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21. 发明申请

WO2005018530A2 PENETRATING PHARMACEUTICAL FOAM 审中-公开
标题翻译：渗透药物泡沫
公开(公告)号：WO2005018530A2
公开(公告)日：2005-03-03
申请号：PCT/IB2004002965
申请日：2004-08-20
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR
IPC分类号： A61K8/04 , A61K8/365 , A61K8/42 , A61K9/12 , A61K31/167 , A61K31/196 , A61K31/496 , A61Q19/00 , C08J9/00 , A61K
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/342 , A61K8/37 , A61K8/39 , A61K8/731 , A61K9/0014 , A61K47/10 , A61K2800/91 , A61Q19/00 , A01N53/00
摘要： The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a hydrophobic solvent, a surface-active agent and a gelling agent. The foam carrier further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.
摘要翻译：本发明涉及包含水，疏水性溶剂，表面活性剂和胶凝剂的无酒精化妆品或药物泡沫载体。泡沫载体还包含具有增强的皮肤渗透性的治疗特性的活性剂和赋形剂。

22. 发明申请

WO2008032212A3 COLORED OR COLORABLE FOAMABLE COMPOSITION AND FOAM 审中-公开
标题翻译：有色或有色可泡沫组合物和泡沫
公开(公告)号：WO2008032212A3
公开(公告)日：2009-04-23
申请号：PCT/IB2007003351
申请日：2007-09-10
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR
IPC分类号： A61K8/00 , A61K8/18 , A61Q17/04
CPC分类号： A61K8/046 , A61K31/47 , A61K2800/42 , A61K2800/45 , A61Q19/00
摘要： There is described a colored or colorable topical composition, comprising: a) a foamable base composition comprising, 1 ) a flowable carrier composition; 2) a color agent; wherein the color agent is effective to impart, increase, decrease or otherwise affect color of a foam produced from the foamable composition and wherein the color agent is one or more agents selected from the group consisting of a colored active agent, a colored indicator, a colored excipient, a pigment, a dye, a colorant and a coloring agent; b) a propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the base composition has a first color; and wherein the foam comprising the colored or colorable topical composition has a second color upon dispensing from an aerosol container, and wherein the first color and the second color are visually different. There is also described a method of changing color, a method of administration, a use as a diagnostic and a kit.
摘要翻译：描述了一种有色或可着色的局部组合物，其包含：a）可发泡基质组合物，其包含：1）可流动的载体组合物; 2）着色剂; 其中所述着色剂有效地赋予，增加，减少或以其他方式影响由所述可发泡组合物产生的泡沫的颜色，并且其中所述着色剂是选自以下的一种或多种试剂：有色活性剂，着色指示剂，彩色赋形剂，颜料，染料，着色剂和着色剂; b）以总组合物重量计约3％至约25％的浓度的推进剂; 其中所述基础组合物具有第一颜色; 并且其中包含着色或可着色的局部组合物的泡沫在从气溶胶容器分配时具有第二颜色，并且其中第一颜色和第二颜色在视觉上不同。还描述了改变颜色，给药方法，用作诊断和试剂盒的方法。

23. 发明申请

WO2007085899A3 FOAMABLE ARTHROPOCIDAL COMPOSITION FOR TROPICAL APPLICATION 审中-公开
标题翻译：用于热应用的可燃性ARTHROCOCAL组合物
公开(公告)号：WO2007085899A3
公开(公告)日：2008-07-10
申请号：PCT/IB2006004026
申请日：2006-07-06
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR
IPC分类号： A01N25/16 , A01N43/30 , A01N53/08 , A01N57/12 , A01N65/00 , A01P7/00
CPC分类号： A01N25/16 , A01N25/06 , A01N65/08 , A61K9/1075 , A61K9/122 , Y02A50/335 , Y02A50/337 , Y02A50/338 , Y02A50/34 , Y02A50/342 , Y02A50/343 , Y02A50/347 , Y02A50/352 , A01N43/30 , A01N53/00 , A01N57/12 , A01N65/00 , A01N65/12
摘要： The present invention provides a safe and effective insecticide composition suitable for treating a subject infested with a parasitic anthropode or to prevent infestation by an arthropod. The insecticide composition is a foamable composition, including a first insecticide; at least one organic carrier selected from a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 5%, or about 5% to about 10%;or about 10% to about 20%; or about 20% to about 50% by weight; about 0.1 % to about 5% by weight of a surface-active agent; about 0.01 % to about 5% by weight of at least one polymeric agent selected from a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; and (5) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明提供了一种安全有效的杀虫剂组合物，适用于治疗受寄生人体受体侵染的受试者或防止节肢动物侵染。杀虫剂组合物是可发泡组合物，包括第一种杀虫剂; 浓度为约2％至约5％，或约5％至约10％;或约10％至约20种的至少一种选自疏水性有机载体，极性溶剂，软化剂及其混合物的有机载体％; 或约20％至约50％; 约0.1重量％至约5重量％的表面活性剂; 约0.01重量％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物; 和（5）浓度为总组合物重量的约3％至约25％的液化或压缩气体推进剂。

