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21. 发明申请

WO1997027332A1 METHOD FOR DETECTION OF DRUG-INDUCED MUTATIONS IN THE REVERSE TRANSCRIPTASE GENE 审中-公开
标题翻译：用于检测逆转录酶基因中药物诱导突变的方法
公开(公告)号：WO1997027332A1
公开(公告)日：1997-07-31
申请号：PCT/EP1997000211
申请日：1997-01-17
申请人： INNOGENETICS N.V. , STUYVER, Lieven , LOUWAGIE, Joost , ROSSAU, Rudi
发明人： INNOGENETICS N.V.
IPC分类号： C12Q01/70
CPC分类号： C12Q1/703
摘要： The present invention relates to a method for the rapid and reliable detection of drug-induced mutations in the reverse transcriptase gene allowing the simultaneous characterization of a range of codons involved in drug resistance using specific sets of probes optimized to function together in a reverse-hybridization assay. More particularly, the present invention relates to a method for determining the susceptibility to antiviral drugs of HIV strains present in a biological sample, comprising: (i) if need be releasing, isolating or concentrating the polynucleic acids present in the sample; (ii) if need be amplifying the relevant part of the reverse transcriptase genes present in said sample with at least one suitable primer pair; (iii) hybridizing the polynucleic acids of step (i) or (ii) with at least two RT gene probes hybridizing specifically to one or more target sequences with said probes being applied to known locations on a solid support and with said probes being capable of simultaneously hybridizing to their respective target regions under appropriate hybridization and wash conditions allowing the detection of homologous targets, or said probes hybridizing specifically with a sequence complementary to any of said target sequences, or a sequence wherein T is replaced by U; (iv) detecting the hybrids formed in step (iii); (v) inferring the nucleotide sequence at the codons of interest and/or the amino acids of the codons of interest and/or antiviral drug resistance spectrum, and possibly the type of HIV isolates involved from the differential hybridization signal(s) obtained in step (iv).
摘要翻译：本发明涉及用于快速和可靠地检测逆转录酶基因中的药物诱发突变的方法，其允许使用经优化以在反向杂交中一起起作用的特定的探针组来同时表征涉及耐药性的一系列密码子检测。更具体地说，本发明涉及确定存在于生物样品中的HIV病毒抗病毒药物易感性的方法，其包括：（i）如果需要释放，分离或浓缩样品中存在的多核酸; （ii）如果需要用至少一个合适的引物对扩增所述样品中存在的逆转录酶基因的相关部分; （iii）将步骤（i）或（ii）中的多核苷酸与至少两个与一个或多个靶序列特异性杂交的RT基因探针杂交，所述探针被施加到固体支持物上的已知位置，并且所述探针能够在适当的杂交和洗涤条件下同时与其各自的靶区域杂交，允许检测同源靶标，或所述探针与与任何所述靶序列互补的序列特异性杂交，或其中T被U替代的序列; （iv）检测步骤（iii）中形成的杂交体; （v）推断感兴趣的密码子和/或感兴趣的密码子的氨基酸和/或抗病毒药物抗性谱的核苷酸序列，以及可能的步骤中获得的差异杂交信号所涉及的HIV分离物的类型（ⅳ）。

22. 发明申请

WO1997027300A1 TOXOPLASMA GONDII ANTIGEN Tg20 审中-公开
公开(公告)号：WO1997027300A1
公开(公告)日：1997-07-31
申请号：PCT/EP1997000394
申请日：1997-01-27
申请人： INNOGENETICS N.V. , JACOBS, Dirk , SAMAN, Eric , VAN HEUVERSWYN, Hugo
发明人： INNOGENETICS N.V.
IPC分类号： C12N15/30
CPC分类号： C07K14/45 , A61K39/00 , A61K48/00 , A61K2039/51 , C07K2319/00 , Y10S435/961 , Y10S435/968 , Y10S435/971 , Y10S435/973 , Y10S435/975
摘要： The present invention relates to isolated and pure Toxoplasma gondii antigenic fragments, recombinant polypeptides, nucleic acids encoding them, primers and probes derived from the same, as well as the use of these polypeptides, nucleic acids, primers and probes in methods and kits for the diagnosis and prevention of T. gondii infection in mammals (humans and animals).
摘要翻译：本发明涉及分离和纯的弓形体抗原片段，重组多肽，编码它们的核酸，来自其的引物和探针，以及这些多肽，核酸，引物和探针在用于诊断和预防哺乳动物（人和动物）感染弓形虫感染。

