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21. 发明申请

WO2006050236A2 COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：化合物及其使用方法
公开(公告)号：WO2006050236A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/039204
申请日：2005-10-27
申请人： NUADA, LLC , DIDSBURY, John R. , DYAKONOV, Tatyana , HAYDAR, Simon N. , JONES, Michael L. , LI, Francine F. , MARKWORTH, Christopher J. , MATHEW, Jessymol , SCHOENEN, Frank J. , SCICINSKI, Jan J. , MIDDLEMISS, David N.
发明人： DIDSBURY, John R. , DYAKONOV, Tatyana , HAYDAR, Simon N. , JONES, Michael L. , LI, Francine F. , MARKWORTH, Christopher J. , MATHEW, Jessymol , SCHOENEN, Frank J. , SCICINSKI, Jan J. , MIDDLEMISS, David N.
IPC分类号： C07D207/02
CPC分类号： C07D491/04 , C07D209/08 , C07F5/025
摘要： Indole boronic acid compounds, and analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.
摘要翻译：还描述了吲哚硼酸化合物及其类似物和药物制剂，以及其用于抑制有需要的受试者中的炎性细胞因子如肿瘤坏死因子α（TNF-α）的方法。

22. 发明申请

WO2006050054A2 COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：化合物及其使用方法
公开(公告)号：WO2006050054A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/038854
申请日：2005-10-27
申请人： NUADA, LLC , DYAKONOV, Tatyana , JONES, Michael, L. , MARKWORTH, Christopher, J. , MATHEW, JessyMol , SCHOENEN, Frank, J. , VANVLIET, David, N. , MIDDLEMISS, David, N.
发明人： DYAKONOV, Tatyana , JONES, Michael, L. , MARKWORTH, Christopher, J. , MATHEW, JessyMol , SCHOENEN, Frank, J. , VANVLIET, David, N. , MIDDLEMISS, David, N.
CPC分类号： C07F5/025
摘要： Benzolactam boronic acid compounds and pharmaceutical formulations are described along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.
摘要翻译：描述了苯并内酰胺硼酸化合物和药物制剂以及其用于在有需要的受试者中抑制炎性细胞因子如肿瘤坏死因子α（TNF-α）的方法。

23. 发明申请

WO0239905A9 DOPPLER DIRECTED SUTURE LIGATION DEVICE AND METHOD 审中-公开
标题翻译：多普勒方向定位设备和方法
公开(公告)号：WO0239905A9
公开(公告)日：2003-03-27
申请号：PCT/US0127792
申请日：2001-11-01
申请人： VASCULAR CONTROL SYSTEMS INC , BURBANK FRED , JONES MICHAEL L , UYENO JILL , ALTIERI GREIG E , SERRA R J
发明人： BURBANK FRED , JONES MICHAEL L , UYENO JILL , ALTIERI GREIG E , SERRA R J
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61B17/30 , A61B17/32 , A61B18/00 , A61B18/14 , A61B19/00
CPC分类号： A61B17/32056 , A61B17/0469 , A61B17/0482 , A61B17/12009 , A61B18/1477 , A61B18/1482 , A61B2017/00349 , A61B2017/00867 , A61B2017/0472 , A61B2017/06104 , A61B2018/00601 , A61B2018/0063 , A61B2018/126 , A61B2018/1425 , A61B2090/378
摘要： A ligation device (100) includes a cannula (104) having first and second extendable members (120, 122) and a Doppler wand (140). The Doppler wand (140) permits an anatomical vessel, such as a blood vessel, to be located in close proximity to the distal end of the cannula (104). The extendable members (120, 122) are extendable on two opposite sides of the vessel. A length of ligation material, such as suture material, extends through the first extendable member and is attached to a detachable element (124) mounted to the distal most end of the extendable member. The second extendable member (122) includes a snare (126). The first extendable member (120) includes curved portions which, when the member (120) is extended distally, extend the detachable element (124) into position for the snare (126) so that the snare (126) can grab the loop. Once ensnared, the detachable element (124) is released from the first extendable member (120), which pulls the ligation material around the vessel. The ligation device (100) does not require prior visualization or dissection of the area around the vessel.
摘要翻译：连接装置（100）包括具有第一和第二可延伸构件（120,122）和多普勒杆（140）的套管（104）。多普勒棒（140）允许诸如血管的解剖血管位于紧邻套管（104）的远端附近。可延伸构件（120,122）可在容器的两个相对侧上延伸。连接材料（例如缝合材料）的长度延伸穿过第一可延伸构件并且附接到安装到可延伸构件的最远端的可拆卸元件（124）。第二可延伸构件（122）包括圈套（126）。第一可延伸构件（120）包括弯曲部分，当构件（120）向远侧延伸时，该部分将可拆卸元件（124）延伸到圈套（126）的位置，使得圈套（126）能抓住环路。一旦被捕获，可拆卸元件（124）从第一可延伸构件（120）释放，其将结扎材料拉回容器周围。结扎装置（100）不需要事先观察或解剖血管周围区域。

