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    • 21. 发明申请
    • POWER CONTROL FOR HIGH-SPEED PACKET DATA TRANSMISSION
    • 用于高速分组数据传输的功率控制
    • WO2005062489A1
    • 2005-07-07
    • PCT/SE2003/002053
    • 2003-12-22
    • TELEFONAKTIEBOLAGET LM ERICSSON (publ)CARLSSON, RolandKARLSSON, Torbjörn
    • CARLSSON, RolandKARLSSON, Torbjörn
    • H04B7/005
    • H04W52/60H04W52/262H04W52/286H04W52/34H04W52/367
    • A transmitting unit comprising a first unit (CM_SCHDR) receiving scheduled first data (DATA2, DATA3) for transmission on at least a first channel, a power control unit (PWR_CTRL) for the first channel responsive to a respective closed loop power regulation signal (TCP_CMD), under which at least the transmit power rate of change is limited to a predetermined value per time unit, a packet data scheduler (HS_SCHDR) scheduling second data packets (DATA1), such as HSPDA data, for transmission on at least a second channel at an actual power level (P_H(t)), and a power amplifier (POWER_AMP) amplifying and outputting the scheduled first and second data, whereby the outputted first and second channels are subject to interference from one another, is shown. A possible power (P_POS(t)) is determined at a given instance as the maximum value of either the actual power (P_HS(t-1)) at a previous instance or the possible power determined at a previous instance (P_POS(t-1)), decreasing the maximum value by a predetermined value (d). Moreover, a permitted power (P_PERM(t)) at a given instance as the maximum value of either the actual power of a previous instance (P_HS(t-1)) added with the predetermined value (d) or the determined possible power (P_POS(t)). Finally, the scheduling is performed within these limits.
    • 一种传输单元,包括接收用于在至少第一信道上传输的调度的第一数据(DATA2,DATA3)的第一单元(CM_SCHDR),用于响应于各自的闭环功率调节信号(TCP_CMD)的第一信道的功率控制单元(PWR_CTRL) ),其中至少发射功率变化率被限制为每时间单位的预定值,分组数据调度器(HS_SCHDR)调度第二数据分组(DATA1),诸如HSPDA数据,用于在至少第二信道上进行传输 (P_H(t))和放大并输出调度的第一和第二数据的功率放大器(POWER_AMP),由此输出的第一和第二通道彼此受到干扰。 在给定情况下确定可能的功率(P_POS(t))作为先前情况下的实际功率(P_HS(t-1))或在先前情况下确定的可能功率的最大值(P_POS(t- 1)),将最大值减小预定值(d)。 此外,给定情况下的允许功率(P_PERM(t))作为与预定值(d)相加的先前实例的实际功率(P_HS(t-1))的最大值或所确定的可能功率 P_POS(T))。 最后,在这些限制内进行调度。
    • 22. 发明申请
    • METHOD AND ARRAGEMENT FOR MINIMIZING INTRACELL INTERFERENEC IN A DATA TRANSMISSION SYSTEM
    • 用于在数据传输系统中最小化INTRACELL干扰的方法和装置
    • WO2005060295A1
    • 2005-06-30
    • PCT/SE2003/002047
    • 2003-12-19
    • TELEFONAKTIEBOLAGET LM ERICSSON (publ)CARLSSON, Roland
    • CARLSSON, Roland
    • H04Q7/36
    • H04W72/082H04W16/02H04W16/10H04W16/24H04W64/00H04W72/0413H04W72/0446
    • The invention refers to an arrangement and a method for minimizing intracell and/or intercell interference for a data transmission system comprising a scheduler (2). A first base station (BS) receives information from user equipments (UE1-UE4) in a first cell (1), by means of a first antenna system (Rx, Tx). The scheduler (2) identifies the position of each user is and allots a first time slot (TS1) to at least one user equipment (UE1) in a first cell segment (CS1) in the first cell (1). The scheduler (2) also allots the first time slot to at least one user (UE3) equipment in a second cell segment (CS2) in the first cell (1). The antenna system (Rx, Tx) then sends information from the base station (BS) simultaneously to all user equipments (UE1, UE3) allotted to the first time slot.