23. 发明申请

WO1997023619A1 SEQUENCES CODING FOR NEW BACTERIOCINS 审中-公开
标题翻译：新型细菌的序列编码
公开(公告)号：WO1997023619A1
公开(公告)日：1997-07-03
申请号：PCT/EP1996005235
申请日：1996-11-27
申请人： INNOGENETICS N.V. , CONTRERAS, Bart , DE VUYST, Luc , VANDAMME, Erik , SABLON, Erwin
发明人： INNOGENETICS N.V.
IPC分类号： C12N15/31
CPC分类号： C07K14/335 , A61K38/00 , A61K39/00
摘要： The present invention relates to novel sequences encoding a novel bacteriocin, the uses thereof, as well as the use of sequences for homologous and heterologous protein expression and secretion purposes. The present invention relates more particularly to a polynucleic acid comprising: (a) at least 30 contiguous nucleotides of a sequence selected from the polynucleic acid sequence as shown in Figure 2 (SEQ ID NO: 19), (b) a polynucleic acid sequence which hybridizes to the polynucleic acid as defined in (a), or (c) a polynucleic acid with a sequence that is degenerated to a polynucleic acid as defined in (a) or (b) as a result of the genetic code. The polynucleic acid sequence represented as SEQ ID NO: 19 in Figure 2 comprises five operons (see Figure 3). The first two are composed of three open reading frames: two "bacteriocin-like" genes, followed by an "immunity gene". The third operon is composed of two open reading frames, the first is coding for an ATP-dependent transporter protein, the second is coding for an accessory protein. The fourth operon is composed of two open reading frames, one "bacteriocin-like" gene followed by an "immunity gene". The fifht operon is composed of three open reading frames: two "bacteriocin-like" genes, followed by an "immunity gene". Each operon is preced by a promoter.
摘要翻译：本发明涉及编码新型细菌素的新型序列，其用途，以及序列用于同源和异源蛋白质表达和分泌目的。本发明更具体地涉及多核酸，其包含：（a）选自如图2所示的多核酸序列（SEQ ID NO：19）的序列的至少30个连续核苷酸，（b）多核酸序列，与如（a）或（c）中定义的多核酸杂交，如（a）或（b）所定义的具有退化为多核酸的序列的多核酸作为遗传密码的结果。图2中以SEQ ID NO：19表示的多核苷酸序列包含五个操纵子（参见图3）。前两个由三个开放阅读框组成：两个“细菌素样”基因，其次是“免疫基因”。第三个操纵子由两个开放阅读框组成，第一个编码ATP依赖性转运蛋白，第二个编码辅助蛋白。第四个操纵子由两个开放阅读框组成，一个是“细菌素样”基因，随后是“免疫基因”。五个操纵子由三个开放阅读框架组成：两个“细菌素样”基因，其次是“免疫基因”。每个操纵子前面都有一个启动子。

