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21. 发明申请

WO2012074588A2 SHEAR CONTROLLED RELEASE FOR STENOTIC LESIONS AND THROMBOLYTIC THERAPIES 审中-公开
标题翻译：剪切控制释放用于椎间盘突出症和血栓治疗
公开(公告)号：WO2012074588A2
公开(公告)日：2012-06-07
申请号：PCT/US2011/049691
申请日：2011-08-30
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , INGBER, Donald, E. , KORIN, Netanel , KANAPATHIPILLAI, Mathumai
发明人： INGBER, Donald, E. , KORIN, Netanel , KANAPATHIPILLAI, Mathumai
CPC分类号： A61K38/02 , A61K9/1617 , A61K9/5153 , A61K31/721 , A61K38/49 , Y02A50/411
摘要： The invention provides compositions and methods for treating or imaging stenosis, stenotic lesions, occluded lumens, embolic phenomena or thrombotic disorders. The invention further provides compositions and methods for treating internal hemorrhage.
摘要翻译：本发明提供了用于治疗或成像狭窄，狭窄病变，闭塞腔，栓塞现象或血栓形成障碍的组合物和方法。本发明还提供了治疗内部出血的组合物和方法。

22. 发明申请

WO2002092783A2 METHODS AND APPARATUS FOR APPLICATION OF MICRO-MECHANICAL FORCES TO TISSUES 审中-公开
标题翻译：将微机械应用于组织的方法和装置
公开(公告)号：WO2002092783A2
公开(公告)日：2002-11-21
申请号：PCT/US2002/018355
申请日：2002-05-15
申请人： CHILDREN'S MEDICAL CENTER CORPORATION
发明人： ORGILL, Dennis, P. , EICHBAUM, Quentin, Gavin , HUANG, Sui , HWANG, Chao-Wei , INGBER, Donald, E. , SAXENA, Vishal , GARFEIN, Evan, Stuart
IPC分类号： C12N
CPC分类号： A61M1/0088 , A61B2017/00747 , A61B2090/401 , A61F13/00 , A61F13/00008 , A61F13/00034 , A61F13/00063 , A61F13/00068 , A61F13/00987 , A61F2002/286 , A61F2002/30062 , A61F2002/30955 , A61F2013/00174 , A61F2013/00221 , A61F2013/00327 , A61F2013/00365 , A61F2013/0054 , A61F2013/00574 , A61F2013/00927 , A61F2210/0004 , A61L15/42 , A61L15/425 , A61M1/0023
摘要： Methods and devices for transmitting micromechanical forces locally to induce surface convolutions into tissues on the millimeter to micron scale for promoting wound healing presented. These convolutions induce a moderate stretching of individual cells stimulating cellular proliferation and elaboration of natural growth factors without increasing the size of the wound. Micromechanical forces can be applied directly to tissue, through biomolecules or the extracellular matrix. This invention can be used with biosensors biodegradable materials and drug delivery systems. This invention will also be useful in pre-conditoned tissue-engineering constructs in vitro . Application of this invention will shorten healing times for wounds and reduce the need for invasive surgery.
摘要翻译：用于传递微机械力的方法和装置，以在毫米至微米级上局部地诱导表面卷入组织中以促进伤口愈合。这些卷积引起个体细胞的适度拉伸，刺激细胞增殖和自然生长因子的制备，而不增加伤口的大小。微机械力可以通过生物分子或细胞外基质直接施用于组织。本发明可用于生物传感器生物降解材料和药物递送系统。本发明还可用于体外预条件组织工程结构。本发明的应用将缩短伤口的愈合时间并减少对侵入性手术的需要。

