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21. 发明申请

WO2006081190A3 COMPOSITIONS AND METHODS FOR TREATING CARDIAC CONDITIONS 审中-公开
标题翻译：治疗心脏病症的组合物和方法
公开(公告)号：WO2006081190A3
公开(公告)日：2008-02-21
申请号：PCT/US2006002313
申请日：2006-01-25
申请人： FIVE PRIME THERAPEUTICS INC , WILLIAMS LEWIS T , ZHANG HONGBING , WANG YAN , MASUOKA LORIANE , DOBERSTEIN STEPHEN
发明人： WILLIAMS LEWIS T , ZHANG HONGBING , WANG YAN , MASUOKA LORIANE , DOBERSTEIN STEPHEN
IPC分类号： A61K38/18 , A61K38/21 , A61P9/00
CPC分类号： A61K9/0019 , A61K38/1808 , A61K38/1825 , A61K38/1858 , A61K38/1866 , A61K38/2006 , A61K38/2093 , A61K38/212 , A61K38/2285 , A61K38/2292 , A61K38/30 , A61K2300/00
摘要： Pharmaceutical polypeptide compositions promote the survival of cardiac cells, recruit cardiac cells to the cardiac area, stimulate the differentiation of cardiac cells, stimulate the proliferation of cardiac cells, and promote the activity of cardiac cells, thereby treating cardiac conditions. Methods of providing these compositions to the cardiac area include catheterization and direct injection. In preferred embodiements, the compositions comprise one of more of the following growth factors: EGF, bFGF, cardiotrophin-1, thrombin, PDGF-BB, amphiregulin, epiregulin, HB-EGF, TGFalpha, betacellulin, heregulin alpha, NRG-1-betal-HRG-betal, FGF 9.
摘要翻译：药物多肽组合物促进心脏细胞的存活，将心脏细胞募集到心脏区域，刺激心脏细胞的分化，刺激心脏细胞的增殖，并促进心脏细胞的活性，从而治疗心脏病。将这些组合物提供给心脏区域的方法包括导管插入和直接注射。在优选的实施方案中，组合物包含以下生长因子之一：EGF，bFGF，心肌营养因子-1，凝血酶，PDGF-BB，双调蛋白，表孕霉素，HB-EGF，TGFα，细胞素，调节蛋白α，NRG-1-betal -HRG-betal，FGF 9。

22. 发明申请

WO2004042023A2 STEM CELL LIBRARIES 审中-公开
公开(公告)号：WO2004042023A2
公开(公告)日：2004-05-21
申请号：PCT/US0334811
申请日：2003-10-31
申请人： FIVE PRIME THERAPEUTICS INC , ZHANG HONGBING , WILLIAMS LEWIS T , CHU KETTING , COHEN FRED
发明人： ZHANG HONGBING , WILLIAMS LEWIS T , CHU KETTING , COHEN FRED
IPC分类号： A01K67/00 , A01K67/033 , C12N20060101 , C12N5/00 , C12N5/02 , C12N5/0735 , C12N15/85 , G01N33/00 , C12N
CPC分类号： C12N5/0606
摘要： A stem cell library is created by genetically modifying stem cells with nucleic acids encoding polypeptides which can promote stem cell differentiation into specific cell types. Alternatively, the stem cell library is exposed to an externally added factor that promotes stem cell differentiation into a desired cell line, e.g., neuronal or muscle. The library is used to determine the effect of the encoded protein on the differentiation process. The library is also used to produce nucleic acids for insertion into embryonic stem cells to produce transfected embryonic stem cells. The nucleic acids are inserted into a locus that permits widespread expression of the encoded polypeptide in animals produced from blastocysts that incorporate the transfected cells. Non-human chimeric animals produced by combining blastocysts derived from animal models of human disease and embryonic stem cells transfected with molecules from the library provide an in vivo system for therapeutic design.