24. 发明申请

WO02078522A2 MULTI-AXIAL UTERINE ARTERY IDENTIFICATION, CHARACTERIZATION, AND OCCLUSION DEVICES AND METHODS 审中-公开
标题翻译：多轴异位子宫动脉识别，特征和消融装置及方法
公开(公告)号：WO02078522A2
公开(公告)日：2002-10-10
申请号：PCT/US0209549
申请日：2002-03-28
申请人： VASCULAR CONTROL SYSTEMS INC , BURBANK FRED , ALTIERI GRIEG E , JONES MICHAEL L
发明人： BURBANK FRED , ALTIERI GRIEG E , JONES MICHAEL L
IPC分类号： A61B17/12 , A61B5/026 , A61B8/06 , A61B17/00 , A61B17/122 , A61B17/128 , A61B17/42 , A61B18/00 , A61M25/00 , A61B
CPC分类号： A61B17/12 , A61B5/026 , A61B5/415 , A61B5/418 , A61B8/06 , A61B8/12 , A61B17/00234 , A61B17/122 , A61B17/128 , A61B17/1285 , A61B17/2812 , A61B17/42 , A61B2017/0046 , A61B2017/4216
摘要： A system is provided for compressing one or both of the uterine arteries of a patient which is at least in part shaped to complement the shape of the exterior of the cervix, which allows the system to be self-positioning. One or more Doppler chips can be mounted or incorporated into the system which permit the practitioner to better identify the uterine artery and monitor blood flow therein. A tenaculum-like element can be further included which secures the system to the patient's cervix.
摘要翻译：提供了一种用于压缩患者的一个或两个子宫动脉的系统，其至少部分地形状以补充子宫颈外部的形状，这允许系统自我定位。可以将一个或多个多普勒芯片安装或并入系统中，这允许从业者更好地识别子宫动脉并监测其中的血液流动。可以进一步包括将系统固定到患者的子宫颈上的一个类似元件的元件。

25. 发明申请

WO0180713A3 METHODS FOR NON-PERMANENT OCCLUSION OF A UTERINE ARTERY 审中-公开
标题翻译：非永久性肛门动脉闭塞的方法
公开(公告)号：WO0180713A3
公开(公告)日：2002-02-28
申请号：PCT/US0110803
申请日：2001-04-16
申请人： HYSTERX INC , BURBANK FRED , ALTIERI GREIG E , JONES MICHAEL L
发明人： BURBANK FRED , ALTIERI GREIG E , JONES MICHAEL L
IPC分类号： A61B17/00 , A61B17/12 , A61B17/42 , A61K31/045 , A61K31/10 , A61K31/734 , A61K45/06 , A61L24/00 , A61B19/00 , A61B18/18 , A61L15/00 , A61M29/00 , A61B17/36
CPC分类号： A61B17/12136 , A61B17/12009 , A61B17/12022 , A61B17/1204 , A61B17/12186 , A61B17/1219 , A61B2017/00004 , A61B2017/4216 , A61K31/045 , A61K31/10 , A61K31/734 , A61K45/06 , A61L24/0031 , A61L24/0042
摘要： Non-permanent occlusion of the uterine arteries (22) is sufficient to cause the demise of uterine myomata without unnecessarily exposing other tissues and anatomical structures to hypoxia attendant to prior permanent occlusion techniques. A therapeutically effective transient time of occlusion of a uterine artery (22) to treat uterine fibroid tumors (12) is from 1 hours to 24 hours, and preferably is at least about 4 hours. A therapeutically effective temporary time of occlusion of a uterine artery (22) to treat uterine fibroid tumors (12) is from 1 day (24 hours) to 7 days (168 hours), and preferably is about 4 days (96 hours).
摘要翻译：子宫动脉（22）的非永久性闭塞足以引起子宫肌瘤的消失，而不会使其他组织和解剖结构暴露于以前永久闭塞技术的缺氧。子宫动脉（22）闭塞治疗子宫肌瘤（12）的治疗有效瞬时时间为1小时至24小时，优选为至少约4小时。子宫动脉（22）闭塞治疗子宫肌瘤（12）的治疗有效暂时时间为1天（24小时）至7天（168小时），优选约4天（96小时）。

