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    • 22. 发明申请
    • 1-(AZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS
    • 1-(AZOLIN-2-YL)氨基-1,2-二苯醚化合物,用于组合动物饲料
    • WO2009004032A1
    • 2009-01-08
    • PCT/EP2008/058517
    • 2008-07-02
    • BASF SEKORDES, MarkusKORADIN, ChristopherLE VEZOUET, RonanBAUMANN, ErnstCULBERTSON, Deborah L.ANSPAUGH, Douglas D.OLOUMI-SADEGHI, HassanEBUENGA, Cecile
    • KORDES, MarkusKORADIN, ChristopherLE VEZOUET, RonanBAUMANN, ErnstCULBERTSON, Deborah L.ANSPAUGH, Douglas D.OLOUMI-SADEGHI, HassanEBUENGA, Cecile
    • C07D233/48C07D263/28C07D277/18C07D417/12C07D417/06A01N43/50A01N43/76A01N43/78
    • C07D263/28A01N43/50A01N43/76A01N43/78A01N47/12A01N47/16C07D233/48C07D277/18C07D417/06C07D417/12
    • The present invention relates to 1-(azolin-2-yl)amino-1,2-diphenylethane compounds of the formula I and to their salts which are useful for combating animal pests. The invention also relates to a method for controlling animal pests by using these compounds, to seed and to an agricultural and veterinary composition comprising said compounds, wherein A is a radical of formulae A.1 or A.2 wherein # denotes the bond to the remaining compound of formula I, X is selected from O, S and NR x , R 1 is selected from the group consisting of -OR A , -NR B1 R B2 , -C(=O)-R C , -C(=O)-OR D , -C(=O)-SR E , -C(=O)-NR B1 R B2' , -C(=S)-R C' , -C(=S)-OR D' , -C(=S)-SR E' , -C(=S)-NR B1 R B2 , -C(=NR 1a )-R C' , -C(=NR 1b )-OR D' , -C(=NR 1c )-SR E' , -C(=NR 1d )-NR B1 R B2 , -S(=O)-R F , -S(=O) 2 -R G , -S(=O) 2 -NR B1 R B2' , -P(=O)R H1 R H2 , -P(=S)R H1 R H2 , -B-C(=O)-R I , -B-O-C(=O)-R I , -B-S-C(=O)-R I , -B-N(R J )-C(=O)-R K , -B-C(=S)-R K , -B-O-C(=S)-R K , -B-S-C(=S)-R K , -B-N(R J )-C(=S)-R K , C 1 -C 8 -alkenyl, C 1 -C 8 -alkynyl, C 3 -C 8 -cycloalkyl, which is unsubstituted or may carry 1 to 4 substituents R 1e , naphthyl, which is unsubstituted or may carry 1 to 4 substituents R 1f , a saturated or partially unsaturated heterocycle, which is unsubstituted or may carry 1 to 4 substituents R 1g , hetaryl, which is unsubstituted or may carry 1 to 4 substituents R 1h , and C 1 -C 6 -alkyl, which carries a radical selected from the group consisting of -NR 1i R 1j , C 1 -C 4 -alkoxycarbonyl, C 3 -C 8 -cycloalkyl, aryl, aryloxy, arylthio, heterocyclyl, heterocyclyloxy and heterocyclylthio, R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are each independently hydrogen, halogen, OH, SH, NH 2 , SO 3 H, COOH, cyano, nitro, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino etc.
    • 本发明涉及式I的1-(吡唑-2-基)氨基-1,2-二苯基乙烷化合物及其盐,其可用于防治动物害虫。 本发明还涉及通过使用这些化合物,种子和包含所述化合物的农业和兽医组合物来控制动物害虫的方法,其中A是式A.1或A.2的基团,其中#表示与 剩余的式I化合物,X选自O,S和NR x,R1选自-ORA,-NRB1RB2,-C(= O)-RC,-C(= O)-OR,-C (= O)-SRE,-C(= O)-NRB1RB2',-C(= S)-RC',-C(= S)-OR',-C(= S)-SRE' =(NR1c)-SR',-C(= NR1d)-NRB1RB2,-S(= O) )-RF,-S(= O)2 -RG,-S(= O)2 -NRB 1 R B 2',-P(= O)RH1RH 2,-P(= S)RH1RH 2,-BC(= O) -BOC(= O)-RI,-BSC(= O)-RI,-BN(RJ)-C(= O)-RK,-BC(= S)-RK,-BOC(= S)-RK, -BSC(= S)-RK,-BN(RJ)-C(= S)-RK,C1-C8-烯基,C1-C8-炔基,C3-C8-环烷基,其未被取代或可携带1至4 取代基R 1e,萘基,其是未取代的或可以携带1至4个取代基R 1f,饱和或部分不饱和的杂环,其为未制备的 或可以携带1至4个未取代的或可以携带1至4个取代基R 1h的取代基R 1g,杂芳基,其中C 1 -C 6 - 烷基带有选自以下的基团:-NR 1 1 R 1,C 1 -C 4 - 烷氧基羰基, C 3 -C 8 - 环烷基,芳基,芳氧基,芳硫基,杂环基,杂环基氧基和杂环硫基,R 2,R 3,R 4,R 5,R 6和R 7各自独立地为氢,卤素,OH,SH,NH 2,SO 3 H,COOH,氰基,硝基, C 1 -C 6 - 烷基,C 1 -C 6 - 烷氧基,C 1 -C 6烷基氨基等
    • 25. 发明申请
    • AZOLIN-2-YLAMINO COMPOUNDS FOR COMBATING ANIMAL PESTS
    • 用于组合动物饲料的AZOLIN-2-YLAMINO化合物
    • WO2009115491A1
    • 2009-09-24
    • PCT/EP2009/053079
    • 2009-03-16
    • BASF SELE VEZOUET, RonanKORDES, MarkusKORADIN, ChristopherBAUMANN, ErnstCULBERTSON, Deborah, L.