    • 本发明涉及一种用于使包含调度器(2)的数据传输系统的小区内和/或小区间干扰最小化的装置和方法。 第一基站(BS)通过第一天线系统(Rx,Tx)从第一小区(1)中的用户设备(UE1-UE4)接收信息。 调度器(2)识别每个用户的位置,并将第一时隙(TS1)分配给第一小区(1)中的第一小区段(CS1)中的至少一个用户设备(UE1)。 调度器(2)还向第一小区(1)中的第二小区段(CS2)中的至少一个用户(UE3)设备分配第一时隙。 然后,天线系统(Rx,Tx)同时向基站(BS)发送分配给第一时隙的所有用户设备(UE1,UE3)的信息。
    • 23. 发明申请
    • A METHOD FOR IN VITRO MOLECULAR EVOLUTION OF PROTEIN FUNCTION
    • WO2003097834A3
    • 2003-11-27
    • PCT/GB2003/002102
    • 2003-05-16
    • ALLIGATOR BIOSCIENCE ABTHOMAS, Philip, John, DuvalFUREBRING, ChristinaCARLSSON, RolandBORREBAECK, Carl, Arne, KristerMALMBORG, Hager, Ann-Christin
    • FUREBRING, ChristinaCARLSSON, RolandBORREBAECK, Carl, Arne, KristerMALMBORG, Hager, Ann-Christin
    • C12N15/10
    • A method for in vitro molecular evolution of protein function The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single-stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of (a) providing a first population of single-stranded polynucleotide molecules and a second population of single-stranded polynucleotide molecules, the first and second populations together constituting plus and minus strands of parent polynucleotide sequences, (b) carrying out a reaction for digesting the first and second populations of single-stranded polynucleotide molecules with an exonuclease to generate corresponding populations of single-stranded polynucleotide fragments, (c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3'and 5'ends of at least one of the parent polynucleotides under annealing conditions, and (d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by said parent polynucleotides, wherein, in step (b), at least one parameter of the reaction used for digestion of the first population of single-stranded polynucleotide molecules is different from the equivalent parameter(s) used in the reaction for digestion of the second population of single-stranded polynucleotide molecules. Preferably, the reaction parameter is selected from exonuclease type, exonuclease concentration, reaction volume, duration of the digestion reaction, temperature of the reaction mixture, pH of the reaction mixture, length of parent single­-stranded polynucleotide sequences, amount of single-stranded polynucleotide molecules and buffer composition of the reaction mixture.
    • 24. 发明申请
    • A METHOD FOR <i>IN VITRO</i> MOLECULAR EVOLUTION OF ANTIBODY FUNCTION
    • 抗体功能的体外分子生物学方法
    • WO0175091A3
    • 2002-04-18
    • PCT/EP0104065
    • 2001-04-04
    • BIOINVENT INT ABOHLIN MATSSODERLIND ESKILCARLSSON ROLAND
    • OHLIN MATSSODERLIND ESKILCARLSSON ROLAND
    • C12N15/09C07K16/00C12N15/13C40B10/00C07K16/46C12N15/10C12N15/92
    • C12N15/1058C07K16/00C07K2317/56C07K2317/565C07K2317/567C07K2317/622C40B10/00
    • The present invention provides a method for producing a polynucleotide sequence encoding an antibody variable domain, the variable domain comprising complementarity-determining regions (CDRs) located within a selected framework (the 'master framework'), the method comprising the steps of (a) providing at least one nucleic acid molecule encoding one or more CDRs and associated framework regions (the 'original framework'), (b) amplifying at least one CDR-encoding portion of the nucleic acid molecule(s) of step (a) using one or more pairs of oligonucleotides as amplification primers and (c) assembling a polynucleotide sequence encoding an antibody variable domain by combining the amplified CDR-encoding nucleotide sequences produced in step (b) with nucleotide sequences encoding said master framework, wherein the oligonucleotide primers of step (b) comprise nucleotide sequences which differ from the corresponding nucleotide sequences encoding said master framework. The invention further provides an antibody library, such as a phage display library, and methods of making the same.
    • 本发明提供了一种制备编码抗体可变结构域的多核苷酸序列的方法,该可变结构域包含位于选定框架内的互补决定区(CDR)(该“主框架”),该方法包括以下步骤:(a) 提供至少一个编码一个或多个CDR和相关框架区的核酸分子(“原始框架”),(b)使用一个或多个CDR扩增步骤(a)的核酸分子的至少一个CDR编码部分 或更多对寡核苷酸作为扩增引物,和(c)通过将步骤(b)中产生的扩增的CDR编码核苷酸序列与编码所述主框架的核苷酸序列组合来组装编码抗体可变结构域的多核苷酸序列,其中步骤 (b)包含与编码所述主框架的相应核苷酸序列不同的核苷酸序列。 本发明还提供了抗体文库,例如噬菌体展示文库,及其制备方法。
    • 26. 发明申请
    • PACKET LATENCY ESTIMATION
    • 分组预测估计
    • WO2009141012A1
    • 2009-11-26
    • PCT/EP2008/056367
    • 2008-05-23
    • TELEFONAKTIEBOLAGET L M ERICSSON (PUBL)CARLSSON, RolandMÄLLO, Aare
    • CARLSSON, RolandMÄLLO, Aare
    • H04L12/56
    • H04L43/16H04L43/0852H04L2001/0097
    • Intermediary node (14) adapted for receiving a sequence of a packets from a server (10) the intermediary node comprising a time estimator (103) adapted for performing the following steps - resolving the sequence number (k) and time of arrival to the intermediary node for at least a plurality (q) of incoming packets (21); - establishing the frame period of the incoming packets (T)(22); - establishing (23) a sequence of normalized packet arrival times (e k ) as corresponding to the sensed frame period (T); - calculating (24) the relative arrival time rtr ec, k of the plurality (q) of incoming packets in relation to the normalized packet arrival times; - creating (25) a cumulative density function (CDF) for a given sequence of packets; - establishing (26) the threshold value for the relative arrival time rt PL yielding the predefined packet loss (PL) based on the cumulative density function (CDF).