23. 发明申请

WO2005116070A3 Reporter system for detecting signal pathway activation in multiple cell types 审中-公开
标题翻译：用于检测多种细胞类型信号通路激活的记录系统
公开(公告)号：WO2005116070A3
公开(公告)日：2006-06-15
申请号：PCT/US2005014199
申请日：2005-04-27
申请人： FIVE PRIME THERAPEUTICS INC , WILLIAMS LEWIS T , ZHANG HONGBING , BEAURANG PIERRE ALVARO , KOTHAKOTA SRINIVAS , PIERCE KRISTEN
发明人： WILLIAMS LEWIS T , ZHANG HONGBING , BEAURANG PIERRE ALVARO , KOTHAKOTA SRINIVAS , PIERCE KRISTEN
IPC分类号： A01K67/027 , C07K14/705 , C12N15/85 , C12N5/10 , C12N15/87
CPC分类号： A01K67/0271 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , C12N15/8509 , C12N2517/02 , C12N2830/00
摘要： The invention provides a reporter system for studying signal transduction pathways. The reporter system includes a gene encoding a detectable gene product expressed in multiple cell types. A gene of interest can be used to target a specific locus in an embryonic stem cell, for example, the ROSA26 locus. The transformed stem cell is introduced into a blastocyst, which develops into a chimeric animal that produces the gene product of interest in multiple tissues, such that the effect of the gene product on the animal can be determined, both during development and in adulthood. Cell lines can be produced from cells or tissues obtained from the chimeric animal or its progeny. This reporter system can elucidate the components of signal transduction pathways when the reporter gene is activated under the regulatory control of a response element.
摘要翻译：本发明提供了一种用于研究信号转导途径的报告系统。记者系统包括编码以多种细胞类型表达的可检测基因产物的基因。感兴趣的基因可以用于靶向胚胎干细胞中的特定基因座，例如ROSA26基因座。转化的干细胞被引入囊胚，其发育成在多个组织中产生感兴趣的基因产物的嵌合动物，从而可以在发育和成年期间确定基因产物对动物的影响。可以从嵌合动物或其后代获得的细胞或组织产生细胞系。当报告基因在响应元件的调节控制下被激活时，该报道系统可以阐明信号转导途径的组分。

24. 发明申请

WO2004042023B1 STEM CELL LIBRARIES 审中-公开
公开(公告)号：WO2004042023B1
公开(公告)日：2004-10-21
申请号：PCT/US0334811
申请日：2003-10-31
申请人： FIVE PRIME THERAPEUTICS INC , ZHANG HONGBING , WILLIAMS LEWIS T , CHU KETTING , COHEN FRED
发明人： ZHANG HONGBING , WILLIAMS LEWIS T , CHU KETTING , COHEN FRED
IPC分类号： A01K67/00 , A01K67/033 , C12N20060101 , C12N5/00 , C12N5/02 , C12N5/0735 , C12N15/85 , G01N33/00
CPC分类号： C12N5/0606
摘要： A stem cell library is created by genetically modifying stem cells with nucleic acids encoding polypeptides which can promote stem cell differentiation into specific cell types. Alternatively, the stem cell library is exposed to an externally added factor that promotes stem cell differentiation into a desired cell line, e.g., neuronal or muscle. The library is used to determine the effect of the encoded protein on the differentiation process. The library is also used to produce nucleic acids for insertion into embryonic stem cells to produce transfected embryonic stem cells. The nucleic acids are inserted into a locus that permits widespread expression of the encoded polypeptide in animals produced from blastocysts that incorporate the transfected cells. Non-human chimeric animals produced by combining blastocysts derived from animal models of human disease and embryonic stem cells transfected with molecules from the library provide an in vivo system for therapeutic design.
摘要翻译：通过用能够促进干细胞分化成特定细胞类型的多肽的核酸对遗传修饰干细胞产生干细胞文库。或者，将干细胞文库暴露于外部添加的因子，其促进干细胞分化成期望的细胞系，例如神经元或肌肉。该文库用于确定编码的蛋白质对分化过程的影响。该文库还用于生产用于插入胚胎干细胞以产生转染的胚胎干细胞的核酸。将核酸插入到允许编码的多肽在掺入转染细胞的囊胚产生的动物中广泛表达的基因座。通过将源自人类疾病的动物模型的胚泡和来自文库的分子转染的胚胎干细胞组合产生的非人类嵌合动物提供用于治疗设计的体内系统。