    • LE VEZOUET, RonanKORDES, MarkusKORADIN, ChristopherBAUMANN, ErnstCULBERTSON, Deborah, L.
    • C07D233/48C07D263/28C07D277/18C07C275/24C07C335/12A01N43/50A01N43/76A01N43/78A61P33/14A61P33/10
    • C07D263/28C07C275/24C07C335/12C07D233/48C07D277/18
    • The present invention relates to azolin-2-ylamino compounds of formulae (I) and (II), wherein n is 0 to 3; Ar is phenyl; A is a radical of formulae A 1 or A 2 , wherein * indicates the point of attachment; X is S, O or N(R 10 ); R 7a-d are H, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino or C 3 -C 6 -cycloalkyl; R 8-10 are H, CN, NO 2 , C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, Ar 3 , -B-C(=O)R a , -B-C(=S)R a , -B-C(=NR f )R a , etc., wherein B is a single bond or C 1 -C 4 -alkanediyl; R 1 is H, halogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 6 -cycloalkyl, phenyl or benzyl; R 2,3 are H, halogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 6 -cycloalkyl, phenyl or benzyl; R 4 is H, halogen, CN, N 3 , NO 2 , C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, a heterocycle, Ar 5 , -C(=O)R a, -C(=S)R a , -C(=NR f )R a , etc.; or R 4 and R 5 together form a carbocycle or heterocycle; R 5,6 are H, halogen, CN, N 3 , NO 2 , C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, heterocycle, Ar 8 , -C(=O)R a , -C(=S)R a , -C(=NR f )R a , etc.; or R 5 and R 6 together form a carbocycle or heterocycle; R a-h are H, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, heterocycles or Ar 10 ; Ar 1 to 11 are phenyl, naphthyl or heteroaryl; and A' is a radical of formula A 3 , wherein W is halogen or OR 11 ; R 11 is H or -C(=O)-R i ; R i is H, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C3-C8-cycloalkyl, heterocycle or Ar 12 ; and Ar 12 is phenyl, naphthyl or heteroaryl; as well as to agricultural composition containing such compounds, the use of such compounds for controlling animal pests, seed, comprising such compounds, a method for controlling animal pests and a method for treating or protecting an animal from infestation or infection by parasites.
    • 本发明涉及式(I)和(II)的唑啉-2-基氨基化合物,其中n为0至3; Ar是苯基; A是式A1或A2的基团,其中*表示连接点; X是S,O或N(R10); R7a-d为H,卤素,C1-C6-烷基,C1-C6-烷氧基,C1-C6-烷基氨基或C3-C6-环烷基; R8-10是H,CN,NO2,C1-C6-烷基,C2-C6-烯基,C2-C6-炔基,C3-C8-环烷基,Ar3,-BC(= O)Ra,-BC(= S) Ra,-BC(= NRf)Ra等,其中B为单键或C1-C4-烷二基; R1是H,卤素,C1-C6-烷基,C2-C6-烯基,C2-C6-炔基,C3-C6-环烷基,苯基或苄基; R2,3是H,卤素,C1-C6-烷基,C2-C6-烯基,C2-C6-炔基,C3-C6-环烷基,苯基或苄基; R4是H,卤素,CN,N3,NO2,C1-C6-烷基,C2-C6-烯基,C2-C6-炔基,C3-C8-环烷基,杂环,Ar5,-C(= O) C(= S)Ra,-C(= NRf)Ra等; 或R4和R5一起形成碳环或杂环; R5,6是H,卤素,CN,N3,NO2,C1-C6-烷基,C2-C6-烯基,C2-C6-炔基,C3-C8-环烷基,杂环,Ar8,-C(= O) -C(= S)R a,-C(= NR f)R a等; 或R5和R6一起形成碳环或杂环; R h为H,C 1 -C 6烷基,C 2 -C 6 - 烯基,C 2 -C 6炔基,C 3 -C 8 - 环烷基,杂环或Ar 10; Ar 1至11是苯基,萘基或杂芳基; 并且A'是式A3的基团,其中W是卤素或OR 11; R 11为H或-C(= O)-R i; R 1是H,C 1 -C 6烷基,C 2 -C 6 - 烯基,C 2 -C 6炔基,C 3 -C 8环烷基,杂环或Ar 12; 和Ar 12是苯基,萘基或杂芳基; 以及含有这种化合物的农业组合物,这些化合物用于控制动物害虫,种子,包含这些化合物的用途,控制动物害虫的方法以及用于治疗或保护动物不受寄生虫感染或感染的方法。