀刻配置每个微尖端中的贮存器，向每个贮存器填充待递送的物质，然后弯曲每个微尖端以使其不具有平面性，使得每个微尖端包括相对于大致平面的基底片成角度设置的物质负载突起。

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