23. 发明申请

WO1994025487A1 A METHOD FOR RAPID FORMATION AND ISOLATION OF FOCAL ADHESION COMPLEXES 审中-公开
标题翻译：一种快速形成和分离胶粘剂复合物的方法
公开(公告)号：WO1994025487A1
公开(公告)日：1994-11-10
申请号：PCT/US1994004481
申请日：1994-04-22
申请人： CHILDREN'S MEDICAL CENTER CORPORATION
发明人： CHILDREN'S MEDICAL CENTER CORPORATION , INGBER, Donald, E. , PLOPPER, George, E.
IPC分类号： C07K15/00
CPC分类号： C07K14/7055 , C07K1/145 , C07K17/14
摘要： A method using microbeads coated with specific extracellular matrix ligands, for example, fibronectin or RGD-containing peptide, or any molecule that ligates integrins and thereby mediates attachment and spreading, even through receptors other than integrins, can be applied to the surface of microbeads to induce integrin clustering and isolate functional focal adhesion complexes (FACs) from eukaryotic cells such as mammalian, insect, or plant cells. In the preferred embodiment, magnetic microbeads are utilized. Bead-associated proteins are then isolated and collected for biochemical analysis using a combination of cytoskeletal extraction, sonication, dounce homogenization, and magnetic pelleting of the beads. The FACs are demonstrated to be functionally active and to contain a number of enzymatically and otherwise biologically active proteins. This method for FAC isolation facilitates analysis of molecular interactions and chemical and mechanical signaling mechanims within functionally intact FACs, independent of global changes in cells shape or cytoskeletal organization. It also serves as a means to isolate and identify proteins not previously known or known to be present in FACs, which can be used to form diagnostics such as peptides, nucleic acid probes or antibodies. The isolated FACs can also be used to screen for molecules which impact on the mechanical and chemical signalling systems within the FACs.
摘要翻译：使用包被特定细胞外基质配体的微珠，例如含纤连蛋白或含RGD的肽，或连接整联蛋白并由此介导附着和扩散的分子，即使通过非整联蛋白的受体也可以应用于微珠表面的方法诱导整合素聚集并从真核细胞如哺乳动物，昆虫或植物细胞分离功能性粘附复合物（FAC）。在优选实施例中，使用磁性微珠。然后分离并收集珠相关蛋白用于生物化学分析，其使用细胞骨架提取，超声处理，均匀均匀化和珠粒的磁性沉淀的组合。 FAC被证明具有功能活性并且含有许多酶促和其它生物活性的蛋白质。这种FAC分离方法有助于在功能完整的FAC中分子相互作用和化学和机械信号传导机制的分析，与细胞形状或细胞骨架组织的全局变化无关。它还可用于分离和鉴定以前已知或已知存在于FAC中的蛋白质，可用于形成诊断例如肽，核酸探针或抗体。分离的FAC也可用于筛选影响FAC内机械和化学信号系统的分子。

24. 发明申请

WO2012118956A2 THERMAL MANAGEMENT OF TRANSPARENT MEDIA 审中-公开
标题翻译：透明介质的热管理
公开(公告)号：WO2012118956A2
公开(公告)日：2012-09-07
申请号：PCT/US2012/027253
申请日：2012-03-01
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , INGBER, Donald, E. , HATTON, Benjamin, D. , WHEELDON, Ian, R.
发明人： INGBER, Donald, E. , HATTON, Benjamin, D. , WHEELDON, Ian, R.
IPC分类号： H05B3/84
CPC分类号： E06B3/6715 , E06B3/66323 , E06B3/66333 , E06B3/6722 , F24D17/0015 , F24S10/50 , F24S20/63 , Y02B10/20 , Y02E10/44
摘要： A bio-inspired window can be created by applying one or more heat exchange layers to one or more surfaces of a window of a building, boat, vehicle or any other structure. The heat exchange layer can include an interconnected network or array of channels or microchannels that can be used to flow a fluid over the surface of the window. The fluid can be used to heat or cool the surface of the window panel to control the flow of heat across the window and reduce the heating or cooling energy load of building. The fluid can be heated or cooled using the ambient air in the building. The refractive index of the fluid can be adjusted to change of optical transparency properties of the window. In some embodiments, the window can appear nearly as clear as an ordinary panel of glass. In other embodiments, the window can color, block or scatter the incoming light.
摘要翻译：可以通过将一个或多个热交换层应用于建筑物，船，车辆或任何其他结构的窗户的一个或多个表面来创建生物启发式窗户。热交换层可以包括可用于使流体流过窗口表面的互连网络或通道阵列或微通道。流体可用于加热或冷却窗户面板的表面，以控制穿过窗户的热量流动并减少建筑物的加热或冷却能量负荷。可以使用建筑物中的环境空气加热或冷却流体。可以调节流体的折射率以改变窗户的光学透明性。在一些实施例中，窗户可以看起来几乎与普通玻璃板一样清晰。在其他实施例中，该窗口可以着色，阻挡或散射入射光。