24. 发明申请

WO2007102052A3 FOAM CONTAINING UNIQUE OIL GLOBULES 审中-公开
标题翻译：包含独特油类的泡沫
公开(公告)号：WO2007102052A3
公开(公告)日：2008-01-03
申请号：PCT/IB2006004170
申请日：2006-09-14
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , BESONOV ALEX , EINI MEIR
发明人： TAMARKIN DOV , FRIEDMAN DORON , BESONOV ALEX , EINI MEIR
IPC分类号： A61K8/04 , A61K8/06 , A61K8/14 , A61K9/00 , A61K9/107 , A61K9/12 , A61K9/127 , A61K31/00 , A61K47/06 , A61Q19/00 , A61Q19/08
CPC分类号： A61K8/046 , A61K8/06 , A61K8/062 , A61K8/068 , A61K8/37 , A61K8/375 , A61K8/42 , A61K8/73 , A61K8/731 , A61K8/86 , A61K8/97 , A61K9/0014 , A61K9/0034 , A61K9/006 , A61K9/122 , A61K2800/21 , A61K2800/413 , A61Q19/00 , B82Y5/00
摘要： The present invention provides a foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum. The foamable oil in water emulsion composition includes: an oil globule system, selected from the group consisting of oil bodies; and sub-micron oil globules, about 0.1 % to about 5% by weight of an agent, selected from the group consisting of a surface-active agent, having an HLB value between 9 and 16; and a polymeric agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition, water and optional ingredients are added to complete the total mass to 100%. Upon release from an aerosol container, the foamable composition forms and expanded foam suitable for topical administration.
摘要翻译：本发明提供一种用于给予皮肤，体表，体腔或粘膜表面的发泡组合物，例如鼻，口，眼，耳，呼吸系统，阴道或直肠的粘膜。可发泡水包油乳液组合物包括：油球系统，其选自油体; 和亚微米级油球，约0.1％至约5％重量的选自HLB值在9和16之间的表面活性剂的试剂; 和聚合物剂，以及总组合物重量的约3％至约25％浓度的液化或压缩气体推进剂，加入水和任选的成分以使总质量达到100％。当从气溶胶容器释放时，可发泡组合物形成适合局部给药的膨胀泡沫。

25. 发明申请

WO2005076697A2 COSMETIC AND PHARMACEUTICAL FOAM WITH SOLID MATTER 审中-公开
标题翻译：化学和药物泡沫与固体物质
公开(公告)号：WO2005076697A2
公开(公告)日：2005-08-25
申请号：PCT/IB2005001227
申请日：2005-02-04
申请人： FOAMIX LTD , TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
发明人： TAMARKIN DOV , FRIEDMAN DORON , EINI MEIR , BESONOV ALEX
IPC分类号： A61K9/00 , A61K9/10 , A61K9/12 , A61K47/38 , A61L9/04
CPC分类号： A61K9/0014 , A61K8/046 , A61K8/19 , A61K8/25 , A61K8/27 , A61K8/29 , A61K9/10 , A61K9/12 , A61K47/38 , A61Q17/04 , A61Q19/008
摘要： A foamable composition includes about 2 to about 30% by weight solid particles; about 2 to about 75% by weight hydrophobic solvent; about 10 to about 85% by weight water; about 0.1 % to about 5% by weight surface-active agent; about 0.1 % to about 5 wt% by weight stabilizer/gelling agent; and a liquefied or compressed gas propellant in a container, which upon release provides a breakable foam suitable for topical administration.
摘要翻译：可发泡组合物包含约2至约30重量％的固体颗粒; 约2至约75％重量的疏水性溶剂; 约10至约85重量％的水; 约0.1％至约5％重量的表面活性剂; 约0.1重量％至约5重量％的稳定剂/胶凝剂; 以及在容器中的液化或压缩气体推进剂，其在释放时提供适于局部施用的可破裂泡沫。