25. 发明申请

WO0038706A9 METHODS FOR TREATING CANCER AND FOR MEDIATING CHEMOTAXIS OF DENDRITIC CELLS 审中-公开
标题翻译：用于治疗癌症和介导感染细胞化学的方法
公开(公告)号：WO0038706A9
公开(公告)日：2002-08-22
申请号：PCT/US9931096
申请日：1999-12-28
申请人： CHIRON CORP , CHU KETING , XIN HONG , CHAN VIVIEN W F , KOTHAKOTA SRINIVAS , WILLIAMS LEWIS T , WINTER JILL A
发明人： CHU KETING , XIN HONG , CHAN VIVIEN W F , KOTHAKOTA SRINIVAS , WILLIAMS LEWIS T , WINTER JILL A
IPC分类号： C12N15/02 , A61K31/711 , A61K38/00 , A61K38/19 , A61K38/20 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/47
CPC分类号： A61K38/195 , A61K38/2013 , A61K2300/00
摘要： The invention is based on the novel observation, reported herein, that SLC inhibits the growth of tumors in vivo and is a potent chemokine for Dendritic Cells (DC). Thus, the invention provides a method of treating cancer or hyperproliferative disorder in a mammalian subject, comprising: administering a therapeutically effective amount of an SLC to said subject. SLCs useful in the methods of the invention include SLC polypeptides, variants and fragments and related nucleic acids. The methods of the invention are useful in the treatment of cancer and hyperproliferative disorders. In addition, the invention provides methods for modulating dendritic cell function in a mammal, said method comprising administering a therapeutically effective amount of an SLC agent to said mammal, said agent selected from the group consisting of: SLC plypeptides, SLC polypeptide variants, SLC polypeptide fragments, polynucleotides encoding SLC polypeptides, variants and fragments, anti-SLC antibodies and ligands for the CCR7 receptor. Such methods can be used to increase or decrease an immune response, particularly a primary immune response, in a mammal. The methods are particularly useful in the prevention of graft rejection and in the treatment of autoimmune disease. Alternatively, the methods may be used to enhance an immune response.
摘要翻译：本发明基于本文报道的新观察，SLC抑制体内肿瘤的生长，并且是树突状细胞（DC）的有效趋化因子。因此，本发明提供了在哺乳动物受试者中治疗癌症或过度增殖性疾病的方法，其包括：向所述受试者施用治疗有效量的SLC。可用于本发明方法的SLC包括SLC多肽，变体和片段及相关核酸。本发明的方法可用于治疗癌症和过度增殖性疾病。另外，本发明提供调节哺乳动物树突状细胞功能的方法，所述方法包括向所述哺乳动物施用治疗有效量的SLC剂，所述药物选自：SLC多肽，SLC多肽变体，SLC多肽片段，编码SLC多肽的多核苷酸，变体和片段，抗SLC抗体和CCR7受体的配体。这样的方法可用于增加或减少哺乳动物的免疫应答，特别是初级免疫应答。该方法特别可用于预防移植物排斥和治疗自身免疫性疾病。或者，所述方法可用于增强免疫应答。

26. 发明申请

WO0172781A9 HUMAN GENES AND EXPRESSION PRODUCTS 审中-公开
标题翻译：人类基因和表达产物
公开(公告)号：WO0172781A9
公开(公告)日：2003-03-06
申请号：PCT/US0109952
申请日：2001-03-27
申请人： CHIRON CORP , HYSEQ INC , WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , SUDDUTH-KLINGER JULIE , REINHARD CHRISTOPH , HE ZHIJUN , RANDAZZO FILIPPO , KENNEDY GIULIA C , POT DAVID A , KASSAM ALTAF , LAMSON GEORGE , DRMANAC RADOJE , CRKVENJAKOV RADOMIR , DICKSON MARK , DRMANAC SNEZANA , LABAT IVAN , LESHKOWITZ DENA , KITA DAVID , GARCIA VERONICA , JONES LEE WILLIAM , STACHE-CRAIN BIRGIT
发明人： WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , SUDDUTH-KLINGER JULIE , REINHARD CHRISTOPH , HE ZHIJUN , RANDAZZO FILIPPO , KENNEDY GIULIA C , POT DAVID A , KASSAM ALTAF , LAMSON GEORGE , DRMANAC RADOJE , CRKVENJAKOV RADOMIR , DICKSON MARK , DRMANAC SNEZANA , LABAT IVAN , LESHKOWITZ DENA , KITA DAVID , GARCIA VERONICA , JONES LEE WILLIAM , STACHE-CRAIN BIRGIT
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P35/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/68 , C12N15/12
CPC分类号： C07K14/47
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variant thereof, to genes corresponding to theses polynucleotides and to proteins expressed by the genes. This invention also relates to diagnostic and therapeutic agents employing such novel polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及新的人多核苷酸及其变体，其编码的多肽及其变体，涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质。本发明还涉及使用这种新型多核苷酸的诊断和治疗剂，它们相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