25. 发明申请

WO2016190939A2 FLUIDIC DEVICE FOR QUANTIFYING THE DYNAMIC PERMEABILITY AND HYDRAULIC CONDUCTIVITY OF LIVING TISSUE LAYERS 审中-公开
标题翻译：用于定量生活组织层的动态渗透性和液压电导率的流体装置
公开(公告)号：WO2016190939A2
公开(公告)日：2016-12-01
申请号：PCT/US2016/021025
申请日：2016-03-04
申请人： LEVNER, Daniel , HINOJOSA, Christopher, David , VAN DER MEER, Andries , VAN DER HELM, Marinke , JAIN, Abhishek , INGBER, Donald, E. , ZAMANI, Marjon
发明人： LEVNER, Daniel , HINOJOSA, Christopher, David , VAN DER MEER, Andries , VAN DER HELM, Marinke , JAIN, Abhishek , INGBER, Donald, E. , ZAMANI, Marjon
IPC分类号： C12Q1/00 , C12M1/34
CPC分类号： G01N33/4833 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2300/0654 , B01L2300/0877 , B01L2300/0883 , B01L2400/0457 , B01L2400/0487 , B01L2400/082 , B01L2400/084 , B01L2400/086 , G01N15/0826 , G01N33/50 , G01N33/5005 , G01N2015/0065
摘要： Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid reservoirs, and one or more fluid-resistance element. The microfluidic device includes a first microchannel, a second microchannel, and a barrier therebetween. The barrier includes a cell layer adhered thereto. The working fluids are delivered to the microfluidic device. The fluid-resistance elements are coupled to one or more of the fluid paths and provide fluidic resistance to cause a pressure drop across the fluid-resistance elements. Mass transfer occurs between the first microchannel and the second microchannel, which is indicative of the hydraulic conductivity and/or dynamic permeability associated with the cells.
摘要翻译：公开了用于测量与电池层相关的动态水力传导性和磁导率的系统和方法。一些系统包括微流体装置，一个或多个工作流体储存器和一个或多个流体阻力元件。微流体装置包括第一微通道，第二微通道和它们之间的阻挡层。屏障包括附着在其上的电池层。将工作流体输送到微流体装置。流体阻力元件联接到一个或多个流体路径并且提供流体阻力以引起穿过流体阻力元件的压降。在第一微通道和第二微通道之间发生质量转移，其指示与电池相关联的水力传导性和/或动态磁导率。

26. 发明申请

WO2012118799A2 CELL CULTURE SYSTEM 审中-公开
标题翻译：细胞培养系统
公开(公告)号：WO2012118799A2
公开(公告)日：2012-09-07
申请号：PCT/US2012/026934
申请日：2012-02-28
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , INGBER, Donald, E. , KIM, Hyun, Jung
发明人： INGBER, Donald, E. , KIM, Hyun, Jung
IPC分类号： C12M3/02 , C12N5/071 , C12N1/20 , C12N1/14
CPC分类号： C12N5/0697 , C12M21/08 , C12M23/20 , C12M23/26 , C12M23/34 , C12M23/38 , C12M25/02 , C12M27/02 , C12M29/04 , C12M29/06 , C12M35/04 , C12M35/08 , C12M41/12 , C12M41/26 , C12M41/40 , C12M41/44 , C12N1/14 , C12N1/20 , C12N5/0679 , C12N5/068 , C12N5/0696
摘要： The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora.
摘要翻译：本文描述的本发明的实施方案涉及体外培养和/或维持肠细胞，组织和/或组织的系统和方法。根据本文所述的方法和系统培养的细胞，组织和/或组织可以模拟或再现天然肠上皮结构和行为以及支持肠道微生物群落的共培养。

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