26. 发明申请

WO2008038147A3 FOAMABLE VEHICLE COMPRISING DICARBOXYLIC ACID OR DICARBOXYLIC ACID ESTER AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译：包含二羧酸或二羧酸酯及其药物组合物的可燃性车辆
公开(公告)号：WO2008038147A3
公开(公告)日：2008-10-16
申请号：PCT/IB2007003759
申请日：2007-07-05
申请人： FOAMIX LTD , FRIEDMAN DORON , TAMARKIN DOV
发明人： FRIEDMAN DORON , TAMARKIN DOV
IPC分类号： A61K9/12 , A61K8/04 , A61K9/107 , A61K47/12 , A61K47/14
CPC分类号： A61Q19/10 , A61K8/046 , A61K8/362 , A61K8/365 , A61K8/37 , A61K9/0014 , A61K9/122 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/183 , A61K47/26 , A61K47/28 , A61K47/34 , A61K47/36 , A61K47/38 , A61Q5/12 , A61Q13/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/04
摘要： The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
摘要翻译：本发明教导了一种可发泡药物载体，其包含选自二羧酸和二羧酸酯的有益剂; 选自由至少一种表面活性剂组成的组的稳定剂; 至少一种聚合物及其混合物; 选自水，亲水溶剂，疏水溶剂，有效溶剂，极性溶剂，硅氧烷，软化剂及其混合物的溶剂，其中选择有益剂，稳定剂和溶剂以提供组合物其基本上耐老化和相分离，或基本上稳定其它活性成分。本发明还涉及另外含有液化烃气体推进剂的可发泡组合物。

27. 发明申请

WO2007039825A3 SACCHARIDE FOAMABLE COMPOSITIONS 审中-公开
标题翻译： SACCHARIDE可发泡组合物
公开(公告)号：WO2007039825A3
公开(公告)日：2008-03-06
申请号：PCT/IB2006003628
申请日：2006-05-09
申请人： FOAMIX LTD , TAMARKIN DOV , BESONOV ALEX , FRIEDMAN DORON
发明人： TAMARKIN DOV , BESONOV ALEX , FRIEDMAN DORON
IPC分类号： A61K9/12 , A61K47/10 , A61K47/38
CPC分类号： A61K9/122 , A61K8/046 , A61K8/39 , A61K8/60 , A61K8/988 , A61K9/0014 , A61K9/7015 , A61K47/26 , A61K47/38 , A61Q19/00 , Y10S514/945
摘要： A foamable composition, containing a saccharide for use in the treatment of various disorders including: water, a saccharide, about 0.2% to about 5% by weight of a surface- active agent, about 0.01% to about 5% by weight of at least one polymeric agent selected from a bio-adhesive agent, a gelling agent, a film forming agent and a phase change agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：一种可发泡组合物，其含有用于治疗各种疾病的糖类，包括：水，糖类，约0.2％至约5％重量的表面活性剂，至少约0.01％至约5％一种选自生物粘合剂，胶凝剂，成膜剂和相变剂的聚合物，以及以总组合物重量计约3％至约25％浓度的液化或压缩气体推进剂。

28. 发明申请

WO2007031620B1 METRONIDAZOLE-BASED DERMATOLOGICAL FOAM AND EMULSIONS FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：基于METRONIDAZOLE的皮肤发泡及其生产乳液
公开(公告)号：WO2007031620B1
公开(公告)日：2007-06-21
申请号：PCT/FR2006002037
申请日：2006-09-05
申请人： GALDERMA SA , TAMARKIN DOV , FRIEDMAN DORON
发明人： TAMARKIN DOV , FRIEDMAN DORON
IPC分类号： A61K9/12 , A61K9/107 , A61K31/40
CPC分类号： A61K9/122 , A61K9/0014 , A61K9/107
摘要： The invention relates to emulsions comprising the following components expressed in mass percentage with respect to the total mass of the composition thereof: (a) 70-81 mass % water, (b) 0.1-5 mass % gelling agent of the emulsion aqueous phase, (c) 0.75-2 mass% metronidazole, (d) 4-10 mass % mineral oil, (e) 0.5-20 mass% surfactant agent, (f) 0.5-5 mass % fatty acid, (g) 0.1-5 mass % preservative agent and (h) 0-5 mass % metronidazole absorption promoter. A metronidazole-based foams obtainable from said emulsions and the use thereof are also disclosed.
摘要翻译：本发明涉及相对于其组合物的总质量以质量百分数表示的以下组分的乳液：（a）70-81质量％的水，（b）0.1-5质量％的乳液水相胶凝剂，（c）0.75-2质量％甲硝唑，（d）4-10质量％矿物油，（e）0.5-20质量％表面活性剂，（f）0.5-5质量％脂肪酸，（g）0.1-5质量％％防腐剂和（h）0-5质量％甲硝唑吸收促进剂。还公开了可从所述乳液获得的基于甲硝唑的泡沫及其用途。