27. 发明申请

WO0166753A3 HUMAN GENES AND GENE EXPRESSION PRODUCTS 审中-公开
标题翻译：人类基因和基因表达产物
公开(公告)号：WO0166753A3
公开(公告)日：2002-08-15
申请号：PCT/US0107787
申请日：2001-03-09
申请人： CHIRON CORP , HYSEQ INC , WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , SUDDUTH-KLINGER JULIE , REINHARD CHRISTOPH , RANDAZZO FILIPPO , KENNEDY GIULIA C , POT DAVID , KASSAM ALTAF , LAMSON GEORGE , DRMANAC RADOJE , CRKVENJAKOV RADOMIR , DICKSON MARK , DRMANAC SNEZANA , LABAT IVAN , LESHKOWITZ DENA , KITA DAVID , GARCIA VERONICA , JONES WILLIAM LEE , STACHE-CRAIN BIRGIT
发明人： WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , SUDDUTH-KLINGER JULIE , REINHARD CHRISTOPH , RANDAZZO FILIPPO , KENNEDY GIULIA C , POT DAVID , KASSAM ALTAF , LAMSON GEORGE , DRMANAC RADOJE , CRKVENJAKOV RADOMIR , DICKSON MARK , DRMANAC SNEZANA , LABAT IVAN , LESHKOWITZ DENA , KITA DAVID , GARCIA VERONICA , JONES WILLIAM LEE , STACHE-CRAIN BIRGIT
IPC分类号： C12N15/09 , A61K45/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/10 , G01N33/574
CPC分类号： C07K14/47
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及新的人多核苷酸及其变体，它们的编码多肽及其变体，对应于这些多核苷酸的基因以及由这些基因表达的蛋白质。本发明还涉及采用这种新型人多核苷酸，其相应基因或基因产物（例如这些基因和蛋白质，包括探针，反义构建体和抗体）的诊断和治疗剂。

28. 发明申请

WO9938972A8 HUMAN GENES AND GENE EXPRESSION PRODUCTS II 审中-公开
标题翻译：人类基因和基因表达产物II
公开(公告)号：WO9938972A8
公开(公告)日：2000-04-06
申请号：PCT/US9901619
申请日：1999-01-28
申请人： CHIRON CORP , HYSEQ INC , WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , SUDDUTH KLINGER JULIE , REINHARD CHRISTOPH , GIESE KLAUS , RANDAZZO FILIPPO , KENNEDY GIULIA C , POT DAVID , KASSAM ALTAF , LAMSON GEORGE , DRMANAC RADOJE , CRKVENJAKOV RADOMIR , DICKSON MARK , DRMANAC SNEZANA , LABAT IVAN , LESHKOWITZ DENA , KITA DAVID , GARCIA VERONICA , JONES LEE WILLIAM , STACHE CRAIN BIRGIT
发明人： WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , SUDDUTH-KLINGER JULIE , REINHARD CHRISTOPH , GIESE KLAUS , RANDAZZO FILIPPO , KENNEDY GIULIA C , POT DAVID , KASSAM ALTAF , LAMSON GEORGE , DRMANAC RADOJE , CRKVENJAKOV RADOMIR , DICKSON MARK , DRMANAC SNEZANA , LABAT IVAN , LESHKOWITZ DENA , KITA DAVID , GARCIA VERONICA , JONES LEE WILLIAM , STACHE-CRAIN BIRGIT
IPC分类号： C12N15/09 , C07K14/47 , C07K14/82 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