26. 发明申请

WO1997004657A1 NOVEL EMBOLIZING COMPOSITIONS 审中-公开
标题翻译：新颖的组合
公开(公告)号：WO1997004657A1
公开(公告)日：1997-02-13
申请号：PCT/US1996012436
申请日：1996-07-29
申请人： MICRO THERAPEUTICS, INC. , GREFF, Richard, J. , JONES, Michael, L. , EVANS, Scott
发明人： MICRO THERAPEUTICS, INC.
IPC分类号： A01N59/08
CPC分类号： A61L24/08 , A61K49/0414 , A61K49/0419 , A61L24/001 , A61L24/046 , A61L24/06 , A61L2430/36 , C08L29/04 , C08L1/26
摘要： Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery. In one embodiment, the compositions of this invention comprise a biocompatible polymer, a biocompatible solvent and a biocompatible water insoluble contrast agent characterized by having an average particle size of less than about 10 mu m. In another embodiment, the biocompatible polymer in these compositions is replaced with a biocompatible prepolymer.
摘要翻译：公开了用于栓塞血管的新型组合物，其特别适用于通过导管递送治疗血管病变。在一个实施方案中，本发明的组合物包含生物相容性聚合物，生物相容性溶剂和生物相容性水不溶性造影剂，其特征在于平均粒度小于约10μm。在另一个实施方案中，这些组合物中的生物相容性聚合物被生物相容性预聚物代替。

27. 发明申请

WO2011017634A8 PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE 审中-公开
标题翻译： D-氨基酸氧化酶的融合杂环抑制剂的研究进展
公开(公告)号：WO2011017634A8
公开(公告)日：2011-04-14
申请号：PCT/US2010044743
申请日：2010-08-06
申请人： SEPRACOR INC , HEFFERNAN MICHELE L R , DENNIS RICHARD , DORSEY JAMES M , FOGLESONG ROBERT J , JONES MICHAEL L , OGBU CYPRIAN O , SOUKRI MUSTAPHA , SPEAR KERRY L , ORSINI MICHAEL ANTHONY
发明人： HEFFERNAN MICHELE L R , DENNIS RICHARD , DORSEY JAMES M , FOGLESONG ROBERT J , JONES MICHAEL L , OGBU CYPRIAN O , SOUKRI MUSTAPHA , SPEAR KERRY L , ORSINI MICHAEL ANTHONY
IPC分类号： C07D491/153 , A61K31/407 , A61P25/00 , A61P25/28 , C07D491/048
CPC分类号： C07D491/04 , C07D491/14
摘要： The invention relates to prodrugs of fused heterocyclic inhibitors of D-amino oxidase (DAAO) and methods of treating diseases and conditions, wherein modulation of D-amino acid oxidase activity, D-serine levels, D-serine oxidative products and NMDA receptor activity in the nervous system of a mammalian subject is effective.
摘要翻译：本发明涉及D-氨基氧化酶（DAAO）的稠合杂环抑制剂的前药和治疗疾病和病症的方法，其中D-氨基酸氧化酶活性，D-丝氨酸水平，D-丝氨酸氧化产物和NMDA受体活性的调节哺乳动物受试者的神经系统是有效的。