29. 发明申请

WO2007031621A3 METRONIDAZOLE-BASED DERMATOLOGICAL FOAM AND EMULSIONS FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：基于METRONIDAZOLE的皮肤发泡及其生产乳液
公开(公告)号：WO2007031621A3
公开(公告)日：2007-05-03
申请号：PCT/FR2006002038
申请日：2006-09-05
申请人： GALDERMA SA , TAMARKIN DOV , FRIEDMAN DORON
发明人： TAMARKIN DOV , FRIEDMAN DORON
IPC分类号： A61K9/12 , A61K9/107 , A61K31/40 , A61P17/00
CPC分类号： A61K9/0014 , A61K9/107 , A61K9/122
摘要： The invention relates to emulsions comprising the following components expressed in mass percentage with respect to the total mass of the composition thereof: (a) 72-76 mass % water, (b) 0.1-5 mass % gelling agent of the emulsion aqueous phase, (c) 0.75-2 mass % metronidazole, (d) 5-10 mass % mineral oil, (e) 0.5-10 mass % surfactant agent, (f) 0.5-5 mass % fatty acid, (g) 0-4 mass % metronidazole (c) absorption promoter and (h) 0.1-5 mass % preservative agent selected from a group consisting of methylparabene, propylparabene, phenoxyethanol and the mixture thereof. A metronidazole-based foams obtainable from said emulsions and the use thereof are also disclosed.
摘要翻译：本发明涉及相对于其组合物的总质量以质量百分比表示的以下组分的乳液：（a）72-76质量％的水，（b）0.1-5质量％的乳液水相胶凝剂，（c）0.75-2质量％甲硝唑，（d）5-10质量％矿物油，（e）0.5-10质量％表面活性剂，（f）0.5-5质量％脂肪酸，（g）0-4质量％％甲硝唑（c）吸收促进剂和（h）0.1-5质量％的选自对羟基苯甲酸甲酯，对羟基苯甲酸丙酯，苯氧基乙醇及其混合物的防腐剂。还公开了可从所述乳液获得的基于甲硝唑的泡沫及其用途。

30. 发明申请

WO2007031620A3 METRONIDAZOLE-BASED DERMATOLOGICAL FOAM AND EMULSIONS FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：基于甲基咪唑的皮肤病学泡沫和用于其生产的乳液
公开(公告)号：WO2007031620A3
公开(公告)日：2007-05-03
申请号：PCT/FR2006002037
申请日：2006-09-05
申请人： GALDERMA SA , TAMARKIN DOV , FRIEDMAN DORON
发明人： TAMARKIN DOV , FRIEDMAN DORON
IPC分类号： A61K9/12 , A61K9/107 , A61K31/40
CPC分类号： A61K9/122 , A61K9/0014 , A61K9/107
摘要： The invention relates to emulsions comprising the following components expressed in mass percentage with respect to the total mass of the composition thereof: (a) 70-81 mass % water, (b) 0.1-5 mass % gelling agent of the emulsion aqueous phase, (c) 0.75-2 mass% metronidazole, (d) 4-10 mass % mineral oil, (e) 0.5-20 mass% surfactant agent, (f) 0.5-5 mass % fatty acid, (g) 0.1-5 mass % preservative agent and (h) 0-5 mass % metronidazole absorption promoter. A metronidazole-based foams obtainable from said emulsions and the use thereof are also disclosed.
摘要翻译：（a）70-81质量％的水，（b）乳液含水相的0.1-5质量％胶凝剂，以及（b）（c）0.75-2质量％甲硝唑，（d）4-10质量％矿物油，（e）0.5-20质量％表面活性剂，（f）0.5-5质量％脂肪酸，（g）0.1-5质量％防腐剂和（h）0-5质量％甲硝唑吸收促进剂。还公开了由所述乳液得到的基于甲硝唑的泡沫及其用途。

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