24. 发明申请

WO1997011187A1 SUBTILISIN INHIBITOR OF STREPTOMYCES VENEZUELAE, AND USE OF THE GENE SEQUENCES FOR EXPRESSION AND/OR SECRETION OF HETEROLOGOUS PROTEINS IN STREPTOMYCES 审中-公开
标题翻译：分支杆菌抑制剂维A酶的抑制剂，以及基因序列用于表达和/或分泌杂交蛋白质在结构域中的用途
公开(公告)号：WO1997011187A1
公开(公告)日：1997-03-27
申请号：PCT/EP1996004146
申请日：1996-09-23
申请人： INNOGENETICS N.V. , ANNÉ, Jozef , VAN MELLAERT, Lieve , LAMMERTYN, Elke , SCARCEZ, Thierry , VAN BROEKHOVEN, Annie
发明人： INNOGENETICS N.V.
IPC分类号： C12N15/62
CPC分类号： C12N15/76 , A61K38/00 , C07K14/36 , C07K14/525 , C07K14/535 , C07K14/5428 , C07K14/55 , C07K14/76 , C07K14/811 , C07K2319/00 , C07K2319/02
摘要： The present invention relates to a polynucleic acid coding for a protein of Streptomyces venezuelae with subtilisin inhibitor activity. The gene regulating sequences (promoter, secretion signal sequence etc.) can be used in a vector for the expression and secretion of heterologous proteins in Streptomyces.
摘要翻译：本发明涉及编码具有枯草杆菌蛋白酶抑制剂活性的维生素链霉菌的蛋白质的多核酸。基因调控序列（启动子，分泌信号序列等）可以用于在链霉菌中表达和分泌异源蛋白质的载体中。

25. 发明申请

WO1997004106A2 NEW SACCHAROMYCES CEREVISIAE PECTINASE SEQUENCES AND HETEROLOGOUS EXPRESSION SYSTEMS DERIVED THEREFROM 审中-公开
标题翻译：新的细菌鉴定序列及其衍生的异位表达系统
公开(公告)号：WO1997004106A2
公开(公告)日：1997-02-06
申请号：PCT/EP1996003091
申请日：1996-07-15
申请人： INNOGENETICS N.V. , SCARCEZ, Thierry , VAN BROEKHOVEN, Annie
发明人： INNOGENETICS N.V.
IPC分类号： C12N15/56
CPC分类号： C12Y302/01015 , A23L2/84 , A23L29/231 , C12N9/2402
摘要： The present invention relates to new pectinases, more particularly to the nucleic acids encoding the same as well as homologous and heterologous expression systems using the regulatory and/or coding sequences comprised in said pectinase nucleic acids. More particularly, the present invention relates to new yeast pectinase polynucleic acid and amino acid sequences, and yeast (heterologous) expression systems based thereon. The present invention also relates to new pectinases or fragments or derivatives thereof for use in food processing.
摘要翻译：本发明涉及新的果胶酶，更具体地涉及编码相同的核酸以及使用所述果胶酶核酸中包含的调节和/或编码序列的同源和异源表达系统。更具体地，本发明涉及新的酵母果胶酶多核酸和氨基酸序列，以及基于其的酵母（异源）表达系统。本发明还涉及用于食品加工的新的果胶酶或其片段或衍生物。

26. 发明申请

WO1995032734A1 NEW METHODS AND COMPOUNDS FOR THE SELECTIVE MODULATION OF ANTIGEN-SPECIFIC T-CELL RESPONSIVENESS 审中-公开
标题翻译：用于选择性调节抗原特异性T细胞应答的新方法和化合物
公开(公告)号：WO1995032734A1
公开(公告)日：1995-12-07
申请号：PCT/EP1995002012
申请日：1995-05-26
申请人： INNOGENETICS N.V. , DE BOER, Mark , BARCY, Serge
发明人： INNOGENETICS N.V.
IPC分类号： A61K39/395
CPC分类号： C07K16/065 , A61K38/00 , A61K2039/5154 , C07K14/70535 , C07K16/283
摘要： The present invention relates to new Fc gamma RII bridging compositions for impairing the capacity of antigen presenting cells (APCs) to stimulate the activation of antigen-specific T-cells, resulting in modulation of antigen-specific T-cell responsiveness. More particularly, said Fc gamma RII bridging agents are chosen from the group consisting of: aggregated human IgG molecules; aggregated Fc fragments of human IgG molecules; a bivalent monoclonal antibody to the Fc gamma RII; a multivalent monoclonal antibody to the Fc gamma RII; a functionally active fragment of said bivalent or multivalent monoclonal antibody; a recombinant fusion protein of 2 or more human IgG Fc parts; liposome vesicles comprising any of the foregoing, provided that said Fc gamma RII composition prevents the expression of the co-stimulatory molecules B7-1/2 and/or down modulates the ICAM-3 molecule expression by these professional APCs. The present invention also relates to prophylactic and therapeutic methods and compositions to prevent or treat the rejection of solid organs, tissues and cells after transplantation; for inducing T-cell anergy or T-cell tolerance; for treating allergic diseases; or for the treatment of autoimmune diseases. The present invention also relates to Fc gamma RII bridged professional APCs prepared by bridging APCs with an Fc gamma RII bridging agent according to the present invention.
摘要翻译：本发明涉及用于损害抗原呈递细胞（APC）刺激抗原特异性T细胞活化的能力的新的FcγRII桥接组合物，导致抗原特异性T细胞应答性的调节。更具体地说，所述FcγRII桥连剂选自：聚集的人IgG分子; 人IgG分子的聚集的Fc片段; 针对FcγRII的二价单克隆抗体; 针对FcγRII的多价单克隆抗体; 所述二价或多价单克隆抗体的功能活性片段; 2个以上人IgG Fc部分的重组融合蛋白; 包含任何前述的脂质体囊泡，条件是所述FcγRII组合物可防止共刺激分子B7-1 / 2的表达和/或通过这些专业APC下调ICAM-3分子的表达。本发明还涉及用于预防或治疗移植后固体器官，组织和细胞排斥的预防和治疗方法和组合物; 用于诱导T细胞无反应性或T细胞耐受性; 用于治疗过敏性疾病; 或用于治疗自身免疫性疾病。本发明还涉及通过用本发明的FcγRII桥连桥桥连APC制备的FcγRII桥连专业APC。