28. 发明申请

WO2010039184A2 POROUS BIOABSORBABLE IMPLANT 审中-公开
标题翻译：多孔可生物植入
公开(公告)号：WO2010039184A2
公开(公告)日：2010-04-08
申请号：PCT/US2009005268
申请日：2009-09-22
申请人： SENORX INC , GOVIL AMIT , JONES MICHAEL L , LUBOCK PAUL
发明人： GOVIL AMIT , JONES MICHAEL L , LUBOCK PAUL
IPC分类号： A61L27/20 , A61L27/50 , A61L27/56 , A61L27/58
CPC分类号： A61L31/146 , A61F2/0077 , A61F2/02 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/148 , A61L31/18 , A61L2300/102 , A61L2300/104 , A61L2300/44
摘要： The bioabsorbable implant described has a porous body formed of bioabsorbable materials that have an in vivo life span of at least 2 weeks, preferably at least three weeks and not greater than 20 weeks, preferably no greater than ten weeks. The implant has a scaffolding structure which facilitates tissue in-growth and ultimately tissue replacement of the scaffolding structure. The implant has a radiopaque imaging agent at least at the exterior margins and an orientation plurality of radiopaque elements in the interior of implant. The implant preferably has three radiopaque elements within the interior that form a plane within the implant interior.
摘要翻译：所描述的生物可吸收植入物具有由生物可吸收材料形成的多孔体，其具有至少2周，优选至少3周且不超过20周，优选不超过10周的体内寿命。植入物具有促进组织生长并最终组织替代脚手架结构的脚手架结构。植入物至少在外部边缘具有不透射线的成像剂，并且在植入物内部具有多个不透射线元件的取向。植入物优选地在内部内具有三个不透射线的元件，其在植入物内部形成平面。

29. 发明申请

WO2009058186A2 SOFT BODY CATHETER WITH LOW FRICTION LUMEN 审中-公开
标题翻译：柔软的身体导管与低摩擦的温度
公开(公告)号：WO2009058186A2
公开(公告)日：2009-05-07
申请号：PCT/US2008011435
申请日：2008-10-03
申请人： SENORX INC , JONES MICHAEL L , LOUW FRANK R
发明人： JONES MICHAEL L , LOUW FRANK R
IPC分类号： A61L29/06 , A61L29/14
CPC分类号： A61L29/18 , A61L29/06 , A61L29/085 , A61L29/14 , A61L2420/06 , C08L75/04
摘要： The disclosure is directed to radiation catheter devices, methods for controlled application of irradiation to tissue at a body site, such as a cavity formed after removal of tissue, e.g. cancer, using such radiation catheter devices, solutions for forming a more lubricious luminal surface and method for lining lumens of such devices to improve the frictional characteristics thereof. The catheter device includes a flexible elongated shaft which is formed of low durometer polymeric material, which can be readily folded or coiled for securing the shaft to or under the skin of the patient and a radiation lumen lined with high durometer polymeric material and finely divided particulate to improve the frictional characteristics. The elongated shaft has at least one inner lumen for receiving a radiation source which has a layer of high durometer polymeric material that provides lower surface friction to facilitate advancement of a radiation source therein.
摘要翻译：本公开涉及辐射导管装置，用于受控地应用照射到身体部位的组织的方法，例如在去除组织后形成的空腔，例如，癌症，使用这种辐射导管装置，用于形成更加光滑的腔表面的解决方案和用于衬里这些装置的流明以提高其摩擦特性的方法。导管装置包括柔性细长轴，其由低硬度聚合物材料形成，其可以容易地折叠或卷绕以将轴固定到患者的皮肤上或皮下，并且内衬有高硬度聚合物材料和细碎颗粒以提高摩擦特性。细长轴具有用于接收辐射源的至少一个内腔，辐射源具有提供较低表面摩擦以便促进其中的辐射源的高硬度聚合材料层。

30. 发明申请

WO2008063638A2 MRI DETECTABLE OBTURATOR 审中-公开
标题翻译： MRI检测器
公开(公告)号：WO2008063638A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/024255
申请日：2007-11-20
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L. , BROADAWAY, Ethan , LOUW, Frank, R.
发明人： LUBOCK, Paul , JONES, Michael, L. , BROADAWAY, Ethan , LOUW, Frank, R.
IPC分类号： A61B19/00
CPC分类号： A61B17/32 , A61B17/3417 , A61B17/3431 , A61B17/3468 , A61B17/3496 , A61B17/3498 , A61B90/39 , A61B2017/00477 , A61B2017/00911 , A61B2090/062 , A61B2090/3908 , A61B2090/3954 , A61B2090/3987
摘要： An obturator with an elongated shaft, a proximal end, a substantially closed distal end and a MRI detectable distal shaft portion, which does not interfere with magnetic resonance imaging of tissue proximate thereto. Preferably, the distal shaft portion has an effective MRI detectable mass so as to provide a clear, T1-weighted image within an outline of the distal shaft portion upon magnetic resonance imaging.
摘要翻译：具有细长轴，近端，基本上封闭的远端和MRI可检测远端轴部分的闭孔器，其不干扰邻近于其的组织的磁共振成像。优选地，远侧轴部分具有有效的MRI检测质量，以便在磁共振成像时在远侧轴部分的轮廓内提供清晰的T1加权图像。

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