    • 适于从服务器(10)接收包的序列的中间节点(14),所述中间节点包括适于执行以下步骤的时间估计器(103) - 解析所述序列号(k)和到达所述中间件的到达时间 用于至少多个(q)输入分组(21)的节点; - 建立传入分组(T)(22)的帧周期; - 建立(23)对应于所感测的帧周期(T)的归一化分组到达时间(ek)的序列; - 计算(24)相对于归一化分组到达时间的多个(q)输入分组的相对到达时间rtrec,k; - 为给定的分组序列创建(25)累积密度函数(CDF); - 建立(26)基于累积密度函数(CDF)产生预定义分组丢失(PL)的相对到达时间rtPL的阈值。
    • 28. 发明申请
    • POWER CONTROL FOR HIGH-SPEED PACKET DATA TRANSMISSION
    • 用于高速分组数据传输的功率控制
    • WO2005062490A1
    • 2005-07-07
    • PCT/SE2004/001422
    • 2004-10-05
    • TELEFONAKTIEBOLAGET LM ERICSSON (publ)CARLSSON, RolandKARLSSON, Torbjörn
    • CARLSSON, RolandKARLSSON, Torbjörn
    • H04B7/005
    • H04W52/60H04W52/262H04W52/286H04W52/34H04W52/367
    • Transmission unit comprising a first unit (CM_SCHDR) receiving scheduled first data (DATA2, DATA3) for transmission on at least a first channel, a power control unit (PWR_CTRL) for the first channel responsive to a respective closed loop power regula-tion signal (TCP_CMD), under which at least the transmit power rate of change is limited to a predetermined value per time unit, a packet data scheduler (HS_SCHDR) schedul-ing second data packets (DATA1), such as HSDPA data. A permitted power (P_PERM(t)) is defined as the maximum value of either the actual power of a previous instance (P_HS(t-1)) added with the predetermined value (d) or the determined possible power (P_POS(t)). Moreover, an available power is resolved. According to one aspect, the scheduling is performed within these limits. According to a further aspect the power level of the signaling and control channel (HS-SCCH) is further regulated during a transmission interval taking account of shared packet data channel (HS-PDSCH) power level.
    • 传输单元包括接收用于在至少第一信道上传输的调度的第一数据(DATA2,DATA3)的第一单元(CM_SCHDR),用于响应于各自的闭环功率调节信号的第一信道的功率控制单元(PWR_CTRL) TCP_CMD),其中至少发射功率变化率被限制为每时间单位的预定值,分组数据调度器(HS_SCHDR)调度第二数据分组(DATA1),诸如HSDPA数据。 允许功率(P_PERM(t))被定义为加上预定值(d)或所确定的可能功率(P_POS(t))的先前实例的实际功率(P_HS(t-1))的最大值 )。 此外,解决了可用功率。 根据一个方面,在这些限制内进行调度。 根据另一方面,信令和控制信道(HS-SCCH)的功率电平在考虑共享分组数据信道(HS-PDSCH)功率电平的传输间隔期间被进一步调节。
    • 29. 发明申请
    • ANTIBODIES FOR USE IN CANCER THERAPY AND DIAGNOSIS
    • 用于癌症治疗和诊断的抗体
    • WO1996022310A1
    • 1996-07-25
    • PCT/SE1996000029
    • 1996-01-15
    • BIOINVENT INTERNATIONAL ABCARLSSON, RolandJANSSON, Bo
    • BIOINVENT INTERNATIONAL AB
    • C07K16/30
    • C07K16/3046A61K38/00C07K2317/732
    • The present invention discloses the PA1-3F10 monoclonal antibody and a hybridoma cell line producing it. The antibody is shown to bind to a variety of carcinomas and malignant cells with haematopoietic origin with a high intensity and degree of selectivity as demonstrated by immunohistochemistry analysis and cell binding assays. The invention also includes antibodies having substantially the same binding specificity as the monoclonal antibody PA1-3F10, and mutants, derivatives, functional equivalents or fragments of the antibody. Applications of the antibodies include the therapy or diagnosis of cancer, e.g. in targetting cytotoxic compounds to cancer cells. In particular, the present invention relates to cancer therapy and diagnosis of colorectal cancer.
    • 本发明公开了PA1-3F10单克隆抗体和产生它的杂交瘤细胞系。 抗体通过免疫组织化学分析和细胞结合测定证明可以与造血来源的多种癌和恶性细胞结合,具有高强度和高度的选择性。 本发明还包括具有与单克隆抗体PA1-3F10基本相同的结合特异性的抗体,以及抗体的突变体,衍生物,功能等同物或片段。 抗体的应用包括癌症的治疗或诊断,例如。 将细胞毒性化合物靶向癌细胞。 特别地,本发明涉及癌症治疗和结肠直肠癌的诊断。