27. 发明申请

WO1995017429A1 MONOCLONAL ANTIBODIES SPECIFIC FOR PHF-TAU, HYBRIDOMAS SECRETING THEM, ANTIGEN RECOGNITION BY THESE ANTIBODIES AND THEIR APPLICATIONS 审中-公开
标题翻译： PHF-TAU，HYBRIDOMAS分泌的特异性单克隆抗体，这些抗体的抗原识别及其应用
公开(公告)号：WO1995017429A1
公开(公告)日：1995-06-29
申请号：PCT/EP1994004146
申请日：1994-12-14
申请人： INNOGENETICS N.V. , VANDERMEEREN, Marc , VANMECHELEN, Eugeen , VAN DE VOORDE, André
发明人： INNOGENETICS N.V.
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K14/4711
摘要： The present invention relates more particularly to a monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to abnormally phosphorylated tau (PHF-tau) residing in the region spanning positions (143-254), and with said monoclonal antibody being characterized by the fact that it is capable of specifically detecting abnormally phosphorylated tau protein (PHF-tau) in cerebrospinal fluid (CSF).
摘要翻译：本发明更具体地涉及与位于跨越位置区域（143-254）的属于异常磷酸化tau（PHF-τ）的抗原的磷酸化表位形成免疫复合物的单克隆抗体，并且所述单克隆抗体是其特征在于其能够特异性检测脑脊液（CSF）中异常磷酸化的tau蛋白（PHF-τ）。

28. 发明申请

WO1989012094A1 HIV-3 RETROVIRUS AND ITS USE 审中-公开
标题翻译： HIV-3 RETROVIRUS及其使用
公开(公告)号：WO1989012094A1
公开(公告)日：1989-12-14
申请号：PCT/EP1989000643
申请日：1989-06-08
申请人： INNOGENETICS N.V. , DE LEYS, Robert , VANDERBORGHT, Bart , SAMAN, Eric , VAN HEUVERSWYN, Hugo
发明人： INNOGENETICS N.V.
IPC分类号： C12N07/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , C07K16/1045 , C07K16/1054 , C12N7/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , G01N33/56988 , G01N2333/16 , Y10S435/974 , Y10S435/975 , Y10S530/809
摘要： Described is a new retrovirus designated HIV-3 and deposited in the European Collection of Animal Cell Cultures (ECACC) under V88060301. Further described are antigens obtained from the virus, particularly proteins p12, p16, p26 and glycoproteins gp41 and gp120 to be used in the diagnosis of ARC or AIDS caused by HIV-3. Immunogenic compositions to be used as vaccines contain an envelope glycoprotein of HIV-3 such as gp41 or gp120.

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