29. 发明申请

WO9938972A9 HUMAN GENES AND GENE EXPRESSION PRODUCTS II 审中-公开
标题翻译：人类基因和基因表达产物II
公开(公告)号：WO9938972A9
公开(公告)日：2001-05-17
申请号：PCT/US9901619
申请日：1999-01-28
申请人： CHIRON CORP , HYSEQ INC , WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , SUDDUTH KLINGER JULIE , REINHARD CHRISTOPH , GIESE KLAUS , RANDAZZO FILIPPO , KENNEDY GIULIA C , POT DAVID , KASSAM ALTAF , LAMSON GEORGE , DRMANAC RADOJE , CRKVENJAKOV RADOMIR , DICKSON MARK , DRMANAC SNEZANA , LABAT IVAN , LESHKOWITZ DENA , KITA DAVID , GARCIA VERONICA , JONES LEE WILLIAM , STACHE CRAIN BIRGIT
发明人： WILLIAMS LEWIS T , ESCOBEDO JAIME , INNIS MICHAEL A , GARCIA PABLO DOMINGUEZ , SUDDUTH-KLINGER JULIE , REINHARD CHRISTOPH , GIESE KLAUS , RANDAZZO FILIPPO , KENNEDY GIULIA C , POT DAVID , KASSAM ALTAF , LAMSON GEORGE , DRMANAC RADOJE , CRKVENJAKOV RADOMIR , DICKSON MARK , DRMANAC SNEZANA , LABAT IVAN , LESHKOWITZ DENA , KITA DAVID , GARCIA VERONICA , JONES LEE WILLIAM , STACHE-CRAIN BIRGIT
IPC分类号： C12N15/09 , C07K14/47 , C07K14/82 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译：本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

30. 发明申请

WO0038706A2 METHODS FOR TREATING CANCER AND FOR MEDIATING CHEMOTAXIS OF DENDRITIC CELLS 审中-公开
标题翻译：治疗癌症和介导树突状细胞化学治疗的方法
公开(公告)号：WO0038706A2
公开(公告)日：2000-07-06
申请号：PCT/US9931096
申请日：1999-12-28
申请人： CHIRON CORP , KETING CHU , XIN HONG , CHAN VIVIEN W F , KOTHAKOTA SRINIVAS , WILLIAMS LEWIS T , WINTER JILL A
发明人： KETING CHU , XIN HONG , CHAN VIVIEN W F , KOTHAKOTA SRINIVAS , WILLIAMS LEWIS T , WINTER JILL A
IPC分类号： C12N15/02 , A61K31/711 , A61K38/00 , A61K38/19 , A61K38/20 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/47
CPC分类号： A61K38/195 , A61K38/2013 , A61K2300/00
摘要： The invention is based on the novel observation, reported herein, that SLC inhibits the growth of tumors in vivo and is a potent chemokine for Dendritic Cells (DC). Thus, the invention provides a method of treating cancer or hyperproliferative disorder in a mammalian subject, comprising: administering a therapeutically effective amount of an SLC to said subject. SLCs useful in the methods of the invention include SLC polypeptides, variants and fragments and related nucleic acids. The methods of the invention are useful in the treatment of cancer and hyperproliferative disorders. In addition, the invention provides methods for modulating dendritic cell function in a mammal, said method comprising administering a therapeutically effective amount of an SLC agent to said mammal, said agent selected from the group consisting of: SLC plypeptides, SLC polypeptide variants, SLC polypeptide fragments, polynucleotides encoding SLC polypeptides, variants and fragments, anti-SLC antibodies and ligands for the CCR7 receptor. Such methods can be used to increase or decrease an immune response, particularly a primary immune response, in a mammal. The methods are particularly useful in the prevention of graft rejection and in the treatment of autoimmune disease. Alternatively, the methods may be used to enhance an immune response.
摘要翻译：本发明基于本文报道的新观察结果，即SLC在体内抑制肿瘤生长并且是树突细胞（DC）的有效趋化因子。因此，本发明提供了治疗哺乳动物受试者中的癌症或过度增殖性病症的方法，其包括：向所述受试者施用治疗有效量的SLC。用于本发明方法的SLC包括SLC多肽，变体和片段以及相关核酸。本发明的方法可用于治疗癌症和过度增殖性疾病。此外，本发明提供了用于调节哺乳动物的树突细胞功能的方法，所述方法包括向所述哺乳动物施用治疗有效量的SLC试剂，所述试剂选自：SLC多肽，SLC多肽变体，SLC多肽片段，编码SLC多肽的多核苷酸，变体和片段，抗SLC抗体和CCR7受体的配体。这些方法可用于增加或减少哺乳动物的免疫应答，特别是初次免疫应答。该方法在预防移植排斥和治疗自身免疫性疾病方面特别有用。或者，该方法可用于增强免疫应答。

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